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Mixed cell uveal melanoma

MedGen UID:
235330
Concept ID:
C1334782
Neoplastic Process
Synonyms: Mixed Cell Uveal Melanoma; mixed cell uveal melanoma; Uveal Mixed Cell Melanoma
 
Monarch Initiative: MONDO:0003910

Definition

A melanoma arising from the choroid, ciliary body, or the iris. It is characterized by the presence of a mixture of spindle A melanoma cells, spindle B melanoma cells, and epithelioid melanoma cells. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Krishna Y, Kalirai H, Thornton S, Damato BE, Heimann H, Coupland SE
Br J Ophthalmol 2016 Jul;100(7):1012-1016. Epub 2016 Apr 20 doi: 10.1136/bjophthalmol-2015-308301. PMID: 27098748

Recent clinical studies

Etiology

Taskaeva I, Shatruk A, Bgatova N, Yeremina A, Trunov A, Kononova N, Chernykh V
Microsc Res Tech 2024 Jan;87(1):122-132. Epub 2023 Sep 12 doi: 10.1002/jemt.24417. PMID: 37698482
Andreoli MT, Mieler WF, Leiderman YI
Br J Ophthalmol 2015 Nov;99(11):1550-3. Epub 2015 Apr 22 doi: 10.1136/bjophthalmol-2015-306810. PMID: 25904122
Griewank KG, van de Nes J, Schilling B, Moll I, Sucker A, Kakavand H, Haydu LE, Asher M, Zimmer L, Hillen U, Thompson JF, Scolyer RA, Schadendorf D, Murali R
Mod Pathol 2014 Feb;27(2):175-83. Epub 2013 Jul 26 doi: 10.1038/modpathol.2013.138. PMID: 23887304
Chappell MC, Char DH, Cole TB, Harbour JW, Mishra K, Weinberg VK, Phillips TL
Am J Ophthalmol 2012 Aug;154(2):227-232.e2. Epub 2012 Apr 27 doi: 10.1016/j.ajo.2012.02.022. PMID: 22541662Free PMC Article
Char DH, Miller T, Crawford JB
Trans Am Ophthalmol Soc 2000;98:153-9; discussion 159-61. PMID: 11190019Free PMC Article

Diagnosis

Zewar A, Nawaiseh I, Jaradat I, Khzouz J, Alrawashdeh K, Abdeen G, Mehyar M, Khurma S, Yousef YA
Turk Patoloji Derg 2016;32(3):186-92. doi: 10.5146/tjpath.2015.01357. PMID: 27562393
Hamadeh F, Medina CA, Singh AD, Reynolds JP, Biscotti CV
Diagn Cytopathol 2016 May;44(5):377-83. Epub 2016 Feb 15 doi: 10.1002/dc.23450. PMID: 26876235
Medina CA, Biscotti CV, Singh N, Singh AD
Ophthalmology 2015 Aug;122(8):1580-4. Epub 2015 May 23 doi: 10.1016/j.ophtha.2015.04.013. PMID: 26012864
Andreoli MT, Mieler WF, Leiderman YI
Br J Ophthalmol 2015 Nov;99(11):1550-3. Epub 2015 Apr 22 doi: 10.1136/bjophthalmol-2015-306810. PMID: 25904122
Holfort SK, Lindegaard J, Isager P, Prause JU, Heegaard S
Br J Ophthalmol 2009 May;93(5):641-4. Epub 2008 Dec 17 doi: 10.1136/bjo.2008.145664. PMID: 19091854

Therapy

Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
Hussain RN, Heimann H, Damato B
Melanoma Res 2020 Feb;30(1):102-106. doi: 10.1097/CMR.0000000000000635. PMID: 31425478
Aaberg MT, Aaberg TM Jr
Retin Cases Brief Rep 2017 Fall;11(4):348-351. doi: 10.1097/ICB.0000000000000368. PMID: 27490976
Chew AL, Spilsbury K, Isaacs TW
Clin Exp Ophthalmol 2015 Jul;43(5):422-8. Epub 2015 Feb 12 doi: 10.1111/ceo.12490. PMID: 25556534
Am J Ophthalmol 1998 Jun;125(6):745-66. doi: 10.1016/s0002-9394(98)00040-3. PMID: 9645714

Prognosis

Beasley AB, Preen DB, McLenachan S, Gray ES, Chen FK
Br J Ophthalmol 2023 Mar;107(3):406-411. Epub 2021 Dec 8 doi: 10.1136/bjophthalmol-2021-319700. PMID: 34880052Free PMC Article
Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
Sevim DG, Kiratli H
Melanoma Res 2016 Apr;26(2):164-72. doi: 10.1097/CMR.0000000000000226. PMID: 26630661
Andreoli MT, Mieler WF, Leiderman YI
Br J Ophthalmol 2015 Nov;99(11):1550-3. Epub 2015 Apr 22 doi: 10.1136/bjophthalmol-2015-306810. PMID: 25904122
Griewank KG, van de Nes J, Schilling B, Moll I, Sucker A, Kakavand H, Haydu LE, Asher M, Zimmer L, Hillen U, Thompson JF, Scolyer RA, Schadendorf D, Murali R
Mod Pathol 2014 Feb;27(2):175-83. Epub 2013 Jul 26 doi: 10.1038/modpathol.2013.138. PMID: 23887304

Clinical prediction guides

Zewar A, Nawaiseh I, Jaradat I, Khzouz J, Alrawashdeh K, Abdeen G, Mehyar M, Khurma S, Yousef YA
Turk Patoloji Derg 2016;32(3):186-92. doi: 10.5146/tjpath.2015.01357. PMID: 27562393
Sevim DG, Kiratli H
Melanoma Res 2016 Apr;26(2):164-72. doi: 10.1097/CMR.0000000000000226. PMID: 26630661
Andreoli MT, Mieler WF, Leiderman YI
Br J Ophthalmol 2015 Nov;99(11):1550-3. Epub 2015 Apr 22 doi: 10.1136/bjophthalmol-2015-306810. PMID: 25904122
Krohn J, Svenmarker P, Xu CT, Mørk SJ, Andersson-Engels S
Invest Ophthalmol Vis Sci 2012 Aug 9;53(9):5379-85. doi: 10.1167/iovs.12-9840. PMID: 22729436
Holfort SK, Lindegaard J, Isager P, Prause JU, Heegaard S
Br J Ophthalmol 2009 May;93(5):641-4. Epub 2008 Dec 17 doi: 10.1136/bjo.2008.145664. PMID: 19091854

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