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Ampulla of vater adenocarcinoma

MedGen UID:
231054
•Concept ID:
C1332243
•
Neoplastic Process
Synonym: Adenocarcinoma of ampulla of Vater
 
Monarch Initiative: MONDO:0002670

Definition

An invasive carcinoma with glandular differentiation arising from the ampulla of Vater. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss. [from NCI]

Professional guidelines

PubMed

Controversies in the diagnosis and treatment of periampullary tumours.
Skórzewska M, Kurzawa P, Ciszewski T, Pelc Z, Polkowski WP
Surg Oncol 2022 Sep;44:101853. Epub 2022 Sep 14 doi: 10.1016/j.suronc.2022.101853. PMID: 36152420
Treatment Approach to Adenocarcinoma of the Ampulla of Vater.
Patel M, Uboha NV
Curr Treat Options Oncol 2021 Sep 29;22(11):103. doi: 10.1007/s11864-021-00894-5. PMID: 34586537
Ampullary and periampullary adenocarcinoma: new challenges in management of recurrence.
Ramfidis VS, Syrigos KN, Saif MW
JOP 2013 Mar 10;14(2):158-60. doi: 10.6092/1590-8577/1471. PMID: 23474562

Recent clinical studies

Etiology

Primary malignant pericardial tumour in Lynch syndrome.
Paolisso P, Saturi G, Foà A, Saponara M, Nannini M, Pantaleo MA, Leone O, Turchetti D, Calistri D, Savini C, Pacini D, Pizzi C, Galiè N
BMC Cancer 2020 Mar 6;20(1):191. doi: 10.1186/s12885-020-6677-y. PMID: 32143595Free PMC Article
Evaluation of POSSUM for patients undergoing pancreatoduodenectomy.
de Castro SM, Houwert JT, Lagarde SM, Reitsma JB, Busch OR, van Gulik TM, Obertop H, Gouma DJ
World J Surg 2009 Jul;33(7):1481-7. doi: 10.1007/s00268-009-0037-z. PMID: 19384458Free PMC Article
Adenocarcinoma of the ampulla of Vater: T-stage, chromosome 17p allelic loss, and extended pancreaticoduodenectomy are relevant prognostic factors.
Iacono C, Verlato G, Zamboni G, Scarpa A, Montresor E, Capelli P, Bortolasi L, Serio G
J Gastrointest Surg 2007 May;11(5):578-88. doi: 10.1007/s11605-007-0136-9. PMID: 17468917
Maspin expression in adenocarcinoma of the ampulla of Vater: relation with clinicopathological parameters and apoptosis.
Blandamura S, D'Alessandro E, Guzzardo V, Giacomelli L, Moschino P, Parenti A, Ninfo V
Anticancer Res 2007 Mar-Apr;27(2):1059-65. PMID: 17465244
Endobronchial metastases from extrathoracic malignancies.
Akoglu S, Uçan ES, Celik G, Sener G, Sevinç C, Kilinç O, Itil O
Clin Exp Metastasis 2005;22(7):587-91. Epub 2006 Feb 11 doi: 10.1007/s10585-005-5787-x. PMID: 16475029

Diagnosis

Immunohistochemical study of mucin expression in periampullary adenomyoma.
Higashi M, Goto M, Saitou M, Shimizu T, Rousseau K, Batra SK, Yonezawa S
J Hepatobiliary Pancreat Sci 2010 May;17(3):275-83. Epub 2009 Sep 26 doi: 10.1007/s00534-009-0176-5. PMID: 19784541
Evaluation of POSSUM for patients undergoing pancreatoduodenectomy.
de Castro SM, Houwert JT, Lagarde SM, Reitsma JB, Busch OR, van Gulik TM, Obertop H, Gouma DJ
World J Surg 2009 Jul;33(7):1481-7. doi: 10.1007/s00268-009-0037-z. PMID: 19384458Free PMC Article
Endobronchial metastases from extrathoracic malignancies.
Akoglu S, Uçan ES, Celik G, Sener G, Sevinç C, Kilinç O, Itil O
Clin Exp Metastasis 2005;22(7):587-91. Epub 2006 Feb 11 doi: 10.1007/s10585-005-5787-x. PMID: 16475029
Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2.
Chu PG, Schwarz RE, Lau SK, Yen Y, Weiss LM
Am J Surg Pathol 2005 Mar;29(3):359-67. doi: 10.1097/01.pas.0000149708.12335.6a. PMID: 15725805
A novel cell line and xenograft model of ampulla of Vater adenocarcinoma.
Sorio C, Moore PS, Ennas MG, Tecchio C, Bonora A, Sartoris S, Balzarini P, Grigolato P, Scarpa A
Virchows Arch 2004 Mar;444(3):269-77. Epub 2003 Dec 16 doi: 10.1007/s00428-003-0936-6. PMID: 14677066

Therapy

Adenocarcinoma of the ampulla of Vater: what treatment options are available?
Senatore FJ, Ynson ML, Dasanu CA
J Oncol Pharm Pract 2015 Oct;21(5):364-9. Epub 2014 Jun 5 doi: 10.1177/1078155214538086. PMID: 24906539
Ampulla of vater adenocarcinoma in a BRCA2 germline mutation carrier.
Aburjania N, Truskinovsky AM, Overman MJ, Lou E
J Gastrointest Cancer 2014 Mar;45(1):87-90. doi: 10.1007/s12029-013-9479-5. PMID: 23417715
A novel cell line and xenograft model of ampulla of Vater adenocarcinoma.
Sorio C, Moore PS, Ennas MG, Tecchio C, Bonora A, Sartoris S, Balzarini P, Grigolato P, Scarpa A
Virchows Arch 2004 Mar;444(3):269-77. Epub 2003 Dec 16 doi: 10.1007/s00428-003-0936-6. PMID: 14677066
Percutaneous transhepatic biliary biopsy using gastrofiberscopic biopsy forceps.
Kim CS, Han YM, Song HY, Choi KC, Kim DG, Cho BH
J Korean Med Sci 1992 Dec;7(4):325-32. doi: 10.3346/jkms.1992.7.4.325. PMID: 1299235Free PMC Article

Prognosis

The correlation of cortactin and fascin-1 expression with clinicopathological parameters in pancreatic and ampulla of Vater adenocarcinoma.
Tsai WC, Lin CK, Lee HS, Gao HW, Nieh S, Chan DC, Jin JS
APMIS 2013 Mar;121(3):171-81. Epub 2012 Aug 13 doi: 10.1111/j.1600-0463.2012.02952.x. PMID: 23030700
Skull metastasis of ampulla of Vater adenocarcinoma 5 years after Whipple operation: case report and literature review.
Hopf S, Buchalla R, Scheil F, Heusermann U, Börm W
J Neurooncol 2009 Oct;95(1):141-145. Epub 2009 May 15 doi: 10.1007/s11060-009-9906-4. PMID: 19444594
Adenocarcinoma of the ampulla of Vater: T-stage, chromosome 17p allelic loss, and extended pancreaticoduodenectomy are relevant prognostic factors.
Iacono C, Verlato G, Zamboni G, Scarpa A, Montresor E, Capelli P, Bortolasi L, Serio G
J Gastrointest Surg 2007 May;11(5):578-88. doi: 10.1007/s11605-007-0136-9. PMID: 17468917
Maspin expression in adenocarcinoma of the ampulla of Vater: relation with clinicopathological parameters and apoptosis.
Blandamura S, D'Alessandro E, Guzzardo V, Giacomelli L, Moschino P, Parenti A, Ninfo V
Anticancer Res 2007 Mar-Apr;27(2):1059-65. PMID: 17465244
A novel cell line and xenograft model of ampulla of Vater adenocarcinoma.
Sorio C, Moore PS, Ennas MG, Tecchio C, Bonora A, Sartoris S, Balzarini P, Grigolato P, Scarpa A
Virchows Arch 2004 Mar;444(3):269-77. Epub 2003 Dec 16 doi: 10.1007/s00428-003-0936-6. PMID: 14677066

Clinical prediction guides

Adenocarcinoma of the ampulla of Vater: what treatment options are available?
Senatore FJ, Ynson ML, Dasanu CA
J Oncol Pharm Pract 2015 Oct;21(5):364-9. Epub 2014 Jun 5 doi: 10.1177/1078155214538086. PMID: 24906539
The correlation of cortactin and fascin-1 expression with clinicopathological parameters in pancreatic and ampulla of Vater adenocarcinoma.
Tsai WC, Lin CK, Lee HS, Gao HW, Nieh S, Chan DC, Jin JS
APMIS 2013 Mar;121(3):171-81. Epub 2012 Aug 13 doi: 10.1111/j.1600-0463.2012.02952.x. PMID: 23030700
Evaluation of POSSUM for patients undergoing pancreatoduodenectomy.
de Castro SM, Houwert JT, Lagarde SM, Reitsma JB, Busch OR, van Gulik TM, Obertop H, Gouma DJ
World J Surg 2009 Jul;33(7):1481-7. doi: 10.1007/s00268-009-0037-z. PMID: 19384458Free PMC Article
Adenocarcinoma of the ampulla of Vater: T-stage, chromosome 17p allelic loss, and extended pancreaticoduodenectomy are relevant prognostic factors.
Iacono C, Verlato G, Zamboni G, Scarpa A, Montresor E, Capelli P, Bortolasi L, Serio G
J Gastrointest Surg 2007 May;11(5):578-88. doi: 10.1007/s11605-007-0136-9. PMID: 17468917
Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2.
Chu PG, Schwarz RE, Lau SK, Yen Y, Weiss LM
Am J Surg Pathol 2005 Mar;29(3):359-67. doi: 10.1097/01.pas.0000149708.12335.6a. PMID: 15725805

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