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Gastric Germ Cell Tumor

MedGen UID:: 234296
•Concept ID:: C1333769
•: Neoplastic Process

Synonyms:

Gastric Germ Cell Neoplasm; Germ Cell Neoplasm of Stomach; Germ Cell Neoplasm of the Stomach; Germ Cell Tumor of Stomach; Germ Cell Tumor of the Stomach; Stomach Germ Cell Neoplasm; Stomach Germ Cell Tumor

Definition

A benign or malignant germ cell tumor that arises from the stomach. Representative examples include teratoma and choriocarcinoma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVGastric Germ Cell Tumor

Pathological process
- Disease
  - Neoplasm
    - Neoplasm by Morphology
      - Germ cell tumor
        Extragonadal germ cell tumor
        Gastric Germ Cell Tumor
        Gastric teratoma
        Immature gastric teratoma
        Mature gastric teratoma
        Malignant gastric germ cell tumor
        Gastric choriocarcinoma

Professional guidelines

PubMed

Gastrinomas: Medical or Surgical Treatment.

Norton JA, Foster DS, Ito T, Jensen RT
Endocrinol Metab Clin North Am 2018 Sep;47(3):577-601. doi: 10.1016/j.ecl.2018.04.009. PMID: 30098717 Free PMC Article

ENETS Consensus Guidelines Update for Gastroduodenal Neuroendocrine Neoplasms.

Delle Fave G, O'Toole D, Sundin A, Taal B, Ferolla P, Ramage JK, Ferone D, Ito T, Weber W, Zheng-Pei Z, De Herder WW, Pascher A, Ruszniewski P; Vienna Consensus Conference participants
Neuroendocrinology 2016;103(2):119-24. Epub 2016 Jan 19 doi: 10.1159/000443168. PMID: 26784901

ENETS Consensus Guidelines for High-Grade Gastroenteropancreatic Neuroendocrine Tumors and Neuroendocrine Carcinomas.

Garcia-Carbonero R, Sorbye H, Baudin E, Raymond E, Wiedenmann B, Niederle B, Sedlackova E, Toumpanakis C, Anlauf M, Cwikla JB, Caplin M, O'Toole D, Perren A; Vienna Consensus Conference participants
Neuroendocrinology 2016;103(2):186-94. Epub 2016 Jan 5 doi: 10.1159/000443172. PMID: 26731334

See all (290)

Recent clinical studies

Etiology

Multimodal management of foregut neuroendocrine neoplasms.

Zhou Y, Li JW, Uedo N
Best Pract Res Clin Gastroenterol 2024 Feb;68:101889. Epub 2024 Feb 2 doi: 10.1016/j.bpg.2024.101889. PMID: 38522885

New Developments in Gastric Neuroendocrine Neoplasms.

Exarchou K, Stephens NA, Moore AR, Howes NR, Pritchard DM
Curr Oncol Rep 2022 Jan;24(1):77-88. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01175-y. PMID: 35059996 Free PMC Article

Neuroendocrine neoplasms of the esophagus and stomach.

Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305 Free PMC Article

Somatostatin analogs for gastric carcinoids: For many, but not all.

Massironi S, Zilli A, Conte D
World J Gastroenterol 2015 Jun 14;21(22):6785-93. doi: 10.3748/wjg.v21.i22.6785. PMID: 26078554 Free PMC Article

Endoscopic resection of submucosal tumors.

Longcroft-Wheaton G, Bhandari P
Expert Rev Gastroenterol Hepatol 2015 May;9(5):659-69. Epub 2015 Jan 29 doi: 10.1586/17474124.2015.1003366. PMID: 25634074

See all (1521)

Diagnosis

European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for gastroduodenal neuroendocrine tumours (NETs) G1-G3.

Panzuto F, Ramage J, Pritchard DM, van Velthuysen MF, Schrader J, Begum N, Sundin A, Falconi M, O'Toole D
J Neuroendocrinol 2023 Aug;35(8):e13306. Epub 2023 Jul 4 doi: 10.1111/jne.13306. PMID: 37401795

Microbiome and Gastric Cancer.

Engstrand L, Graham DY
Dig Dis Sci 2020 Mar;65(3):865-873. doi: 10.1007/s10620-020-06101-z. PMID: 32040665 Free PMC Article

Primary gastric choriocarcinoma.

Picazo Ferrera K, Herrera Servin MÁ, Hernández Guerrero AI
Rev Esp Enferm Dig 2020 Mar;112(3):241. doi: 10.17235/reed.2020.6478/2019. PMID: 32022576

Gastric Schwannoma.

Albshesh A, Kaufmann MI, Levy I
Clin Gastroenterol Hepatol 2020 Nov;18(12):e142-e143. Epub 2019 Aug 21 doi: 10.1016/j.cgh.2019.08.027. PMID: 31445167

GASTRIC NEUROENDOCRINE TUMOR: REVIEW AND UPDATE.

Dias AR, Azevedo BC, Alban LBV, Yagi OK, Ramos MFKP, Jacob CE, Barchi LC, Cecconello I, Ribeiro U Jr, Zilberstein B
Arq Bras Cir Dig 2017 Apr-Jun;30(2):150-154. doi: 10.1590/0102-6720201700020016. PMID: 29257854 Free PMC Article

See all (2179)

Therapy

What Is the Status of Immunotherapy in Neuroendocrine Neoplasms?

Garcia-Alvarez A, Cubero JH, Capdevila J
Curr Oncol Rep 2022 Apr;24(4):451-461. Epub 2022 Feb 16 doi: 10.1007/s11912-022-01235-x. PMID: 35171460

Multifocal Gastrointestinal Melanoma.

Kouvaras S, Rokkas T, Goga H, Gakiopoulou H, Arapantoni P, Haliotis G, Mantas D
J Gastrointestin Liver Dis 2019 Jun 1;28:237-240. doi: 10.15403/jgld-185. PMID: 31204403

Avelumab in gastric cancer.

Roviello G, D'Angelo A, Generali D, Pittacolo M, Ganzinelli M, Iezzi G, Manzini N, Sobhani N
Immunotherapy 2019 Jun;11(9):759-768. Epub 2019 May 6 doi: 10.2217/imt-2019-0011. PMID: 31060469

Radionuclide Therapy for Neuroendocrine Tumors.

Cives M, Strosberg J
Curr Oncol Rep 2017 Feb;19(2):9. doi: 10.1007/s11912-017-0567-8. PMID: 28220446

Carcinoid tumours.

Janmohamed S, Bloom SR
Postgrad Med J 1997 Apr;73(858):207-14. doi: 10.1136/pgmj.73.858.207. PMID: 9156122 Free PMC Article

See all (918)

Prognosis

Cancer statistics, 2024.

Siegel RL, Giaquinto AN, Jemal A
CA Cancer J Clin 2024 Jan-Feb;74(1):12-49. Epub 2024 Jan 17 doi: 10.3322/caac.21820. PMID: 38230766

European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for gastroduodenal neuroendocrine tumours (NETs) G1-G3.

Neuroendocrine neoplasms of the esophagus and stomach.

Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305 Free PMC Article

GASTRIC NEUROENDOCRINE TUMOR: REVIEW AND UPDATE.

Epidemiology of gastroenteropancreatic neuroendocrine tumours.

Fraenkel M, Kim MK, Faggiano A, Valk GD
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):691-703. doi: 10.1016/j.bpg.2013.01.006. PMID: 23582913

See all (1608)

Clinical prediction guides

Neuroendocrine neoplasms of the esophagus and stomach.

Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305 Free PMC Article

Gastroenteropancreatic Neuroendocrine Tumors.

Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930

Major hereditary gastrointestinal cancer syndromes: a narrative review.

Chintalacheruvu LM, Shaw T, Buddam A, Diab O, Kassim T, Mukherjee S, Lynch HT
J Gastrointestin Liver Dis 2017 Jun;26(2):157-163. doi: 10.15403/jgld.2014.1121.262.maj. PMID: 28617886

Pathophysiology of Gastric NETs: Role of Gastrin and Menin.

Sundaresan S, Kang AJ, Merchant JL
Curr Gastroenterol Rep 2017 Jul;19(7):32. doi: 10.1007/s11894-017-0572-y. PMID: 28608155 Free PMC Article

Atypical gastric carcinoids.

Sweeney EC, McDonnell LM
Histopathology 1980 Mar;4(2):215-24. doi: 10.1111/j.1365-2559.1980.tb02914.x. PMID: 7358349

See all (1110)

Recent systematic reviews

Risk of extracolonic second primary cancers following a primary colorectal cancer: a systematic review and meta-analysis.

Robertson D, Ng SK, Baade PD, Lam AK
Int J Colorectal Dis 2022 Mar;37(3):541-551. Epub 2022 Feb 12 doi: 10.1007/s00384-022-04105-x. PMID: 35152308 Free PMC Article

Metastasis to the rectum: A systematic review of the literature.

Janjic O, Labgaa I, Hübner M, Demartines N, Joliat GR
Eur J Surg Oncol 2022 Apr;48(4):822-833. Epub 2021 Oct 10 doi: 10.1016/j.ejso.2021.10.004. PMID: 34656391

Imaging pediatric gastrointestinal stromal tumor (GIST).

Herzberg M, Beer M, Anupindi S, Vollert K, Kröncke T
J Pediatr Surg 2018 Sep;53(9):1862-1870. Epub 2018 Mar 29 doi: 10.1016/j.jpedsurg.2018.03.022. PMID: 29685489

Escalated-dose somatostatin analogues for antiproliferative effect in GEPNETS: a systematic review.

Chan DL, Ferone D, Albertelli M, Pavlakis N, Segelov E, Singh S
Endocrine 2017 Sep;57(3):366-375. Epub 2017 Jul 19 doi: 10.1007/s12020-017-1360-z. PMID: 28726183

Spinal cord ependymomas and the appearance of other de novo tumors: a systematic review.

Fotakopoulos G, Vagkopoulos K, Gatos C, Kotlia P, Brotis A
J Med Case Rep 2014 Dec 18;8:438. doi: 10.1186/1752-1947-8-438. PMID: 25519213 Free PMC Article

See all (43)

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Gastric Germ Cell Tumor

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

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