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Unclassified Renal Cell Carcinoma

MedGen UID:
234967
•Concept ID:
C1336853
•
Neoplastic Process

Definition

A renal cell carcinoma characterized by morphologic features that do not fit easily into one of the other well-defined categories of renal cell carcinoma. Examples of such features include mixtures of morphologic patterns, mucin production, and sarcomatoid morphology. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnclassified Renal Cell Carcinoma

Professional guidelines

PubMed

The Differential Diagnosis of Medullary-Based Renal Masses.
Baniak N, Tsai H, Hirsch MS
Arch Pathol Lab Med 2021 Sep 1;145(9):1148-1170. doi: 10.5858/arpa.2020-0464-RA. PMID: 33406251
Difficulty in differential diagnosis for renal cancer with microscopic papillary architecture: overlapped pathological features among papillary renal cell carcinoma (RCC), mutinous tubular and spindle cell carcinoma, and unclassified RCC. Lessons from a Japanese multicenter study.
Ito K, Mikami S, Kuroda N, Nagashima Y, Tatsugami K, Masumori N, Kondo T, Takagi T, Nakanishi S, Eto M, Kamba T, Tomita Y, Matsuyama H, Tsushima T, Nakazawa H, Oya M, Kimura G, Shinohara N, Asano T
Jpn J Clin Oncol 2020 Oct 22;50(11):1313-1320. doi: 10.1093/jjco/hyaa114. PMID: 33089867
Updated Recommendations on the Diagnosis, Management, and Clinical Trial Eligibility Criteria for Patients With Renal Medullary Carcinoma.
Msaouel P, Hong AL, Mullen EA, Atkins MB, Walker CL, Lee CH, Carden MA, Genovese G, Linehan WM, Rao P, Merino MJ, Grodman H, Dome JS, Fernandez CV, Geller JI, Apolo AB, Daw NC, Hodges HC, Moxey-Mims M, Wei D, Bottaro DP, Staehler M, Karam JA, Rathmell WK, Tannir NM
Clin Genitourin Cancer 2019 Feb;17(1):1-6. Epub 2018 Sep 12 doi: 10.1016/j.clgc.2018.09.005. PMID: 30287223Free PMC Article

Recent clinical studies

Etiology

Unclassified Oncocytic Renal Neoplasm with Rib and Liver Metastases: Metastatic Oncocytoma?
Tomaszewski Z, Littler Y
Int J Surg Pathol 2022 Oct;30(7):810-815. Epub 2022 Mar 11 doi: 10.1177/10668969221084265. PMID: 35274993
Predictors of postoperative recurrence in patients with non-metastatic pT3a renal cell carcinoma.
Ohsugi H, Ohe C, Yoshida T, Ikeda J, Sugi M, Kinoshita H, Matsuda T
Int J Urol 2021 Oct;28(10):1060-1066. Epub 2021 Aug 3 doi: 10.1111/iju.14648. PMID: 34346110
Contemporary Characterization and Recategorization of Adult Unclassified Renal Cell Carcinoma.
Kwon R, Argani P, Epstein JI, Lombardo KA, Wang X, Pierorazio PM, Mehra R, Matoso A
Am J Surg Pathol 2021 Apr 1;45(4):450-462. doi: 10.1097/PAS.0000000000001629. PMID: 33239504
Immunophenotypic and pathologic heterogeneity of unclassified renal cell carcinoma: a study of 300 cases.
Akgul M, Cheng L
Hum Pathol 2020 Aug;102:70-78. Epub 2020 Jun 30 doi: 10.1016/j.humpath.2020.06.007. PMID: 32619439
Clinicopathological characterisation of renal cell carcinoma in young adults: a contemporary update and review of literature.
Abdulfatah E, Kennedy JM, Hafez K, Davenport MS, Xiao H, Weizer AZ, Palapattu GS, Morgan TM, Mannan R, Wang XM, Dhanasekaran SM, Kaffenberger SD, Spratt DE, Kunju L, Wu A, Lew M, Udager AM, Chinnaiyan AM, Mehra R
Histopathology 2020 May;76(6):875-887. Epub 2020 Apr 27 doi: 10.1111/his.14051. PMID: 31872452

Diagnosis

Kidney Tumors: New and Emerging Kidney Tumor Entities.
Siadat F, Mansoor M, Hes O, Trpkov K
Clin Lab Med 2023 Jun;43(2):275-298. doi: 10.1016/j.cll.2023.03.003. PMID: 37169446
Kidney Tumors: New and Emerging Kidney Tumor Entities.
Siadat F, Mansoor M, Hes O, Trpkov K
Surg Pathol Clin 2022 Dec;15(4):713-728. Epub 2022 Oct 13 doi: 10.1016/j.path.2022.07.006. PMID: 36344185
Unclassified Oncocytic Renal Neoplasm with Rib and Liver Metastases: Metastatic Oncocytoma?
Tomaszewski Z, Littler Y
Int J Surg Pathol 2022 Oct;30(7):810-815. Epub 2022 Mar 11 doi: 10.1177/10668969221084265. PMID: 35274993
Immunophenotypic and pathologic heterogeneity of unclassified renal cell carcinoma: a study of 300 cases.
Akgul M, Cheng L
Hum Pathol 2020 Aug;102:70-78. Epub 2020 Jun 30 doi: 10.1016/j.humpath.2020.06.007. PMID: 32619439
Clinicopathological characterisation of renal cell carcinoma in young adults: a contemporary update and review of literature.
Abdulfatah E, Kennedy JM, Hafez K, Davenport MS, Xiao H, Weizer AZ, Palapattu GS, Morgan TM, Mannan R, Wang XM, Dhanasekaran SM, Kaffenberger SD, Spratt DE, Kunju L, Wu A, Lew M, Udager AM, Chinnaiyan AM, Mehra R
Histopathology 2020 May;76(6):875-887. Epub 2020 Apr 27 doi: 10.1111/his.14051. PMID: 31872452

Therapy

Updated Recommendations on the Diagnosis, Management, and Clinical Trial Eligibility Criteria for Patients With Renal Medullary Carcinoma.
Msaouel P, Hong AL, Mullen EA, Atkins MB, Walker CL, Lee CH, Carden MA, Genovese G, Linehan WM, Rao P, Merino MJ, Grodman H, Dome JS, Fernandez CV, Geller JI, Apolo AB, Daw NC, Hodges HC, Moxey-Mims M, Wei D, Bottaro DP, Staehler M, Karam JA, Rathmell WK, Tannir NM
Clin Genitourin Cancer 2019 Feb;17(1):1-6. Epub 2018 Sep 12 doi: 10.1016/j.clgc.2018.09.005. PMID: 30287223Free PMC Article
Lingual metastasis as an initial presentation of renal cell carcinoma: a case report.
Raiss H, Duplomb S, Tartas S, Layachi M, Errihani H
J Med Case Rep 2017 Nov 7;11(1):314. doi: 10.1186/s13256-017-1470-5. PMID: 29110685Free PMC Article
Unclassified Renal Cell Carcinoma With Significant Response to Nivolumab.
Adra N, Cheng L, Pili R
Clin Genitourin Cancer 2017 Jun;15(3):e517-e519. Epub 2016 Dec 29 doi: 10.1016/j.clgc.2016.12.019. PMID: 28110836
Grade 4 unclassified renal cell carcinoma with sarcomatoid component expressing S-100 protein. A case report with peculiar diagnostic and therapeutic implications.
Miolo G, Ash A, Buonadonna A, Lo Re G, Torrisi E, Cervo S, Santeufemia DA, Tuzi A, Canzonieri V
Cancer Biol Ther 2014;15(11):1439-43. doi: 10.4161/15384047.2014.956642. PMID: 25482943Free PMC Article
Surgical resection of renal cell carcinoma after targeted therapy.
Thomas AA, Rini BI, Stephenson AJ, Garcia JA, Fergany A, Krishnamurthi V, Novick AC, Gill IS, Klein EA, Zhou M, Campbell SC
J Urol 2009 Sep;182(3):881-6. Epub 2009 Jul 17 doi: 10.1016/j.juro.2009.05.014. PMID: 19616232

Prognosis

Kidney Tumors: New and Emerging Kidney Tumor Entities.
Siadat F, Mansoor M, Hes O, Trpkov K
Clin Lab Med 2023 Jun;43(2):275-298. doi: 10.1016/j.cll.2023.03.003. PMID: 37169446
Kidney Tumors: New and Emerging Kidney Tumor Entities.
Siadat F, Mansoor M, Hes O, Trpkov K
Surg Pathol Clin 2022 Dec;15(4):713-728. Epub 2022 Oct 13 doi: 10.1016/j.path.2022.07.006. PMID: 36344185
Predictors of postoperative recurrence in patients with non-metastatic pT3a renal cell carcinoma.
Ohsugi H, Ohe C, Yoshida T, Ikeda J, Sugi M, Kinoshita H, Matsuda T
Int J Urol 2021 Oct;28(10):1060-1066. Epub 2021 Aug 3 doi: 10.1111/iju.14648. PMID: 34346110
Contemporary Characterization and Recategorization of Adult Unclassified Renal Cell Carcinoma.
Kwon R, Argani P, Epstein JI, Lombardo KA, Wang X, Pierorazio PM, Mehra R, Matoso A
Am J Surg Pathol 2021 Apr 1;45(4):450-462. doi: 10.1097/PAS.0000000000001629. PMID: 33239504
Unclassified renal cell carcinoma: a report of 56 cases.
Lopez-Beltran A, Kirkali Z, Montironi R, Blanca A, Algaba F, Scarpelli M, Yorukoglu K, Hartmann A, Cheng L
BJU Int 2012 Sep;110(6):786-93. Epub 2012 Mar 8 doi: 10.1111/j.1464-410X.2012.10934.x. PMID: 22404824

Clinical prediction guides

Birt-Hogg-Dubé syndrome with rare unclassified renal cell carcinoma: A case report.
Ren S, Luo C, Wang Y, Wei Y, Ou Y, Yuan J, Li X, Wang J, Lv Q, Yang B, Fan S, Zhou F, Chen Z, Nie Y, Wang D
Medicine (Baltimore) 2021 Dec 23;100(51):e28380. doi: 10.1097/MD.0000000000028380. PMID: 34941164Free PMC Article
Predictors of postoperative recurrence in patients with non-metastatic pT3a renal cell carcinoma.
Ohsugi H, Ohe C, Yoshida T, Ikeda J, Sugi M, Kinoshita H, Matsuda T
Int J Urol 2021 Oct;28(10):1060-1066. Epub 2021 Aug 3 doi: 10.1111/iju.14648. PMID: 34346110
Unclassified renal cell carcinoma: a clinicopathological, comparative genomic hybridization, and whole-genome exon sequencing study.
Hu ZY, Pang LJ, Qi Y, Kang XL, Hu JM, Wang L, Liu KP, Ren Y, Cui M, Song LL, Li HA, Zou H, Li F
Int J Clin Exp Pathol 2014;7(7):3865-75. Epub 2014 Jun 15 PMID: 25120763Free PMC Article
Evaluation of morphologically unclassified renal cell carcinoma with electron microscopy and novel renal markers: implications for tumor reclassification.
Talento R, Hewan-Lowe K, Yin M
Ultrastruct Pathol 2013 Feb;37(1):70-6. doi: 10.3109/01913123.2012.739595. PMID: 23383617
Unclassified renal cell carcinoma: a report of 56 cases.
Lopez-Beltran A, Kirkali Z, Montironi R, Blanca A, Algaba F, Scarpelli M, Yorukoglu K, Hartmann A, Cheng L
BJU Int 2012 Sep;110(6):786-93. Epub 2012 Mar 8 doi: 10.1111/j.1464-410X.2012.10934.x. PMID: 22404824

Recent systematic reviews

Eosinophilic Solid and Cystic Renal Cell Carcinoma-A Systematic Review and Meta-Analysis.
Loghin A, Popelea MC, Todea-Moga CD, Cocuz IG, Borda A
Int J Mol Sci 2024 May 30;25(11) doi: 10.3390/ijms25115982. PMID: 38892169Free PMC Article

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