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Dermal Fibroma

MedGen UID:
234198
•Concept ID:
C1333275
•
Neoplastic Process
Synonym: Skin fibromas

Definition

A benign neoplasm arising from the dermis. It is characterized by the presence of spindle-shaped fibroblasts. [from NCI]

Professional guidelines

PubMed

Targeting Myofibroblasts as a Treatment Modality for Dupuytren Disease.
Ziegler ME, Staben A, Lem M, Pham J, Alaniz L, Halaseh FF, Obagi S, Leis A, Widgerow AD
J Hand Surg Am 2023 Sep;48(9):914-922. Epub 2023 Jul 20 doi: 10.1016/j.jhsa.2023.06.007. PMID: 37480917
Management of full-thickness abdominal wall defects following tumor resection.
Yezhelyev MV, Deigni O, Losken A
Ann Plast Surg 2012 Aug;69(2):186-91. doi: 10.1097/SAP.0b013e31821d0715. PMID: 21629064

Recent clinical studies

Etiology

Solitary Fibrous Tumors in Pediatric Patients: A Rare and Potentially Overdiagnosed Neoplasm, Confirmed by STAT6 Immunohistochemistry.
Tan SY, Szymanski LJ, Galliani C, Parham D, Zambrano E
Pediatr Dev Pathol 2018 Jul-Aug;21(4):389-400. Epub 2017 Dec 11 doi: 10.1177/1093526617745431. PMID: 29228868
Hypocellular Plaque-Like CD34-Positive Dermal Fibroma (Medallion-Like Dermal Dendrocyte Hamartoma) Presenting as a Skin-Colored Dermal Nodule.
Mutgi KA, Chitgopeker P, Ciliberto H, Stone MS
Pediatr Dermatol 2016 Jan-Feb;33(1):e16-9. Epub 2015 Dec 8 doi: 10.1111/pde.12726. PMID: 26645569

Diagnosis

Case Report: Diagnosis of a Rare Plaque-Like Dermal Fibroma Successfully Treated With Mohs Surgery.
Gill P, Arlette J, Shiau CJ, Abi Daoud MS
J Cutan Med Surg 2018 Jan/Feb;22(1):89-93. Epub 2017 Jul 27 doi: 10.1177/1203475417722733. PMID: 28750558
Fibroblastic connective tissue nevus: Clinicopathological and immunohistochemical study of 14 cases.
Pennacchia I, Kutzner H, Kazakov DV, Mentzel T
J Cutan Pathol 2017 Oct;44(10):827-834. Epub 2017 Jul 19 doi: 10.1111/cup.12993. PMID: 28632950
Hypocellular medallion-like dermal dendrocyte hamartoma (plaque-like CD34-positive dermal fibroma).
Bagazgoitia L, Moreno C
Dermatol Online J 2011 Sep 15;17(9):8. PMID: 21971273
Plaque-like CD34-positive dermal fibroma ("medallion-like dermal dendrocyte hamartoma"): clinicopathologic, immunohistochemical, and molecular analysis of 5 cases emphasizing its distinction from superficial, plaque-like dermatofibrosarcoma protuberans.
Kutzner H, Mentzel T, Palmedo G, Hantschke M, Rütten A, Paredes BE, Schärer L, Guillen CS, Requena L
Am J Surg Pathol 2010 Feb;34(2):190-201. doi: 10.1097/PAS.0b013e3181c7cf11. PMID: 20061935
Sclerotic fibromas of the skin.
Rapini RP, Golitz LE
J Am Acad Dermatol 1989 Feb;20(2 Pt 1):266-71. doi: 10.1016/s0190-9622(89)70033-5. PMID: 2464630

Prognosis

Novel KHDRBS1-NTRK3 rearrangement in a congenital pediatric CD34-positive skin tumor: a case report.
Tallegas M, Fraitag S, Binet A, Orbach D, Jourdain A, Reynaud S, Pierron G, Machet MC, Maruani A
Virchows Arch 2019 Jan;474(1):111-115. Epub 2018 Sep 6 doi: 10.1007/s00428-018-2415-0. PMID: 30187166

Clinical prediction guides

Novel KHDRBS1-NTRK3 rearrangement in a congenital pediatric CD34-positive skin tumor: a case report.
Tallegas M, Fraitag S, Binet A, Orbach D, Jourdain A, Reynaud S, Pierron G, Machet MC, Maruani A
Virchows Arch 2019 Jan;474(1):111-115. Epub 2018 Sep 6 doi: 10.1007/s00428-018-2415-0. PMID: 30187166
Congenital myxoid and pigmented dermatofibrosarcoma protuberans: a case report.
El Hachem M, Diociaiuti A, Latella E, Zama M, Lambiase C, Giraldi L, Surrenti T, Callea F
Pediatr Dermatol 2013 Sep-Oct;30(5):e74-7. Epub 2013 Mar 28 doi: 10.1111/pde.12131. PMID: 23534369

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