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Head and Neck Keratinizing Squamous Cell Carcinoma

MedGen UID:
317808
•Concept ID:
C1708602
•
Neoplastic Process
Synonym: Keratinizing Head and Neck Squamous Cell Carcinoma

Definition

A squamous cell carcinoma that arises from the head and neck region and is characterized by prominent production of keratin. [from NCI]

Professional guidelines

PubMed

Treatment of Metastatic Eyelid Carcinoma.
Bonavolontà P, Dell'Aversana Orabona G, Abbate V, Iaconetta G, Bonavolontà G, Califano L
J Craniofac Surg 2017 Nov;28(8):e722-e725. doi: 10.1097/SCS.0000000000003847. PMID: 28885435
How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
López F, Williams MD, Cardesa A, Hunt JL, Strojan P, Rinaldo A, Nixon IJ, Rodrigo JP, Saba NF, Mendenhall WM, Quer M, Suárez C, Ferlito A
Eur Arch Otorhinolaryngol 2017 Jul;274(7):2709-2726. Epub 2017 Mar 31 doi: 10.1007/s00405-017-4533-8. PMID: 28364287
Role of cytology in the diagnosis and management of HPV-associated head and neck carcinoma.
Krane JF
Acta Cytol 2013;57(2):117-26. Epub 2013 Feb 28 doi: 10.1159/000346715. PMID: 23406782

Recent clinical studies

Etiology

Comprehensive single-cell transcriptomic and proteomic analysis reveals NK cell exhaustion and unique tumor cell evolutionary trajectory in non-keratinizing nasopharyngeal carcinoma.
Chen C, Wang C, Pang R, Liu H, Yin W, Chen J, Tao L
J Transl Med 2023 Apr 25;21(1):278. doi: 10.1186/s12967-023-04112-8. PMID: 37098551Free PMC Article
Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus-Unrelated Head and Neck Cancer: A Multicenter, Phase II Trial.
Uppaluri R, Campbell KM, Egloff AM, Zolkind P, Skidmore ZL, Nussenbaum B, Paniello RC, Rich JT, Jackson R, Pipkorn P, Michel LS, Ley J, Oppelt P, Dunn GP, Barnell EK, Spies NC, Lin T, Li T, Mulder DT, Hanna Y, Cirlan I, Pugh TJ, Mudianto T, Riley R, Zhou L, Jo VY, Stachler MD, Hanna GJ, Kass J, Haddad R, Schoenfeld JD, Gjini E, Lako A, Thorstad W, Gay HA, Daly M, Rodig SJ, Hagemann IS, Kallogjeri D, Piccirillo JF, Chernock RD, Griffith M, Griffith OL, Adkins DR
Clin Cancer Res 2020 Oct 1;26(19):5140-5152. Epub 2020 Jul 14 doi: 10.1158/1078-0432.CCR-20-1695. PMID: 32665297Free PMC Article
Survival outcomes after treatment of cancer of the oral cavity (1985-2015).
Zanoni DK, Montero PH, Migliacci JC, Shah JP, Wong RJ, Ganly I, Patel SG
Oral Oncol 2019 Mar;90:115-121. Epub 2019 Feb 15 doi: 10.1016/j.oraloncology.2019.02.001. PMID: 30846169Free PMC Article
Infectious Agents Associated with Head and Neck Carcinomas.
Hettmann A, Demcsák A, Decsi G, Bach Á, Pálinkó D, Rovó L, Nagy K, Takács M, Minarovits J
Adv Exp Med Biol 2016;897:63-80. doi: 10.1007/5584_2015_5005. PMID: 26563307
Carcinoma of the head and neck in the HPV era.
Cardesa A, Nadal A
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):161-73. PMID: 22131117

Diagnosis

Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
Human papillomavirus-related head and neck squamous cell carcinoma variants.
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342
New insights into human papillomavirus-associated head and neck squamous cell carcinoma.
Boscolo-Rizzo P, Del Mistro A, Bussu F, Lupato V, Baboci L, Almadori G, DA Mosto MC, Paludetti G
Acta Otorhinolaryngol Ital 2013 Apr;33(2):77-87. PMID: 23853396Free PMC Article
Desmoplastic seborrheic keratosis.
King R, Page RN, Googe PB
Am J Dermatopathol 2003 Jun;25(3):210-4. doi: 10.1097/00000372-200306000-00005. PMID: 12775983
Desmosomes and cancer.
Garrod DR
Cancer Surv 1995;24:97-111. PMID: 7553665

Therapy

MicroRNA-485-5p targets keratin 17 to regulate oral cancer stemness and chemoresistance via the integrin/FAK/Src/ERK/β-catenin pathway.
Jang TH, Huang WC, Tung SL, Lin SC, Chen PM, Cho CY, Yang YY, Yen TC, Lo GH, Chuang SE, Wang LH
J Biomed Sci 2022 Jun 15;29(1):42. doi: 10.1186/s12929-022-00824-z. PMID: 35706019Free PMC Article
Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus-Unrelated Head and Neck Cancer: A Multicenter, Phase II Trial.
Uppaluri R, Campbell KM, Egloff AM, Zolkind P, Skidmore ZL, Nussenbaum B, Paniello RC, Rich JT, Jackson R, Pipkorn P, Michel LS, Ley J, Oppelt P, Dunn GP, Barnell EK, Spies NC, Lin T, Li T, Mulder DT, Hanna Y, Cirlan I, Pugh TJ, Mudianto T, Riley R, Zhou L, Jo VY, Stachler MD, Hanna GJ, Kass J, Haddad R, Schoenfeld JD, Gjini E, Lako A, Thorstad W, Gay HA, Daly M, Rodig SJ, Hagemann IS, Kallogjeri D, Piccirillo JF, Chernock RD, Griffith M, Griffith OL, Adkins DR
Clin Cancer Res 2020 Oct 1;26(19):5140-5152. Epub 2020 Jul 14 doi: 10.1158/1078-0432.CCR-20-1695. PMID: 32665297Free PMC Article
Diagnostic accuracy of Cyfra 21-1 for head and neck squamous cell carcinoma: a meta-analysis.
Wang YX, Hu D, Yan X
Eur Rev Med Pharmacol Sci 2013 Sep;17(17):2383-9. PMID: 24065233
New insights into human papillomavirus-associated head and neck squamous cell carcinoma.
Boscolo-Rizzo P, Del Mistro A, Bussu F, Lupato V, Baboci L, Almadori G, DA Mosto MC, Paludetti G
Acta Otorhinolaryngol Ital 2013 Apr;33(2):77-87. PMID: 23853396Free PMC Article
Carcinoma of the head and neck in the HPV era.
Cardesa A, Nadal A
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):161-73. PMID: 22131117

Prognosis

DEK-AFF2 Carcinoma of the Sinonasal Region and Skull Base: Detailed Clinicopathologic Characterization of a Distinctive Entity.
Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J, Hartmann A, Khararjian A, London NR, MacMillan CM, Palsgrove DN, Nix JS, Sandison A, Stoehr R, Truong T, Weinreb I, Bishop JA
Am J Surg Pathol 2021 Dec 1;45(12):1682-1693. doi: 10.1097/PAS.0000000000001741. PMID: 34049316
Survival outcomes after treatment of cancer of the oral cavity (1985-2015).
Zanoni DK, Montero PH, Migliacci JC, Shah JP, Wong RJ, Ganly I, Patel SG
Oral Oncol 2019 Mar;90:115-121. Epub 2019 Feb 15 doi: 10.1016/j.oraloncology.2019.02.001. PMID: 30846169Free PMC Article
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
Human papillomavirus-related head and neck squamous cell carcinoma variants.
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342
Carcinoma of the head and neck in the HPV era.
Cardesa A, Nadal A
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):161-73. PMID: 22131117

Clinical prediction guides

MicroRNA-485-5p targets keratin 17 to regulate oral cancer stemness and chemoresistance via the integrin/FAK/Src/ERK/β-catenin pathway.
Jang TH, Huang WC, Tung SL, Lin SC, Chen PM, Cho CY, Yang YY, Yen TC, Lo GH, Chuang SE, Wang LH
J Biomed Sci 2022 Jun 15;29(1):42. doi: 10.1186/s12929-022-00824-z. PMID: 35706019Free PMC Article
Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus-Unrelated Head and Neck Cancer: A Multicenter, Phase II Trial.
Uppaluri R, Campbell KM, Egloff AM, Zolkind P, Skidmore ZL, Nussenbaum B, Paniello RC, Rich JT, Jackson R, Pipkorn P, Michel LS, Ley J, Oppelt P, Dunn GP, Barnell EK, Spies NC, Lin T, Li T, Mulder DT, Hanna Y, Cirlan I, Pugh TJ, Mudianto T, Riley R, Zhou L, Jo VY, Stachler MD, Hanna GJ, Kass J, Haddad R, Schoenfeld JD, Gjini E, Lako A, Thorstad W, Gay HA, Daly M, Rodig SJ, Hagemann IS, Kallogjeri D, Piccirillo JF, Chernock RD, Griffith M, Griffith OL, Adkins DR
Clin Cancer Res 2020 Oct 1;26(19):5140-5152. Epub 2020 Jul 14 doi: 10.1158/1078-0432.CCR-20-1695. PMID: 32665297Free PMC Article
Survival outcomes after treatment of cancer of the oral cavity (1985-2015).
Zanoni DK, Montero PH, Migliacci JC, Shah JP, Wong RJ, Ganly I, Patel SG
Oral Oncol 2019 Mar;90:115-121. Epub 2019 Feb 15 doi: 10.1016/j.oraloncology.2019.02.001. PMID: 30846169Free PMC Article
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
Human papillomavirus-related head and neck squamous cell carcinoma variants.
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342

Recent systematic reviews

The diagnostic value of CYFRA 21-1 in oral squamous cell carcinoma: a meta-analysis.
Liang Y, Yi Z, Li J, Ye J
Expert Rev Anticancer Ther 2024 Nov;24(11):1161-1168. Epub 2024 Sep 23 doi: 10.1080/14737140.2024.2405225. PMID: 39279566
Diagnostic accuracy of Cyfra 21-1 for head and neck squamous cell carcinoma: a meta-analysis.
Wang YX, Hu D, Yan X
Eur Rev Med Pharmacol Sci 2013 Sep;17(17):2383-9. PMID: 24065233

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