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Squamous metaplasia

MedGen UID:
44384
•Concept ID:
C0025570
•
Cell or Molecular Dysfunction
Synonym: Squamous Metaplasia
SNOMED CT: Squamous metaplasia (83577005)

Definition

A morphologic finding indicating the transformation of glandular or transitional epithelial cells to, usually, mature squamous epithelial cells. Representative examples include squamous metaplasia of bronchial epithelium, cervix, urinary bladder, and prostate gland. [from NCI]

Professional guidelines

PubMed

Management of Mastitis, Abscess, and Fistula.
Snider HC
Surg Clin North Am 2022 Dec;102(6):1103-1116. doi: 10.1016/j.suc.2022.06.007. PMID: 36335928
Dry Eye Management: Targeting the Ocular Surface Microenvironment.
Zhang X, M VJ, Qu Y, He X, Ou S, Bu J, Jia C, Wang J, Wu H, Liu Z, Li W
Int J Mol Sci 2017 Jun 29;18(7) doi: 10.3390/ijms18071398. PMID: 28661456Free PMC Article
Dry eye: diagnosis and current treatment strategies.
O'Brien PD, Collum LM
Curr Allergy Asthma Rep 2004 Jul;4(4):314-9. doi: 10.1007/s11882-004-0077-2. PMID: 15175147

Recent clinical studies

Etiology

Incidence of Pancreatic Intraepithelial Neoplasia in an Autopsy Series.
Longnecker DS, Suriawinata AA
Pancreas 2022 Apr 1;51(4):305-309. doi: 10.1097/MPA.0000000000002027. PMID: 35775638
Keratinising squamous metaplasia of the bladder.
Bell C, Meara N, Gulur D, Middela S
BMJ Case Rep 2018 Aug 16;2018 doi: 10.1136/bcr-2018-225303. PMID: 30115715Free PMC Article
Rathke's cleft cyst.
Larkin S, Karavitaki N, Ansorge O
Handb Clin Neurol 2014;124:255-69. doi: 10.1016/B978-0-444-59602-4.00017-4. PMID: 25248592
HPV infections and lung cancer.
Syrjänen KJ
J Clin Pathol 2002 Dec;55(12):885-91. doi: 10.1136/jcp.55.12.885. PMID: 12461047Free PMC Article
Chemoprevention of lung cancer.
Benner SE, Lippman SM, Hong WK
Chest 1995 Jun;107(6 Suppl):316S-321S. doi: 10.1378/chest.107.6_supplement.316s. PMID: 7781413

Diagnosis

Management of Mastitis, Abscess, and Fistula.
Snider HC
Surg Clin North Am 2022 Dec;102(6):1103-1116. doi: 10.1016/j.suc.2022.06.007. PMID: 36335928
Squamous Metaplasia of the Stomach Associated with Lymphoma Infiltration.
Iwamuro M, Fujii N, Tanaka T, Kanzaki H, Kawano S, Kawahara Y, Okada H
Intern Med 2021 Jul 15;60(14):2229-2234. Epub 2021 Feb 22 doi: 10.2169/internalmedicine.6271-20. PMID: 33612676Free PMC Article
Pleomorphic adenoma: the great mimicker of malignancy.
Hernandez-Prera JC, Skálová A, Franchi A, Rinaldo A, Vander Poorten V, Zbären P, Ferlito A, Wenig BM
Histopathology 2021 Sep;79(3):279-290. Epub 2021 Apr 22 doi: 10.1111/his.14322. PMID: 33368685
Keratinising squamous metaplasia of the bladder.
Bell C, Meara N, Gulur D, Middela S
BMJ Case Rep 2018 Aug 16;2018 doi: 10.1136/bcr-2018-225303. PMID: 30115715Free PMC Article
Colposcopy: the scientific basis.
Bappa LA, Yakasai IA
Ann Afr Med 2013 Apr-Jun;12(2):86-9. doi: 10.4103/1596-3519.112396. PMID: 23713014

Therapy

Development of an inhalation reference concentration for diethanolamine.
Haney JT Jr, McCant D, Honeycutt ME, Lange S
Regul Toxicol Pharmacol 2018 Feb;92:55-66. Epub 2017 Nov 21 doi: 10.1016/j.yrtph.2017.11.011. PMID: 29158042
Dry Eye Management: Targeting the Ocular Surface Microenvironment.
Zhang X, M VJ, Qu Y, He X, Ou S, Bu J, Jia C, Wang J, Wu H, Liu Z, Li W
Int J Mol Sci 2017 Jun 29;18(7) doi: 10.3390/ijms18071398. PMID: 28661456Free PMC Article
Normal and abnormal epithelial differentiation in the female reproductive tract.
Kurita T
Differentiation 2011 Oct;82(3):117-26. Epub 2011 May 25 doi: 10.1016/j.diff.2011.04.008. PMID: 21612855Free PMC Article
Chemoprevention of lung cancer.
Benner SE, Lippman SM, Hong WK
Chest 1995 Jun;107(6 Suppl):316S-321S. doi: 10.1378/chest.107.6_supplement.316s. PMID: 7781413
Necrotizing sialometaplasia.
Nilsen R, Bernhoft CH, Gilhuus-Moe O
Int J Oral Surg 1978 Dec;7(6):580-4. doi: 10.1016/s0300-9785(78)80077-5. PMID: 103857

Prognosis

Incidence of Pancreatic Intraepithelial Neoplasia in an Autopsy Series.
Longnecker DS, Suriawinata AA
Pancreas 2022 Apr 1;51(4):305-309. doi: 10.1097/MPA.0000000000002027. PMID: 35775638
Assessment of Ocular Surface in Patients With Ankylosing Spondylitis.
Oltulu R, Turk HB, Oltulu P, Turk N, Satirtav G, Gunduz MK
Eye Contact Lens 2020 Jan;46(1):31-34. doi: 10.1097/ICL.0000000000000592. PMID: 30817331
Primary squamous cell carcinoma of endometrium: case report and literature review.
Farhane FZ, Alami Z, Bouhafa T, Elmazghi A, Hassouni K
Pan Afr Med J 2018;30:208. Epub 2018 Jul 16 doi: 10.11604/pamj.2018.30.208.9654. PMID: 30574227Free PMC Article
Primary squamous cell carcinoma of endometrium: case report and literature review.
Farhane FZ, Alami Z, Bouhafa T, Elmazghi A, Hassouni K
Pan Afr Med J 2018;30:8. Epub 2018 May 4 doi: 10.11604/pamj.2018.30.8.8983. PMID: 30123411Free PMC Article
Hashimoto's thyroiditis as a risk factor of thyroid lymphoma.
Aozasa K
Acta Pathol Jpn 1990 Jul;40(7):459-68. doi: 10.1111/j.1440-1827.1990.tb01587.x. PMID: 2220394

Clinical prediction guides

Incidence of Pancreatic Intraepithelial Neoplasia in an Autopsy Series.
Longnecker DS, Suriawinata AA
Pancreas 2022 Apr 1;51(4):305-309. doi: 10.1097/MPA.0000000000002027. PMID: 35775638
Squamous Metaplasia of the Stomach Associated with Lymphoma Infiltration.
Iwamuro M, Fujii N, Tanaka T, Kanzaki H, Kawano S, Kawahara Y, Okada H
Intern Med 2021 Jul 15;60(14):2229-2234. Epub 2021 Feb 22 doi: 10.2169/internalmedicine.6271-20. PMID: 33612676Free PMC Article
Development of an inhalation reference concentration for diethanolamine.
Haney JT Jr, McCant D, Honeycutt ME, Lange S
Regul Toxicol Pharmacol 2018 Feb;92:55-66. Epub 2017 Nov 21 doi: 10.1016/j.yrtph.2017.11.011. PMID: 29158042
Giant destructive sinonasal polyposis.
Dimitrijević MV, Arsović NA, Dudvarski ZR, Boričić IV
Srp Arh Celok Lek 2015 Mar-Apr;143(3-4):186-9. doi: 10.2298/sarh1504186d. PMID: 26012129
Inflammatory mechanisms and remodeling in chronic rhinosinusitis and nasal polyps.
Pawankar R, Nonaka M
Curr Allergy Asthma Rep 2007 Jun;7(3):202-8. doi: 10.1007/s11882-007-0073-4. PMID: 17448332

Recent systematic reviews

Breast Implant Capsule-Associated Squamous Cell Carcinoma: A Systematic Review and Case Presentation.
Badri D, Copertino N
Aesthetic Plast Surg 2024 Jun;48(12):2287-2293. Epub 2023 Oct 5 doi: 10.1007/s00266-023-03693-5. PMID: 37798500Free PMC Article
Histologic Findings in Surgical Pathology Specimens From Individuals Taking Feminizing Hormone Therapy for the Purpose of Gender Transition.
Andrews AR, Kakadekar A, Schmidt RL, Murugan P, Greene DN
Arch Pathol Lab Med 2022 Jan 2;146(2):252-261. doi: 10.5858/arpa.2020-0704-RA. PMID: 33983412
Immunophenotype of Atypical Polypoid Adenomyoma of the Uterus: Diagnostic Value and Insight on Pathogenesis.
Travaglino A, Raffone A, Saccone G, Fuggi M, De Placido G, Mascolo M, Mollo A, Insabato L, Zullo F
Appl Immunohistochem Mol Morphol 2020 Sep;28(8):646-653. doi: 10.1097/PAI.0000000000000780. PMID: 31855579
Understanding primary parotid squamous cell carcinoma - A systematic review.
Edafe O, Hughes B, Tsirevelou P, Goswamy J, Kumar R
Surgeon 2020 Feb;18(1):44-48. Epub 2019 Apr 28 doi: 10.1016/j.surge.2019.03.006. PMID: 31040083
Rathke's cleft cysts: review of natural history and surgical outcomes.
Han SJ, Rolston JD, Jahangiri A, Aghi MK
J Neurooncol 2014 Apr;117(2):197-203. Epub 2013 Oct 22 doi: 10.1007/s11060-013-1272-6. PMID: 24146189

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