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Mediastinal Mature Teratoma

MedGen UID:
233671
•Concept ID:
C1334636
•
Neoplastic Process
Synonyms: Mature Mediastinal Teratoma; Mature Teratoma of Mediastinum; Mature Teratoma of the Mediastinum

Definition

An extragonadal mature teratoma that arises from the mediastinum. It is usually encapsulated and characterized by the presence of unilocular or multilocular cysts. The cysts can contain clear fluid, mucoid material, sebaceous debris, fat, hair, cartilage, and rarely teeth or bone. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMediastinal Mature Teratoma

Professional guidelines

PubMed

Primary mediastinal germ cell tumours with high prevalence of somatic malignancy: An experience from a single tertiary care oncology centre.
Beg A, Kumar R, Sahay A, Janu A, Joshi A, Noronha V, Prabhash K, Karimundackal G, Jiwnani S, Agarwal JP, Pramesh CS
Ann Diagn Pathol 2021 Aug;53:151763. Epub 2021 May 26 doi: 10.1016/j.anndiagpath.2021.151763. PMID: 34111707
Clinical Characteristics and Treatment Outcomes of Patients with Primary Mediastinal Germ Cell Tumors: 10-Years' Experience at a Single Institution with a Bleomycin-Containing Regimen.
Dechaphunkul A, Sakdejayont S, Sathitruangsak C, Sunpaweravong P
Oncol Res Treat 2016;39(11):688-694. Epub 2016 Oct 20 doi: 10.1159/000452259. PMID: 27855414
Extragonadal germ cell tumors: a review with emphasis on pathologic features, clinical prognostic variables, and differential diagnostic considerations.
McKenney JK, Heerema-McKenney A, Rouse RV
Adv Anat Pathol 2007 Mar;14(2):69-92. doi: 10.1097/PAP.0b013e31803240e6. PMID: 17471115

Recent clinical studies

Etiology

Thoracoscopic surgery approach to mediastinal mature teratomas: a single-center experience.
Pham LH, Trinh DK, Nguyen AV, Nguyen LS, Le DT, Nguyen DH, Doan HQ, Nguyen UH
J Cardiothorac Surg 2020 Feb 12;15(1):35. doi: 10.1186/s13019-020-1076-7. PMID: 32051013Free PMC Article
Analysis of chromosome 12p over-representation and clinicopathological features in mediastinal teratomas.
Lee T, Seo Y, Han J, Kwon GY
Pathology 2019 Jan;51(1):62-66. Epub 2018 Nov 20 doi: 10.1016/j.pathol.2018.10.002. PMID: 30470411
Experience with thoracoscopic resection for mediastinal mature teratoma: a retrospective analysis of 15 patients.
Shintani Y, Funaki S, Nakagiri T, Inoue M, Sawabata N, Minami M, Kadota Y, Okumura M
Interact Cardiovasc Thorac Surg 2013 Apr;16(4):441-4. Epub 2013 Jan 3 doi: 10.1093/icvts/ivs543. PMID: 23287591Free PMC Article
18 years surgical experience with mediastinal mature teratoma.
Chang CC, Chang YL, Lee JM, Chen JS, Hsu HH, Huang PM, Lee YC
J Formos Med Assoc 2010 Apr;109(4):287-92. doi: 10.1016/S0929-6646(10)60054-X. PMID: 20434038
Mediastinal mature teratoma: imaging features.
Moeller KH, Rosado-de-Christenson ML, Templeton PA
AJR Am J Roentgenol 1997 Oct;169(4):985-90. doi: 10.2214/ajr.169.4.9308448. PMID: 9308448

Diagnosis

A neuroendocrine tumor within an anterior mediastinal mature teratoma: a case report.
Sato D, Izu A, Sakakibara M, Hayashi S, Kawachi R, Shimamura M, Masuda S, Sakurai H
J Cardiothorac Surg 2022 Dec 22;17(1):333. doi: 10.1186/s13019-022-02091-3. PMID: 36550490Free PMC Article
A ruptured giant mediastinal mature teratoma mimicking an encapsulated empyema.
Zhang J, Zhu X, Jiang M, Lv Y
Interact Cardiovasc Thorac Surg 2022 Jan 6;34(1):159-161. Epub 2021 Sep 11 doi: 10.1093/icvts/ivab222. PMID: 34999805Free PMC Article
Metastatic mediastinal mature teratoma with malignant transformation in a young man with an adenocarcinoma in a Klinefelter's syndrome: Case report and review of the literature.
Le Fèvre C, Vigneron C, Schuster H, Walter A, Marcellin L, Massard G, Lutz P, Noël G
Cancer Radiother 2018 May;22(3):255-263. Epub 2018 Apr 16 doi: 10.1016/j.canrad.2017.10.006. PMID: 29673950
Glioblastoma arising within a mediastinal mature teratoma.
Liu L, Jentoft ME, Boland JM
Hum Pathol 2016 Oct;56:109-13. Epub 2016 Jun 17 doi: 10.1016/j.humpath.2016.05.019. PMID: 27327191
18 years surgical experience with mediastinal mature teratoma.
Chang CC, Chang YL, Lee JM, Chen JS, Hsu HH, Huang PM, Lee YC
J Formos Med Assoc 2010 Apr;109(4):287-92. doi: 10.1016/S0929-6646(10)60054-X. PMID: 20434038

Therapy

Primary Mediastinal HER2-positive Apocrine Carcinoma in Mature Teratoma Treated With Anti-HER2 Therapy and Chemoradiation.
Sugiyama K, Iwakoshi A, Satoh M, Shiraishi K, Nozawa K, Kogure Y, Kitagawa C, Moritani S, Katoh E, Saka H
In Vivo 2019 Mar-Apr;33(2):551-557. doi: 10.21873/invivo.11509. PMID: 30804140Free PMC Article
Extraction of mediastinal teratoma contents for complete thoracoscopic resection.
Tsubochi H, Endo S, Nakano T, Minegishi K, Tetsuka K, Hasegawa T
Asian Cardiovasc Thorac Ann 2015 Jan;23(1):42-5. Epub 2014 May 16 doi: 10.1177/0218492314536173. PMID: 24838232
Experience with thoracoscopic resection for mediastinal mature teratoma: a retrospective analysis of 15 patients.
Shintani Y, Funaki S, Nakagiri T, Inoue M, Sawabata N, Minami M, Kadota Y, Okumura M
Interact Cardiovasc Thorac Surg 2013 Apr;16(4):441-4. Epub 2013 Jan 3 doi: 10.1093/icvts/ivs543. PMID: 23287591Free PMC Article
Adenocarcinoma arising in anterior mediastinal mature cystic teratoma: report of a case.
Sakurai H, Miyashita Y, Oyama T
Surg Today 2008;38(4):348-51. Epub 2008 Mar 27 doi: 10.1007/s00595-007-3633-2. PMID: 18368326
Mediastinal mature teratoma with complex rupture into the pleura, lung, and bronchus complicated with mycoplasma pneumonia.
Yu CW, Hsieh MJ, Hwang KP, Huang CC, Ng SH, Ko SF
J Thorac Cardiovasc Surg 2007 Apr;133(4):1114-5. doi: 10.1016/j.jtcvs.2007.01.006. PMID: 17382673

Prognosis

Coexistence of the BRCA1 and KRAS mutations in a patient with salivary gland carcinoma arising in mediastinal mature teratoma.
Zhu YT, Chen Y, Li YH, Chen N, Zhang HW, Xu LM, Liu JY
Anticancer Drugs 2020 Sep;31(8):876-879. doi: 10.1097/CAD.0000000000000958. PMID: 32796407
Analysis of chromosome 12p over-representation and clinicopathological features in mediastinal teratomas.
Lee T, Seo Y, Han J, Kwon GY
Pathology 2019 Jan;51(1):62-66. Epub 2018 Nov 20 doi: 10.1016/j.pathol.2018.10.002. PMID: 30470411
Metastatic mediastinal mature teratoma with malignant transformation in a young man with an adenocarcinoma in a Klinefelter's syndrome: Case report and review of the literature.
Le Fèvre C, Vigneron C, Schuster H, Walter A, Marcellin L, Massard G, Lutz P, Noël G
Cancer Radiother 2018 May;22(3):255-263. Epub 2018 Apr 16 doi: 10.1016/j.canrad.2017.10.006. PMID: 29673950
Mediastinal Mature Teratoma With Malignant Carcinomatous Transformation (Somatic-Type Malignancy) With Metastatic Course.
Habougit C, Yvorel V, Sulaiman A, Hag B, Péoc'h M, Forest F
Int J Surg Pathol 2015 Dec;23(8):682-4. Epub 2015 Jun 24 doi: 10.1177/1066896915591583. PMID: 26113666
Mediastinal mature teratoma with complex rupture into the lung, bronchus and skin: a case report.
Serraj M, Lakranbi M, Ghalimi J, Ouadnouni Y, Smahi M
World J Surg Oncol 2013 Jun 1;11:125. doi: 10.1186/1477-7819-11-125. PMID: 23725382Free PMC Article

Clinical prediction guides

Mature cystic teratoma with malignant transformation to adenocarcinoma.
Muramatsu T, Nishii T, Ohmori K, Shiono M
Ann Thorac Surg 2011 Jun;91(6):1971-3. doi: 10.1016/j.athoracsur.2010.11.025. PMID: 21619995
Mediastinal mature teratoma: imaging features.
Moeller KH, Rosado-de-Christenson ML, Templeton PA
AJR Am J Roentgenol 1997 Oct;169(4):985-90. doi: 10.2214/ajr.169.4.9308448. PMID: 9308448

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