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Recurrent Childhood Cerebellar Astrocytoma

MedGen UID:
137885
•Concept ID:
C0338338
•
Neoplastic Process
Synonyms: Recurrent Childhood Astrocytoma of Cerebellum; Recurrent Childhood Astrocytoma of the Cerebellum; Recurrent Pediatric Astrocytoma of Cerebellum; Recurrent Pediatric Astrocytoma of the Cerebellum; Recurrent Pediatric Cerebellar Astrocytoma; Relapsed Childhood Astrocytoma of Cerebellum; Relapsed Childhood Astrocytoma of the Cerebellum; Relapsed Childhood Cerebellar Astrocytoma; Relapsed Pediatric Astrocytoma of Cerebellum; Relapsed Pediatric Astrocytoma of the Cerebellum; Relapsed Pediatric Cerebellar Astrocytoma

Definition

Regrowth of benign and malignant childhood cerebellar astrocytomas that have previously been subjected to surgical resection and less frequently other forms of therapy such as radiation or chemotherapy. Recurrence of benign tumors (e.g., (pilocytic astrocytoma) may respond to a second surgical procedure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Childhood Cerebellar Astrocytoma

Professional guidelines

PubMed

Magnetic Resonance Imaging in the Contemporary Management of Medulloblastoma: Current and Emerging Applications.
Dasgupta A, Maitre M, Pungavkar S, Gupta T
Methods Mol Biol 2022;2423:187-214. doi: 10.1007/978-1-0716-1952-0_18. PMID: 34978700

Recent clinical studies

Etiology

Magnetic Resonance Imaging in the Contemporary Management of Medulloblastoma: Current and Emerging Applications.
Dasgupta A, Maitre M, Pungavkar S, Gupta T
Methods Mol Biol 2022;2423:187-214. doi: 10.1007/978-1-0716-1952-0_18. PMID: 34978700
The benefit of surveillance imaging for paediatric cerebellar pilocytic astrocytoma.
McAuley E, Brophy H, Hayden J, Pettorini B, Parks C, Avula S, Mallucci C, Pizer B
Childs Nerv Syst 2019 May;35(5):801-805. Epub 2019 Feb 15 doi: 10.1007/s00381-019-04078-3. PMID: 30770993
Surveillance imaging strategies following surgery and/or radiotherapy for childhood cerebellar low-grade astrocytoma.
Saunders DE, Phipps KP, Wade AM, Hayward RD
J Neurosurg 2005 Mar;102(2 Suppl):172-8. doi: 10.3171/jns.2005.102.2.0172. PMID: 16156227
Cerebellar astrocytoma of childhood: long-term follow-up.
Sgouros S, Fineron PW, Hockley AD
Childs Nerv Syst 1995 Feb;11(2):89-96. doi: 10.1007/BF00303812. PMID: 7758018
Cerebellar astrocytomas in childhood.
Lapras C, Patet JD, Lapras C Jr, Mottolese C
Childs Nerv Syst 1986;2(2):55-9. doi: 10.1007/BF00286219. PMID: 3731169

Diagnosis

Magnetic Resonance Imaging in the Contemporary Management of Medulloblastoma: Current and Emerging Applications.
Dasgupta A, Maitre M, Pungavkar S, Gupta T
Methods Mol Biol 2022;2423:187-214. doi: 10.1007/978-1-0716-1952-0_18. PMID: 34978700
The benefit of surveillance imaging for paediatric cerebellar pilocytic astrocytoma.
McAuley E, Brophy H, Hayden J, Pettorini B, Parks C, Avula S, Mallucci C, Pizer B
Childs Nerv Syst 2019 May;35(5):801-805. Epub 2019 Feb 15 doi: 10.1007/s00381-019-04078-3. PMID: 30770993
Surveillance imaging strategies following surgery and/or radiotherapy for childhood cerebellar low-grade astrocytoma.
Saunders DE, Phipps KP, Wade AM, Hayward RD
J Neurosurg 2005 Mar;102(2 Suppl):172-8. doi: 10.3171/jns.2005.102.2.0172. PMID: 16156227
Predicting disease progression in childhood cerebellar astrocytoma.
Smoots DW, Geyer JR, Lieberman DM, Berger MS
Childs Nerv Syst 1998 Nov;14(11):636-48. doi: 10.1007/s003810050290. PMID: 9840364
Management of recurrent pilocytic astrocytoma with leptomeningeal dissemination in childhood.
Tamura M, Zama A, Kurihara H, Fujimaki H, Imai H, Kano T, Saitoh F
Childs Nerv Syst 1998 Nov;14(11):617-22. doi: 10.1007/s003810050286. PMID: 9840361

Therapy

Metachronous secondary atypical meningioma and anaplastic astrocytoma after postoperative craniospinal irradiation for medulloblastoma.
Hope AJ, Mansur DB, Tu PH, Simpson JR
Childs Nerv Syst 2006 Sep;22(9):1201-7. Epub 2006 Mar 29 doi: 10.1007/s00381-006-0062-2. PMID: 16570196
Second surgery for recurrent pilocytic astrocytoma in children.
Bowers DC, Krause TP, Aronson LJ, Barzi A, Burger PC, Carson BS, Weingart JD, Wharam MD, Melhem ER, Cohen KJ
Pediatr Neurosurg 2001 May;34(5):229-34. doi: 10.1159/000056027. PMID: 11423771
Cisplatin, ara-C and etoposide (PAE) in the treatment of recurrent childhood brain tumors.
Corden BJ, Strauss LC, Killmond T, Carson BS, Wharam MD, Kumar AJ, Piantadosi S, Robb PA, Phillips PC
J Neurooncol 1991 Aug;11(1):57-63. doi: 10.1007/BF00166998. PMID: 1919647
Carboplatin in childhood brain tumors. A Children's Cancer Study Group Phase II trial.
Gaynon PS, Ettinger LJ, Baum ES, Siegel SE, Krailo MD, Hammond GD
Cancer 1990 Dec 15;66(12):2465-9. doi: 10.1002/1097-0142(19901215)66:12<2465::aid-cncr2820661204>3.0.co;2-n. PMID: 2249186
Malignant supratentorial gliomas in childhood.
Prados M, Levin V
Pediatr Neurosci 1987;13(3):144-51. doi: 10.1159/000120320. PMID: 3331428

Prognosis

Magnetic Resonance Imaging in the Contemporary Management of Medulloblastoma: Current and Emerging Applications.
Dasgupta A, Maitre M, Pungavkar S, Gupta T
Methods Mol Biol 2022;2423:187-214. doi: 10.1007/978-1-0716-1952-0_18. PMID: 34978700
The benefit of surveillance imaging for paediatric cerebellar pilocytic astrocytoma.
McAuley E, Brophy H, Hayden J, Pettorini B, Parks C, Avula S, Mallucci C, Pizer B
Childs Nerv Syst 2019 May;35(5):801-805. Epub 2019 Feb 15 doi: 10.1007/s00381-019-04078-3. PMID: 30770993
Cerebellar astrocytoma of childhood: long-term follow-up.
Sgouros S, Fineron PW, Hockley AD
Childs Nerv Syst 1995 Feb;11(2):89-96. doi: 10.1007/BF00303812. PMID: 7758018
Malignant transformation of benign cerebellar astrocytoma.
Schwartz AM, Ghatak NR
Cancer 1990 Jan 15;65(2):333-6. doi: 10.1002/1097-0142(19900115)65:2<333::aid-cncr2820650225>3.0.co;2-3. PMID: 2403835
Cerebellar astrocytomas. Part II. Pathologic features indicative of malignancy.
Ilgren EB, Stiller CA
Clin Neuropathol 1987 Sep-Oct;6(5):201-14. PMID: 3319332

Clinical prediction guides

Magnetic Resonance Imaging in the Contemporary Management of Medulloblastoma: Current and Emerging Applications.
Dasgupta A, Maitre M, Pungavkar S, Gupta T
Methods Mol Biol 2022;2423:187-214. doi: 10.1007/978-1-0716-1952-0_18. PMID: 34978700
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.
Jones DT, Hutter B, Jäger N, Korshunov A, Kool M, Warnatz HJ, Zichner T, Lambert SR, Ryzhova M, Quang DA, Fontebasso AM, Stütz AM, Hutter S, Zuckermann M, Sturm D, Gronych J, Lasitschka B, Schmidt S, Seker-Cin H, Witt H, Sultan M, Ralser M, Northcott PA, Hovestadt V, Bender S, Pfaff E, Stark S, Faury D, Schwartzentruber J, Majewski J, Weber UD, Zapatka M, Raeder B, Schlesner M, Worth CL, Bartholomae CC, von Kalle C, Imbusch CD, Radomski S, Lawerenz C, van Sluis P, Koster J, Volckmann R, Versteeg R, Lehrach H, Monoranu C, Winkler B, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, Ebinger M, Schuhmann MU, Cho YJ, Pomeroy SL, von Deimling A, Witt O, Taylor MD, Wolf S, Karajannis MA, Eberhart CG, Scheurlen W, Hasselblatt M, Ligon KL, Kieran MW, Korbel JO, Yaspo ML, Brors B, Felsberg J, Reifenberger G, Collins VP, Jabado N, Eils R, Lichter P, Pfister SM; International Cancer Genome Consortium PedBrain Tumor Project
Nat Genet 2013 Aug;45(8):927-32. Epub 2013 Jun 30 doi: 10.1038/ng.2682. PMID: 23817572Free PMC Article
Predicting disease progression in childhood cerebellar astrocytoma.
Smoots DW, Geyer JR, Lieberman DM, Berger MS
Childs Nerv Syst 1998 Nov;14(11):636-48. doi: 10.1007/s003810050290. PMID: 9840364
Malignant transformation of benign cerebellar astrocytoma.
Schwartz AM, Ghatak NR
Cancer 1990 Jan 15;65(2):333-6. doi: 10.1002/1097-0142(19900115)65:2<333::aid-cncr2820650225>3.0.co;2-3. PMID: 2403835
Cerebellar astrocytomas in childhood.
Lapras C, Patet JD, Lapras C Jr, Mottolese C
Childs Nerv Syst 1986;2(2):55-9. doi: 10.1007/BF00286219. PMID: 3731169

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