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Squamous metaplasia

MedGen UID:
44384
•Concept ID:
C0025570
•
Cell or Molecular Dysfunction
Synonym: Squamous Metaplasia
SNOMED CT: Squamous metaplasia (83577005)

Definition

A morphologic finding indicating the transformation of glandular or transitional epithelial cells to, usually, mature squamous epithelial cells. Representative examples include squamous metaplasia of bronchial epithelium, cervix, urinary bladder, and prostate gland. [from NCI]

Professional guidelines

PubMed

Management of Mastitis, Abscess, and Fistula.
Snider HC
Surg Clin North Am 2022 Dec;102(6):1103-1116. doi: 10.1016/j.suc.2022.06.007. PMID: 36335928
Dry Eye Management: Targeting the Ocular Surface Microenvironment.
Zhang X, M VJ, Qu Y, He X, Ou S, Bu J, Jia C, Wang J, Wu H, Liu Z, Li W
Int J Mol Sci 2017 Jun 29;18(7) doi: 10.3390/ijms18071398. PMID: 28661456Free PMC Article
Dry eye: diagnosis and current treatment strategies.
O'Brien PD, Collum LM
Curr Allergy Asthma Rep 2004 Jul;4(4):314-9. doi: 10.1007/s11882-004-0077-2. PMID: 15175147

Recent clinical studies

Etiology

Oncogenic LncRNA CASC9 in Cancer Progression.
Qi Y, Song C, Zhang J, Guo C, Yuan C
Curr Pharm Des 2021;27(4):575-582. doi: 10.2174/1381612826666200917150130. PMID: 32940174
Precursor lesions of the urinary bladder.
McKenney JK
Histopathology 2019 Jan;74(1):68-76. doi: 10.1111/his.13762. PMID: 30565304
Rathke's cleft cyst.
Larkin S, Karavitaki N, Ansorge O
Handb Clin Neurol 2014;124:255-69. doi: 10.1016/B978-0-444-59602-4.00017-4. PMID: 25248592
Squamous cell carcinogenesis and squamous cell carcinoma of the urinary bladder: a contemporary review with focus on nonbilharzial squamous cell carcinoma.
Rausch S, Lotan Y, Youssef RF
Urol Oncol 2014 Jan;32(1):32.e11-6. Epub 2013 Feb 20 doi: 10.1016/j.urolonc.2012.11.020. PMID: 23433891
Rathke's cleft cysts.
Trifanescu R, Ansorge O, Wass JA, Grossman AB, Karavitaki N
Clin Endocrinol (Oxf) 2012 Feb;76(2):151-60. doi: 10.1111/j.1365-2265.2011.04235.x. PMID: 21951110

Diagnosis

Management of Mastitis, Abscess, and Fistula.
Snider HC
Surg Clin North Am 2022 Dec;102(6):1103-1116. doi: 10.1016/j.suc.2022.06.007. PMID: 36335928
Pleomorphic adenoma: the great mimicker of malignancy.
Hernandez-Prera JC, Skálová A, Franchi A, Rinaldo A, Vander Poorten V, Zbären P, Ferlito A, Wenig BM
Histopathology 2021 Sep;79(3):279-290. Epub 2021 Apr 22 doi: 10.1111/his.14322. PMID: 33368685
Incidental morphological findings in colorectal adenomas.
Dabir PD, van der Post RS, Nagtegaal ID
Histopathology 2021 Feb;78(3):348-357. Epub 2020 Nov 17 doi: 10.1111/his.14263. PMID: 32981102Free PMC Article
Precursor lesions of the urinary bladder.
McKenney JK
Histopathology 2019 Jan;74(1):68-76. doi: 10.1111/his.13762. PMID: 30565304
Rathke's cleft cysts.
Trifanescu R, Ansorge O, Wass JA, Grossman AB, Karavitaki N
Clin Endocrinol (Oxf) 2012 Feb;76(2):151-60. doi: 10.1111/j.1365-2265.2011.04235.x. PMID: 21951110

Therapy

Dry Eye Management: Targeting the Ocular Surface Microenvironment.
Zhang X, M VJ, Qu Y, He X, Ou S, Bu J, Jia C, Wang J, Wu H, Liu Z, Li W
Int J Mol Sci 2017 Jun 29;18(7) doi: 10.3390/ijms18071398. PMID: 28661456Free PMC Article
Vitamin A and its derivatives in experimental photocarcinogenesis: preventive effects and relevance to humans.
Shapiro SS, Seiberg M, Cole CA
J Drugs Dermatol 2013 Apr;12(4):458-63. PMID: 23652895
Contact lens wear and the development of squamous metaplasia of the surface cells of the conjunctiva.
Doughty MJ
Eye Contact Lens 2011 Sep;37(5):274-81. doi: 10.1097/ICL.0b013e318227f8c1. PMID: 21808196
Preservatives in eyedrops: the good, the bad and the ugly.
Baudouin C, Labbé A, Liang H, Pauly A, Brignole-Baudouin F
Prog Retin Eye Res 2010 Jul;29(4):312-34. Epub 2010 Mar 17 doi: 10.1016/j.preteyeres.2010.03.001. PMID: 20302969
Necrotizing sialometaplasia.
Nilsen R, Bernhoft CH, Gilhuus-Moe O
Int J Oral Surg 1978 Dec;7(6):580-4. doi: 10.1016/s0300-9785(78)80077-5. PMID: 103857

Prognosis

Incidental morphological findings in colorectal adenomas.
Dabir PD, van der Post RS, Nagtegaal ID
Histopathology 2021 Feb;78(3):348-357. Epub 2020 Nov 17 doi: 10.1111/his.14263. PMID: 32981102Free PMC Article
Immunohistochemistry and in situ hybridization for the diagnosis and classification of squamous lesions of the anogenital region.
Pirog EC
Semin Diagn Pathol 2015 Sep;32(5):409-18. Epub 2015 Feb 7 doi: 10.1053/j.semdp.2015.02.015. PMID: 25862555
Squamous cell carcinogenesis and squamous cell carcinoma of the urinary bladder: a contemporary review with focus on nonbilharzial squamous cell carcinoma.
Rausch S, Lotan Y, Youssef RF
Urol Oncol 2014 Jan;32(1):32.e11-6. Epub 2013 Feb 20 doi: 10.1016/j.urolonc.2012.11.020. PMID: 23433891
Squamous epithelial changes of the larynx: diagnosis and therapy.
Ferlito A, Devaney KO, Woolgar JA, Slootweg PJ, Paleri V, Takes RP, Strojan P, Bradley PJ, Rinaldo A
Head Neck 2012 Dec;34(12):1810-6. Epub 2011 Oct 3 doi: 10.1002/hed.21862. PMID: 21971762
A review of in vitro modelling approaches to the identification and modulation of squamous metaplasia in the human tracheobronchial epithelium.
Gray AC, McLeod JD, Clothier RH
Altern Lab Anim 2007 Oct;35(5):493-504. doi: 10.1177/026119290703500509. PMID: 18001171

Clinical prediction guides

Incidental morphological findings in colorectal adenomas.
Dabir PD, van der Post RS, Nagtegaal ID
Histopathology 2021 Feb;78(3):348-357. Epub 2020 Nov 17 doi: 10.1111/his.14263. PMID: 32981102Free PMC Article
Immunohistochemistry and in situ hybridization for the diagnosis and classification of squamous lesions of the anogenital region.
Pirog EC
Semin Diagn Pathol 2015 Sep;32(5):409-18. Epub 2015 Feb 7 doi: 10.1053/j.semdp.2015.02.015. PMID: 25862555
Vitamin A and its derivatives in experimental photocarcinogenesis: preventive effects and relevance to humans.
Shapiro SS, Seiberg M, Cole CA
J Drugs Dermatol 2013 Apr;12(4):458-63. PMID: 23652895
Rathke's cleft cysts.
Trifanescu R, Ansorge O, Wass JA, Grossman AB, Karavitaki N
Clin Endocrinol (Oxf) 2012 Feb;76(2):151-60. doi: 10.1111/j.1365-2265.2011.04235.x. PMID: 21951110
Contact lens wear and the development of squamous metaplasia of the surface cells of the conjunctiva.
Doughty MJ
Eye Contact Lens 2011 Sep;37(5):274-81. doi: 10.1097/ICL.0b013e318227f8c1. PMID: 21808196

Recent systematic reviews

Histologic Findings in Surgical Pathology Specimens From Individuals Taking Feminizing Hormone Therapy for the Purpose of Gender Transition.
Andrews AR, Kakadekar A, Schmidt RL, Murugan P, Greene DN
Arch Pathol Lab Med 2022 Jan 2;146(2):252-261. doi: 10.5858/arpa.2020-0704-RA. PMID: 33983412
Immunophenotype of Atypical Polypoid Adenomyoma of the Uterus: Diagnostic Value and Insight on Pathogenesis.
Travaglino A, Raffone A, Saccone G, Fuggi M, De Placido G, Mascolo M, Mollo A, Insabato L, Zullo F
Appl Immunohistochem Mol Morphol 2020 Sep;28(8):646-653. doi: 10.1097/PAI.0000000000000780. PMID: 31855579
Understanding primary parotid squamous cell carcinoma - A systematic review.
Edafe O, Hughes B, Tsirevelou P, Goswamy J, Kumar R
Surgeon 2020 Feb;18(1):44-48. Epub 2019 Apr 28 doi: 10.1016/j.surge.2019.03.006. PMID: 31040083
Rathke's cleft cysts: review of natural history and surgical outcomes.
Han SJ, Rolston JD, Jahangiri A, Aghi MK
J Neurooncol 2014 Apr;117(2):197-203. Epub 2013 Oct 22 doi: 10.1007/s11060-013-1272-6. PMID: 24146189

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