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Pulmonary large cell neuroendocrine carcinoma

MedGen UID:
233608
Concept ID:
C1334363
Neoplastic Process
Synonyms: Large Cell Lung Carcinoma with Neuroendocrine Differentiation; large cell lung carcinoma with neuroendocrine differentiation; Large Cell Lung Neuroendocrine Carcinoma; large cell lung neuroendocrine carcinoma; Large Cell Neuroendocrine Carcinoma of Lung; large cell neuroendocrine carcinoma of lung; Large Cell Neuroendocrine Carcinoma of the Lung; large cell neuroendocrine carcinoma of the lung; LCNEC of the Lung; LCNEC of the lung; Lung Large Cell Neuroendocrine Carcinoma; lung large cell neuroendocrine carcinoma; Pulmonary Large Cell Neuroendocrine Carcinoma; pulmonary large cell neuroendocrine carcinoma
 
Monarch Initiative: MONDO:0003960

Definition

A high grade carcinoma that arises from the lung and is characterized by the presence of large neuroendocrine cells. It usually has an aggressive clinical course. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Yang Z, Wang Y, Chen Y, Qian F, Zhang Y, Hu M, Zhang W, Han B
Eur J Cardiothorac Surg 2022 Jul 11;62(2) doi: 10.1093/ejcts/ezac069. PMID: 35147672
Derks JL, Leblay N, Thunnissen E, van Suylen RJ, den Bakker M, Groen HJM, Smit EF, Damhuis R, van den Broek EC, Charbrier A, Foll M, McKay JD, Fernandez-Cuesta L, Speel EM, Dingemans AC; PALGA-Group
Clin Cancer Res 2018 Jan 1;24(1):33-42. Epub 2017 Oct 24 doi: 10.1158/1078-0432.CCR-17-1921. PMID: 29066508
Kim KW, Kim HK, Kim J, Shim YM, Ahn MJ, Choi YL
World J Surg 2017 Jul;41(7):1820-1827. doi: 10.1007/s00268-017-3908-8. PMID: 28204910

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

Recent clinical studies

Etiology

Iida Y, Wakuda K, Kenmotsu H, Doshita K, Kodama H, Nishioka N, Miyawaki E, Miyawaki T, Mamesaya N, Kobayashi H, Omori S, Ko R, Ono A, Naito T, Murakami H, Sugino T, Gon Y, Takahashi T
Sci Rep 2024 Apr 1;14(1):7641. doi: 10.1038/s41598-024-58327-w. PMID: 38561461Free PMC Article
Wan S, Shen Z, Hu S, Zhang L, Yu H, Chen Y, Wang J, Wang D, Zhang J, Zhang P
Ann Thorac Surg 2024 Aug;118(2):385-393. Epub 2024 Jan 17 doi: 10.1016/j.athoracsur.2024.01.002. PMID: 38242341
Burns L, Tukachinsky H, Raskina K, Huang RSP, Schrock AB, Sands J, Kulke MH, Oxnard GR, Tapan U
Lung Cancer 2024 Feb;188:107454. Epub 2023 Dec 29 doi: 10.1016/j.lungcan.2023.107454. PMID: 38159439
Rekhtman N, Pietanza MC, Hellmann MD, Naidoo J, Arora A, Won H, Halpenny DF, Wang H, Tian SK, Litvak AM, Paik PK, Drilon AE, Socci N, Poirier JT, Shen R, Berger MF, Moreira AL, Travis WD, Rudin CM, Ladanyi M
Clin Cancer Res 2016 Jul 15;22(14):3618-29. Epub 2016 Mar 9 doi: 10.1158/1078-0432.CCR-15-2946. PMID: 26960398Free PMC Article
Hage R, Seldenrijk K, de Bruin P, van Swieten H, van den Bosch J
Eur J Cardiothorac Surg 2003 Apr;23(4):457-60. doi: 10.1016/s1010-7940(02)00837-0. PMID: 12694759

Diagnosis

Wan S, Shen Z, Hu S, Zhang L, Yu H, Chen Y, Wang J, Wang D, Zhang J, Zhang P
Ann Thorac Surg 2024 Aug;118(2):385-393. Epub 2024 Jan 17 doi: 10.1016/j.athoracsur.2024.01.002. PMID: 38242341
Burns L, Tukachinsky H, Raskina K, Huang RSP, Schrock AB, Sands J, Kulke MH, Oxnard GR, Tapan U
Lung Cancer 2024 Feb;188:107454. Epub 2023 Dec 29 doi: 10.1016/j.lungcan.2023.107454. PMID: 38159439
Yang L, Fan Y, Lu H
Pathol Oncol Res 2022;28:1610730. Epub 2022 Oct 11 doi: 10.3389/pore.2022.1610730. PMID: 36304941Free PMC Article
Yang Z, Wang Y, Chen Y, Qian F, Zhang Y, Hu M, Zhang W, Han B
Eur J Cardiothorac Surg 2022 Jul 11;62(2) doi: 10.1093/ejcts/ezac069. PMID: 35147672
Hage R, Seldenrijk K, de Bruin P, van Swieten H, van den Bosch J
Eur J Cardiothorac Surg 2003 Apr;23(4):457-60. doi: 10.1016/s1010-7940(02)00837-0. PMID: 12694759

Therapy

Iida Y, Wakuda K, Kenmotsu H, Doshita K, Kodama H, Nishioka N, Miyawaki E, Miyawaki T, Mamesaya N, Kobayashi H, Omori S, Ko R, Ono A, Naito T, Murakami H, Sugino T, Gon Y, Takahashi T
Sci Rep 2024 Apr 1;14(1):7641. doi: 10.1038/s41598-024-58327-w. PMID: 38561461Free PMC Article
Wang Y, Chen Y, Yang Z, Qian F, Hu M, Lu J, Zhang Y, Zhang W, Wang K, Han B
Ann Surg Oncol 2022 Sep;29(9):5666-5678. Epub 2022 May 11 doi: 10.1245/s10434-022-11610-4. PMID: 35543906
Yang Z, Wang Y, Chen Y, Qian F, Zhang Y, Hu M, Zhang W, Han B
Eur J Cardiothorac Surg 2022 Jul 11;62(2) doi: 10.1093/ejcts/ezac069. PMID: 35147672
Kadota N, Hatakeyama N, Hino H, Kunishige M, Kondo Y, Okano Y, Machida H, Naruse K, Shinohara T, Sakiyama S, Ogushi F, Takeuchi E
Cancer Rep (Hoboken) 2022 Aug;5(8):e1589. Epub 2021 Nov 24 doi: 10.1002/cnr2.1589. PMID: 34817132Free PMC Article
Derks JL, Leblay N, Thunnissen E, van Suylen RJ, den Bakker M, Groen HJM, Smit EF, Damhuis R, van den Broek EC, Charbrier A, Foll M, McKay JD, Fernandez-Cuesta L, Speel EM, Dingemans AC; PALGA-Group
Clin Cancer Res 2018 Jan 1;24(1):33-42. Epub 2017 Oct 24 doi: 10.1158/1078-0432.CCR-17-1921. PMID: 29066508

Prognosis

Wan S, Shen Z, Hu S, Zhang L, Yu H, Chen Y, Wang J, Wang D, Zhang J, Zhang P
Ann Thorac Surg 2024 Aug;118(2):385-393. Epub 2024 Jan 17 doi: 10.1016/j.athoracsur.2024.01.002. PMID: 38242341
Yang L, Fan Y, Lu H
Pathol Oncol Res 2022;28:1610730. Epub 2022 Oct 11 doi: 10.3389/pore.2022.1610730. PMID: 36304941Free PMC Article
Yang Z, Wang Y, Chen Y, Qian F, Zhang Y, Hu M, Zhang W, Han B
Eur J Cardiothorac Surg 2022 Jul 11;62(2) doi: 10.1093/ejcts/ezac069. PMID: 35147672
Lowczak A, Kolasinska-Cwikla A, Osowiecka K, Glinka L, Palucki J, Rzepko R, Doboszynska A, Cwikla JB
Medicina (Kaunas) 2021 Jan 28;57(2) doi: 10.3390/medicina57020118. PMID: 33525370Free PMC Article
Hage R, Seldenrijk K, de Bruin P, van Swieten H, van den Bosch J
Eur J Cardiothorac Surg 2003 Apr;23(4):457-60. doi: 10.1016/s1010-7940(02)00837-0. PMID: 12694759

Clinical prediction guides

Iida Y, Wakuda K, Kenmotsu H, Doshita K, Kodama H, Nishioka N, Miyawaki E, Miyawaki T, Mamesaya N, Kobayashi H, Omori S, Ko R, Ono A, Naito T, Murakami H, Sugino T, Gon Y, Takahashi T
Sci Rep 2024 Apr 1;14(1):7641. doi: 10.1038/s41598-024-58327-w. PMID: 38561461Free PMC Article
Wan S, Shen Z, Hu S, Zhang L, Yu H, Chen Y, Wang J, Wang D, Zhang J, Zhang P
Ann Thorac Surg 2024 Aug;118(2):385-393. Epub 2024 Jan 17 doi: 10.1016/j.athoracsur.2024.01.002. PMID: 38242341
Khan J, Yasinzai AQK, Matosz S, Khan M, Heneidi S, Mesa H, Chauhan A, Del Rivero J, Karim NA, Ullah A
Clin Exp Med 2023 Nov;23(7):3947-3955. Epub 2023 Apr 15 doi: 10.1007/s10238-023-01071-8. PMID: 37060529
Yang Z, Wang Y, Chen Y, Qian F, Zhang Y, Hu M, Zhang W, Han B
Eur J Cardiothorac Surg 2022 Jul 11;62(2) doi: 10.1093/ejcts/ezac069. PMID: 35147672
Hage R, Seldenrijk K, de Bruin P, van Swieten H, van den Bosch J
Eur J Cardiothorac Surg 2003 Apr;23(4):457-60. doi: 10.1016/s1010-7940(02)00837-0. PMID: 12694759

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    • PubMed
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    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

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