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Middle ear squamous cell carcinoma

MedGen UID:
233191
•Concept ID:
C1334762
•
Neoplastic Process
Synonyms: Epidermoid Carcinoma of Middle Ear; epidermoid carcinoma of middle Ear; Epidermoid Carcinoma of the Middle Ear; epidermoid carcinoma of the middle Ear; epidermoid carcinoma of the middle ear; Middle Ear Epidermoid Carcinoma; middle Ear epidermoid carcinoma; Middle Ear Squamous Cell Carcinoma; middle ear squamous cell carcinoma; Squamous Cell Carcinoma of Middle Ear; squamous cell carcinoma of middle Ear; squamous cell carcinoma of middle ear; Squamous Cell Carcinoma of the Middle Ear; squamous cell carcinoma of the middle Ear
 
Monarch Initiative: MONDO:0006303

Definition

A rare squamous cell carcinoma that arises from the middle ear. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMiddle ear squamous cell carcinoma

Professional guidelines

PubMed

Treatment outcomes after definitive radio(chemo)therapy for 17 lacrimal sac squamous cell carcinoma.
Song X, He H, Zhu Y, Wang S, Wang J, Wang W, Li Y
Br J Radiol 2020 Nov 1;93(1115):20190633. Epub 2020 Oct 6 doi: 10.1259/bjr.20190633. PMID: 32970475Free PMC Article
Clinical management and outcomes of lacrimal sac squamous cell carcinoma.
Song X, Wang S, Wang J, Wang W, Wang S, Yang G, Li J, Zhu Y, Chen F, Zhu W
Head Neck 2019 Apr;41(4):974-981. Epub 2019 Jan 10 doi: 10.1002/hed.25529. PMID: 30629760
Head and Neck Cancer: A Review of the Impact of Treatment Delay on Outcome.
Coca-Pelaz A, Takes RP, Hutcheson K, Saba NF, Haigentz M Jr, Bradford CR, de Bree R, Strojan P, Lund VJ, Mendenhall WM, Nixon IJ, Quer M, Rinaldo A, Ferlito A
Adv Ther 2018 Feb;35(2):153-160. Epub 2018 Feb 2 doi: 10.1007/s12325-018-0663-7. PMID: 29396681

Recent clinical studies

Etiology

Clinical outcomes of temporal bone squamous cell carcinoma: A single-institution experience.
Zheng Y, Qiu K, Fu Y, Yang W, Cheng D, Rao Y, Mao M, Song Y, Xu W, Ren J, Zhao Y
Cancer Med 2023 Mar;12(5):5304-5311. Epub 2022 Oct 13 doi: 10.1002/cam4.5338. PMID: 36229984Free PMC Article
Expression of reversion-inducing cysteine-rich protein with kazal motifs and matrix metalloproteinase 9 in middle ear squamous cell carcinoma.
Liu X, Wang W, Chen J, Chen C, Zhou J, Cao L
ORL J Otorhinolaryngol Relat Spec 2012;74(1):16-21. Epub 2011 Dec 16 doi: 10.1159/000334243. PMID: 22178867
Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma.
Cristalli G, Manciocco V, Pichi B, Marucci L, Arcangeli G, Telera S, Spriano G
J Craniofac Surg 2009 May;20(3):816-21. doi: 10.1097/SCS.0b013e3181a14b99. PMID: 19381105
Bilateral middle ear squamous cell carcinoma and clinical review of an additional 5 cases of middle ear carcinomas.
Suzuki K, Takahashi M, Ito Y, Tsuge I, Motai H, Takeichi Y, Baba S
Auris Nasus Larynx 1999 Jan;26(1):33-8. doi: 10.1016/s0385-8146(98)00025-x. PMID: 10077254

Diagnosis

Clinical outcomes of temporal bone squamous cell carcinoma: A single-institution experience.
Zheng Y, Qiu K, Fu Y, Yang W, Cheng D, Rao Y, Mao M, Song Y, Xu W, Ren J, Zhao Y
Cancer Med 2023 Mar;12(5):5304-5311. Epub 2022 Oct 13 doi: 10.1002/cam4.5338. PMID: 36229984Free PMC Article
Left Chronic Otitis Media with Squamous Cell Carcinoma of the Middle Ear and Postauricular Mastoid Fistula: A Case Report.
Acharya SP, Pathak C, Giri S, Bista M, Mandal D
JNMA J Nepal Med Assoc 2020 May 30;58(225):341-344. doi: 10.31729/jnma.4954. PMID: 32538931Free PMC Article
Giant middle ear squamous cell carcinoma mimicking as cholesteatoma.
Tomazic PV, Ropposch T, Karpf EF, Nemetz U, Braun EM, Lackner A, Walch C
Otol Neurotol 2012 Jul;33(5):e39-40. doi: 10.1097/MAO.0b013e31823dbd1b. PMID: 22193618
A case of bilateral middle-ear squamous cell carcinoma.
Takano A, Takasaki K, Kumagami H, Higami Y, Kobayashi T
J Laryngol Otol 2001 Oct;115(10):815-8. doi: 10.1258/0022215011909035. PMID: 11667995
Bilateral middle ear squamous cell carcinoma and clinical review of an additional 5 cases of middle ear carcinomas.
Suzuki K, Takahashi M, Ito Y, Tsuge I, Motai H, Takeichi Y, Baba S
Auris Nasus Larynx 1999 Jan;26(1):33-8. doi: 10.1016/s0385-8146(98)00025-x. PMID: 10077254

Prognosis

Clinical outcomes of temporal bone squamous cell carcinoma: A single-institution experience.
Zheng Y, Qiu K, Fu Y, Yang W, Cheng D, Rao Y, Mao M, Song Y, Xu W, Ren J, Zhao Y
Cancer Med 2023 Mar;12(5):5304-5311. Epub 2022 Oct 13 doi: 10.1002/cam4.5338. PMID: 36229984Free PMC Article
Evaluating the prognostic contributions of TNM classifications and building novel staging schemes for middle ear squamous cell carcinoma.
Qiu K, Pang W, Qiu J, Li J, Cheng D, Rao Y, Dong Y, Mao M, Liu Q, Mu X, Zhang W, Xu W, Ren J, Zhao Y
Cancer Med 2021 Nov;10(22):7958-7967. Epub 2021 Sep 24 doi: 10.1002/cam4.4306. PMID: 34559476Free PMC Article
Expression of reversion-inducing cysteine-rich protein with kazal motifs and matrix metalloproteinase 9 in middle ear squamous cell carcinoma.
Liu X, Wang W, Chen J, Chen C, Zhou J, Cao L
ORL J Otorhinolaryngol Relat Spec 2012;74(1):16-21. Epub 2011 Dec 16 doi: 10.1159/000334243. PMID: 22178867
Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma.
Cristalli G, Manciocco V, Pichi B, Marucci L, Arcangeli G, Telera S, Spriano G
J Craniofac Surg 2009 May;20(3):816-21. doi: 10.1097/SCS.0b013e3181a14b99. PMID: 19381105
Bilateral middle ear squamous cell carcinoma and clinical review of an additional 5 cases of middle ear carcinomas.
Suzuki K, Takahashi M, Ito Y, Tsuge I, Motai H, Takeichi Y, Baba S
Auris Nasus Larynx 1999 Jan;26(1):33-8. doi: 10.1016/s0385-8146(98)00025-x. PMID: 10077254

Clinical prediction guides

Clinical outcomes of temporal bone squamous cell carcinoma: A single-institution experience.
Zheng Y, Qiu K, Fu Y, Yang W, Cheng D, Rao Y, Mao M, Song Y, Xu W, Ren J, Zhao Y
Cancer Med 2023 Mar;12(5):5304-5311. Epub 2022 Oct 13 doi: 10.1002/cam4.5338. PMID: 36229984Free PMC Article
Evaluating the prognostic contributions of TNM classifications and building novel staging schemes for middle ear squamous cell carcinoma.
Qiu K, Pang W, Qiu J, Li J, Cheng D, Rao Y, Dong Y, Mao M, Liu Q, Mu X, Zhang W, Xu W, Ren J, Zhao Y
Cancer Med 2021 Nov;10(22):7958-7967. Epub 2021 Sep 24 doi: 10.1002/cam4.4306. PMID: 34559476Free PMC Article
Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma.
Cristalli G, Manciocco V, Pichi B, Marucci L, Arcangeli G, Telera S, Spriano G
J Craniofac Surg 2009 May;20(3):816-21. doi: 10.1097/SCS.0b013e3181a14b99. PMID: 19381105
Bilateral middle ear squamous cell carcinoma and clinical review of an additional 5 cases of middle ear carcinomas.
Suzuki K, Takahashi M, Ito Y, Tsuge I, Motai H, Takeichi Y, Baba S
Auris Nasus Larynx 1999 Jan;26(1):33-8. doi: 10.1016/s0385-8146(98)00025-x. PMID: 10077254

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