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Childhood Brain Anaplastic Astrocytoma

MedGen UID:
234121
Concept ID:
C1332947
Neoplastic Process
Synonyms: Anaplastic Childhood Astrocytoma of Brain; Anaplastic Childhood Astrocytoma of the Brain; Anaplastic Childhood Brain Astrocytoma; Anaplastic Pediatric Astrocytoma of Brain; Anaplastic Pediatric Astrocytoma of the Brain; Anaplastic Pediatric Brain Astrocytoma; Grade 3 Childhood Astrocytic Neoplasm of Brain; Grade 3 Childhood Astrocytic Neoplasm of the Brain; Grade 3 Childhood Astrocytic Tumor of Brain; Grade 3 Childhood Astrocytic Tumor of the Brain; Grade 3 Childhood Astrocytoma of Brain; Grade 3 Childhood Astrocytoma of the Brain; Grade 3 Childhood Brain Astrocytic Neoplasm; Grade 3 Childhood Brain Astrocytic Tumor; Grade 3 Childhood Brain Astrocytoma; Grade 3 Pediatric Astrocytic Neoplasm of Brain; Grade 3 Pediatric Astrocytic Neoplasm of the Brain; Grade 3 Pediatric Astrocytic Tumor of Brain; Grade 3 Pediatric Astrocytic Tumor of the Brain; Grade 3 Pediatric Astrocytoma of Brain; Grade 3 Pediatric Astrocytoma of the Brain; Grade 3 Pediatric Brain Astrocytic Neoplasm; Grade 3 Pediatric Brain Astrocytic Tumor; Grade 3 Pediatric Brain Astrocytoma; Grade III Childhood Astrocytic Neoplasm of Brain; Grade III Childhood Astrocytic Neoplasm of the Brain; Grade III Childhood Astrocytic Tumor of Brain; Grade III Childhood Astrocytic Tumor of the Brain; Grade III Childhood Astrocytoma of Brain; Grade III Childhood Astrocytoma of the Brain; Grade III Childhood Brain Astrocytic Neoplasm; Grade III Childhood Brain Astrocytic Tumor; Grade III Childhood Brain Astrocytoma; Grade III Pediatric Astrocytic Neoplasm of Brain; Grade III Pediatric Astrocytic Neoplasm of the Brain; Grade III Pediatric Astrocytic Tumor of Brain; Grade III Pediatric Astrocytic Tumor of the Brain; Grade III Pediatric Astrocytoma of Brain; Grade III Pediatric Astrocytoma of the Brain; Grade III Pediatric Brain Astrocytic Neoplasm; Grade III Pediatric Brain Astrocytic Tumor; Grade III Pediatric Brain Astrocytoma

Definition

An anaplastic astrocytoma that arises from the brain and occurs during childhood. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Hodžić M, Ercegović Z, Korkut D, Moranjkić M, Brkić H, Jakupović S
Acta Med Acad 2020;49 Suppl 1:37-44. doi: 10.5644/ama2006-124.305. PMID: 33543629
Pollack IF, Agnihotri S, Broniscer A
J Neurosurg Pediatr 2019 Mar 1;23(3):261-273. doi: 10.3171/2018.10.PEDS18377. PMID: 30835699Free PMC Article
Hwang SW, Su JM, Jea A
Semin Fetal Neonatal Med 2012 Aug;17(4):202-206. Epub 2012 Mar 30 doi: 10.1016/j.siny.2012.03.001. PMID: 22465555

Recent clinical studies

Etiology

Okonechnikov K, Joshi P, Sepp M, Leiss K, Sarropoulos I, Murat F, Sill M, Beck P, Chan KC, Korshunov A, Sah F, Deng MY, Sturm D, DeSisto J, Donson AM, Foreman NK, Green AL, Robinson G, Orr BA, Gao Q, Darrow E, Hadley JL, Northcott PA, Gojo J, Kawauchi D, Hovestadt V, Filbin MG, von Deimling A, Zuckermann M, Pajtler KW, Kool M, Jones DTW, Jäger N, Kutscher LM, Kaessmann H, Pfister SM
Neuro Oncol 2023 Oct 3;25(10):1895-1909. doi: 10.1093/neuonc/noad124. PMID: 37534924Free PMC Article
Howell AE, Relton C, Martin RM, Zheng J, Kurian KM
Sci Rep 2023 Apr 21;13(1):6590. doi: 10.1038/s41598-023-33621-1. PMID: 37085538Free PMC Article
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy AS, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD
Nature 2019 Aug;572(7767):67-73. Epub 2019 May 1 doi: 10.1038/s41586-019-1158-7. PMID: 31043743Free PMC Article
Pollack IF, Agnihotri S, Broniscer A
J Neurosurg Pediatr 2019 Mar 1;23(3):261-273. doi: 10.3171/2018.10.PEDS18377. PMID: 30835699Free PMC Article

Diagnosis

Formentin C, Joaquim AF, Ghizoni E
Eur J Pediatr 2023 Nov;182(11):4833-4850. Epub 2023 Sep 8 doi: 10.1007/s00431-023-05189-5. PMID: 37679511
Howell AE, Relton C, Martin RM, Zheng J, Kurian KM
Sci Rep 2023 Apr 21;13(1):6590. doi: 10.1038/s41598-023-33621-1. PMID: 37085538Free PMC Article
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Brandão LA, Young Poussaint T
Neuroimaging Clin N Am 2017 Feb;27(1):1-37. doi: 10.1016/j.nic.2016.08.001. PMID: 27889018
Appin CL, Brat DJ
Cancer J 2014 Jan-Feb;20(1):66-72. doi: 10.1097/PPO.0000000000000020. PMID: 24445767

Therapy

Schraw JM, Petridou ET, Bonaventure A, Dockerty JD, Karalexi M, Ntzani E, Infante-Rivard C, Clavel J, Bracci PM, McKean-Cowdin R, Roman E, Kane E, Erdmann F, Schüz J, Mueller BA, Scheurer ME
Cancer Causes Control 2023 Nov;34(11):1005-1015. Epub 2023 Jul 8 doi: 10.1007/s10552-023-01746-3. PMID: 37421504
Howell AE, Relton C, Martin RM, Zheng J, Kurian KM
Sci Rep 2023 Apr 21;13(1):6590. doi: 10.1038/s41598-023-33621-1. PMID: 37085538Free PMC Article
Vitanza NA, Johnson AJ, Wilson AL, Brown C, Yokoyama JK, Künkele A, Chang CA, Rawlings-Rhea S, Huang W, Seidel K, Albert CM, Pinto N, Gust J, Finn LS, Ojemann JG, Wright J, Orentas RJ, Baldwin M, Gardner RA, Jensen MC, Park JR
Nat Med 2021 Sep;27(9):1544-1552. Epub 2021 Jul 12 doi: 10.1038/s41591-021-01404-8. PMID: 34253928
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Pollack IF, Agnihotri S, Broniscer A
J Neurosurg Pediatr 2019 Mar 1;23(3):261-273. doi: 10.3171/2018.10.PEDS18377. PMID: 30835699Free PMC Article

Prognosis

Formentin C, Joaquim AF, Ghizoni E
Eur J Pediatr 2023 Nov;182(11):4833-4850. Epub 2023 Sep 8 doi: 10.1007/s00431-023-05189-5. PMID: 37679511
Lucas CG, Sloan EA, Gupta R, Wu J, Pratt D, Vasudevan HN, Ravindranathan A, Barreto J, Williams EA, Shai A, Whipple NS, Bruggers CS, Maher O, Nabors B, Rodriguez M, Samuel D, Brown M, Carmichael J, Lu R, Mirchia K, Sullivan DV, Pekmezci M, Tihan T, Bollen AW, Perry A, Banerjee A, Mueller S, Gupta N, Hervey-Jumper SL, Oberheim Bush NA, Daras M, Taylor JW, Butowski NA, de Groot J, Clarke JL, Raleigh DR, Costello JF, Phillips JJ, Reddy AT, Chang SM, Berger MS, Solomon DA
Acta Neuropathol 2022 Oct;144(4):747-765. Epub 2022 Aug 9 doi: 10.1007/s00401-022-02478-5. PMID: 35945463Free PMC Article
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy AS, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD
Nature 2019 Aug;572(7767):67-73. Epub 2019 May 1 doi: 10.1038/s41586-019-1158-7. PMID: 31043743Free PMC Article
Pollack IF, Agnihotri S, Broniscer A
J Neurosurg Pediatr 2019 Mar 1;23(3):261-273. doi: 10.3171/2018.10.PEDS18377. PMID: 30835699Free PMC Article

Clinical prediction guides

Formentin C, Joaquim AF, Ghizoni E
Eur J Pediatr 2023 Nov;182(11):4833-4850. Epub 2023 Sep 8 doi: 10.1007/s00431-023-05189-5. PMID: 37679511
Foss-Skiftesvik J, Li S, Rosenbaum A, Hagen CM, Stoltze UK, Ljungqvist S, Hjalmars U, Schmiegelow K, Morimoto L, de Smith AJ, Mathiasen R, Metayer C, Hougaard D, Melin B, Walsh KM, Bybjerg-Grauholm J, Dahlin AM, Wiemels JL
Neuro Oncol 2023 Sep 5;25(9):1709-1720. doi: 10.1093/neuonc/noad042. PMID: 36810956Free PMC Article
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Appin CL, Brat DJ
Cancer J 2014 Jan-Feb;20(1):66-72. doi: 10.1097/PPO.0000000000000020. PMID: 24445767
Jones DT, Hutter B, Jäger N, Korshunov A, Kool M, Warnatz HJ, Zichner T, Lambert SR, Ryzhova M, Quang DA, Fontebasso AM, Stütz AM, Hutter S, Zuckermann M, Sturm D, Gronych J, Lasitschka B, Schmidt S, Seker-Cin H, Witt H, Sultan M, Ralser M, Northcott PA, Hovestadt V, Bender S, Pfaff E, Stark S, Faury D, Schwartzentruber J, Majewski J, Weber UD, Zapatka M, Raeder B, Schlesner M, Worth CL, Bartholomae CC, von Kalle C, Imbusch CD, Radomski S, Lawerenz C, van Sluis P, Koster J, Volckmann R, Versteeg R, Lehrach H, Monoranu C, Winkler B, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, Ebinger M, Schuhmann MU, Cho YJ, Pomeroy SL, von Deimling A, Witt O, Taylor MD, Wolf S, Karajannis MA, Eberhart CG, Scheurlen W, Hasselblatt M, Ligon KL, Kieran MW, Korbel JO, Yaspo ML, Brors B, Felsberg J, Reifenberger G, Collins VP, Jabado N, Eils R, Lichter P, Pfister SM; International Cancer Genome Consortium PedBrain Tumor Project
Nat Genet 2013 Aug;45(8):927-32. Epub 2013 Jun 30 doi: 10.1038/ng.2682. PMID: 23817572Free PMC Article

Recent systematic reviews

Sherman SJ, Tanaka R, Qaddoumi I
J Psychiatr Res 2022 Apr;148:240-249. Epub 2022 Feb 2 doi: 10.1016/j.jpsychires.2022.01.056. PMID: 35149436
Espiritu AI, Terencio BB, Jamora RDG
World Neurosurg 2020 Jul;139:90-96. Epub 2020 Apr 13 doi: 10.1016/j.wneu.2020.03.212. PMID: 32298818
Girardi F, Allemani C, Coleman MP
J Glob Oncol 2019 Oct;5:1-25. doi: 10.1200/JGO.19.00140. PMID: 31682549Free PMC Article
Georgakis MK, Kalogirou EI, Liaskas A, Karalexi MA, Papathoma P, Ladopoulou K, Kantzanou M, Tsivgoulis G; NARECHEM-BT Working Group, Petridou ET
Eur J Cancer 2017 Apr;75:117-131. Epub 2017 Feb 20 doi: 10.1016/j.ejca.2016.12.033. PMID: 28219020
Hanzlik E, Woodrome SE, Abdel-Baki M, Geller TJ, Elbabaa SK
Childs Nerv Syst 2015 Oct;31(10):1869-75. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2867-3. PMID: 26351236

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