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AJCC Grade 4 Sarcoma

MedGen UID:
272264
•Concept ID:
C1332069
•
Neoplastic Process
Synonyms: AJCC G4 Sarcoma; AJCC Grade IV Sarcoma

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAJCC Grade 4 Sarcoma

Professional guidelines

PubMed

Management and outcomes among patients with sarcomatoid hepatocellular carcinoma: A population-based analysis.
Wu L, Tsilimigras DI, Farooq A, Hyer JM, Merath K, Paredes AZ, Mehta R, Sahara K, Shen F, Pawlik TM
Cancer 2019 Nov 1;125(21):3767-3775. Epub 2019 Jul 12 doi: 10.1002/cncr.32396. PMID: 31299092

Recent clinical studies

Etiology

The inflammatory-nutritional score and nomogram for R0 resected head and neck soft tissue sarcoma.
Xu B, Qiu H, Ou B, Chen S, Du D, Liu Y, Zhang X, Liang Y
Oral Dis 2024 Apr;30(3):1139-1151. Epub 2023 Jan 20 doi: 10.1111/odi.14499. PMID: 36630573
Subcutaneous Leiomyosarcoma: An Aggressive Malignancy Portending a Significant Risk of Metastasis and Death.
Bresler SC, Gosnell HL, Ko JS, Angeles CV, Ronen S, Billings SD, Patel RM
Am J Surg Pathol 2023 Dec 1;47(12):1417-1424. Epub 2023 Sep 19 doi: 10.1097/PAS.0000000000002126. PMID: 37727934
Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial.
Long GV, Luke JJ, Khattak MA, de la Cruz Merino L, Del Vecchio M, Rutkowski P, Spagnolo F, Mackiewicz J, Chiarion-Sileni V, Kirkwood JM, Robert C, Grob JJ, de Galitiis F, Schadendorf D, Carlino MS, Mohr P, Dummer R, Gershenwald JE, Yoon CH, Wu XL, Fukunaga-Kalabis M, Krepler C, Eggermont AMM, Ascierto PA; KEYNOTE-716 Investigators
Lancet Oncol 2022 Nov;23(11):1378-1388. Epub 2022 Oct 18 doi: 10.1016/S1470-2045(22)00559-9. PMID: 36265502
A prognostic model for resectable soft tissue and cutaneous angiosarcoma.
Sinnamon AJ, Neuwirth MG, McMillan MT, Ecker BL, Bartlett EK, Zhang PJ, Kelz RR, Fraker DL, Roses RE, Karakousis GC
J Surg Oncol 2016 Oct;114(5):557-563. Epub 2016 Jul 4 doi: 10.1002/jso.24352. PMID: 27378102
When to consider adjuvant/neoadjuvant therapy for adult soft-tissue sarcoma.
Bramwell V
Oncology (Williston Park) 2007 Apr;21(4):511-4. PMID: 17474349

Diagnosis

Subcutaneous Leiomyosarcoma: An Aggressive Malignancy Portending a Significant Risk of Metastasis and Death.
Bresler SC, Gosnell HL, Ko JS, Angeles CV, Ronen S, Billings SD, Patel RM
Am J Surg Pathol 2023 Dec 1;47(12):1417-1424. Epub 2023 Sep 19 doi: 10.1097/PAS.0000000000002126. PMID: 37727934
Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial.
Long GV, Luke JJ, Khattak MA, de la Cruz Merino L, Del Vecchio M, Rutkowski P, Spagnolo F, Mackiewicz J, Chiarion-Sileni V, Kirkwood JM, Robert C, Grob JJ, de Galitiis F, Schadendorf D, Carlino MS, Mohr P, Dummer R, Gershenwald JE, Yoon CH, Wu XL, Fukunaga-Kalabis M, Krepler C, Eggermont AMM, Ascierto PA; KEYNOTE-716 Investigators
Lancet Oncol 2022 Nov;23(11):1378-1388. Epub 2022 Oct 18 doi: 10.1016/S1470-2045(22)00559-9. PMID: 36265502
Evaluation of head and neck soft tissue sarcoma 8th edition pathologic staging system and proposal of a novel stage grouping system.
Lee NCJ, Eskander A, Miccio JA, Park HS, Shah C, Rutenberg M, Hosni A, Husain ZA
Oral Oncol 2021 Mar;114:105137. Epub 2021 Jan 8 doi: 10.1016/j.oraloncology.2020.105137. PMID: 33422859
Surgical resection for recurrent retroperitoneal leiomyosarcoma and liposarcoma.
Nathenson MJ, Barysauskas CM, Nathenson RA, Regine WF, Hanna N, Sausville E
World J Surg Oncol 2018 Oct 11;16(1):203. doi: 10.1186/s12957-018-1505-4. PMID: 30309356Free PMC Article
Pediatric head and neck bone sarcomas: An analysis of 204 cases.
Brady JS, Chung SY, Marchiano E, Eloy JA, Baredes S, Park RCW
Int J Pediatr Otorhinolaryngol 2017 Sep;100:71-76. Epub 2017 Jun 15 doi: 10.1016/j.ijporl.2017.06.003. PMID: 28802390

Therapy

Prognostic nomogram in patients with epithelioid sarcoma: A SEER-based study.
Zhang D, Hu J, Liu Z, Wu H, Cheng H, Li C
Cancer Med 2023 Feb;12(3):3079-3088. Epub 2022 Sep 8 doi: 10.1002/cam4.5230. PMID: 36073670Free PMC Article
Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial.
Long GV, Luke JJ, Khattak MA, de la Cruz Merino L, Del Vecchio M, Rutkowski P, Spagnolo F, Mackiewicz J, Chiarion-Sileni V, Kirkwood JM, Robert C, Grob JJ, de Galitiis F, Schadendorf D, Carlino MS, Mohr P, Dummer R, Gershenwald JE, Yoon CH, Wu XL, Fukunaga-Kalabis M, Krepler C, Eggermont AMM, Ascierto PA; KEYNOTE-716 Investigators
Lancet Oncol 2022 Nov;23(11):1378-1388. Epub 2022 Oct 18 doi: 10.1016/S1470-2045(22)00559-9. PMID: 36265502
Collaborating with our adult colleagues: A case series of robotic surgery for suspicious and cancerous lesions in children and young adults performed in a free-standing children's hospital.
Varda BK, Cho P, Wagner AA, Lee RS
J Pediatr Urol 2018 Apr;14(2):182.e1-182.e8. Epub 2018 Mar 2 doi: 10.1016/j.jpurol.2018.01.003. PMID: 29503221Free PMC Article
Should High-grade Extraosseous Osteosarcoma Be Treated With Multimodality Therapy Like Other Soft Tissue Sarcomas?
Fan Z, Patel S, Lewis VO, Guadagnolo BA, Lin PP
Clin Orthop Relat Res 2015 Nov;473(11):3604-11. Epub 2015 Jul 22 doi: 10.1007/s11999-015-4463-y. PMID: 26197952Free PMC Article
When to consider adjuvant/neoadjuvant therapy for adult soft-tissue sarcoma.
Bramwell V
Oncology (Williston Park) 2007 Apr;21(4):511-4. PMID: 17474349

Prognosis

The inflammatory-nutritional score and nomogram for R0 resected head and neck soft tissue sarcoma.
Xu B, Qiu H, Ou B, Chen S, Du D, Liu Y, Zhang X, Liang Y
Oral Dis 2024 Apr;30(3):1139-1151. Epub 2023 Jan 20 doi: 10.1111/odi.14499. PMID: 36630573
Subcutaneous Leiomyosarcoma: An Aggressive Malignancy Portending a Significant Risk of Metastasis and Death.
Bresler SC, Gosnell HL, Ko JS, Angeles CV, Ronen S, Billings SD, Patel RM
Am J Surg Pathol 2023 Dec 1;47(12):1417-1424. Epub 2023 Sep 19 doi: 10.1097/PAS.0000000000002126. PMID: 37727934
Prognostic nomogram in patients with epithelioid sarcoma: A SEER-based study.
Zhang D, Hu J, Liu Z, Wu H, Cheng H, Li C
Cancer Med 2023 Feb;12(3):3079-3088. Epub 2022 Sep 8 doi: 10.1002/cam4.5230. PMID: 36073670Free PMC Article
Evaluation of head and neck soft tissue sarcoma 8th edition pathologic staging system and proposal of a novel stage grouping system.
Lee NCJ, Eskander A, Miccio JA, Park HS, Shah C, Rutenberg M, Hosni A, Husain ZA
Oral Oncol 2021 Mar;114:105137. Epub 2021 Jan 8 doi: 10.1016/j.oraloncology.2020.105137. PMID: 33422859
A prognostic model for resectable soft tissue and cutaneous angiosarcoma.
Sinnamon AJ, Neuwirth MG, McMillan MT, Ecker BL, Bartlett EK, Zhang PJ, Kelz RR, Fraker DL, Roses RE, Karakousis GC
J Surg Oncol 2016 Oct;114(5):557-563. Epub 2016 Jul 4 doi: 10.1002/jso.24352. PMID: 27378102

Clinical prediction guides

The inflammatory-nutritional score and nomogram for R0 resected head and neck soft tissue sarcoma.
Xu B, Qiu H, Ou B, Chen S, Du D, Liu Y, Zhang X, Liang Y
Oral Dis 2024 Apr;30(3):1139-1151. Epub 2023 Jan 20 doi: 10.1111/odi.14499. PMID: 36630573
Prognostic nomogram in patients with epithelioid sarcoma: A SEER-based study.
Zhang D, Hu J, Liu Z, Wu H, Cheng H, Li C
Cancer Med 2023 Feb;12(3):3079-3088. Epub 2022 Sep 8 doi: 10.1002/cam4.5230. PMID: 36073670Free PMC Article
Evaluation of head and neck soft tissue sarcoma 8th edition pathologic staging system and proposal of a novel stage grouping system.
Lee NCJ, Eskander A, Miccio JA, Park HS, Shah C, Rutenberg M, Hosni A, Husain ZA
Oral Oncol 2021 Mar;114:105137. Epub 2021 Jan 8 doi: 10.1016/j.oraloncology.2020.105137. PMID: 33422859
Simple staging system for osteosarcoma performs equivalently to the AJCC and MSTS systems.
Cates JMM
J Orthop Res 2018 Oct;36(10):2802-2808. Epub 2018 Jun 13 doi: 10.1002/jor.24032. PMID: 29718558
Predictors of survival after resection of retroperitoneal sarcoma: a population-based analysis and critical appraisal of the AJCC staging system.
Nathan H, Raut CP, Thornton K, Herman JM, Ahuja N, Schulick RD, Choti MA, Pawlik TM
Ann Surg 2009 Dec;250(6):970-6. doi: 10.1097/SLA.0b013e3181b25183. PMID: 19644351Free PMC Article

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