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Extragonadal germ cell tumor

MedGen UID:
75506
Concept ID:
C0262963
Neoplastic Process
Synonyms: Extragonadal Germ Cell Neoplasm; extragonadal germ cell neoplasm; Extragonadal Germ Cell Neoplasms; extragonadal germ cell neoplasms; Extragonadal Germ Cell Tumor; extragonadal germ cell tumor; Neoplasm of Extragonadal Germ Cell; neoplasm of extragonadal germ cell; Neoplasm of the Extragonadal Germ Cell; neoplasm of the extragonadal germ cell; Primary Extragonadal Germ Cell Tumor; primary extragonadal germ cell tumor; primary extragonadal germ cell tumour; Tumor of Extragonadal Germ Cell; tumor of extragonadal germ cell; Tumor of the Extragonadal Germ Cell; tumor of the extragonadal germ cell; tumour of extragonadal germ cell; tumour of the extragonadal germ cell
 
Monarch Initiative: MONDO:0018201
Orphanet: ORPHA363579

Definition

A germ cell tumor arising in an anatomic site other than the testis or ovary (e.g., central nervous system, lung, mediastinum, and retroperitoneum). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExtragonadal germ cell tumor

Professional guidelines

PubMed

Fumino S, Tajiri T, Usui N, Tamura M, Sago H, Ono S, Nosaka S, Yoneda A, Souzaki R, Higashi M, Sakai K, Takahashi K, Sugiura T, Taguchi T
Pediatr Int 2019 Jul;61(7):672-678. Epub 2019 Jun 18 doi: 10.1111/ped.13844. PMID: 30903638
Makino T, Konaka H, Namiki M
Anticancer Res 2016 Jan;36(1):313-7. PMID: 26722059
Hainsworth JD, Fizazi K
Semin Oncol 2009 Feb;36(1):44-51. doi: 10.1053/j.seminoncol.2008.10.006. PMID: 19179187

Recent clinical studies

Etiology

Rosti G, Secondino S, Necchi A, Fornarini G, Pedrazzoli P
Semin Oncol 2019 Apr;46(2):107-111. Epub 2019 Apr 24 doi: 10.1053/j.seminoncol.2019.04.001. PMID: 31076171
Fumino S, Tajiri T, Usui N, Tamura M, Sago H, Ono S, Nosaka S, Yoneda A, Souzaki R, Higashi M, Sakai K, Takahashi K, Sugiura T, Taguchi T
Pediatr Int 2019 Jul;61(7):672-678. Epub 2019 Jun 18 doi: 10.1111/ped.13844. PMID: 30903638
Inoue Y, Nakamura T, Nakanishi H, Oishi M, Hongo F, Okihara K, Mizutani S, Kuroda J, Ukimura O
Int J Urol 2018 Jul;25(7):678-683. Epub 2018 May 11 doi: 10.1111/iju.13597. PMID: 29752743
Bokemeyer C, Nichols CR, Droz JP, Schmoll HJ, Horwich A, Gerl A, Fossa SD, Beyer J, Pont J, Kanz L, Einhorn L, Hartmann JT
J Clin Oncol 2002 Apr 1;20(7):1864-73. doi: 10.1200/JCO.2002.07.062. PMID: 11919246
Hainsworth JD, Greco FA
Hematol Oncol Clin North Am 1991 Dec;5(6):1223-31. PMID: 1663941

Diagnosis

Rescorla F, Dicken B, Billmire D, Weil B, Stark R, Madenci A, Ramaraj A
Semin Pediatr Surg 2023 Oct;32(5):151344. Epub 2023 Nov 21 doi: 10.1016/j.sempedsurg.2023.151344. PMID: 38039830
Xiu W, Pang J, Hu Y, Shi H
Front Immunol 2023;14:1145788. Epub 2023 Apr 17 doi: 10.3389/fimmu.2023.1145788. PMID: 37138865Free PMC Article
Han X, Wang S, He H, Sun Y, Li J
J Int Med Res 2022 Jan;50(1):3000605211069202. doi: 10.1177/03000605211069202. PMID: 34986675Free PMC Article
Wong V, Geynisman DM
JAAPA 2020 Apr;33(4):35-37. doi: 10.1097/01.JAA.0000657172.30545.a3. PMID: 32217905Free PMC Article
Hainsworth JD, Greco FA
Hematol Oncol Clin North Am 1991 Dec;5(6):1223-31. PMID: 1663941

Therapy

Wong V, Geynisman DM
JAAPA 2020 Apr;33(4):35-37. doi: 10.1097/01.JAA.0000657172.30545.a3. PMID: 32217905Free PMC Article
Ting J, Bell D, Ahmed S, Ying A, Waguespack SG, Tu SM, Weber R, Zafereo M
Thyroid 2019 Feb;29(2):229-236. doi: 10.1089/thy.2018.0206. PMID: 30759052
Inoue Y, Nakamura T, Nakanishi H, Oishi M, Hongo F, Okihara K, Mizutani S, Kuroda J, Ukimura O
Int J Urol 2018 Jul;25(7):678-683. Epub 2018 May 11 doi: 10.1111/iju.13597. PMID: 29752743
Bassetto MA, Pasini F, Franceschi T, Mustacchi G, Cetto GL
Anticancer Res 1995 Nov-Dec;15(6B):2751-4. PMID: 8669858
Hainsworth JD, Greco FA
Hematol Oncol Clin North Am 1991 Dec;5(6):1223-31. PMID: 1663941

Prognosis

Lavi A, Winquist E, Nair SM, Chin JL, Izawa J, Fernandes R, Ernst S, Power NE
Curr Oncol 2020 Dec 8;28(1):78-85. doi: 10.3390/curroncol28010010. PMID: 33704177Free PMC Article
Rosti G, Secondino S, Necchi A, Fornarini G, Pedrazzoli P
Semin Oncol 2019 Apr;46(2):107-111. Epub 2019 Apr 24 doi: 10.1053/j.seminoncol.2019.04.001. PMID: 31076171
Ting J, Bell D, Ahmed S, Ying A, Waguespack SG, Tu SM, Weber R, Zafereo M
Thyroid 2019 Feb;29(2):229-236. doi: 10.1089/thy.2018.0206. PMID: 30759052
Inoue Y, Nakamura T, Nakanishi H, Oishi M, Hongo F, Okihara K, Mizutani S, Kuroda J, Ukimura O
Int J Urol 2018 Jul;25(7):678-683. Epub 2018 May 11 doi: 10.1111/iju.13597. PMID: 29752743
Hainsworth JD, Greco FA
Hematol Oncol Clin North Am 1991 Dec;5(6):1223-31. PMID: 1663941

Clinical prediction guides

Li Y, Huang X, Meng X, Luo Y, Luo S, Wang J
Diagn Pathol 2023 Feb 20;18(1):26. doi: 10.1186/s13000-023-01312-0. PMID: 36805679Free PMC Article
van den Akker M, Vervloessem D, Huybrechs A, Declercq S, van der Werff Ten Bosch J
J Med Case Rep 2017 Feb 20;11(1):47. doi: 10.1186/s13256-017-1216-4. PMID: 28215183Free PMC Article
Kobayashi T, Kawakita M, Terachi T, Habuchi T, Ogawa O, Kamoto T
J Surg Oncol 2006 Dec 1;94(7):619-23. doi: 10.1002/jso.20418. PMID: 17111392
Coskun U, Günel N, Yildirim Y, Memis L, Boyacioglu ZM
Med Princ Pract 2002 Oct-Dec;11(4):218-20. doi: 10.1159/000065812. PMID: 12424419

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