U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dermal Fibroma

MedGen UID:
234198
•Concept ID:
C1333275
•
Neoplastic Process
Synonym: Skin fibromas

Definition

A benign neoplasm arising from the dermis. It is characterized by the presence of spindle-shaped fibroblasts. [from NCI]

Professional guidelines

PubMed

Targeting Myofibroblasts as a Treatment Modality for Dupuytren Disease.
Ziegler ME, Staben A, Lem M, Pham J, Alaniz L, Halaseh FF, Obagi S, Leis A, Widgerow AD
J Hand Surg Am 2023 Sep;48(9):914-922. Epub 2023 Jul 20 doi: 10.1016/j.jhsa.2023.06.007. PMID: 37480917
Management of full-thickness abdominal wall defects following tumor resection.
Yezhelyev MV, Deigni O, Losken A
Ann Plast Surg 2012 Aug;69(2):186-91. doi: 10.1097/SAP.0b013e31821d0715. PMID: 21629064

Recent clinical studies

Etiology

Solitary Fibrous Tumors in Pediatric Patients: A Rare and Potentially Overdiagnosed Neoplasm, Confirmed by STAT6 Immunohistochemistry.
Tan SY, Szymanski LJ, Galliani C, Parham D, Zambrano E
Pediatr Dev Pathol 2018 Jul-Aug;21(4):389-400. Epub 2017 Dec 11 doi: 10.1177/1093526617745431. PMID: 29228868
Hypocellular Plaque-Like CD34-Positive Dermal Fibroma (Medallion-Like Dermal Dendrocyte Hamartoma) Presenting as a Skin-Colored Dermal Nodule.
Mutgi KA, Chitgopeker P, Ciliberto H, Stone MS
Pediatr Dermatol 2016 Jan-Feb;33(1):e16-9. Epub 2015 Dec 8 doi: 10.1111/pde.12726. PMID: 26645569

Diagnosis

ALK-rearranged, CD34-positive spindle cell neoplasms resembling dermatofibrosarcoma protuberans: a study of seven cases.
Agrawal S, Ameline B, Folpe AL, Azzato E, Astbury C, Mentzel T, Knapp C, Rütten A, Creytens D, Sukov W, Baumhoer D, Billings SD, Fritchie KJ
Histopathology 2024 Oct;85(4):649-659. Epub 2024 Jun 13 doi: 10.1111/his.15239. PMID: 38867577
Case Report: Diagnosis of a Rare Plaque-Like Dermal Fibroma Successfully Treated With Mohs Surgery.
Gill P, Arlette J, Shiau CJ, Abi Daoud MS
J Cutan Med Surg 2018 Jan/Feb;22(1):89-93. Epub 2017 Jul 27 doi: 10.1177/1203475417722733. PMID: 28750558
Hypocellular medallion-like dermal dendrocyte hamartoma (plaque-like CD34-positive dermal fibroma).
Bagazgoitia L, Moreno C
Dermatol Online J 2011 Sep 15;17(9):8. PMID: 21971273
Plaque-like CD34-positive dermal fibroma ("medallion-like dermal dendrocyte hamartoma"): clinicopathologic, immunohistochemical, and molecular analysis of 5 cases emphasizing its distinction from superficial, plaque-like dermatofibrosarcoma protuberans.
Kutzner H, Mentzel T, Palmedo G, Hantschke M, Rütten A, Paredes BE, Schärer L, Guillen CS, Requena L
Am J Surg Pathol 2010 Feb;34(2):190-201. doi: 10.1097/PAS.0b013e3181c7cf11. PMID: 20061935
Sclerotic fibromas of the skin.
Rapini RP, Golitz LE
J Am Acad Dermatol 1989 Feb;20(2 Pt 1):266-71. doi: 10.1016/s0190-9622(89)70033-5. PMID: 2464630

Prognosis

Novel KHDRBS1-NTRK3 rearrangement in a congenital pediatric CD34-positive skin tumor: a case report.
Tallegas M, Fraitag S, Binet A, Orbach D, Jourdain A, Reynaud S, Pierron G, Machet MC, Maruani A
Virchows Arch 2019 Jan;474(1):111-115. Epub 2018 Sep 6 doi: 10.1007/s00428-018-2415-0. PMID: 30187166

Clinical prediction guides

Novel KHDRBS1-NTRK3 rearrangement in a congenital pediatric CD34-positive skin tumor: a case report.
Tallegas M, Fraitag S, Binet A, Orbach D, Jourdain A, Reynaud S, Pierron G, Machet MC, Maruani A
Virchows Arch 2019 Jan;474(1):111-115. Epub 2018 Sep 6 doi: 10.1007/s00428-018-2415-0. PMID: 30187166
Congenital myxoid and pigmented dermatofibrosarcoma protuberans: a case report.
El Hachem M, Diociaiuti A, Latella E, Zama M, Lambiase C, Giraldi L, Surrenti T, Callea F
Pediatr Dermatol 2013 Sep-Oct;30(5):e74-7. Epub 2013 Mar 28 doi: 10.1111/pde.12131. PMID: 23534369

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...