U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Minor salivary gland adenoid cystic carcinoma

MedGen UID:
233709
•Concept ID:
C1334769
•
Neoplastic Process
Synonyms: Adenoid Cystic Carcinoma of Minor Salivary Gland; adenoid cystic carcinoma of minor salivary gland; Adenoid Cystic Carcinoma of the Minor Salivary Gland; adenoid cystic carcinoma of the minor salivary gland; Minor Salivary Gland Adenoid Cystic Carcinoma; minor salivary gland adenoid cystic carcinoma
 
Monarch Initiative: MONDO:0045068

Definition

An aggressive carcinoma that arises from the minor salivary glands. It is characterized by the presence of malignant epithelial and myoepithelial cells forming cribriform, tubular, and solid patterns. It usually presents as a slow growing mass. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMinor salivary gland adenoid cystic carcinoma

Professional guidelines

PubMed

The Evaluation and Management of Carcinoma of the Minor Salivary Glands.
Walvekar R, Phalke NP
Otolaryngol Clin North Am 2021 Jun;54(3):629-639. doi: 10.1016/j.otc.2021.02.011. PMID: 34024489
Postoperative Management of Salivary Gland Tumors.
Joshi NP, Broughman JR
Curr Treat Options Oncol 2021 Feb 9;22(3):23. doi: 10.1007/s11864-021-00820-9. PMID: 33560478
Management of salivary gland carcinomas - a review.
Wang X, Luo Y, Li M, Yan H, Sun M, Fan T
Oncotarget 2017 Jan 17;8(3):3946-3956. doi: 10.18632/oncotarget.13952. PMID: 27992367Free PMC Article

Recent clinical studies

Etiology

Early stage minor salivary gland adenoid cystic carcinoma has favourable prognosis.
Hämetoja H, Hirvonen K, Hagström J, Leivo I, Saarilahti K, Apajalahti S, Haglund C, Mäkitie A, Bäck L
Virchows Arch 2017 Dec;471(6):785-792. Epub 2017 Jun 10 doi: 10.1007/s00428-017-2163-6. PMID: 28600602
Response to oxaliplatin with cetuximab in minor salivary gland adenoid cystic carcinoma.
De Dosso S, Mazzucchelli L, Ghielmini M, Saletti P
Tumori 2009 May-Jun;95(3):378-81. doi: 10.1177/030089160909500319. PMID: 19688981
Adenoid cystic carcinoma of the minor salivary glands.
Witt RL
Ear Nose Throat J 1991 Apr;70(4):218-22. PMID: 1651839
Adenoid cystic carcinoma. Analysis of fifty oral cases.
Tarpley TM Jr, Giansanti JS
Oral Surg Oral Med Oral Pathol 1976 Apr;41(4):484-97. doi: 10.1016/0030-4220(76)90276-0. PMID: 177922

Diagnosis

Immunoexpression pattern of TLR3 and TLR7 in minor salivary gland adenoid cystic carcinoma and its role in prognosis.
Rytkönen A, Eray M, Suominen A, Mäkitie A, Haglund C, Hagström J, Laine HK
Cancer Treat Res Commun 2024;40:100822. Epub 2024 May 22 doi: 10.1016/j.ctarc.2024.100822. PMID: 38810370
Antizyme inhibitor 2 (AZIN2) associates with better prognosis of head and neck minor salivary gland adenoid cystic carcinoma.
Hämetoja H, Andersson LC, Mäkitie A, Bäck L, Hagström J, Haglund C
APMIS 2021 Aug;129(8):503-511. Epub 2021 Jun 25 doi: 10.1111/apm.13158. PMID: 34046926
Fine-needle aspiration biopsy as an auxiliary diagnostic tool on intraoral minor salivary gland adenoid cystic carcinoma.
Netto Jde N, Miranda AM, da Silveira HM, dos Santos TC, Pires FR
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008 Aug;106(2):242-5. doi: 10.1016/j.tripleo.2008.04.015. PMID: 18644520
Adenoid cystic carcinoma. Analysis of fifty oral cases.
Tarpley TM Jr, Giansanti JS
Oral Surg Oral Med Oral Pathol 1976 Apr;41(4):484-97. doi: 10.1016/0030-4220(76)90276-0. PMID: 177922

Therapy

Response to oxaliplatin with cetuximab in minor salivary gland adenoid cystic carcinoma.
De Dosso S, Mazzucchelli L, Ghielmini M, Saletti P
Tumori 2009 May-Jun;95(3):378-81. doi: 10.1177/030089160909500319. PMID: 19688981

Prognosis

Immunoexpression pattern of TLR3 and TLR7 in minor salivary gland adenoid cystic carcinoma and its role in prognosis.
Rytkönen A, Eray M, Suominen A, Mäkitie A, Haglund C, Hagström J, Laine HK
Cancer Treat Res Commun 2024;40:100822. Epub 2024 May 22 doi: 10.1016/j.ctarc.2024.100822. PMID: 38810370
Antizyme inhibitor 2 (AZIN2) associates with better prognosis of head and neck minor salivary gland adenoid cystic carcinoma.
Hämetoja H, Andersson LC, Mäkitie A, Bäck L, Hagström J, Haglund C
APMIS 2021 Aug;129(8):503-511. Epub 2021 Jun 25 doi: 10.1111/apm.13158. PMID: 34046926
Matrix metalloproteinase-7, -8, -9, -15, and -25 in minor salivary gland adenoid cystic carcinoma.
Hämetoja H, Mäkitie A, Bäck L, Leivo I, Haglund C, Sorsa T, Hagström J
Pathol Res Pract 2021 Jan;217:153293. Epub 2020 Nov 22 doi: 10.1016/j.prp.2020.153293. PMID: 33278774
Early stage minor salivary gland adenoid cystic carcinoma has favourable prognosis.
Hämetoja H, Hirvonen K, Hagström J, Leivo I, Saarilahti K, Apajalahti S, Haglund C, Mäkitie A, Bäck L
Virchows Arch 2017 Dec;471(6):785-792. Epub 2017 Jun 10 doi: 10.1007/s00428-017-2163-6. PMID: 28600602
Adenoid cystic carcinoma of the minor salivary glands.
Witt RL
Ear Nose Throat J 1991 Apr;70(4):218-22. PMID: 1651839

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On
    • Minor salivary gland adenoid cystic carcinoma
      Minor salivary gland adenoid cystic carcinoma
      MedGen
    • Dextrocardia
      Dextrocardia
      A congenital defect in which the heart is located on the right side of the THORAX instead of on the left side (levocardia, the normal position). When dextrocardia is accompani...<br/>Year introduced: 1991(1984)1963
      MeSH

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...