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Small cell variant anaplastic large cell lymphoma

MedGen UID:
234787
•Concept ID:
C1335983
•
Neoplastic Process
Synonyms: Anaplastic small cell lymphoma; Small cell variant of anaplastic large cell lymphoma
 
Monarch Initiative: MONDO:0021879

Definition

A histologic variant of anaplastic large cell lymphoma characterized by the presence of a predominant population of small to medium size malignant cells with irregular nuclei. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall cell variant anaplastic large cell lymphoma

Professional guidelines

PubMed

ALK rearrangement in a large series of consecutive non-small cell lung cancers: comparison between a new immunohistochemical approach and fluorescence in situ hybridization for the screening of patients eligible for crizotinib treatment.
Alì G, Proietti A, Pelliccioni S, Niccoli C, Lupi C, Sensi E, Giannini R, Borrelli N, Menghi M, Chella A, Ribechini A, Cappuzzo F, Melfi F, Lucchi M, Mussi A, Fontanini G
Arch Pathol Lab Med 2014 Nov;138(11):1449-58. Epub 2014 Jun 2 doi: 10.5858/arpa.2013-0388-OA. PMID: 24885803
PAX-5: a valuable immunohistochemical marker in the differential diagnosis of lymphoid neoplasms.
Desouki MM, Post GR, Cherry D, Lazarchick J
Clin Med Res 2010 Jul;8(2):84-8. doi: 10.3121/cmr.2010.891. PMID: 20660931Free PMC Article

Recent clinical studies

Diagnosis

Small cell variant anaplastic large cell lymphoma presenting as leukemia: A case report and review of Literature.
Dutta R, Ramteke P, Mathur SR, Saxena R, Pati HP, Mallick S
Indian J Pathol Microbiol 2022 Jul-Sep;65(3):705-708. doi: 10.4103/ijpm.ijpm_443_21. PMID: 35900509
Successful treatment of small cell variant anaplastic large cell lymphoma with allogeneic peripheral blood stem cell transplantation, and review of the literature.
Imamura R, Mouri F, Nomura K, Nakamura T, Oku E, Morishige S, Takata Y, Seki R, Osaki K, Hashiguchi M, Yoshimoto K, Ohshima K, Nagafuji K, Okamura T
Int J Hematol 2013 Jan;97(1):139-43. Epub 2012 Dec 20 doi: 10.1007/s12185-012-1242-3. PMID: 23264126
Leukaemic small cell variant anaplastic large cell lymphoma during pregnancy.
Lesesve JF, Buisine J, Grégoire MJ, Raby P, Lederlin P, Béné MC, Froment N, Labouyrie E
Clin Lab Haematol 2000 Oct;22(5):297-301. doi: 10.1046/j.1365-2257.2000.00144.x. PMID: 11122273

Prognosis

Successful treatment of small cell variant anaplastic large cell lymphoma with allogeneic peripheral blood stem cell transplantation, and review of the literature.
Imamura R, Mouri F, Nomura K, Nakamura T, Oku E, Morishige S, Takata Y, Seki R, Osaki K, Hashiguchi M, Yoshimoto K, Ohshima K, Nagafuji K, Okamura T
Int J Hematol 2013 Jan;97(1):139-43. Epub 2012 Dec 20 doi: 10.1007/s12185-012-1242-3. PMID: 23264126
Leukaemic small cell variant anaplastic large cell lymphoma during pregnancy.
Lesesve JF, Buisine J, Grégoire MJ, Raby P, Lederlin P, Béné MC, Froment N, Labouyrie E
Clin Lab Haematol 2000 Oct;22(5):297-301. doi: 10.1046/j.1365-2257.2000.00144.x. PMID: 11122273
Leukaemic presentation of small cell variant anaplastic large cell lymphoma: report of four cases.
Bayle C, Charpentier A, Duchayne E, Manel AM, Pages MP, Robert A, Lamant L, Dastugue N, Bertrand Y, Dijoud F, Emile JF, Machover D, Brugiéres L, Delsol G
Br J Haematol 1999 Mar;104(4):680-8. doi: 10.1046/j.1365-2141.1999.01238.x. PMID: 10192426

Clinical prediction guides

Successful treatment of small cell variant anaplastic large cell lymphoma with allogeneic peripheral blood stem cell transplantation, and review of the literature.
Imamura R, Mouri F, Nomura K, Nakamura T, Oku E, Morishige S, Takata Y, Seki R, Osaki K, Hashiguchi M, Yoshimoto K, Ohshima K, Nagafuji K, Okamura T
Int J Hematol 2013 Jan;97(1):139-43. Epub 2012 Dec 20 doi: 10.1007/s12185-012-1242-3. PMID: 23264126

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