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Salivary gland oncocytoma

MedGen UID:
233431
•Concept ID:
C1335906
•
Neoplastic Process
Synonyms: Benign oncocytoma of salivary gland; Oncocytoma of Salivary Gland; Oncocytoma of the Salivary Gland; Oxyphilic adenoma of salivary gland; Oxyphilic Adenoma of Salivary Gland; Oxyphilic Adenoma of the Salivary Gland; Parotid oncocytoma; Salivary Gland Oncocytoma; Salivary Gland Oxyphilic Adenoma
SNOMED CT: Benign oncocytoma of salivary gland (424567005); Oxyphilic adenoma of salivary gland (424567005)
 
HPO: HP:0031523

Definition

A benign epithelial neoplasm composed of layers of oncocytes (small round nucleus, micro-granular, eosinophilic cytoplasm with numerous tightly-packed mitochondria) [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary gland oncocytoma

Professional guidelines

PubMed

Oncocytoid Salivary Tumors: Differential Diagnosis and Utility of Newly Described Immunohistochemistry.
Katabi N
Head Neck Pathol 2024 Mar 19;18(1):20. doi: 10.1007/s12105-024-01622-9. PMID: 38502259Free PMC Article
Molecular Profiling of Salivary Oncocytic Mucoepidermoid Carcinomas Helps to Resolve Differential Diagnostic Dilemma With Low-grade Oncocytic Lesions.
Skálová A, Agaimy A, Stanowska O, Baneckova M, Ptáková N, Ardighieri L, Nicolai P, Lombardi D, Durzynska M, Corcione L, Laco J, Koshyk O, Žalud R, Michal M, Vanecek T, Leivo I
Am J Surg Pathol 2020 Dec;44(12):1612-1622. doi: 10.1097/PAS.0000000000001590. PMID: 33002921
Estimation of Second Primary Cancer Risk After Treatment with Radioactive Iodine for Differentiated Thyroid Carcinoma.
Corrêa NL, de Sá LV, de Mello RC
Thyroid 2017 Feb;27(2):261-270. Epub 2016 Nov 21 doi: 10.1089/thy.2016.0266. PMID: 27762670

Recent clinical studies

Diagnosis

Granular cell ameloblastoma: case report of a particular ameloblastoma histologically resembling oncocytoma.
Matsushita Y, Fujita S, Kawasaki G, Hirota Y, Rokutanda S, Yamashita K, Yanamoto S, Ikeda T, Umeda M
Pathol Int 2015 Jan;65(1):43-7. Epub 2014 Nov 25 doi: 10.1111/pin.12231. PMID: 25421074
p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma.
McHugh JB, Hoschar AP, Dvorakova M, Parwani AV, Barnes EL, Seethala RR
Head Neck Pathol 2007 Dec;1(2):123-31. Epub 2007 Oct 26 doi: 10.1007/s12105-007-0031-4. PMID: 20614263Free PMC Article
Immunophenotypic comparison of salivary gland oncocytoma and metastatic renal cell carcinoma.
Ozolek JA, Bastacky SI, Myers EN, Hunt JL
Laryngoscope 2005 Jun;115(6):1097-100. doi: 10.1097/01.MLG.0000163497.61332.77. PMID: 15933529

Prognosis

p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma.
McHugh JB, Hoschar AP, Dvorakova M, Parwani AV, Barnes EL, Seethala RR
Head Neck Pathol 2007 Dec;1(2):123-31. Epub 2007 Oct 26 doi: 10.1007/s12105-007-0031-4. PMID: 20614263Free PMC Article

Clinical prediction guides

Granular cell ameloblastoma: case report of a particular ameloblastoma histologically resembling oncocytoma.
Matsushita Y, Fujita S, Kawasaki G, Hirota Y, Rokutanda S, Yamashita K, Yanamoto S, Ikeda T, Umeda M
Pathol Int 2015 Jan;65(1):43-7. Epub 2014 Nov 25 doi: 10.1111/pin.12231. PMID: 25421074
p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma.
McHugh JB, Hoschar AP, Dvorakova M, Parwani AV, Barnes EL, Seethala RR
Head Neck Pathol 2007 Dec;1(2):123-31. Epub 2007 Oct 26 doi: 10.1007/s12105-007-0031-4. PMID: 20614263Free PMC Article
Coordinate expression of nuclear and mitochondrial genes involved in energy production in carcinoma and oncocytoma.
Heddi A, Faure-Vigny H, Wallace DC, Stepien G
Biochim Biophys Acta 1996 Aug 23;1316(3):203-9. doi: 10.1016/0925-4439(96)00026-9. PMID: 8781539
Benign parotid oncocytoma with the chromosomal abnormality trisomy 7.
Mark J, Dahlenfors R, Havel G, Böckmann P
Anticancer Res 1991 Sep-Oct;11(5):1735-7. PMID: 1768045

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