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Prostate Myeloid Sarcoma

MedGen UID:: 235501
•Concept ID:: C1335514
•: Neoplastic Process

Synonyms:

Extramedullary Myeloid Neoplasm of Prostate; Extramedullary Myeloid Neoplasm of the Prostate; Extramedullary Myeloid Tumor of Prostate; Extramedullary Myeloid Tumor of the Prostate; Prostate Extramedullary Myeloid Neoplasm; Prostate Extramedullary Myeloid Tumor; Prostatic Chloroma; Prostatic Extramedullary Myeloid Neoplasm; Prostatic Extramedullary Myeloid Tumor; Prostatic Myeloid Sarcoma

Definition

Myeloid sarcoma that affects the prostate gland. It may present in association with or as a site of relapse of acute myeloid leukemia. Cases of myeloid sarcoma of the prostate gland preceding acute myeloid leukemia have also been reported. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVProstate Myeloid Sarcoma

Disorder of the genitourinary system
- Diseases, Genital
  - Disorder of male genital organ
    - Male reproductive system neoplasm
      - Malignant Male Reproductive System Neoplasm
        Malignant tumor of prostate
        Prostate Myeloid Sarcoma

Recent clinical studies

Etiology

Antitumor Profile of Carbon-Bridged Steroids (CBS) and Triterpenoids.

Dembitsky VM, Gloriozova TA, Poroikov VV
Mar Drugs 2021 Jun 3;19(6) doi: 10.3390/md19060324. PMID: 34205074 Free PMC Article

B-cell acute lymphoblastic leukemia in an elderly man with plasma cell myeloma and long-term exposure to thalidomide and lenalidomide: a case report and literature review.

Sinit RB, Hwang DG, Vishnu P, Peterson JF, Aboulafia DM
BMC Cancer 2019 Nov 27;19(1):1147. doi: 10.1186/s12885-019-6286-9. PMID: 31775673 Free PMC Article

A Five-year Survey of Cancer Prevalence in Sudan.

Saeed ME, Cao J, Fadul B, Kadioglu O, Khalid HE, Yassin Z, Mustafa SM, Saeed E, Efferth T
Anticancer Res 2016 Jan;36(1):279-86. PMID: 26722054

Molecular pathways: the role of NR4A orphan nuclear receptors in cancer.

Mohan HM, Aherne CM, Rogers AC, Baird AW, Winter DC, Murphy EP
Clin Cancer Res 2012 Jun 15;18(12):3223-8. Epub 2012 May 7 doi: 10.1158/1078-0432.CCR-11-2953. PMID: 22566377

Second cancers in patients with male breast cancer: a literature review.

Grenader T, Goldberg A, Shavit L
J Cancer Surviv 2008 Jun;2(2):73-8. Epub 2008 Apr 1 doi: 10.1007/s11764-008-0042-5. PMID: 18648975

See all (9)

Diagnosis

Very late extramedullary relapse of acute myeloid leukaemia as prostatic myeloid sarcoma occurring 24 years post-allograft.

Taylor T, Byrne J, Errico G, Clark D
Br J Haematol 2022 May;197(3):243. Epub 2022 Feb 22 doi: 10.1111/bjh.18038. PMID: 35191543

B-cell acute lymphoblastic leukemia in an elderly man with plasma cell myeloma and long-term exposure to thalidomide and lenalidomide: a case report and literature review.

Sinit RB, Hwang DG, Vishnu P, Peterson JF, Aboulafia DM
BMC Cancer 2019 Nov 27;19(1):1147. doi: 10.1186/s12885-019-6286-9. PMID: 31775673 Free PMC Article

A Five-year Survey of Cancer Prevalence in Sudan.

Saeed ME, Cao J, Fadul B, Kadioglu O, Khalid HE, Yassin Z, Mustafa SM, Saeed E, Efferth T
Anticancer Res 2016 Jan;36(1):279-86. PMID: 26722054

Second cancers in patients with male breast cancer: a literature review.

Grenader T, Goldberg A, Shavit L
J Cancer Surviv 2008 Jun;2(2):73-8. Epub 2008 Apr 1 doi: 10.1007/s11764-008-0042-5. PMID: 18648975

Is Kaposi's sarcoma--associated herpesvirus ubiquitous in urogenital and prostate tissues?

Tasaka T, Said JW, Morosetti R, Park D, Verbeek W, Nagai M, Takahara J, Koeffler HP
Blood 1997 Mar 1;89(5):1686-9. PMID: 9057651

See all (10)

Therapy

B-cell acute lymphoblastic leukemia in an elderly man with plasma cell myeloma and long-term exposure to thalidomide and lenalidomide: a case report and literature review.

Sinit RB, Hwang DG, Vishnu P, Peterson JF, Aboulafia DM
BMC Cancer 2019 Nov 27;19(1):1147. doi: 10.1186/s12885-019-6286-9. PMID: 31775673 Free PMC Article

Myeloid sarcoma of the prostate as first clinical manifestation of acute myeloid leukaemia.

Spethmann S, Heuer R, Hopfer H, Tuinmann G
Lancet Oncol 2004 Jan;5(1):62-3. doi: 10.1016/s1470-2045(03)01326-3. PMID: 14700611

Thalidomide: a review of approved and investigational uses.

Matthews SJ, McCoy C
Clin Ther 2003 Feb;25(2):342-95. doi: 10.1016/s0149-2918(03)80085-1. PMID: 12749503

Second malignancies as a consequence of nucleoside analog therapy for chronic lymphoid leukemias.

Cheson BD, Vena DA, Barrett J, Freidlin B
J Clin Oncol 1999 Aug;17(8):2454-60. doi: 10.1200/JCO.1999.17.8.2454. PMID: 10561309

Mortality among plutonium and other radiation workers at a plutonium weapons facility.

Wilkinson GS, Tietjen GL, Wiggs LD, Galke WA, Acquavella JF, Reyes M, Voelz GL, Waxweiler RJ
Am J Epidemiol 1987 Feb;125(2):231-50. doi: 10.1093/oxfordjournals.aje.a114523. PMID: 3812431

See all (8)

Prognosis

Galectin-3 inhibition with belapectin combined with anti-OX40 therapy reprograms the tumor microenvironment to favor anti-tumor immunity.

Sturgill ER, Rolig AS, Linch SN, Mick C, Kasiewicz MJ, Sun Z, Traber PG, Shlevin H, Redmond WL
Oncoimmunology 2021 Mar 1;10(1):1892265. doi: 10.1080/2162402X.2021.1892265. PMID: 33717655 Free PMC Article

Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.

Zhang C, Ren X, Zhang W, He L, Qi L, Chen R, Tu C, Li Z
Bioengineered 2020 Dec;11(1):1112-1123. doi: 10.1080/21655979.2020.1831361. PMID: 33124951 Free PMC Article

B-cell acute lymphoblastic leukemia in an elderly man with plasma cell myeloma and long-term exposure to thalidomide and lenalidomide: a case report and literature review.

Sinit RB, Hwang DG, Vishnu P, Peterson JF, Aboulafia DM
BMC Cancer 2019 Nov 27;19(1):1147. doi: 10.1186/s12885-019-6286-9. PMID: 31775673 Free PMC Article

ERG expression in multiple myeloma-A potential diagnostic pitfall.

Knief J, Reddemann K, Gliemroth J, Brede S, Bartscht T, Thorns C
Pathol Res Pract 2017 Feb;213(2):130-132. Epub 2016 Nov 3 doi: 10.1016/j.prp.2016.10.014. PMID: 27913051

ERG is a megakaryocytic oncogene.

Salek-Ardakani S, Smooha G, de Boer J, Sebire NJ, Morrow M, Rainis L, Lee S, Williams O, Izraeli S, Brady HJ
Cancer Res 2009 Jun 1;69(11):4665-73. doi: 10.1158/0008-5472.CAN-09-0075. PMID: 19487285

See all (11)

Clinical prediction guides

Advancing Pan-cancer Gene Expression Survial Analysis by Inclusion of Non-coding RNA.

Ye B, Shi J, Kang H, Oyebamiji O, Hill D, Yu H, Ness S, Ye F, Ping J, He J, Edwards J, Zhao YY, Guo Y
RNA Biol 2020 Nov;17(11):1666-1673. Epub 2019 Oct 18 doi: 10.1080/15476286.2019.1679585. PMID: 31607216 Free PMC Article

ERG transcription factor as an immunohistochemical marker for vascular endothelial tumors and prostatic carcinoma.

Miettinen M, Wang ZF, Paetau A, Tan SH, Dobi A, Srivastava S, Sesterhenn I
Am J Surg Pathol 2011 Mar;35(3):432-41. doi: 10.1097/PAS.0b013e318206b67b. PMID: 21317715 Free PMC Article

ERG is a megakaryocytic oncogene.

Salek-Ardakani S, Smooha G, de Boer J, Sebire NJ, Morrow M, Rainis L, Lee S, Williams O, Izraeli S, Brady HJ
Cancer Res 2009 Jun 1;69(11):4665-73. doi: 10.1158/0008-5472.CAN-09-0075. PMID: 19487285

Mortality among plutonium and other radiation workers at a plutonium weapons facility.

Wilkinson GS, Tietjen GL, Wiggs LD, Galke WA, Acquavella JF, Reyes M, Voelz GL, Waxweiler RJ
Am J Epidemiol 1987 Feb;125(2):231-50. doi: 10.1093/oxfordjournals.aje.a114523. PMID: 3812431

Spirogermanium: a new investigational drug of novel structure and lack of bone marrow toxicity.

Slavik M, Blanc O, Davis J
Invest New Drugs 1983;1(3):225-34. doi: 10.1007/BF00208894. PMID: 6678870

See all (8)