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High Grade Sarcoma

MedGen UID:
234347
Concept ID:
C1334008
Neoplastic Process
Synonyms: High-Grade Sarcoma; Poorly Differentiated or Undifferentiated Sarcoma

Definition

A sarcoma with the morphologic features of a high grade tumor and lack of differentiation. [from NCI]

Professional guidelines

PubMed

Tlemsani C, Larousserie F, De Percin S, Audard V, Hadjadj D, Chen J, Biau D, Anract P, Terris B, Goldwasser F, Pasmant E, Boudou-Rouquette P
Int J Mol Sci 2023 Jan 10;24(2) doi: 10.3390/ijms24021361. PMID: 36674874Free PMC Article
Novetsky AP, Powell MA
Curr Opin Oncol 2013 Sep;25(5):546-52. doi: 10.1097/CCO.0b013e328363e0ef. PMID: 23942299
Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG
Am J Surg Pathol 1998 Jul;22(7):779-94. doi: 10.1097/00000478-199807000-00001. PMID: 9669341

Recent clinical studies

Etiology

Makise N, Shimoi T, Sunami K, Aoyagi Y, Kobayashi H, Tanaka S, Kawai A, Yonemori K, Ushiku T, Yoshida A
Histopathology 2023 Feb;82(3):420-430. Epub 2022 Oct 26 doi: 10.1111/his.14823. PMID: 36217885
Stacchiotti S, Miah AB, Frezza AM, Messiou C, Morosi C, Caraceni A, Antonescu CR, Bajpai J, Baldini E, Bauer S, Biagini R, Bielack S, Blay JY, Bonvalot S, Boukovinas I, Bovee JVMG, Boye K, Brodowicz T, Callegaro D, De Alava E, Deoras-Sutliff M, Dufresne A, Eriksson M, Errani C, Fedenko A, Ferraresi V, Ferrari A, Fletcher CDM, Garcia Del Muro X, Gelderblom H, Gladdy RA, Gouin F, Grignani G, Gutkovich J, Haas R, Hindi N, Hohenberger P, Huang P, Joensuu H, Jones RL, Jungels C, Kasper B, Kawai A, Le Cesne A, Le Grange F, Leithner A, Leonard H, Lopez Pousa A, Martin Broto J, Merimsky O, Merriam P, Miceli R, Mir O, Molinari M, Montemurro M, Oldani G, Palmerini E, Pantaleo MA, Patel S, Piperno-Neumann S, Raut CP, Ravi V, Razak ARA, Reichardt P, Rubin BP, Rutkowski P, Safwat AA, Sangalli C, Sapisochin G, Sbaraglia M, Scheipl S, Schöffski P, Strauss D, Strauss SJ, Sundby Hall K, Tap WD, Trama A, Tweddle A, van der Graaf WTA, Van De Sande MAJ, Van Houdt W, van Oortmerssen G, Wagner AJ, Wartenberg M, Wood J, Zaffaroni N, Zimmermann C, Casali PG, Dei Tos AP, Gronchi A
ESMO Open 2021 Jun;6(3):100170. Epub 2021 Jun 2 doi: 10.1016/j.esmoop.2021.100170. PMID: 34090171Free PMC Article
Saifuddin A, Andrei V, Rajakulasingam R, Oliveira I, Seddon B
Skeletal Radiol 2021 Oct;50(10):1963-1980. Epub 2021 Apr 1 doi: 10.1007/s00256-021-03769-w. PMID: 33792747
Mok Y, Min En N, Chwee Ming L, Petersson F
Head Neck 2016 Sep;38(9):E2483-9. Epub 2016 Apr 15 doi: 10.1002/hed.24462. PMID: 27080524
Singh M, Mann R, Ilankovan V, Hussein K, D'arrigo C
J Oral Maxillofac Surg 2012 Nov;70(11):2713-8. Epub 2012 Apr 10 doi: 10.1016/j.joms.2012.01.019. PMID: 22494510

Diagnosis

Tirabosco R, O'Donnell P, Flanagan AM
Surg Pathol Clin 2021 Dec;14(4):619-643. Epub 2021 Jul 28 doi: 10.1016/j.path.2021.06.006. PMID: 34742484
Stacchiotti S, Miah AB, Frezza AM, Messiou C, Morosi C, Caraceni A, Antonescu CR, Bajpai J, Baldini E, Bauer S, Biagini R, Bielack S, Blay JY, Bonvalot S, Boukovinas I, Bovee JVMG, Boye K, Brodowicz T, Callegaro D, De Alava E, Deoras-Sutliff M, Dufresne A, Eriksson M, Errani C, Fedenko A, Ferraresi V, Ferrari A, Fletcher CDM, Garcia Del Muro X, Gelderblom H, Gladdy RA, Gouin F, Grignani G, Gutkovich J, Haas R, Hindi N, Hohenberger P, Huang P, Joensuu H, Jones RL, Jungels C, Kasper B, Kawai A, Le Cesne A, Le Grange F, Leithner A, Leonard H, Lopez Pousa A, Martin Broto J, Merimsky O, Merriam P, Miceli R, Mir O, Molinari M, Montemurro M, Oldani G, Palmerini E, Pantaleo MA, Patel S, Piperno-Neumann S, Raut CP, Ravi V, Razak ARA, Reichardt P, Rubin BP, Rutkowski P, Safwat AA, Sangalli C, Sapisochin G, Sbaraglia M, Scheipl S, Schöffski P, Strauss D, Strauss SJ, Sundby Hall K, Tap WD, Trama A, Tweddle A, van der Graaf WTA, Van De Sande MAJ, Van Houdt W, van Oortmerssen G, Wagner AJ, Wartenberg M, Wood J, Zaffaroni N, Zimmermann C, Casali PG, Dei Tos AP, Gronchi A
ESMO Open 2021 Jun;6(3):100170. Epub 2021 Jun 2 doi: 10.1016/j.esmoop.2021.100170. PMID: 34090171Free PMC Article
Ulrich UA, Denschlag D
Oncol Res Treat 2018;41(11):693-696. Epub 2018 Oct 17 doi: 10.1159/000494067. PMID: 30326467
Bahk WJ, Mirra JM, Sohn KR, Shin DS
Ann Diagn Pathol 1998 Aug;2(4):241-6. doi: 10.1016/s1092-9134(98)80013-0. PMID: 9845744
Myssiorek D, Patel M, Wasserman P, Rofeim O
Ann Otol Rhinol Laryngol 1998 Jan;107(1):70-4. doi: 10.1177/000348949810700113. PMID: 9439392

Therapy

Huffman V, Andrade DC, Sherman E, Niu J, Eckardt PA
Am J Health Syst Pharm 2021 Jan 1;78(1):36-40. doi: 10.1093/ajhp/zxaa328. PMID: 33037429
Matsumine A, Tsujii M, Nakamura T, Asanuma K, Matsubara T, Kakimoto T, Yada Y, Takada A, Ii N, Nomoto Y, Sudo A
World J Surg Oncol 2016 Aug 12;14(1):214. doi: 10.1186/s12957-016-0968-4. PMID: 27514518Free PMC Article
Guilbert MC, Rougemont AL, Samson Y, Mac-Thiong JM, Fournet JC, Soglio DB
J Pediatr Hematol Oncol 2015 Mar;37(2):e118-20. doi: 10.1097/MPH.0000000000000107. PMID: 24390443
Bendel D, Loong CY
BMJ Case Rep 2014 Sep 25;2014 doi: 10.1136/bcr-2013-202295. PMID: 25257885Free PMC Article
Siddiqi S, Mills J, Matushansky I
Curr Stem Cell Res Ther 2010 Mar;5(1):63-73. doi: 10.2174/157488810790442859. PMID: 19807660Free PMC Article

Prognosis

Tirabosco R, O'Donnell P, Flanagan AM
Surg Pathol Clin 2021 Dec;14(4):619-643. Epub 2021 Jul 28 doi: 10.1016/j.path.2021.06.006. PMID: 34742484
Saifuddin A, Andrei V, Rajakulasingam R, Oliveira I, Seddon B
Skeletal Radiol 2021 Oct;50(10):1963-1980. Epub 2021 Apr 1 doi: 10.1007/s00256-021-03769-w. PMID: 33792747
Ulrich UA, Denschlag D
Oncol Res Treat 2018;41(11):693-696. Epub 2018 Oct 17 doi: 10.1159/000494067. PMID: 30326467
Guilmette J, Laverdière C, Soulières D, Patey N, Soucy G, Trudel D, Bouron-Dal Soglio D
Pediatr Dev Pathol 2017 Jun;20(3):262-266. Epub 2017 Apr 21 doi: 10.1177/1093526617706814. PMID: 28429647
Myssiorek D, Patel M, Wasserman P, Rofeim O
Ann Otol Rhinol Laryngol 1998 Jan;107(1):70-4. doi: 10.1177/000348949810700113. PMID: 9439392

Clinical prediction guides

Stacchiotti S, Tap W, Leonard H, Zaffaroni N, Baldi GG
Curr Treat Options Oncol 2023 Jun;24(6):667-679. Epub 2023 Apr 14 doi: 10.1007/s11864-023-01076-1. PMID: 37058275
Lou S, Balluff B, Cleven AHG, Bovée JVMG, McDonnell LA
Biochim Biophys Acta Proteins Proteom 2017 Jul;1865(7):957-966. Epub 2016 Oct 8 doi: 10.1016/j.bbapap.2016.09.020. PMID: 27725306
Yonemoto T, Takahashi M, Maru M, Tomioka A, Saito M, Araki Y, Tazaki M, Tsuchiya M, Iwata S, Kamoda H, Ishii T
Int J Clin Oncol 2016 Aug;21(4):801-807. Epub 2016 Jan 20 doi: 10.1007/s10147-016-0948-2. PMID: 26792434
Kachare SD, Brinkley J, Vohra NA, Zervos EE, Wong JH, Fitzgerald TL
J Surg Oncol 2015 Sep;112(4):338-43. Epub 2015 Aug 7 doi: 10.1002/jso.23989. PMID: 26250782
Mir O, Berrada N, Domont J, Cioffi A, Boulet B, Terrier P, Bonvalot S, Trichot C, Lokiec F, Le Cesne A
Cancer Chemother Pharmacol 2012 Feb;69(2):357-67. Epub 2011 Jul 19 doi: 10.1007/s00280-011-1707-8. PMID: 21769666

Recent systematic reviews

Horng HC, Wen KC, Wang PH, Chen YJ, Yen MS, Ng HT; Taiwan Association of Gynecology Systematic Review Group
Taiwan J Obstet Gynecol 2016 Aug;55(4):472-9. doi: 10.1016/j.tjog.2016.04.034. PMID: 27590366

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