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Iris spindle cell melanoma

MedGen UID:
232672
•Concept ID:
C1334287
•
Neoplastic Process
Synonyms: Iris Spindle Cell Melanoma; iris spindle cell melanoma; Spindle Cell Melanoma of Iris; spindle cell melanoma of iris; Spindle Cell Melanoma of the Iris; spindle cell melanoma of the iris
 
Monarch Initiative: MONDO:0004188

Definition

A melanoma that arises from the iris. It is characterized by the presence of spindle-shaped melanocytes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIris spindle cell melanoma

Professional guidelines

PubMed

Genetic findings in treatment-naïve and proton-beam-radiated iris melanomas.
Krishna Y, Kalirai H, Thornton S, Damato BE, Heimann H, Coupland SE
Br J Ophthalmol 2016 Jul;100(7):1012-1016. Epub 2016 Apr 20 doi: 10.1136/bjophthalmol-2015-308301. PMID: 27098748
Primary iris melanoma: diagnostic features and outcome of conservative surgical treatment.
Conway RM, Chua WC, Qureshi C, Billson FA
Br J Ophthalmol 2001 Jul;85(7):848-54. doi: 10.1136/bjo.85.7.848. PMID: 11423461Free PMC Article
Tumours of the anterior uvea. III. Oxytalan fibres in the differential diagnosis of leiomyoma and malignant melanoma of the iris.
Noor Sunba MS, Rahi AH, Garner A, Alexander RA, Morgan G
Br J Ophthalmol 1980 Nov;64(11):867-74. doi: 10.1136/bjo.64.11.867. PMID: 7426559Free PMC Article

Recent clinical studies

Etiology

Iris melanoma in an Australian cohort.
McGrath LA, Warrier SK, Glasson WJ, D'Mellow MG, Hamilton HR, Palmer JM, Brooks KM, Johansson PA, Hayward NK
Clin Exp Ophthalmol 2024 Nov;52(8):880-887. Epub 2024 Jul 24 doi: 10.1111/ceo.14424. PMID: 39048918
No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.
Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
Clinical and pathologic characteristics of biopsy-proven iris melanoma: a multicenter international study.
Khan S, Finger PT, Yu GP, Razzaq L, Jager MJ, de Keizer RJ, Sandkull P, Seregard S, Gologorsky D, Schefler AC, Murray TG, Kivelä T, Giuliari GP, McGowan H, Simpson ER, Corriveau C, Coupland SE, Damato BE
Arch Ophthalmol 2012 Jan;130(1):57-64. Epub 2011 Sep 12 doi: 10.1001/archophthalmol.2011.286. PMID: 21911649
Iris melanoma.
Henderson E, Margo CE
Arch Pathol Lab Med 2008 Feb;132(2):268-72. doi: 10.5858/2008-132-268-IM. PMID: 18251588
Iris melanomas.
Geisse LJ, Robertson DM
Am J Ophthalmol 1985 Jun 15;99(6):638-48. doi: 10.1016/s0002-9394(14)76028-3. PMID: 4014387

Diagnosis

Iris melanoma in an Australian cohort.
McGrath LA, Warrier SK, Glasson WJ, D'Mellow MG, Hamilton HR, Palmer JM, Brooks KM, Johansson PA, Hayward NK
Clin Exp Ophthalmol 2024 Nov;52(8):880-887. Epub 2024 Jul 24 doi: 10.1111/ceo.14424. PMID: 39048918
Malignant transformation of multifocal tapioca iris nevus in a child.
Harley MR, Rao R, Lally SE, Shields CL
J AAPOS 2017 Aug;21(4):340-342. Epub 2017 Jun 16 doi: 10.1016/j.jaapos.2017.06.007. PMID: 28630029
Three dermoscopic signs of growth of pigmented lesions.
Woltsche N, Piana S, Ferrara G, Hofmann-Wellenhof R, Zalaudek I
J Am Acad Dermatol 2015 Oct;73(4):e133-5. doi: 10.1016/j.jaad.2015.06.032. PMID: 26369851
Iris melanoma.
Henderson E, Margo CE
Arch Pathol Lab Med 2008 Feb;132(2):268-72. doi: 10.5858/2008-132-268-IM. PMID: 18251588
Iris melanomas.
Geisse LJ, Robertson DM
Am J Ophthalmol 1985 Jun 15;99(6):638-48. doi: 10.1016/s0002-9394(14)76028-3. PMID: 4014387

Therapy

Iris melanoma in an Australian cohort.
McGrath LA, Warrier SK, Glasson WJ, D'Mellow MG, Hamilton HR, Palmer JM, Brooks KM, Johansson PA, Hayward NK
Clin Exp Ophthalmol 2024 Nov;52(8):880-887. Epub 2024 Jul 24 doi: 10.1111/ceo.14424. PMID: 39048918
No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.
Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
Orbital recurrence of iris melanoma 21 years after enucleation.
Bergeron E, Lihimdi N, Bergeron D, Landreville S
BMJ Case Rep 2017 Sep 7;2017 doi: 10.1136/bcr-2017-221137. PMID: 28882848Free PMC Article
Malignant transformation of multifocal tapioca iris nevus in a child.
Harley MR, Rao R, Lally SE, Shields CL
J AAPOS 2017 Aug;21(4):340-342. Epub 2017 Jun 16 doi: 10.1016/j.jaapos.2017.06.007. PMID: 28630029
Nucleolar organizer regions in iris nevi and melanomas.
Marcus DM, Mawn LA, Egan KM, Albert DM
Am J Ophthalmol 1992 Aug 15;114(2):202-7. doi: 10.1016/s0002-9394(14)73985-6. PMID: 1642296

Prognosis

Iris melanoma in an Australian cohort.
McGrath LA, Warrier SK, Glasson WJ, D'Mellow MG, Hamilton HR, Palmer JM, Brooks KM, Johansson PA, Hayward NK
Clin Exp Ophthalmol 2024 Nov;52(8):880-887. Epub 2024 Jul 24 doi: 10.1111/ceo.14424. PMID: 39048918
No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.
Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
Clinical and pathologic characteristics of biopsy-proven iris melanoma: a multicenter international study.
Khan S, Finger PT, Yu GP, Razzaq L, Jager MJ, de Keizer RJ, Sandkull P, Seregard S, Gologorsky D, Schefler AC, Murray TG, Kivelä T, Giuliari GP, McGowan H, Simpson ER, Corriveau C, Coupland SE, Damato BE
Arch Ophthalmol 2012 Jan;130(1):57-64. Epub 2011 Sep 12 doi: 10.1001/archophthalmol.2011.286. PMID: 21911649
Iris melanoma.
Henderson E, Margo CE
Arch Pathol Lab Med 2008 Feb;132(2):268-72. doi: 10.5858/2008-132-268-IM. PMID: 18251588
Iris melanomas.
Geisse LJ, Robertson DM
Am J Ophthalmol 1985 Jun 15;99(6):638-48. doi: 10.1016/s0002-9394(14)76028-3. PMID: 4014387

Clinical prediction guides

No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.
Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
Ciliary body schwannoma successfully treated by local resection.
Goto H, Mori H, Shirato S, Usui M
Jpn J Ophthalmol 2006 Nov-Dec;50(6):543-546. Epub 2006 Dec 18 doi: 10.1007/s10384-006-0362-9. PMID: 17180530
Pathological and prognostic features of uveal melanomas.
McLean IW, Saraiva VS, Burnier MN Jr
Can J Ophthalmol 2004 Jun;39(4):343-50. doi: 10.1016/s0008-4182(04)80004-8. PMID: 15327098
Diffuse iris melanoma: a report of 25 cases.
Demirci H, Shields CL, Shields JA, Eagle RC Jr, Honavar SG
Ophthalmology 2002 Aug;109(8):1553-60. doi: 10.1016/s0161-6420(02)01104-1. PMID: 12153810
Primary iris melanoma: diagnostic features and outcome of conservative surgical treatment.
Conway RM, Chua WC, Qureshi C, Billson FA
Br J Ophthalmol 2001 Jul;85(7):848-54. doi: 10.1136/bjo.85.7.848. PMID: 11423461Free PMC Article

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