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Grade 3 Rectal Adenocarcinoma

MedGen UID:
234320
Concept ID:
C1333858
Neoplastic Process
Synonyms: Grade III Rectal Adenocarcinoma; Poorly Differentiated Rectal Adenocarcinoma

Definition

A rectal adenocarcinoma characterized by the presence of a malignant cellular infiltrate with less than 50% glandular formation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 3 Rectal Adenocarcinoma

Professional guidelines

PubMed

Bádon ES, Beke L, Mokánszki A, András C, Méhes G
Int J Mol Sci 2023 Jan 30;24(3) doi: 10.3390/ijms24032581. PMID: 36768903Free PMC Article
Attard G, Murphy L, Clarke NW, Cross W, Jones RJ, Parker CC, Gillessen S, Cook A, Brawley C, Amos CL, Atako N, Pugh C, Buckner M, Chowdhury S, Malik Z, Russell JM, Gilson C, Rush H, Bowen J, Lydon A, Pedley I, O'Sullivan JM, Birtle A, Gale J, Srihari N, Thomas C, Tanguay J, Wagstaff J, Das P, Gray E, Alzoueb M, Parikh O, Robinson A, Syndikus I, Wylie J, Zarkar A, Thalmann G, de Bono JS, Dearnaley DP, Mason MD, Gilbert D, Langley RE, Millman R, Matheson D, Sydes MR, Brown LC, Parmar MKB, James ND; Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) investigators
Lancet 2022 Jan 29;399(10323):447-460. Epub 2021 Dec 23 doi: 10.1016/S0140-6736(21)02437-5. PMID: 34953525Free PMC Article
Chin RI, Roy A, Pedersen KS, Huang Y, Hunt SR, Glasgow SC, Tan BR, Wise PE, Silviera ML, Smith RK, Suresh R, Badiyan SN, Shetty AS, Henke LE, Mutch MG, Kim H
Int J Radiat Oncol Biol Phys 2022 Mar 1;112(3):715-725. Epub 2021 Oct 12 doi: 10.1016/j.ijrobp.2021.10.004. PMID: 34653579

Recent clinical studies

Etiology

Xia F, Wang Y, Wang H, Shen L, Xiang Z, Zhao Y, Zhang H, Wan J, Zhang H, Wang Y, Wu R, Wang J, Yang W, Zhou M, Zhou S, Chen Y, Zhang Z, Wu X, Xuan Y, Wang R, Sun Y, Tong T, Zhang X, Wang L, Huang D, Sheng W, Yan H, Yang X, Shen Y, Xu Y, Zhao R, Mo M, Cai G, Cai S, Xu Y, Zhang Z
J Clin Oncol 2024 Oct;42(28):3308-3318. Epub 2024 Jul 1 doi: 10.1200/JCO.23.02261. PMID: 38950321
Lu ZH, Hu CH, Qian WX, Cao WH
Clin Imaging 2016 May-Jun;40(3):563-8. Epub 2015 Dec 18 doi: 10.1016/j.clinimag.2015.12.006. PMID: 27133705
Garcia-Aguilar J, Chow OS, Smith DD, Marcet JE, Cataldo PA, Varma MG, Kumar AS, Oommen S, Coutsoftides T, Hunt SR, Stamos MJ, Ternent CA, Herzig DO, Fichera A, Polite BN, Dietz DW, Patil S, Avila K; Timing of Rectal Cancer Response to Chemoradiation Consortium
Lancet Oncol 2015 Aug;16(8):957-66. Epub 2015 Jul 14 doi: 10.1016/S1470-2045(15)00004-2. PMID: 26187751Free PMC Article
Leach R, Thompson IM
Arch Intern Med 2012 Jun 11;172(11):835-6. doi: 10.1001/archinternmed.2012.1226. PMID: 22905350Free PMC Article
Cohen AM, Wood WC, Gunderson LL, Shinnar M
Cancer 1980 Jun 15;45(12):2965-8. doi: 10.1002/1097-0142(19800615)45:12<2965::aid-cncr2820451213>3.0.co;2-m. PMID: 7388739

Diagnosis

Loughrey MB, Shepherd NA
Gastroenterol Clin North Am 2024 Mar;53(1):201-220. Epub 2023 Oct 16 doi: 10.1016/j.gtc.2023.09.007. PMID: 38280748
Cercek A, Lumish M, Sinopoli J, Weiss J, Shia J, Lamendola-Essel M, El Dika IH, Segal N, Shcherba M, Sugarman R, Stadler Z, Yaeger R, Smith JJ, Rousseau B, Argiles G, Patel M, Desai A, Saltz LB, Widmar M, Iyer K, Zhang J, Gianino N, Crane C, Romesser PB, Pappou EP, Paty P, Garcia-Aguilar J, Gonen M, Gollub M, Weiser MR, Schalper KA, Diaz LA Jr
N Engl J Med 2022 Jun 23;386(25):2363-2376. Epub 2022 Jun 5 doi: 10.1056/NEJMoa2201445. PMID: 35660797Free PMC Article
Conroy T, Bosset JF, Etienne PL, Rio E, François É, Mesgouez-Nebout N, Vendrely V, Artignan X, Bouché O, Gargot D, Boige V, Bonichon-Lamichhane N, Louvet C, Morand C, de la Fouchardière C, Lamfichekh N, Juzyna B, Jouffroy-Zeller C, Rullier E, Marchal F, Gourgou S, Castan F, Borg C; Unicancer Gastrointestinal Group and Partenariat de Recherche en Oncologie Digestive (PRODIGE) Group
Lancet Oncol 2021 May;22(5):702-715. Epub 2021 Apr 13 doi: 10.1016/S1470-2045(21)00079-6. PMID: 33862000
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740
Leach R, Thompson IM
Arch Intern Med 2012 Jun 11;172(11):835-6. doi: 10.1001/archinternmed.2012.1226. PMID: 22905350Free PMC Article

Therapy

Thompson HM, Omer DM, Lin S, Kim JK, Yuval JB, Verheij FS, Qin LX, Gollub MJ, Wu AJ, Lee M, Patil S, Hezel AF, Marcet JE, Cataldo PA, Polite BN, Herzig DO, Liska D, Oommen S, Friel CM, Ternent CA, Coveler AL, Hunt SR, Garcia-Aguilar J; OPRA Consortium
JAMA Netw Open 2024 Jan 2;7(1):e2350903. doi: 10.1001/jamanetworkopen.2023.50903. PMID: 38194231Free PMC Article
Gerard JP, Barbet N, Schiappa R, Magné N, Martel I, Mineur L, Deberne M, Zilli T, Dhadda A, Myint AS; ICONE group
Lancet Gastroenterol Hepatol 2023 Apr;8(4):356-367. Epub 2023 Feb 16 doi: 10.1016/S2468-1253(22)00392-2. PMID: 36801007
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740
Garcia-Aguilar J, Chow OS, Smith DD, Marcet JE, Cataldo PA, Varma MG, Kumar AS, Oommen S, Coutsoftides T, Hunt SR, Stamos MJ, Ternent CA, Herzig DO, Fichera A, Polite BN, Dietz DW, Patil S, Avila K; Timing of Rectal Cancer Response to Chemoradiation Consortium
Lancet Oncol 2015 Aug;16(8):957-66. Epub 2015 Jul 14 doi: 10.1016/S1470-2045(15)00004-2. PMID: 26187751Free PMC Article
Leach R, Thompson IM
Arch Intern Med 2012 Jun 11;172(11):835-6. doi: 10.1001/archinternmed.2012.1226. PMID: 22905350Free PMC Article

Prognosis

Xia F, Wang Y, Wang H, Shen L, Xiang Z, Zhao Y, Zhang H, Wan J, Zhang H, Wang Y, Wu R, Wang J, Yang W, Zhou M, Zhou S, Chen Y, Zhang Z, Wu X, Xuan Y, Wang R, Sun Y, Tong T, Zhang X, Wang L, Huang D, Sheng W, Yan H, Yang X, Shen Y, Xu Y, Zhao R, Mo M, Cai G, Cai S, Xu Y, Zhang Z
J Clin Oncol 2024 Oct;42(28):3308-3318. Epub 2024 Jul 1 doi: 10.1200/JCO.23.02261. PMID: 38950321
Vitellaro M, Piozzi G, Signoroni S, Ricci MT, Ciniselli CM, Cardani A, Vecchi I, Mancini A, Magarotto A, Verderio P, Massimino M, Ferrari A, Biasoni D
Pediatr Blood Cancer 2020 Mar;67(3):e28110. Epub 2019 Dec 5 doi: 10.1002/pbc.28110. PMID: 31802619
Lu ZH, Hu CH, Qian WX, Cao WH
Clin Imaging 2016 May-Jun;40(3):563-8. Epub 2015 Dec 18 doi: 10.1016/j.clinimag.2015.12.006. PMID: 27133705
Garcia-Aguilar J, Chow OS, Smith DD, Marcet JE, Cataldo PA, Varma MG, Kumar AS, Oommen S, Coutsoftides T, Hunt SR, Stamos MJ, Ternent CA, Herzig DO, Fichera A, Polite BN, Dietz DW, Patil S, Avila K; Timing of Rectal Cancer Response to Chemoradiation Consortium
Lancet Oncol 2015 Aug;16(8):957-66. Epub 2015 Jul 14 doi: 10.1016/S1470-2045(15)00004-2. PMID: 26187751Free PMC Article
Leach R, Thompson IM
Arch Intern Med 2012 Jun 11;172(11):835-6. doi: 10.1001/archinternmed.2012.1226. PMID: 22905350Free PMC Article

Clinical prediction guides

Attard G, Murphy L, Clarke NW, Cross W, Jones RJ, Parker CC, Gillessen S, Cook A, Brawley C, Amos CL, Atako N, Pugh C, Buckner M, Chowdhury S, Malik Z, Russell JM, Gilson C, Rush H, Bowen J, Lydon A, Pedley I, O'Sullivan JM, Birtle A, Gale J, Srihari N, Thomas C, Tanguay J, Wagstaff J, Das P, Gray E, Alzoueb M, Parikh O, Robinson A, Syndikus I, Wylie J, Zarkar A, Thalmann G, de Bono JS, Dearnaley DP, Mason MD, Gilbert D, Langley RE, Millman R, Matheson D, Sydes MR, Brown LC, Parmar MKB, James ND; Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) investigators
Lancet 2022 Jan 29;399(10323):447-460. Epub 2021 Dec 23 doi: 10.1016/S0140-6736(21)02437-5. PMID: 34953525Free PMC Article
Fokas E, Schlenska-Lange A, Polat B, Klautke G, Grabenbauer GG, Fietkau R, Kuhnt T, Staib L, Brunner T, Grosu AL, Kirste S, Jacobasch L, Allgäuer M, Flentje M, Germer CT, Grützmann R, Hildebrandt G, Schwarzbach M, Bechstein WO, Sülberg H, Friede T, Gaedcke J, Ghadimi M, Hofheinz RD, Rödel C; German Rectal Cancer Study Group
JAMA Oncol 2022 Jan 1;8(1):e215445. Epub 2022 Jan 20 doi: 10.1001/jamaoncol.2021.5445. PMID: 34792531Free PMC Article
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740
Leach R, Thompson IM
Arch Intern Med 2012 Jun 11;172(11):835-6. doi: 10.1001/archinternmed.2012.1226. PMID: 22905350Free PMC Article
Goldenberg SL, Ramsey EW, Jewett MA
CMAJ 1998 Nov 17;159(10):1265-71. PMID: 9861224Free PMC Article

Recent systematic reviews

Lauricella S, Fabris S, Sylla P
Surg Endosc 2023 Jan;37(1):48-61. Epub 2022 Aug 3 doi: 10.1007/s00464-022-09462-w. PMID: 35920906
Piozzi GN, Rusli SM, Baek SJ, Kwak JM, Kim J, Kim SH
Eur J Surg Oncol 2022 Apr;48(4):718-726. Epub 2021 Dec 4 doi: 10.1016/j.ejso.2021.12.005. PMID: 34893366
Martin-Perez B, Andrade-Ribeiro GD, Hunter L, Atallah S
Tech Coloproctol 2014 Sep;18(9):775-88. Epub 2014 May 7 doi: 10.1007/s10151-014-1148-6. PMID: 24848524
Chade DC, Eastham J, Graefen M, Hu JC, Karnes RJ, Klotz L, Montorsi F, van Poppel H, Scardino PT, Shariat SF
Eur Urol 2012 May;61(5):961-71. Epub 2012 Jan 23 doi: 10.1016/j.eururo.2012.01.022. PMID: 22280856
Breukink S, Pierie J, Wiggers T
Cochrane Database Syst Rev 2006 Oct 18;(4):CD005200. doi: 10.1002/14651858.CD005200.pub2. PMID: 17054246

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