Pancreatic delta cell neuroendocrine tumor

MedGen UID:: 233303
•Concept ID:: C1335301
•: Neoplastic Process

Synonyms:	Pancreatic Delta Cell Neoplasm; pancreatic Delta cell neoplasm; pancreatic delta cell neoplasm; Pancreatic Delta Cell NET; pancreatic Delta cell NET; Pancreatic Delta Cell Neuroendocrine Tumor; pancreatic delta cell neuroendocrine tumor; pancreatic Delta cell neuroendocrine tumor; pancreatic Delta cell neuroendocrine tumour; Pancreatic Delta Cell Tumor; pancreatic Delta cell tumor; pancreatic Delta cell tumour

Monarch Initiative:	MONDO:0002994

Definition

A usually malignant neuroendocrine tumor arising from the delta cells of the pancreas. It may be associated with inappropriate secretion of somatostatin and an associated clinical syndrome, or it may be hormonally inactive (non-functioning). [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVPancreatic delta cell neuroendocrine tumor

Abnormality of the digestive system
- Digestive system neoplasm
  - Neoplasm of the gastrointestinal tract
    - Digestive system neuroendocrine neoplasm
      - Digestive system neuroendocrine tumor, grade 1/2
        Neuroendocrine pancreatic tumor
        Pancreatic delta cell neuroendocrine tumor
        Pancreatic non-functioning delta cell tumor
        Pancreatic Somatostatin-Producing Neuroendocrine Tumor
        Pancreatic somatostatinoma
        Malignant Pancreatic Somatostatinoma

Recent clinical studies

Diagnosis

Involvement of the γ1 subunit of the large-conductance Ca(2+)-activated K(+) channel in the proliferation of human somatostatinoma cells.

Noda S, Chikazawa K, Suzuki Y, Imaizumi Y, Yamamura H
Biochem Biophys Res Commun 2020 May 14;525(4):1032-1037. Epub 2020 Mar 13 doi: 10.1016/j.bbrc.2020.02.176. PMID: 32178873

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