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Unclassified Renal Cell Carcinoma

MedGen UID:
234967
Concept ID:
C1336853
Neoplastic Process

Definition

A renal cell carcinoma characterized by morphologic features that do not fit easily into one of the other well-defined categories of renal cell carcinoma. Examples of such features include mixtures of morphologic patterns, mucin production, and sarcomatoid morphology. [from NCI]

Professional guidelines

PubMed

Baniak N, Tsai H, Hirsch MS
Arch Pathol Lab Med 2021 Sep 1;145(9):1148-1170. doi: 10.5858/arpa.2020-0464-RA. PMID: 33406251
Ito K, Mikami S, Kuroda N, Nagashima Y, Tatsugami K, Masumori N, Kondo T, Takagi T, Nakanishi S, Eto M, Kamba T, Tomita Y, Matsuyama H, Tsushima T, Nakazawa H, Oya M, Kimura G, Shinohara N, Asano T
Jpn J Clin Oncol 2020 Oct 22;50(11):1313-1320. doi: 10.1093/jjco/hyaa114. PMID: 33089867
Msaouel P, Hong AL, Mullen EA, Atkins MB, Walker CL, Lee CH, Carden MA, Genovese G, Linehan WM, Rao P, Merino MJ, Grodman H, Dome JS, Fernandez CV, Geller JI, Apolo AB, Daw NC, Hodges HC, Moxey-Mims M, Wei D, Bottaro DP, Staehler M, Karam JA, Rathmell WK, Tannir NM
Clin Genitourin Cancer 2019 Feb;17(1):1-6. Epub 2018 Sep 12 doi: 10.1016/j.clgc.2018.09.005. PMID: 30287223Free PMC Article

Recent clinical studies

Etiology

Tomaszewski Z, Littler Y
Int J Surg Pathol 2022 Oct;30(7):810-815. Epub 2022 Mar 11 doi: 10.1177/10668969221084265. PMID: 35274993
Kwon R, Argani P, Epstein JI, Lombardo KA, Wang X, Pierorazio PM, Mehra R, Matoso A
Am J Surg Pathol 2021 Apr 1;45(4):450-462. doi: 10.1097/PAS.0000000000001629. PMID: 33239504
Akgul M, Cheng L
Hum Pathol 2020 Aug;102:70-78. Epub 2020 Jun 30 doi: 10.1016/j.humpath.2020.06.007. PMID: 32619439
Abdulfatah E, Kennedy JM, Hafez K, Davenport MS, Xiao H, Weizer AZ, Palapattu GS, Morgan TM, Mannan R, Wang XM, Dhanasekaran SM, Kaffenberger SD, Spratt DE, Kunju L, Wu A, Lew M, Udager AM, Chinnaiyan AM, Mehra R
Histopathology 2020 May;76(6):875-887. Epub 2020 Apr 27 doi: 10.1111/his.14051. PMID: 31872452
Lopez-Beltran A, Kirkali Z, Montironi R, Blanca A, Algaba F, Scarpelli M, Yorukoglu K, Hartmann A, Cheng L
BJU Int 2012 Sep;110(6):786-93. Epub 2012 Mar 8 doi: 10.1111/j.1464-410X.2012.10934.x. PMID: 22404824

Diagnosis

Siadat F, Mansoor M, Hes O, Trpkov K
Clin Lab Med 2023 Jun;43(2):275-298. doi: 10.1016/j.cll.2023.03.003. PMID: 37169446
Siadat F, Mansoor M, Hes O, Trpkov K
Surg Pathol Clin 2022 Dec;15(4):713-728. Epub 2022 Oct 13 doi: 10.1016/j.path.2022.07.006. PMID: 36344185
Tomaszewski Z, Littler Y
Int J Surg Pathol 2022 Oct;30(7):810-815. Epub 2022 Mar 11 doi: 10.1177/10668969221084265. PMID: 35274993
Akgul M, Cheng L
Hum Pathol 2020 Aug;102:70-78. Epub 2020 Jun 30 doi: 10.1016/j.humpath.2020.06.007. PMID: 32619439
Abdulfatah E, Kennedy JM, Hafez K, Davenport MS, Xiao H, Weizer AZ, Palapattu GS, Morgan TM, Mannan R, Wang XM, Dhanasekaran SM, Kaffenberger SD, Spratt DE, Kunju L, Wu A, Lew M, Udager AM, Chinnaiyan AM, Mehra R
Histopathology 2020 May;76(6):875-887. Epub 2020 Apr 27 doi: 10.1111/his.14051. PMID: 31872452

Therapy

Msaouel P, Hong AL, Mullen EA, Atkins MB, Walker CL, Lee CH, Carden MA, Genovese G, Linehan WM, Rao P, Merino MJ, Grodman H, Dome JS, Fernandez CV, Geller JI, Apolo AB, Daw NC, Hodges HC, Moxey-Mims M, Wei D, Bottaro DP, Staehler M, Karam JA, Rathmell WK, Tannir NM
Clin Genitourin Cancer 2019 Feb;17(1):1-6. Epub 2018 Sep 12 doi: 10.1016/j.clgc.2018.09.005. PMID: 30287223Free PMC Article
Raiss H, Duplomb S, Tartas S, Layachi M, Errihani H
J Med Case Rep 2017 Nov 7;11(1):314. doi: 10.1186/s13256-017-1470-5. PMID: 29110685Free PMC Article
Adra N, Cheng L, Pili R
Clin Genitourin Cancer 2017 Jun;15(3):e517-e519. Epub 2016 Dec 29 doi: 10.1016/j.clgc.2016.12.019. PMID: 28110836
Miolo G, Ash A, Buonadonna A, Lo Re G, Torrisi E, Cervo S, Santeufemia DA, Tuzi A, Canzonieri V
Cancer Biol Ther 2014;15(11):1439-43. doi: 10.4161/15384047.2014.956642. PMID: 25482943Free PMC Article
Thomas AA, Rini BI, Stephenson AJ, Garcia JA, Fergany A, Krishnamurthi V, Novick AC, Gill IS, Klein EA, Zhou M, Campbell SC
J Urol 2009 Sep;182(3):881-6. Epub 2009 Jul 17 doi: 10.1016/j.juro.2009.05.014. PMID: 19616232

Prognosis

Siadat F, Mansoor M, Hes O, Trpkov K
Clin Lab Med 2023 Jun;43(2):275-298. doi: 10.1016/j.cll.2023.03.003. PMID: 37169446
Siadat F, Mansoor M, Hes O, Trpkov K
Surg Pathol Clin 2022 Dec;15(4):713-728. Epub 2022 Oct 13 doi: 10.1016/j.path.2022.07.006. PMID: 36344185
Ohsugi H, Ohe C, Yoshida T, Ikeda J, Sugi M, Kinoshita H, Matsuda T
Int J Urol 2021 Oct;28(10):1060-1066. Epub 2021 Aug 3 doi: 10.1111/iju.14648. PMID: 34346110
Kwon R, Argani P, Epstein JI, Lombardo KA, Wang X, Pierorazio PM, Mehra R, Matoso A
Am J Surg Pathol 2021 Apr 1;45(4):450-462. doi: 10.1097/PAS.0000000000001629. PMID: 33239504
Lopez-Beltran A, Kirkali Z, Montironi R, Blanca A, Algaba F, Scarpelli M, Yorukoglu K, Hartmann A, Cheng L
BJU Int 2012 Sep;110(6):786-93. Epub 2012 Mar 8 doi: 10.1111/j.1464-410X.2012.10934.x. PMID: 22404824

Clinical prediction guides

Ren S, Luo C, Wang Y, Wei Y, Ou Y, Yuan J, Li X, Wang J, Lv Q, Yang B, Fan S, Zhou F, Chen Z, Nie Y, Wang D
Medicine (Baltimore) 2021 Dec 23;100(51):e28380. doi: 10.1097/MD.0000000000028380. PMID: 34941164Free PMC Article
Ohsugi H, Ohe C, Yoshida T, Ikeda J, Sugi M, Kinoshita H, Matsuda T
Int J Urol 2021 Oct;28(10):1060-1066. Epub 2021 Aug 3 doi: 10.1111/iju.14648. PMID: 34346110
Hu ZY, Pang LJ, Qi Y, Kang XL, Hu JM, Wang L, Liu KP, Ren Y, Cui M, Song LL, Li HA, Zou H, Li F
Int J Clin Exp Pathol 2014;7(7):3865-75. Epub 2014 Jun 15 PMID: 25120763Free PMC Article
Talento R, Hewan-Lowe K, Yin M
Ultrastruct Pathol 2013 Feb;37(1):70-6. doi: 10.3109/01913123.2012.739595. PMID: 23383617
Lopez-Beltran A, Kirkali Z, Montironi R, Blanca A, Algaba F, Scarpelli M, Yorukoglu K, Hartmann A, Cheng L
BJU Int 2012 Sep;110(6):786-93. Epub 2012 Mar 8 doi: 10.1111/j.1464-410X.2012.10934.x. PMID: 22404824

Supplemental Content

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