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Morular Metaplasia of the Endometrium

MedGen UID:
233195
•Concept ID:
C1334803
•
Finding
Synonym: Morular Metaplasia

Definition

A morphologic finding indicating the replacement of part of the glandular endometrial epithelium by nodular structures that contain non-keratinizing squamous cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMorular Metaplasia of the Endometrium

Recent clinical studies

Etiology

The Evolving Spectrum of Endometrial Glandular Proliferations With Corded and Hyalinized Features.
Pors J, Weiel JJ, Ryan E, Longacre TA
Am J Surg Pathol 2023 Sep 1;47(9):1067-1076. Epub 2023 Jul 27 doi: 10.1097/PAS.0000000000002078. PMID: 37493099
Morular endometrial metaplasia: review of the literature and proposal of the management.
Litta P, Codroma A, D'Agostino G, Breda E
Eur J Gynaecol Oncol 2013;34(3):243-7. PMID: 23967555
International Internet-based assessment of observer variability for diagnostically challenging endometrial biopsies.
Marotti JD, Glatz K, Parkash V, Hecht JL
Arch Pathol Lab Med 2011 Apr;135(4):464-70. doi: 10.5858/2010-0139-OA.1. PMID: 21466363
Morules in endometrioid proliferations of the uterus and ovary consistently express the intestinal transcription factor CDX2.
Houghton O, Connolly LE, McCluggage WG
Histopathology 2008 Aug;53(2):156-65. doi: 10.1111/j.1365-2559.2008.03083.x. PMID: 18752499

Diagnosis

P504S/alpha-methylacyl-CoA racemase, HNF1β and napsin A in morular metaplasia and clear cell carcinoma of the endometrium: An immunohistochemical analysis.
Arciuolo D, Travaglino A, Raffone A, Santoro A, Inzani F, Piermattei A, Bui L, Scaglione G, D'Alessandris N, Valente M, Fulgione C, Guida M, Mollo A, Insabato L, Zannoni GF
Pathol Res Pract 2022 Aug;236:153953. Epub 2022 May 27 doi: 10.1016/j.prp.2022.153953. PMID: 35696768
Diagnostic Pitfalls Related to Morular Metaplasia in Endometrioid Carcinoma: An Underestimated Issue.
Travaglino A, Raffone A, Gencarelli A, Saracinelli S, Zullo F, Insabato L
Pathobiology 2021;88(3):261-266. Epub 2021 Apr 22 doi: 10.1159/000515491. PMID: 33887731
Immunohistochemical characterization of squamous differentiation and morular metaplasia in uterine endometrioid adenocarcinoma.
Blanco LZ Jr, Heagley DE, Lee JC, Gown AM, Gattuso P, Rotmensch J, Guirguis A, Dewdney S, Bitterman P
Int J Gynecol Pathol 2013 May;32(3):283-92. doi: 10.1097/PGP.0b013e31826129e1. PMID: 23518912
An immunohistochemical study of morules in endometrioid lesions of the female genital tract: CD10 is a characteristic marker of morular metaplasia.
Chiarelli S, Buriticá C, Litta P, Ciani S, Guarch R, Nogales FF
Clin Cancer Res 2006 Jul 15;12(14 Pt 1):4251-6. doi: 10.1158/1078-0432.CCR-06-0398. PMID: 16857799
Nodular histiocytic hyperplasia of the endometrium.
Kim KR, Lee YH, Ro JY
Int J Gynecol Pathol 2002 Apr;21(2):141-6. doi: 10.1097/00004347-200204000-00006. PMID: 11917223

Prognosis

The Evolving Spectrum of Endometrial Glandular Proliferations With Corded and Hyalinized Features.
Pors J, Weiel JJ, Ryan E, Longacre TA
Am J Surg Pathol 2023 Sep 1;47(9):1067-1076. Epub 2023 Jul 27 doi: 10.1097/PAS.0000000000002078. PMID: 37493099
Endometrial metaplasias and reactive changes: a spectrum of altered differentiation.
Nicolae A, Preda O, Nogales FF
J Clin Pathol 2011 Feb;64(2):97-106. Epub 2010 Dec 1 doi: 10.1136/jcp.2010.085555. PMID: 21126963
Nodular histiocytic hyperplasia of the endometrium.
Kim KR, Lee YH, Ro JY
Int J Gynecol Pathol 2002 Apr;21(2):141-6. doi: 10.1097/00004347-200204000-00006. PMID: 11917223

Clinical prediction guides

The Evolving Spectrum of Endometrial Glandular Proliferations With Corded and Hyalinized Features.
Pors J, Weiel JJ, Ryan E, Longacre TA
Am J Surg Pathol 2023 Sep 1;47(9):1067-1076. Epub 2023 Jul 27 doi: 10.1097/PAS.0000000000002078. PMID: 37493099
International Internet-based assessment of observer variability for diagnostically challenging endometrial biopsies.
Marotti JD, Glatz K, Parkash V, Hecht JL
Arch Pathol Lab Med 2011 Apr;135(4):464-70. doi: 10.5858/2010-0139-OA.1. PMID: 21466363
Morules in endometrioid proliferations of the uterus and ovary consistently express the intestinal transcription factor CDX2.
Houghton O, Connolly LE, McCluggage WG
Histopathology 2008 Aug;53(2):156-65. doi: 10.1111/j.1365-2559.2008.03083.x. PMID: 18752499

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