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Pancreatic Intraepithelial Neoplasia-1

MedGen UID:
232568
•Concept ID:
C1333869
•
Neoplastic Process
Synonyms: Grade 1 Pancreatic Intraepithelial Neoplasia; Grade I Pancreatic Intraepithelial Neoplasia

Definition

A pancreatic intraepithelial neoplasia characterized by the presence of tall columnar cells that form flat or papillary, micropapillary, and basally pseudostratified architectural patterns. Mild cytological atypia is present. [from NCI]

Recent clinical studies

Etiology

Expression of Chosen Carcinoembryonic-Related Cell Adhesion Molecules in Pancreatic Intraepithelial Neoplasia (PanIN) Associated with Chronic Pancreatitis and Pancreatic Ductal Adenocarcinoma (PDAC).
Zińczuk J, Zaręba K, Romaniuk W, Kamińska D, Nizioł M, Baszun M, Kędra B, Guzińska-Ustymowicz K, Pryczynicz A
Int J Med Sci 2019;16(4):583-592. Epub 2019 Apr 25 doi: 10.7150/ijms.32751. PMID: 31171910Free PMC Article
Clinical Characteristics of Patients Experiencing Pathologic Complete Response Following Neoadjuvant Therapy for Borderline Resectable/Locally Advanced Pancreatic Adenocarcinoma.
Hashemi-Sadraei N, Gbolahan OB, Salfity H, O'Neil B, House MG, Shahda S
Am J Clin Oncol 2018 Oct;41(10):982-985. doi: 10.1097/COC.0000000000000409. PMID: 28968257
Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.
Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M
Cancer Cell 2017 Dec 11;32(6):824-839.e8. Epub 2017 Nov 16 doi: 10.1016/j.ccell.2017.10.011. PMID: 29153842Free PMC Article
Can endoscopic ultrasound predict pancreatic intraepithelial neoplasia lesions in chronic pancreatitis?: a retrospective study of pathologic correlation.
LeBlanc JK, Chen JH, Al-Haddad M, Luz L, McHenry L, Sherman S, Juan M, Dewitt J
Pancreas 2014 Aug;43(6):849-54. doi: 10.1097/MPA.0000000000000142. PMID: 24826885
Five years of prospective screening of high-risk individuals from families with familial pancreatic cancer.
Langer P, Kann PH, Fendrich V, Habbe N, Schneider M, Sina M, Slater EP, Heverhagen JT, Gress TM, Rothmund M, Bartsch DK
Gut 2009 Oct;58(10):1410-8. Epub 2009 May 25 doi: 10.1136/gut.2008.171611. PMID: 19470496

Diagnosis

CRABP-II is a highly sensitive and specific diagnostic molecular marker for pancreatic ductal adenocarcinoma in distinguishing from benign pancreatic conditions.
Xiao W, Hong H, Awadallah A, Yu S, Zhou L, Xin W
Hum Pathol 2014 Jun;45(6):1177-83. Epub 2014 Jan 31 doi: 10.1016/j.humpath.2014.01.014. PMID: 24709110Free PMC Article
Immunohistochemistry for cell polarity protein lethal giant larvae 2 differentiates pancreatic intraepithelial neoplasia-3 and ductal adenocarcinoma of the pancreas from lower-grade pancreatic intraepithelial neoplasias.
Lisovsky M, Dresser K, Woda B, Mino-Kenudson M
Hum Pathol 2010 Jun;41(6):902-9. Epub 2010 Mar 16 doi: 10.1016/j.humpath.2009.12.004. PMID: 20233622
Five years of prospective screening of high-risk individuals from families with familial pancreatic cancer.
Langer P, Kann PH, Fendrich V, Habbe N, Schneider M, Sina M, Slater EP, Heverhagen JT, Gress TM, Rothmund M, Bartsch DK
Gut 2009 Oct;58(10):1410-8. Epub 2009 May 25 doi: 10.1136/gut.2008.171611. PMID: 19470496

Therapy

Clinical Characteristics of Patients Experiencing Pathologic Complete Response Following Neoadjuvant Therapy for Borderline Resectable/Locally Advanced Pancreatic Adenocarcinoma.
Hashemi-Sadraei N, Gbolahan OB, Salfity H, O'Neil B, House MG, Shahda S
Am J Clin Oncol 2018 Oct;41(10):982-985. doi: 10.1097/COC.0000000000000409. PMID: 28968257

Prognosis

Clinical Characteristics of Patients Experiencing Pathologic Complete Response Following Neoadjuvant Therapy for Borderline Resectable/Locally Advanced Pancreatic Adenocarcinoma.
Hashemi-Sadraei N, Gbolahan OB, Salfity H, O'Neil B, House MG, Shahda S
Am J Clin Oncol 2018 Oct;41(10):982-985. doi: 10.1097/COC.0000000000000409. PMID: 28968257
Can endoscopic ultrasound predict pancreatic intraepithelial neoplasia lesions in chronic pancreatitis?: a retrospective study of pathologic correlation.
LeBlanc JK, Chen JH, Al-Haddad M, Luz L, McHenry L, Sherman S, Juan M, Dewitt J
Pancreas 2014 Aug;43(6):849-54. doi: 10.1097/MPA.0000000000000142. PMID: 24826885

Clinical prediction guides

Expression of Chosen Carcinoembryonic-Related Cell Adhesion Molecules in Pancreatic Intraepithelial Neoplasia (PanIN) Associated with Chronic Pancreatitis and Pancreatic Ductal Adenocarcinoma (PDAC).
Zińczuk J, Zaręba K, Romaniuk W, Kamińska D, Nizioł M, Baszun M, Kędra B, Guzińska-Ustymowicz K, Pryczynicz A
Int J Med Sci 2019;16(4):583-592. Epub 2019 Apr 25 doi: 10.7150/ijms.32751. PMID: 31171910Free PMC Article
Can endoscopic ultrasound predict pancreatic intraepithelial neoplasia lesions in chronic pancreatitis?: a retrospective study of pathologic correlation.
LeBlanc JK, Chen JH, Al-Haddad M, Luz L, McHenry L, Sherman S, Juan M, Dewitt J
Pancreas 2014 Aug;43(6):849-54. doi: 10.1097/MPA.0000000000000142. PMID: 24826885
CRABP-II is a highly sensitive and specific diagnostic molecular marker for pancreatic ductal adenocarcinoma in distinguishing from benign pancreatic conditions.
Xiao W, Hong H, Awadallah A, Yu S, Zhou L, Xin W
Hum Pathol 2014 Jun;45(6):1177-83. Epub 2014 Jan 31 doi: 10.1016/j.humpath.2014.01.014. PMID: 24709110Free PMC Article

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