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Well Differentiated Prostate Adenocarcinoma

MedGen UID:
235001
•Concept ID:
C1337020
•
Neoplastic Process

Definition

An invasive prostate adenocarcinoma characterized by the presence of well differentiated malignant glandular epithelial components. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWell Differentiated Prostate Adenocarcinoma

Professional guidelines

PubMed

Diagnosis and management of neuroendocrine prostate cancer.
de Kouchkovsky I, Chan E, Schloss C, Poehlein C, Aggarwal R
Prostate 2024 Apr;84(5):426-440. Epub 2024 Jan 3 doi: 10.1002/pros.24664. PMID: 38173302
Beyond Prostate Adenocarcinoma: Expanding the Differential Diagnosis in Prostate Pathologic Conditions.
Li Y, Mongan J, Behr SC, Sud S, Coakley FV, Simko J, Westphalen AC
Radiographics 2016 Jul-Aug;36(4):1055-75. Epub 2016 Jun 17 doi: 10.1148/rg.2016150226. PMID: 27315446
Primary adenocarcinoma of the urinary bladder: differential diagnosis and clinical relevance.
Zhong M, Gersbach E, Rohan SM, Yang XJ
Arch Pathol Lab Med 2013 Mar;137(3):371-81. doi: 10.5858/arpa.2012-0076-RA. PMID: 23451748

Recent clinical studies

Etiology

Diagnosis and management of neuroendocrine prostate cancer.
de Kouchkovsky I, Chan E, Schloss C, Poehlein C, Aggarwal R
Prostate 2024 Apr;84(5):426-440. Epub 2024 Jan 3 doi: 10.1002/pros.24664. PMID: 38173302
Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation.
Chen CC, Tran W, Song K, Sugimoto T, Obusan MB, Wang L, Sheu KM, Cheng D, Ta L, Varuzhanyan G, Huang A, Xu R, Zeng Y, Borujerdpur A, Bayley NA, Noguchi M, Mao Z, Morrissey C, Corey E, Nelson PS, Zhao Y, Huang J, Park JW, Witte ON, Graeber TG
Cancer Cell 2023 Dec 11;41(12):2066-2082.e9. Epub 2023 Nov 22 doi: 10.1016/j.ccell.2023.10.009. PMID: 37995683Free PMC Article
Tumour-like lesions of the urinary bladder.
Samaratunga H, Delahunt B, Yaxley J, Egevad L
Pathology 2021 Jan;53(1):44-55. Epub 2020 Oct 15 doi: 10.1016/j.pathol.2020.08.005. PMID: 33070959
Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study.
Aggarwal R, Huang J, Alumkal JJ, Zhang L, Feng FY, Thomas GV, Weinstein AS, Friedl V, Zhang C, Witte ON, Lloyd P, Gleave M, Evans CP, Youngren J, Beer TM, Rettig M, Wong CK, True L, Foye A, Playdle D, Ryan CJ, Lara P, Chi KN, Uzunangelov V, Sokolov A, Newton Y, Beltran H, Demichelis F, Rubin MA, Stuart JM, Small EJ
J Clin Oncol 2018 Aug 20;36(24):2492-2503. Epub 2018 Jul 9 doi: 10.1200/JCO.2017.77.6880. PMID: 29985747Free PMC Article
The Colorful Palette of Neuroendocrine Neoplasms in the Genitourinary Tract.
Pósfai B, Kuthi L, Varga L, Laczó I, Révész J, Kránicz R, Maráz A
Anticancer Res 2018 Jun;38(6):3243-3254. doi: 10.21873/anticanres.12589. PMID: 29848671

Diagnosis

Diagnosis and management of neuroendocrine prostate cancer.
de Kouchkovsky I, Chan E, Schloss C, Poehlein C, Aggarwal R
Prostate 2024 Apr;84(5):426-440. Epub 2024 Jan 3 doi: 10.1002/pros.24664. PMID: 38173302
Tumour-like lesions of the urinary bladder.
Samaratunga H, Delahunt B, Yaxley J, Egevad L
Pathology 2021 Jan;53(1):44-55. Epub 2020 Oct 15 doi: 10.1016/j.pathol.2020.08.005. PMID: 33070959
Intraductal carcinoma of the prostate.
Szentirmai E, Giannico GA
Pathologica 2020 Mar;112(1):17-24. doi: 10.32074/1591-951X-5-20. PMID: 32202536Free PMC Article
Large-Gland Proliferations of the Prostate.
Iczkowski KA
Surg Pathol Clin 2018 Dec;11(4):687-712. Epub 2018 Oct 17 doi: 10.1016/j.path.2018.07.001. PMID: 30447836
Beyond Prostate Adenocarcinoma: Expanding the Differential Diagnosis in Prostate Pathologic Conditions.
Li Y, Mongan J, Behr SC, Sud S, Coakley FV, Simko J, Westphalen AC
Radiographics 2016 Jul-Aug;36(4):1055-75. Epub 2016 Jun 17 doi: 10.1148/rg.2016150226. PMID: 27315446

Therapy

Diagnosis and management of neuroendocrine prostate cancer.
de Kouchkovsky I, Chan E, Schloss C, Poehlein C, Aggarwal R
Prostate 2024 Apr;84(5):426-440. Epub 2024 Jan 3 doi: 10.1002/pros.24664. PMID: 38173302
A New Framework for Precise Identification of Prostatic Adenocarcinoma.
Ayyad SM, Badawy MA, Shehata M, Alksas A, Mahmoud A, Abou El-Ghar M, Ghazal M, El-Melegy M, Abdel-Hamid NB, Labib LM, Ali HA, El-Baz A
Sensors (Basel) 2022 Feb 26;22(5) doi: 10.3390/s22051848. PMID: 35270995Free PMC Article
Serotonin Pathway in Cancer.
Balakrishna P, George S, Hatoum H, Mukherjee S
Int J Mol Sci 2021 Jan 28;22(3) doi: 10.3390/ijms22031268. PMID: 33525332Free PMC Article
Differential response to neoadjuvant hormonal therapy in prostate cancer: Predictive morphological parameters and molecular markers.
Wang X, Qi M, Zhang J, Sun X, Guo H, Pang Y, Zhang Q, Chen X, Zhang R, Liu Z, Liu L, Hao X, Han B
Prostate 2019 May;79(7):709-719. Epub 2019 Mar 2 doi: 10.1002/pros.23777. PMID: 30825345
Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study.
Aggarwal R, Huang J, Alumkal JJ, Zhang L, Feng FY, Thomas GV, Weinstein AS, Friedl V, Zhang C, Witte ON, Lloyd P, Gleave M, Evans CP, Youngren J, Beer TM, Rettig M, Wong CK, True L, Foye A, Playdle D, Ryan CJ, Lara P, Chi KN, Uzunangelov V, Sokolov A, Newton Y, Beltran H, Demichelis F, Rubin MA, Stuart JM, Small EJ
J Clin Oncol 2018 Aug 20;36(24):2492-2503. Epub 2018 Jul 9 doi: 10.1200/JCO.2017.77.6880. PMID: 29985747Free PMC Article

Prognosis

Diagnosis and management of neuroendocrine prostate cancer.
de Kouchkovsky I, Chan E, Schloss C, Poehlein C, Aggarwal R
Prostate 2024 Apr;84(5):426-440. Epub 2024 Jan 3 doi: 10.1002/pros.24664. PMID: 38173302
Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation.
Chen CC, Tran W, Song K, Sugimoto T, Obusan MB, Wang L, Sheu KM, Cheng D, Ta L, Varuzhanyan G, Huang A, Xu R, Zeng Y, Borujerdpur A, Bayley NA, Noguchi M, Mao Z, Morrissey C, Corey E, Nelson PS, Zhao Y, Huang J, Park JW, Witte ON, Graeber TG
Cancer Cell 2023 Dec 11;41(12):2066-2082.e9. Epub 2023 Nov 22 doi: 10.1016/j.ccell.2023.10.009. PMID: 37995683Free PMC Article
Tumour-like lesions of the urinary bladder.
Samaratunga H, Delahunt B, Yaxley J, Egevad L
Pathology 2021 Jan;53(1):44-55. Epub 2020 Oct 15 doi: 10.1016/j.pathol.2020.08.005. PMID: 33070959
Intraductal carcinoma of the prostate.
Szentirmai E, Giannico GA
Pathologica 2020 Mar;112(1):17-24. doi: 10.32074/1591-951X-5-20. PMID: 32202536Free PMC Article
Large-Gland Proliferations of the Prostate.
Iczkowski KA
Surg Pathol Clin 2018 Dec;11(4):687-712. Epub 2018 Oct 17 doi: 10.1016/j.path.2018.07.001. PMID: 30447836

Clinical prediction guides

Strong PD-L1 expression in granulomatous prostatitis.
Dikov D, Koleva M, Mollova A, Fakirova A
Prostate 2023 Sep;83(13):1285-1289. Epub 2023 Jun 25 doi: 10.1002/pros.24590. PMID: 37357498
Accurate prostate cancer detection based on enrichment and characterization of prostate cancer specific circulating tumor cells.
Limaye S, Chowdhury S, Rohatgi N, Ranade A, Syed N, Riedemann J, Patil D, Akolkar D, Datta V, Patel S, Chougule R, Shejwalkar P, Bendale K, Apurwa S, Schuster S, John J, Srinivasan A, Datar R
Cancer Med 2023 Apr;12(8):9116-9127. Epub 2023 Jan 30 doi: 10.1002/cam4.5649. PMID: 36718027Free PMC Article
A clinical-grade liquid biomarker detects neuroendocrine differentiation in prostate cancer.
Zhao SG, Sperger JM, Schehr JL, McKay RR, Emamekhoo H, Singh A, Schultz ZD, Bade RM, Stahlfeld CN, Gilsdorf CS, Hernandez CI, Wolfe SK, Mayberry RD, Krause HM, Bootsma M, Helzer KT, Rydzewski N, Bakhtiar H, Shi Y, Blitzer G, Kyriakopoulos CE, Kosoff D, Wei XX, Floberg J, Sethakorn N, Sharifi M, Harari PM, Huang W, Beltran H, Choueiri TK, Scher HI, Rathkopf DE, Halabi S, Armstrong AJ, Beebe DJ, Yu M, Sundling KE, Taplin ME, Lang JM
J Clin Invest 2022 Nov 1;132(21) doi: 10.1172/JCI161858. PMID: 36317634Free PMC Article
Intraductal carcinoma of the prostate.
Szentirmai E, Giannico GA
Pathologica 2020 Mar;112(1):17-24. doi: 10.32074/1591-951X-5-20. PMID: 32202536Free PMC Article
Intraductal carcinoma of the prostate: a comprehensive and updated review.
Tsuzuki T
Int J Urol 2015 Feb;22(2):140-5. Epub 2014 Oct 31 doi: 10.1111/iju.12657. PMID: 25358604

Recent systematic reviews

Focal Neuroendocrine Differentiation of Conventional Prostate Adenocarcinoma as a Prognostic Factor after Radical Prostatectomy: A Systematic Review and Meta-Analysis.
Kardoust Parizi M, Iwata T, Kimura S, Janisch F, Abufaraj M, Karakiewicz PI, Enikeev D, Rapoport LM, Hutterer G, Shariat SF
Int J Mol Sci 2019 Mar 19;20(6) doi: 10.3390/ijms20061374. PMID: 30893781Free PMC Article

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