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Childhood cerebellar neoplasm

MedGen UID:
234124
•Concept ID:
C1332959
•
Neoplastic Process
Synonyms: Childhood Cerebellar Neoplasm; childhood cerebellar neoplasm; Childhood Cerebellar Neoplasms; childhood cerebellar neoplasms; Childhood Cerebellar Tumor; childhood cerebellar tumor; Childhood Cerebellar Tumors; childhood cerebellar tumors; childhood cerebellar tumour; childhood cerebellar tumours; Childhood Neoplasm of Cerebellum; childhood neoplasm of cerebellum; Childhood Neoplasm of the Cerebellum; childhood neoplasm of the cerebellum; Childhood Tumor of Cerebellum; childhood tumor of cerebellum; Childhood Tumor of the Cerebellum; childhood tumor of the cerebellum; childhood tumour of cerebellum; childhood tumour of the cerebellum; paediatric cerebellar neoplasm; paediatric cerebellar tumour; paediatric neoplasm of cerebellum; paediatric neoplasm of the cerebellum; paediatric tumour of cerebellum; paediatric tumour of the cerebellum; Pediatric Cerebellar Neoplasm; pediatric cerebellar neoplasm; Pediatric Cerebellar Tumor; pediatric cerebellar tumor; Pediatric Neoplasm of Cerebellum; pediatric neoplasm of cerebellum; Pediatric Neoplasm of the Cerebellum; pediatric neoplasm of the cerebellum; Pediatric Tumor of Cerebellum; pediatric tumor of cerebellum; Pediatric Tumor of the Cerebellum; pediatric tumor of the cerebellum
 
Monarch Initiative: MONDO:0003263

Definition

A neoplasm that affects the cerebellum and occurs during childhood. [from NCI]

Professional guidelines

PubMed

Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma.
Donovan LK, Delaidelli A, Joseph SK, Bielamowicz K, Fousek K, Holgado BL, Manno A, Srikanthan D, Gad AZ, Van Ommeren R, Przelicki D, Richman C, Ramaswamy V, Daniels C, Pallota JG, Douglas T, Joynt ACM, Haapasalo J, Nor C, Vladoiu MC, Kuzan-Fischer CM, Garzia L, Mack SC, Varadharajan S, Baker ML, Hendrikse L, Ly M, Kharas K, Balin P, Wu X, Qin L, Huang N, Stucklin AG, Morrissy AS, Cavalli FMG, Luu B, Suarez R, De Antonellis P, Michealraj A, Rastan A, Hegde M, Komosa M, Sirbu O, Kumar SA, Abdullaev Z, Faria CC, Yip S, Hukin J, Tabori U, Hawkins C, Aldape K, Daugaard M, Maris JM, Sorensen PH, Ahmed N, Taylor MD
Nat Med 2020 May;26(5):720-731. Epub 2020 Apr 27 doi: 10.1038/s41591-020-0827-2. PMID: 32341580Free PMC Article
Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.
Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article
EANO-EURACAN clinical practice guideline for diagnosis, treatment, and follow-up of post-pubertal and adult patients with medulloblastoma.
Franceschi E, Hofer S, Brandes AA, Frappaz D, Kortmann RD, Bromberg J, Dangouloff-Ros V, Boddaert N, Hattingen E, Wiestler B, Clifford SC, Figarella-Branger D, Giangaspero F, Haberler C, Pietsch T, Pajtler KW, Pfister SM, Guzman R, Stummer W, Combs SE, Seidel C, Beier D, McCabe MG, Grotzer M, Laigle-Donadey F, Stücklin ASG, Idbaih A, Preusser M, van den Bent M, Weller M, Hau P
Lancet Oncol 2019 Dec;20(12):e715-e728. doi: 10.1016/S1470-2045(19)30669-2. PMID: 31797797

Recent clinical studies

Etiology

Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis.
Luo Z, Xia M, Shi W, Zhao C, Wang J, Xin D, Dong X, Xiong Y, Zhang F, Berry K, Ogurek S, Liu X, Rao R, Xing R, Wu LMN, Cui S, Xu L, Lin Y, Ma W, Tian S, Xie Q, Zhang L, Xin M, Wang X, Yue F, Zheng H, Liu Y, Stevenson CB, de Blank P, Perentesis JP, Gilbertson RJ, Li H, Ma J, Zhou W, Taylor MD, Lu QR
Nature 2022 Dec;612(7941):787-794. Epub 2022 Nov 30 doi: 10.1038/s41586-022-05487-2. PMID: 36450980
Unified rhombic lip origins of group 3 and group 4 medulloblastoma.
Smith KS, Bihannic L, Gudenas BL, Haldipur P, Tao R, Gao Q, Li Y, Aldinger KA, Iskusnykh IY, Chizhikov VV, Scoggins M, Zhang S, Edwards A, Deng M, Glass IA, Overman LM, Millman J, Sjoboen AH, Hadley J, Golser J, Mankad K, Sheppard H, Onar-Thomas A, Gajjar A, Robinson GW, Hovestadt V, Orr BA, Patay Z, Millen KJ, Northcott PA
Nature 2022 Sep;609(7929):1012-1020. Epub 2022 Sep 21 doi: 10.1038/s41586-022-05208-9. PMID: 36131015Free PMC Article
MRI Radiogenomics of Pediatric Medulloblastoma: A Multicenter Study.
Zhang M, Wong SW, Wright JN, Wagner MW, Toescu S, Han M, Tam LT, Zhou Q, Ahmadian SS, Shpanskaya K, Lummus S, Lai H, Eghbal A, Radmanesh A, Nemelka J, Harward S 2nd, Malinzak M, Laughlin S, Perreault S, Braun KRM, Lober RM, Cho YJ, Ertl-Wagner B, Ho CY, Mankad K, Vogel H, Cheshier SH, Jacques TS, Aquilina K, Fisher PG, Taylor M, Poussaint T, Vitanza NA, Grant GA, Pfister S, Thompson E, Jaju A, Ramaswamy V, Yeom KW
Radiology 2022 Aug;304(2):406-416. Epub 2022 Apr 19 doi: 10.1148/radiol.212137. PMID: 35438562Free PMC Article
Childhood cerebellar tumours mirror conserved fetal transcriptional programs.
Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy AS, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD
Nature 2019 Aug;572(7767):67-73. Epub 2019 May 1 doi: 10.1038/s41586-019-1158-7. PMID: 31043743Free PMC Article
Understanding medulloblastoma.
Quinlan A, Rizzolo D
JAAPA 2017 Oct;30(10):30-36. doi: 10.1097/01.JAA.0000524717.71084.50. PMID: 28953021

Diagnosis

Unified rhombic lip origins of group 3 and group 4 medulloblastoma.
Smith KS, Bihannic L, Gudenas BL, Haldipur P, Tao R, Gao Q, Li Y, Aldinger KA, Iskusnykh IY, Chizhikov VV, Scoggins M, Zhang S, Edwards A, Deng M, Glass IA, Overman LM, Millman J, Sjoboen AH, Hadley J, Golser J, Mankad K, Sheppard H, Onar-Thomas A, Gajjar A, Robinson GW, Hovestadt V, Orr BA, Patay Z, Millen KJ, Northcott PA
Nature 2022 Sep;609(7929):1012-1020. Epub 2022 Sep 21 doi: 10.1038/s41586-022-05208-9. PMID: 36131015Free PMC Article
MRI Radiogenomics of Pediatric Medulloblastoma: A Multicenter Study.
Zhang M, Wong SW, Wright JN, Wagner MW, Toescu S, Han M, Tam LT, Zhou Q, Ahmadian SS, Shpanskaya K, Lummus S, Lai H, Eghbal A, Radmanesh A, Nemelka J, Harward S 2nd, Malinzak M, Laughlin S, Perreault S, Braun KRM, Lober RM, Cho YJ, Ertl-Wagner B, Ho CY, Mankad K, Vogel H, Cheshier SH, Jacques TS, Aquilina K, Fisher PG, Taylor M, Poussaint T, Vitanza NA, Grant GA, Pfister S, Thompson E, Jaju A, Ramaswamy V, Yeom KW
Radiology 2022 Aug;304(2):406-416. Epub 2022 Apr 19 doi: 10.1148/radiol.212137. PMID: 35438562Free PMC Article
EANO-EURACAN clinical practice guideline for diagnosis, treatment, and follow-up of post-pubertal and adult patients with medulloblastoma.
Franceschi E, Hofer S, Brandes AA, Frappaz D, Kortmann RD, Bromberg J, Dangouloff-Ros V, Boddaert N, Hattingen E, Wiestler B, Clifford SC, Figarella-Branger D, Giangaspero F, Haberler C, Pietsch T, Pajtler KW, Pfister SM, Guzman R, Stummer W, Combs SE, Seidel C, Beier D, McCabe MG, Grotzer M, Laigle-Donadey F, Stücklin ASG, Idbaih A, Preusser M, van den Bent M, Weller M, Hau P
Lancet Oncol 2019 Dec;20(12):e715-e728. doi: 10.1016/S1470-2045(19)30669-2. PMID: 31797797
Pediatric Brain Tumors.
Udaka YT, Packer RJ
Neurol Clin 2018 Aug;36(3):533-556. doi: 10.1016/j.ncl.2018.04.009. PMID: 30072070
Understanding medulloblastoma.
Quinlan A, Rizzolo D
JAAPA 2017 Oct;30(10):30-36. doi: 10.1097/01.JAA.0000524717.71084.50. PMID: 28953021

Therapy

MRI Radiogenomics of Pediatric Medulloblastoma: A Multicenter Study.
Zhang M, Wong SW, Wright JN, Wagner MW, Toescu S, Han M, Tam LT, Zhou Q, Ahmadian SS, Shpanskaya K, Lummus S, Lai H, Eghbal A, Radmanesh A, Nemelka J, Harward S 2nd, Malinzak M, Laughlin S, Perreault S, Braun KRM, Lober RM, Cho YJ, Ertl-Wagner B, Ho CY, Mankad K, Vogel H, Cheshier SH, Jacques TS, Aquilina K, Fisher PG, Taylor M, Poussaint T, Vitanza NA, Grant GA, Pfister S, Thompson E, Jaju A, Ramaswamy V, Yeom KW
Radiology 2022 Aug;304(2):406-416. Epub 2022 Apr 19 doi: 10.1148/radiol.212137. PMID: 35438562Free PMC Article
Serial assessment of measurable residual disease in medulloblastoma liquid biopsies.
Liu APY, Smith KS, Kumar R, Paul L, Bihannic L, Lin T, Maass KK, Pajtler KW, Chintagumpala M, Su JM, Bouffet E, Fisher MJ, Gururangan S, Cohn R, Hassall T, Hansford JR, Klimo P Jr, Boop FA, Stewart CF, Harreld JH, Merchant TE, Tatevossian RG, Neale G, Lear M, Klco JM, Orr BA, Ellison DW, Gilbertson RJ, Onar-Thomas A, Gajjar A, Robinson GW, Northcott PA
Cancer Cell 2021 Nov 8;39(11):1519-1530.e4. Epub 2021 Oct 21 doi: 10.1016/j.ccell.2021.09.012. PMID: 34678152Free PMC Article
Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma.
Donovan LK, Delaidelli A, Joseph SK, Bielamowicz K, Fousek K, Holgado BL, Manno A, Srikanthan D, Gad AZ, Van Ommeren R, Przelicki D, Richman C, Ramaswamy V, Daniels C, Pallota JG, Douglas T, Joynt ACM, Haapasalo J, Nor C, Vladoiu MC, Kuzan-Fischer CM, Garzia L, Mack SC, Varadharajan S, Baker ML, Hendrikse L, Ly M, Kharas K, Balin P, Wu X, Qin L, Huang N, Stucklin AG, Morrissy AS, Cavalli FMG, Luu B, Suarez R, De Antonellis P, Michealraj A, Rastan A, Hegde M, Komosa M, Sirbu O, Kumar SA, Abdullaev Z, Faria CC, Yip S, Hukin J, Tabori U, Hawkins C, Aldape K, Daugaard M, Maris JM, Sorensen PH, Ahmed N, Taylor MD
Nat Med 2020 May;26(5):720-731. Epub 2020 Apr 27 doi: 10.1038/s41591-020-0827-2. PMID: 32341580Free PMC Article
Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.
Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article
Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study.
Schwalbe EC, Lindsey JC, Nakjang S, Crosier S, Smith AJ, Hicks D, Rafiee G, Hill RM, Iliasova A, Stone T, Pizer B, Michalski A, Joshi A, Wharton SB, Jacques TS, Bailey S, Williamson D, Clifford SC
Lancet Oncol 2017 Jul;18(7):958-971. Epub 2017 May 22 doi: 10.1016/S1470-2045(17)30243-7. PMID: 28545823Free PMC Article

Prognosis

Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis.
Luo Z, Xia M, Shi W, Zhao C, Wang J, Xin D, Dong X, Xiong Y, Zhang F, Berry K, Ogurek S, Liu X, Rao R, Xing R, Wu LMN, Cui S, Xu L, Lin Y, Ma W, Tian S, Xie Q, Zhang L, Xin M, Wang X, Yue F, Zheng H, Liu Y, Stevenson CB, de Blank P, Perentesis JP, Gilbertson RJ, Li H, Ma J, Zhou W, Taylor MD, Lu QR
Nature 2022 Dec;612(7941):787-794. Epub 2022 Nov 30 doi: 10.1038/s41586-022-05487-2. PMID: 36450980
DICER1 tumor predisposition syndrome: an evolving story initiated with the pleuropulmonary blastoma.
González IA, Stewart DR, Schultz KAP, Field AP, Hill DA, Dehner LP
Mod Pathol 2022 Jan;35(1):4-22. Epub 2021 Oct 1 doi: 10.1038/s41379-021-00905-8. PMID: 34599283Free PMC Article
Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.
Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article
Childhood cerebellar tumours mirror conserved fetal transcriptional programs.
Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy AS, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD
Nature 2019 Aug;572(7767):67-73. Epub 2019 May 1 doi: 10.1038/s41586-019-1158-7. PMID: 31043743Free PMC Article
Understanding medulloblastoma.
Quinlan A, Rizzolo D
JAAPA 2017 Oct;30(10):30-36. doi: 10.1097/01.JAA.0000524717.71084.50. PMID: 28953021

Clinical prediction guides

Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis.
Luo Z, Xia M, Shi W, Zhao C, Wang J, Xin D, Dong X, Xiong Y, Zhang F, Berry K, Ogurek S, Liu X, Rao R, Xing R, Wu LMN, Cui S, Xu L, Lin Y, Ma W, Tian S, Xie Q, Zhang L, Xin M, Wang X, Yue F, Zheng H, Liu Y, Stevenson CB, de Blank P, Perentesis JP, Gilbertson RJ, Li H, Ma J, Zhou W, Taylor MD, Lu QR
Nature 2022 Dec;612(7941):787-794. Epub 2022 Nov 30 doi: 10.1038/s41586-022-05487-2. PMID: 36450980
MRI Radiogenomics of Pediatric Medulloblastoma: A Multicenter Study.
Zhang M, Wong SW, Wright JN, Wagner MW, Toescu S, Han M, Tam LT, Zhou Q, Ahmadian SS, Shpanskaya K, Lummus S, Lai H, Eghbal A, Radmanesh A, Nemelka J, Harward S 2nd, Malinzak M, Laughlin S, Perreault S, Braun KRM, Lober RM, Cho YJ, Ertl-Wagner B, Ho CY, Mankad K, Vogel H, Cheshier SH, Jacques TS, Aquilina K, Fisher PG, Taylor M, Poussaint T, Vitanza NA, Grant GA, Pfister S, Thompson E, Jaju A, Ramaswamy V, Yeom KW
Radiology 2022 Aug;304(2):406-416. Epub 2022 Apr 19 doi: 10.1148/radiol.212137. PMID: 35438562Free PMC Article
Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study.
Schwalbe EC, Lindsey JC, Nakjang S, Crosier S, Smith AJ, Hicks D, Rafiee G, Hill RM, Iliasova A, Stone T, Pizer B, Michalski A, Joshi A, Wharton SB, Jacques TS, Bailey S, Williamson D, Clifford SC
Lancet Oncol 2017 Jul;18(7):958-971. Epub 2017 May 22 doi: 10.1016/S1470-2045(17)30243-7. PMID: 28545823Free PMC Article
Risk stratification of childhood medulloblastoma in the molecular era: the current consensus.
Ramaswamy V, Remke M, Bouffet E, Bailey S, Clifford SC, Doz F, Kool M, Dufour C, Vassal G, Milde T, Witt O, von Hoff K, Pietsch T, Northcott PA, Gajjar A, Robinson GW, Padovani L, André N, Massimino M, Pizer B, Packer R, Rutkowski S, Pfister SM, Taylor MD, Pomeroy SL
Acta Neuropathol 2016 Jun;131(6):821-31. Epub 2016 Apr 4 doi: 10.1007/s00401-016-1569-6. PMID: 27040285Free PMC Article
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.
Jones DT, Hutter B, Jäger N, Korshunov A, Kool M, Warnatz HJ, Zichner T, Lambert SR, Ryzhova M, Quang DA, Fontebasso AM, Stütz AM, Hutter S, Zuckermann M, Sturm D, Gronych J, Lasitschka B, Schmidt S, Seker-Cin H, Witt H, Sultan M, Ralser M, Northcott PA, Hovestadt V, Bender S, Pfaff E, Stark S, Faury D, Schwartzentruber J, Majewski J, Weber UD, Zapatka M, Raeder B, Schlesner M, Worth CL, Bartholomae CC, von Kalle C, Imbusch CD, Radomski S, Lawerenz C, van Sluis P, Koster J, Volckmann R, Versteeg R, Lehrach H, Monoranu C, Winkler B, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, Ebinger M, Schuhmann MU, Cho YJ, Pomeroy SL, von Deimling A, Witt O, Taylor MD, Wolf S, Karajannis MA, Eberhart CG, Scheurlen W, Hasselblatt M, Ligon KL, Kieran MW, Korbel JO, Yaspo ML, Brors B, Felsberg J, Reifenberger G, Collins VP, Jabado N, Eils R, Lichter P, Pfister SM; International Cancer Genome Consortium PedBrain Tumor Project
Nat Genet 2013 Aug;45(8):927-32. Epub 2013 Jun 30 doi: 10.1038/ng.2682. PMID: 23817572Free PMC Article

Recent systematic reviews

The effectiveness and safety of proton beam radiation therapy in children and young adults with Central Nervous System (CNS) tumours: a systematic review.
Wilson JS, Main C, Thorp N, Taylor RE, Majothi S, Kearns PR, English M, Dandapani M, Phillips R, Wheatley K, Pizer B
J Neurooncol 2024 Mar;167(1):1-34. Epub 2024 Jan 31 doi: 10.1007/s11060-023-04510-4. PMID: 38294638Free PMC Article
Atypical teratoid/rhabdoid tumor in adults: a systematic review of the literature with meta-analysis and additional reports of 4 cases.
Broggi G, Gianno F, Shemy DT, Massimino M, Milanaccio C, Mastronuzzi A, Rossi S, Arcella A, Giangaspero F, Antonelli M
J Neurooncol 2022 Mar;157(1):1-14. Epub 2022 Feb 25 doi: 10.1007/s11060-022-03959-z. PMID: 35217948
Neuroimaging Biomarkers and Neurocognitive Outcomes in Pediatric Medulloblastoma Patients: a Systematic Review.
Wauters M, Uyttebroeck A, De Waele L, Sleurs C, Jacobs S
Cerebellum 2021 Jun;20(3):462-480. Epub 2021 Jan 8 doi: 10.1007/s12311-020-01225-4. PMID: 33417160
Medulloblastoma cancer stem cells: molecular signatures and therapeutic targets.
Bahmad HF, Poppiti RJ
J Clin Pathol 2020 May;73(5):243-249. Epub 2020 Feb 7 doi: 10.1136/jclinpath-2019-206246. PMID: 32034059
Neuropsychiatric presentations and outcomes in children and adolescents with primary brain tumours: Systematic review.
Zyrianova Y, Alexander L, Faruqui R
Brain Inj 2016;30(1):1-9. Epub 2015 Nov 5 doi: 10.3109/02699052.2015.1075590. PMID: 26536821

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