U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ampulla of vater mucinous adenocarcinoma

MedGen UID:
233973
•Concept ID:
C1332248
•
Neoplastic Process
Synonyms: Ampulla of Vater Mucinous Adenocarcinoma; ampulla of vater mucinous adenocarcinoma; ampulla of Vater mucinous adenocarcinoma; hepatopancreatic ampulla mucinous adenocarcinoma
 
Monarch Initiative: MONDO:0002736

Definition

A carcinoma with glandular differentiation arising from the ampulla of Vater. Morphologically, it is characterized by the presence of mucoid stroma formation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAmpulla of vater mucinous adenocarcinoma

Recent clinical studies

Etiology

Exosomal miRNA signatures of pancreatic lesions.
Vicentini C, Calore F, Nigita G, Fadda P, Simbolo M, Sperandio N, Luchini C, Lawlor RT, Croce CM, Corbo V, Fassan M, Scarpa A
BMC Gastroenterol 2020 May 6;20(1):137. doi: 10.1186/s12876-020-01287-y. PMID: 32375666Free PMC Article
Cytologic characteristics of circulating epithelioid cells in pancreatic disease.
Rosenbaum MW, Cauley CE, Kulemann B, Liss AS, Castillo CF, Warshaw AL, Lillemoe KD, Thayer SP, Pitman MB
Cancer Cytopathol 2017 May;125(5):332-340. Epub 2017 Mar 3 doi: 10.1002/cncy.21841. PMID: 28257167Free PMC Article
The utility of immunohistochemistry in subtyping adenocarcinoma of the ampulla of vater.
Ang DC, Shia J, Tang LH, Katabi N, Klimstra DS
Am J Surg Pathol 2014 Oct;38(10):1371-9. doi: 10.1097/PAS.0000000000000230. PMID: 24832159
Expression and prognostic significance of 14-3-3sigma and ERM family protein expression in periampullary neoplasms.
Hustinx SR, Fukushima N, Zahurak ML, Riall TS, Maitra A, Brosens L, Cameron JL, Yeo CJ, Offerhaus GJ, Hruban RH, Goggins M
Cancer Biol Ther 2005 May;4(5):596-601. Epub 2005 May 13 doi: 10.4161/cbt.4.5.1748. PMID: 15908786
Mucin-producing neoplasms of the pancreas. Intraductal papillary and mucinous cystic neoplasms.
Shyr YM, Su CH, Tsay SH, Lui WY
Ann Surg 1996 Feb;223(2):141-6. doi: 10.1097/00000658-199602000-00005. PMID: 8597507Free PMC Article

Diagnosis

Role of Immunohistochemistry in the Subtyping of Periampullary Adenocarcinoma.
Bakshi N, Dhawan S, Nundy S, Rao S, Chopra P, Bhalla S
Int J Surg Pathol 2019 Sep;27(6):598-608. Epub 2019 Apr 3 doi: 10.1177/1066896919837606. PMID: 30942099
Tumoral Versus Flat Intraepithelial Neoplasia of Pancreatobiliary Tract, Gallbladder, and Ampulla of Vater.
Jang KT, Ahn S
Arch Pathol Lab Med 2016 May;140(5):429-36. doi: 10.5858/arpa.2015-0319-RA. PMID: 27128300
The utility of immunohistochemistry in subtyping adenocarcinoma of the ampulla of vater.
Ang DC, Shia J, Tang LH, Katabi N, Klimstra DS
Am J Surg Pathol 2014 Oct;38(10):1371-9. doi: 10.1097/PAS.0000000000000230. PMID: 24832159
An introduction to mucin-producing tumors of the pancreas: why they deserve more attention.
Takada T, Yasuda H, Amano H, Yoshida M, Hijikata H, Takada K
Hepatogastroenterology 1998 Nov-Dec;45(24):1967-72. PMID: 9951849
Mucin-producing neoplasms of the pancreas. Intraductal papillary and mucinous cystic neoplasms.
Shyr YM, Su CH, Tsay SH, Lui WY
Ann Surg 1996 Feb;223(2):141-6. doi: 10.1097/00000658-199602000-00005. PMID: 8597507Free PMC Article

Therapy

Long-term survival after hepatectomy for hepatic recurrence of carcinoma of the papilla of Vater.
Kitami CE, Kurosaki I, Koyama Y, Makino H, Hatakeyama K
J Hepatobiliary Pancreat Surg 2005;12(4):321-3. doi: 10.1007/s00534-005-0972-5. PMID: 16133701
Pylorus-preserving total pancreatectomy. Early and late results.
Wagner M, Z'graggen K, Vagianos CE, Redaelli CA, Holzinger F, Sadowski C, Kulli C, Zimmermann H, Baer HU, Büchler MW
Dig Surg 2001;18(3):188-95. doi: 10.1159/000050128. PMID: 11464008

Prognosis

Exosomal miRNA signatures of pancreatic lesions.
Vicentini C, Calore F, Nigita G, Fadda P, Simbolo M, Sperandio N, Luchini C, Lawlor RT, Croce CM, Corbo V, Fassan M, Scarpa A
BMC Gastroenterol 2020 May 6;20(1):137. doi: 10.1186/s12876-020-01287-y. PMID: 32375666Free PMC Article
Role of Immunohistochemistry in the Subtyping of Periampullary Adenocarcinoma.
Bakshi N, Dhawan S, Nundy S, Rao S, Chopra P, Bhalla S
Int J Surg Pathol 2019 Sep;27(6):598-608. Epub 2019 Apr 3 doi: 10.1177/1066896919837606. PMID: 30942099
Intraductal papillary mucinous neoplasms of the pancreas with concurrent pancreatic and periampullary neoplasms.
Sahora K, Crippa S, Zamboni G, Ferrone C, Warshaw AL, Lillemoe K, Mino-Kenudson M, Falconi M, Fernandez-del Castillo C
Eur J Surg Oncol 2016 Feb;42(2):197-204. Epub 2015 Dec 1 doi: 10.1016/j.ejso.2015.10.014. PMID: 26687069
The utility of immunohistochemistry in subtyping adenocarcinoma of the ampulla of vater.
Ang DC, Shia J, Tang LH, Katabi N, Klimstra DS
Am J Surg Pathol 2014 Oct;38(10):1371-9. doi: 10.1097/PAS.0000000000000230. PMID: 24832159
An introduction to mucin-producing tumors of the pancreas: why they deserve more attention.
Takada T, Yasuda H, Amano H, Yoshida M, Hijikata H, Takada K
Hepatogastroenterology 1998 Nov-Dec;45(24):1967-72. PMID: 9951849

Clinical prediction guides

The CT fish mouth ampulla sign: a highly specific finding in main duct and mixed intraductal papillary mucinous neoplasms.
Zhang TT, Sadler TJ, Whitley S, Brais R, Godfrey E
Br J Radiol 2019 Nov;92(1103):20190461. Epub 2019 Aug 28 doi: 10.1259/bjr.20190461. PMID: 31430199Free PMC Article
Cytologic characteristics of circulating epithelioid cells in pancreatic disease.
Rosenbaum MW, Cauley CE, Kulemann B, Liss AS, Castillo CF, Warshaw AL, Lillemoe KD, Thayer SP, Pitman MB
Cancer Cytopathol 2017 May;125(5):332-340. Epub 2017 Mar 3 doi: 10.1002/cncy.21841. PMID: 28257167Free PMC Article
The utility of immunohistochemistry in subtyping adenocarcinoma of the ampulla of vater.
Ang DC, Shia J, Tang LH, Katabi N, Klimstra DS
Am J Surg Pathol 2014 Oct;38(10):1371-9. doi: 10.1097/PAS.0000000000000230. PMID: 24832159
Intestinal-type of differentiation predicts favourable overall survival: confirmatory clinicopathological analysis of 198 periampullary adenocarcinomas of pancreatic, biliary, ampullary and duodenal origin.
Bronsert P, Kohler I, Werner M, Makowiec F, Kuesters S, Hoeppner J, Hopt UT, Keck T, Bausch D, Wellner UF
BMC Cancer 2013 Sep 22;13:428. doi: 10.1186/1471-2407-13-428. PMID: 24053229Free PMC Article
Intraductal papillary mucinous neoplasm of the pancreas: assessment of the likelihood of invasiveness with multisection CT.
Ogawa H, Itoh S, Ikeda M, Suzuki K, Naganawa S
Radiology 2008 Sep;248(3):876-86. Epub 2008 Jul 15 doi: 10.1148/radiol.2482071578. PMID: 18632526

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...