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Locally Advanced Unclassified Renal Cell Carcinoma

MedGen UID:
1737513
•Concept ID:
C5419517
•
Neoplastic Process

Definition

Unclassified renal cell carcinoma that has spread to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Unclassified Renal Cell Carcinoma

Professional guidelines

PubMed

Updated Recommendations on the Diagnosis, Management, and Clinical Trial Eligibility Criteria for Patients With Renal Medullary Carcinoma.
Msaouel P, Hong AL, Mullen EA, Atkins MB, Walker CL, Lee CH, Carden MA, Genovese G, Linehan WM, Rao P, Merino MJ, Grodman H, Dome JS, Fernandez CV, Geller JI, Apolo AB, Daw NC, Hodges HC, Moxey-Mims M, Wei D, Bottaro DP, Staehler M, Karam JA, Rathmell WK, Tannir NM
Clin Genitourin Cancer 2019 Feb;17(1):1-6. Epub 2018 Sep 12 doi: 10.1016/j.clgc.2018.09.005. PMID: 30287223Free PMC Article

Recent clinical studies

Etiology

Clinical outcomes of nivolumab plus ipilimumab in patients with metastatic non-clear cell renal cell carcinoma: Real-world data from a Japanese multicenter retrospective study.
Izumi K, Inoue M, Washino S, Shirotake S, Kagawa M, Takeshita H, Miura Y, Hyodo Y, Oyama M, Kawakami S, Miyagawa T, Saito K, Kageyama Y
Int J Urol 2023 Sep;30(9):714-721. Epub 2022 Dec 21 doi: 10.1111/iju.15128. PMID: 36541136
The Complete Spectrum of Infiltrative Renal Masses: Clinical Characteristics and Prognostic Implications.
Wang Y, Tanaka H, Ye Y, Ding X, Ward RD, Campbell RA, DeWitt-Foy ME, Suk-Ouichai C, Remer EM, Campbell SC
Urology 2019 Aug;130:86-92. Epub 2019 May 8 doi: 10.1016/j.urology.2019.04.033. PMID: 31075276
Surgical resection of renal cell carcinoma after targeted therapy.
Thomas AA, Rini BI, Stephenson AJ, Garcia JA, Fergany A, Krishnamurthi V, Novick AC, Gill IS, Klein EA, Zhou M, Campbell SC
J Urol 2009 Sep;182(3):881-6. Epub 2009 Jul 17 doi: 10.1016/j.juro.2009.05.014. PMID: 19616232
Cytoreductive nephrectomy for T4NxM1 renal cell carcinoma: the M.D. Anderson Cancer Center experience.
Kassouf W, Sanchez-Ortiz R, Tamboli P, Jonasch E, Merchant MM, Spiess PE, Wood CG
Urology 2007 May;69(5):835-8. doi: 10.1016/j.urology.2007.01.034. PMID: 17482917
Sarcomatoid differentiation in renal cell carcinoma: a study of 101 cases.
de Peralta-Venturina M, Moch H, Amin M, Tamboli P, Hailemariam S, Mihatsch M, Javidan J, Stricker H, Ro JY, Amin MB
Am J Surg Pathol 2001 Mar;25(3):275-84. doi: 10.1097/00000478-200103000-00001. PMID: 11224597

Diagnosis

The Complete Spectrum of Infiltrative Renal Masses: Clinical Characteristics and Prognostic Implications.
Wang Y, Tanaka H, Ye Y, Ding X, Ward RD, Campbell RA, DeWitt-Foy ME, Suk-Ouichai C, Remer EM, Campbell SC
Urology 2019 Aug;130:86-92. Epub 2019 May 8 doi: 10.1016/j.urology.2019.04.033. PMID: 31075276
Updated Recommendations on the Diagnosis, Management, and Clinical Trial Eligibility Criteria for Patients With Renal Medullary Carcinoma.
Msaouel P, Hong AL, Mullen EA, Atkins MB, Walker CL, Lee CH, Carden MA, Genovese G, Linehan WM, Rao P, Merino MJ, Grodman H, Dome JS, Fernandez CV, Geller JI, Apolo AB, Daw NC, Hodges HC, Moxey-Mims M, Wei D, Bottaro DP, Staehler M, Karam JA, Rathmell WK, Tannir NM
Clin Genitourin Cancer 2019 Feb;17(1):1-6. Epub 2018 Sep 12 doi: 10.1016/j.clgc.2018.09.005. PMID: 30287223Free PMC Article
Eosinophilic solid and cystic renal cell carcinoma mimicking epithelioid angiomyolipoma: series of 4 primary tumors and 2 metastases.
Tretiakova MS
Hum Pathol 2018 Oct;80:65-75. Epub 2018 Jun 6 doi: 10.1016/j.humpath.2018.05.023. PMID: 29885406
Effect of Stereotactic Body Radiotherapy on the Growth Kinetics and Enhancement Pattern of Primary Renal Tumors.
Sun MR, Brook A, Powell MF, Kaliannan K, Wagner AA, Kaplan ID, Pedrosa I
AJR Am J Roentgenol 2016 Mar;206(3):544-53. doi: 10.2214/AJR.14.14099. PMID: 26901010Free PMC Article

Therapy

Clinical outcomes of nivolumab plus ipilimumab in patients with metastatic non-clear cell renal cell carcinoma: Real-world data from a Japanese multicenter retrospective study.
Izumi K, Inoue M, Washino S, Shirotake S, Kagawa M, Takeshita H, Miura Y, Hyodo Y, Oyama M, Kawakami S, Miyagawa T, Saito K, Kageyama Y
Int J Urol 2023 Sep;30(9):714-721. Epub 2022 Dec 21 doi: 10.1111/iju.15128. PMID: 36541136
Updated Recommendations on the Diagnosis, Management, and Clinical Trial Eligibility Criteria for Patients With Renal Medullary Carcinoma.
Msaouel P, Hong AL, Mullen EA, Atkins MB, Walker CL, Lee CH, Carden MA, Genovese G, Linehan WM, Rao P, Merino MJ, Grodman H, Dome JS, Fernandez CV, Geller JI, Apolo AB, Daw NC, Hodges HC, Moxey-Mims M, Wei D, Bottaro DP, Staehler M, Karam JA, Rathmell WK, Tannir NM
Clin Genitourin Cancer 2019 Feb;17(1):1-6. Epub 2018 Sep 12 doi: 10.1016/j.clgc.2018.09.005. PMID: 30287223Free PMC Article
Pazopanib for the Treatment of Non-clear Cell Renal Cell Carcinoma: A Single-Arm, Open-Label, Multicenter, Phase II Study.
Jung KS, Lee SJ, Park SH, Lee JL, Lee SH, Lim JY, Kang JH, Lee S, Rha SY, Lee KH, Kim HY, Lim HY
Cancer Res Treat 2018 Apr;50(2):488-494. Epub 2017 May 22 doi: 10.4143/crt.2016.584. PMID: 28546525Free PMC Article
Surgical resection of renal cell carcinoma after targeted therapy.
Thomas AA, Rini BI, Stephenson AJ, Garcia JA, Fergany A, Krishnamurthi V, Novick AC, Gill IS, Klein EA, Zhou M, Campbell SC
J Urol 2009 Sep;182(3):881-6. Epub 2009 Jul 17 doi: 10.1016/j.juro.2009.05.014. PMID: 19616232

Prognosis

The Complete Spectrum of Infiltrative Renal Masses: Clinical Characteristics and Prognostic Implications.
Wang Y, Tanaka H, Ye Y, Ding X, Ward RD, Campbell RA, DeWitt-Foy ME, Suk-Ouichai C, Remer EM, Campbell SC
Urology 2019 Aug;130:86-92. Epub 2019 May 8 doi: 10.1016/j.urology.2019.04.033. PMID: 31075276
Updated Recommendations on the Diagnosis, Management, and Clinical Trial Eligibility Criteria for Patients With Renal Medullary Carcinoma.
Msaouel P, Hong AL, Mullen EA, Atkins MB, Walker CL, Lee CH, Carden MA, Genovese G, Linehan WM, Rao P, Merino MJ, Grodman H, Dome JS, Fernandez CV, Geller JI, Apolo AB, Daw NC, Hodges HC, Moxey-Mims M, Wei D, Bottaro DP, Staehler M, Karam JA, Rathmell WK, Tannir NM
Clin Genitourin Cancer 2019 Feb;17(1):1-6. Epub 2018 Sep 12 doi: 10.1016/j.clgc.2018.09.005. PMID: 30287223Free PMC Article
Eosinophilic solid and cystic renal cell carcinoma mimicking epithelioid angiomyolipoma: series of 4 primary tumors and 2 metastases.
Tretiakova MS
Hum Pathol 2018 Oct;80:65-75. Epub 2018 Jun 6 doi: 10.1016/j.humpath.2018.05.023. PMID: 29885406
Renal cell carcinoma with novel VCL-ALK fusion: new representative of ALK-associated tumor spectrum.
Debelenko LV, Raimondi SC, Daw N, Shivakumar BR, Huang D, Nelson M, Bridge JA
Mod Pathol 2011 Mar;24(3):430-42. Epub 2010 Nov 12 doi: 10.1038/modpathol.2010.213. PMID: 21076462
Sarcomatoid differentiation in renal cell carcinoma: a study of 101 cases.
de Peralta-Venturina M, Moch H, Amin M, Tamboli P, Hailemariam S, Mihatsch M, Javidan J, Stricker H, Ro JY, Amin MB
Am J Surg Pathol 2001 Mar;25(3):275-84. doi: 10.1097/00000478-200103000-00001. PMID: 11224597

Clinical prediction guides

The Complete Spectrum of Infiltrative Renal Masses: Clinical Characteristics and Prognostic Implications.
Wang Y, Tanaka H, Ye Y, Ding X, Ward RD, Campbell RA, DeWitt-Foy ME, Suk-Ouichai C, Remer EM, Campbell SC
Urology 2019 Aug;130:86-92. Epub 2019 May 8 doi: 10.1016/j.urology.2019.04.033. PMID: 31075276
Unclassified renal cell carcinoma: a clinicopathological, comparative genomic hybridization, and whole-genome exon sequencing study.
Hu ZY, Pang LJ, Qi Y, Kang XL, Hu JM, Wang L, Liu KP, Ren Y, Cui M, Song LL, Li HA, Zou H, Li F
Int J Clin Exp Pathol 2014;7(7):3865-75. Epub 2014 Jun 15 PMID: 25120763Free PMC Article
Renal cell carcinoma with novel VCL-ALK fusion: new representative of ALK-associated tumor spectrum.
Debelenko LV, Raimondi SC, Daw N, Shivakumar BR, Huang D, Nelson M, Bridge JA
Mod Pathol 2011 Mar;24(3):430-42. Epub 2010 Nov 12 doi: 10.1038/modpathol.2010.213. PMID: 21076462
Young age is an independent prognostic factor for survival of sporadic renal cell carcinoma.
Sánchez-Ortiz RF, Rosser CJ, Madsen LT, Swanson DA, Wood CG
J Urol 2004 Jun;171(6 Pt 1):2160-5. doi: 10.1097/01.ju.0000125487.96469.2e. PMID: 15126777
Sarcomatoid differentiation in renal cell carcinoma: a study of 101 cases.
de Peralta-Venturina M, Moch H, Amin M, Tamboli P, Hailemariam S, Mihatsch M, Javidan J, Stricker H, Ro JY, Amin MB
Am J Surg Pathol 2001 Mar;25(3):275-84. doi: 10.1097/00000478-200103000-00001. PMID: 11224597

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