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Mixed cell uveal melanoma

MedGen UID:
235330
•Concept ID:
C1334782
•
Neoplastic Process
Synonyms: Mixed Cell Uveal Melanoma; mixed cell uveal melanoma; Uveal Mixed Cell Melanoma
 
Monarch Initiative: MONDO:0003910

Definition

A melanoma arising from the choroid, ciliary body, or the iris. It is characterized by the presence of a mixture of spindle A melanoma cells, spindle B melanoma cells, and epithelioid melanoma cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMixed cell uveal melanoma

Professional guidelines

PubMed

Genetic findings in treatment-naïve and proton-beam-radiated iris melanomas.
Krishna Y, Kalirai H, Thornton S, Damato BE, Heimann H, Coupland SE
Br J Ophthalmol 2016 Jul;100(7):1012-1016. Epub 2016 Apr 20 doi: 10.1136/bjophthalmol-2015-308301. PMID: 27098748

Recent clinical studies

Etiology

Autophagy and vesicular trafficking in human uveal melanoma: A histopathological study.
Taskaeva I, Shatruk A, Bgatova N, Yeremina A, Trunov A, Kononova N, Chernykh V
Microsc Res Tech 2024 Jan;87(1):122-132. Epub 2023 Sep 12 doi: 10.1002/jemt.24417. PMID: 37698482
Uveal melanoma: An analysis of cellular features and comparison to monosomy 3 status.
Hamadeh F, Medina CA, Singh AD, Reynolds JP, Biscotti CV
Diagn Cytopathol 2016 May;44(5):377-83. Epub 2016 Feb 15 doi: 10.1002/dc.23450. PMID: 26876235
Genetic and clinico-pathologic analysis of metastatic uveal melanoma.
Griewank KG, van de Nes J, Schilling B, Moll I, Sucker A, Kakavand H, Haydu LE, Asher M, Zimmer L, Hillen U, Thompson JF, Scolyer RA, Schadendorf D, Murali R
Mod Pathol 2014 Feb;27(2):175-83. Epub 2013 Jul 26 doi: 10.1038/modpathol.2013.138. PMID: 23887304
Uveal melanoma: molecular pattern, clinical features, and radiation response.
Chappell MC, Char DH, Cole TB, Harbour JW, Mishra K, Weinberg VK, Phillips TL
Am J Ophthalmol 2012 Aug;154(2):227-232.e2. Epub 2012 Apr 27 doi: 10.1016/j.ajo.2012.02.022. PMID: 22541662Free PMC Article
Eye-wall resection.
Char DH, Miller T, Crawford JB
Trans Am Ophthalmol Soc 2000;98:153-9; discussion 159-61. PMID: 11190019Free PMC Article

Diagnosis

Management and Outcome of Uveal Melanoma in a Single Tertiary Cancer Center in Jordan.
Zewar A, Nawaiseh I, Jaradat I, Khzouz J, Alrawashdeh K, Abdeen G, Mehyar M, Khurma S, Yousef YA
Turk Patoloji Derg 2016;32(3):186-92. doi: 10.5146/tjpath.2015.01357. PMID: 27562393
Uveal melanoma: An analysis of cellular features and comparison to monosomy 3 status.
Hamadeh F, Medina CA, Singh AD, Reynolds JP, Biscotti CV
Diagn Cytopathol 2016 May;44(5):377-83. Epub 2016 Feb 15 doi: 10.1002/dc.23450. PMID: 26876235
Diagnostic Cytologic Features of Uveal Melanoma.
Medina CA, Biscotti CV, Singh N, Singh AD
Ophthalmology 2015 Aug;122(8):1580-4. Epub 2015 May 23 doi: 10.1016/j.ophtha.2015.04.013. PMID: 26012864
Epidemiological trends in uveal melanoma.
Andreoli MT, Mieler WF, Leiderman YI
Br J Ophthalmol 2015 Nov;99(11):1550-3. Epub 2015 Apr 22 doi: 10.1136/bjophthalmol-2015-306810. PMID: 25904122
CXC chemokine receptor 4 is expressed in uveal malignant melanoma and correlates with the epithelioid-mixed cell type.
Scala S, Ieranò C, Ottaiano A, Franco R, La Mura A, Liguori G, Mascolo M, Staibano S, Ascierto PA, Botti G, De Rosa G, Castello G
Cancer Immunol Immunother 2007 Oct;56(10):1589-95. Epub 2007 Apr 5 doi: 10.1007/s00262-007-0303-6. PMID: 17410362Free PMC Article

Therapy

No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.
Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
Neoadjuvant intravitreal ranibizumab treatment in high-risk ocular melanoma patients: a two-stage single-centre phase II single-arm study.
Hussain RN, Heimann H, Damato B
Melanoma Res 2020 Feb;30(1):102-106. doi: 10.1097/CMR.0000000000000635. PMID: 31425478
PEMBROLIZUMAB ADMINISTRATION ASSOCIATED WITH POSTERIOR UVEITIS.
Aaberg MT, Aaberg TM Jr
Retin Cases Brief Rep 2017 Fall;11(4):348-351. doi: 10.1097/ICB.0000000000000368. PMID: 27490976
Survival from uveal melanoma in Western Australia 1981-2005.
Chew AL, Spilsbury K, Isaacs TW
Clin Exp Ophthalmol 2015 Jul;43(5):422-8. Epub 2015 Feb 12 doi: 10.1111/ceo.12490. PMID: 25556534
Histopathologic characteristics of uveal melanomas in eyes enucleated from the Collaborative Ocular Melanoma Study. COMS report no. 6.
Am J Ophthalmol 1998 Jun;125(6):745-66. doi: 10.1016/s0002-9394(98)00040-3. PMID: 9645714

Prognosis

Incidence and mortality of uveal melanoma in Australia (1982-2014).
Beasley AB, Preen DB, McLenachan S, Gray ES, Chen FK
Br J Ophthalmol 2023 Mar;107(3):406-411. Epub 2021 Dec 8 doi: 10.1136/bjophthalmol-2021-319700. PMID: 34880052Free PMC Article
Uveal melanoma: An analysis of cellular features and comparison to monosomy 3 status.
Hamadeh F, Medina CA, Singh AD, Reynolds JP, Biscotti CV
Diagn Cytopathol 2016 May;44(5):377-83. Epub 2016 Feb 15 doi: 10.1002/dc.23450. PMID: 26876235
Serum adiponectin, insulin resistance, and uveal melanoma: clinicopathological correlations.
Sevim DG, Kiratli H
Melanoma Res 2016 Apr;26(2):164-72. doi: 10.1097/CMR.0000000000000226. PMID: 26630661
Genetic and clinico-pathologic analysis of metastatic uveal melanoma.
Griewank KG, van de Nes J, Schilling B, Moll I, Sucker A, Kakavand H, Haydu LE, Asher M, Zimmer L, Hillen U, Thompson JF, Scolyer RA, Schadendorf D, Murali R
Mod Pathol 2014 Feb;27(2):175-83. Epub 2013 Jul 26 doi: 10.1038/modpathol.2013.138. PMID: 23887304
CXC chemokine receptor 4 is expressed in uveal malignant melanoma and correlates with the epithelioid-mixed cell type.
Scala S, Ieranò C, Ottaiano A, Franco R, La Mura A, Liguori G, Mascolo M, Staibano S, Ascierto PA, Botti G, De Rosa G, Castello G
Cancer Immunol Immunother 2007 Oct;56(10):1589-95. Epub 2007 Apr 5 doi: 10.1007/s00262-007-0303-6. PMID: 17410362Free PMC Article

Clinical prediction guides

Management and Outcome of Uveal Melanoma in a Single Tertiary Cancer Center in Jordan.
Zewar A, Nawaiseh I, Jaradat I, Khzouz J, Alrawashdeh K, Abdeen G, Mehyar M, Khurma S, Yousef YA
Turk Patoloji Derg 2016;32(3):186-92. doi: 10.5146/tjpath.2015.01357. PMID: 27562393
Serum adiponectin, insulin resistance, and uveal melanoma: clinicopathological correlations.
Sevim DG, Kiratli H
Melanoma Res 2016 Apr;26(2):164-72. doi: 10.1097/CMR.0000000000000226. PMID: 26630661
Epidemiological trends in uveal melanoma.
Andreoli MT, Mieler WF, Leiderman YI
Br J Ophthalmol 2015 Nov;99(11):1550-3. Epub 2015 Apr 22 doi: 10.1136/bjophthalmol-2015-306810. PMID: 25904122
CNS metastasis from malignant uveal melanoma: a clinical and histopathological characterisation.
Holfort SK, Lindegaard J, Isager P, Prause JU, Heegaard S
Br J Ophthalmol 2009 May;93(5):641-4. Epub 2008 Dec 17 doi: 10.1136/bjo.2008.145664. PMID: 19091854
Expression and distribution of MMPs and TIMPs in human uveal melanoma.
Lai K, Conway RM, Crouch R, Jager MJ, Madigan MC
Exp Eye Res 2008 Jun;86(6):936-41. Epub 2008 Mar 16 doi: 10.1016/j.exer.2008.03.010. PMID: 18423620

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