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Major salivary gland adenoid cystic carcinoma

MedGen UID:
235286
•Concept ID:
C1334548
•
Neoplastic Process
Synonyms: Adenoid Cystic Carcinoma of Major Salivary Gland; adenoid cystic carcinoma of major salivary gland; Adenoid Cystic Carcinoma of the Major Salivary Gland; adenoid cystic carcinoma of the major salivary gland; major salivary gland adenoid cystic cancer; Major Salivary Gland Adenoid Cystic Carcinoma; major salivary gland adenoid cystic carcinoma
 
Monarch Initiative: MONDO:0045063

Definition

An aggressive carcinoma that arises from the major salivary glands. It is characterized by the presence of malignant epithelial and myoepithelial cells forming cribriform, tubular, and solid patterns. It usually presents as a slow growing mass. Patients develop pain because of the tendency of these carcinomas to invade perineural tissues. [from NCI]

Professional guidelines

PubMed

Current opinions on diagnosis and treatment of adenoid cystic carcinoma.
Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026
The Evaluation and Management of Carcinoma of the Minor Salivary Glands.
Walvekar R, Phalke NP
Otolaryngol Clin North Am 2021 Jun;54(3):629-639. doi: 10.1016/j.otc.2021.02.011. PMID: 34024489
Management of salivary gland carcinomas - a review.
Wang X, Luo Y, Li M, Yan H, Sun M, Fan T
Oncotarget 2017 Jan 17;8(3):3946-3956. doi: 10.18632/oncotarget.13952. PMID: 27992367Free PMC Article

Recent clinical studies

Etiology

Impact of lymph node sampling on survival in cN0 major salivary gland adenoid cystic carcinoma.
Qian ZJ, Chen MM, Divi V, Megwalu UC
Head Neck 2019 Jun;41(6):1903-1907. Epub 2019 Jan 8 doi: 10.1002/hed.25628. PMID: 30620437Free PMC Article
Risk of Nodal Metastasis in Major Salivary Gland Adenoid Cystic Carcinoma.
Megwalu UC, Sirjani D
Otolaryngol Head Neck Surg 2017 Apr;156(4):660-664. Epub 2017 Feb 7 doi: 10.1177/0194599817690138. PMID: 28168897
Cervical lymph node metastasis in adenoid cystic carcinoma of the major salivary glands.
INTERNATIONAL HEAD AND NECK SCIENTIFIC GROUP
J Laryngol Otol 2017 Feb;131(2):96-105. Epub 2016 Dec 15 doi: 10.1017/S0022215116009749. PMID: 27974071

Diagnosis

Polar Vessel: A New Ultrasound Sign for Complementary Diagnosis of Major Salivary Gland Adenoid Cystic Carcinoma.
Su HZ, Zhang F, Zhang XD, Hong LC, Huang SJ, Su YQ, Su YM
J Ultrasound Med 2023 Feb;42(3):603-611. Epub 2022 Jun 20 doi: 10.1002/jum.16043. PMID: 35722660
Risk of Nodal Metastasis in Major Salivary Gland Adenoid Cystic Carcinoma.
Megwalu UC, Sirjani D
Otolaryngol Head Neck Surg 2017 Apr;156(4):660-664. Epub 2017 Feb 7 doi: 10.1177/0194599817690138. PMID: 28168897
Fine-needle aspiration biopsy as an auxiliary diagnostic tool on intraoral minor salivary gland adenoid cystic carcinoma.
Netto Jde N, Miranda AM, da Silveira HM, dos Santos TC, Pires FR
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008 Aug;106(2):242-5. doi: 10.1016/j.tripleo.2008.04.015. PMID: 18644520

Prognosis

Polar Vessel: A New Ultrasound Sign for Complementary Diagnosis of Major Salivary Gland Adenoid Cystic Carcinoma.
Su HZ, Zhang F, Zhang XD, Hong LC, Huang SJ, Su YQ, Su YM
J Ultrasound Med 2023 Feb;42(3):603-611. Epub 2022 Jun 20 doi: 10.1002/jum.16043. PMID: 35722660
Impact of lymph node sampling on survival in cN0 major salivary gland adenoid cystic carcinoma.
Qian ZJ, Chen MM, Divi V, Megwalu UC
Head Neck 2019 Jun;41(6):1903-1907. Epub 2019 Jan 8 doi: 10.1002/hed.25628. PMID: 30620437Free PMC Article

Clinical prediction guides

Polar Vessel: A New Ultrasound Sign for Complementary Diagnosis of Major Salivary Gland Adenoid Cystic Carcinoma.
Su HZ, Zhang F, Zhang XD, Hong LC, Huang SJ, Su YQ, Su YM
J Ultrasound Med 2023 Feb;42(3):603-611. Epub 2022 Jun 20 doi: 10.1002/jum.16043. PMID: 35722660

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