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Malignant Male Reproductive System Neoplasm

MedGen UID:
102279
•Concept ID:
C0153606
•
Neoplastic Process
Synonyms: Malignant Male Reproductive System Tumor; Malignant Neoplasm of Male Reproductive System; Malignant Neoplasm of the Male Reproductive System; Malignant tumor of male genital organ; Malignant Tumor of Male Reproductive System; Malignant Tumor of the Male Reproductive System
SNOMED CT: Malignant tumor of male genital organ (363515000)

Definition

A primary or metastatic malignant neoplasm involving the male reproductive system. Representative examples include prostate carcinoma, penile carcinoma, testicular seminoma, and testicular embryonal carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Male Reproductive System Neoplasm

Professional guidelines

PubMed

EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer-2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent.
Mottet N, van den Bergh RCN, Briers E, Van den Broeck T, Cumberbatch MG, De Santis M, Fanti S, Fossati N, Gandaglia G, Gillessen S, Grivas N, Grummet J, Henry AM, van der Kwast TH, Lam TB, Lardas M, Liew M, Mason MD, Moris L, Oprea-Lager DE, van der Poel HG, Rouvière O, Schoots IG, Tilki D, Wiegel T, Willemse PM, Cornford P
Eur Urol 2021 Feb;79(2):243-262. Epub 2020 Nov 7 doi: 10.1016/j.eururo.2020.09.042. PMID: 33172724
Prostate cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Parker C, Castro E, Fizazi K, Heidenreich A, Ost P, Procopio G, Tombal B, Gillessen S; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2020 Sep;31(9):1119-1134. Epub 2020 Jun 25 doi: 10.1016/j.annonc.2020.06.011. PMID: 32593798
Testicular Cancer: Diagnosis and Treatment.
Baird DC, Meyers GJ, Hu JS
Am Fam Physician 2018 Feb 15;97(4):261-268. PMID: 29671528

Recent clinical studies

Etiology

WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
An overview of biomarkers in the diagnosis and management of prostate cancer.
Uhr A, Glick L, Gomella LG
Can J Urol 2020 Aug;27(S3):24-27. PMID: 32875999
Recent advances in pediatric bladder malignancies.
Lopes RI, Mello MF, Lorenzo AJ
F1000Res 2020;9 Epub 2020 Feb 25 doi: 10.12688/f1000research.19396.1. PMID: 32148770Free PMC Article
The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part B: Prostate and Bladder Tumours.
Humphrey PA, Moch H, Cubilla AL, Ulbright TM, Reuter VE
Eur Urol 2016 Jul;70(1):106-119. Epub 2016 Mar 17 doi: 10.1016/j.eururo.2016.02.028. PMID: 26996659
Food safety.
Borchers A, Teuber SS, Keen CL, Gershwin ME
Clin Rev Allergy Immunol 2010 Oct;39(2):95-141. doi: 10.1007/s12016-009-8176-4. PMID: 19911313

Diagnosis

Extracellular vesicles in urological malignancies.
Rimmer MP, Gregory CD, Mitchell RT
Biochim Biophys Acta Rev Cancer 2021 Aug;1876(1):188570. Epub 2021 May 19 doi: 10.1016/j.bbcan.2021.188570. PMID: 34019971Free PMC Article
Diagnosis and management of spermatic cord tumors.
Moschini M, Mattei A
Curr Opin Urol 2017 Jan;27(1):76-79. doi: 10.1097/MOU.0000000000000318. PMID: 27262142
Primary adenocarcinoma of the seminal vesicles. A review of the literature.
Katafigiotis I, Sfoungaristos S, Duvdevani M, Mitsos P, Roumelioti E, Stravodimos K, Anastasiou I, Constantinides CA
Arch Ital Urol Androl 2016 Mar 31;88(1):47-51. doi: 10.4081/aiua.2016.1.47. PMID: 27072175
Male reproductive cancers and infertility: a mutual relationship.
Tvrda E, Agarwal A, Alkuhaimi N
Int J Mol Sci 2015 Mar 31;16(4):7230-60. doi: 10.3390/ijms16047230. PMID: 25837470Free PMC Article
Inguinal canal tumors of adulthood.
Vagnoni V, Brunocilla E, Schiavina R, Borghesi M, Passaretti G, Gentile G, Fiorentino M, Martorana G
Anticancer Res 2013 Jun;33(6):2361-8. PMID: 23749883

Therapy

Metastatic Prostate Cancer: Treatment Options.
Achard V, Putora PM, Omlin A, Zilli T, Fischer S
Oncology 2022;100(1):48-59. Epub 2021 Nov 15 doi: 10.1159/000519861. PMID: 34781285
Treating Prostate Cancer by Antibody-Drug Conjugates.
Rosellini M, Santoni M, Mollica V, Rizzo A, Cimadamore A, Scarpelli M, Storti N, Battelli N, Montironi R, Massari F
Int J Mol Sci 2021 Feb 4;22(4) doi: 10.3390/ijms22041551. PMID: 33557050Free PMC Article
Prostate Radiotherapy With Adjuvant Androgen Deprivation Therapy (ADT) Improves Metastasis-Free Survival Compared to Neoadjuvant ADT: An Individual Patient Meta-Analysis.
Spratt DE, Malone S, Roy S, Grimes S, Eapen L, Morgan SC, Malone J, Craig J, Dess RT, Jackson WC, Hartman HE, Kishan AU, Mehra R, Kaffenberger S, Morgan TM, Reichert ZR, Alumkal JJ, Michalski J, Lee WR, Pisansky TM, Feng FY, Shipley W, Sandler HM, Schipper MJ, Roach M 3rd, Sun Y, Lawton CAF
J Clin Oncol 2021 Jan 10;39(2):136-144. Epub 2020 Dec 4 doi: 10.1200/JCO.20.02438. PMID: 33275486Free PMC Article
High-intensity focused ultrasound for prostate cancer.
Napoli A, Alfieri G, Scipione R, Leonardi A, Fierro D, Panebianco V, De Nunzio C, Leonardo C, Catalano C
Expert Rev Med Devices 2020 May;17(5):427-433. doi: 10.1080/17434440.2020.1755258. PMID: 32275187
Inmunotherapy in prostate cancer.
Anselmo da Costa I, Stenzl A, Bedke J
Arch Esp Urol 2019 Mar;72(2):211-222. PMID: 30855023

Prognosis

Extracellular vesicles in urological malignancies.
Rimmer MP, Gregory CD, Mitchell RT
Biochim Biophys Acta Rev Cancer 2021 Aug;1876(1):188570. Epub 2021 May 19 doi: 10.1016/j.bbcan.2021.188570. PMID: 34019971Free PMC Article
Surgical Management of Primary Scrotal Cancer.
Huang JH, Broggi M, Osunkoya AO, Master VA
Urol Clin North Am 2016 Nov;43(4):531-544. Epub 2016 Sep 3 doi: 10.1016/j.ucl.2016.06.014. PMID: 27717439
Mammary and extramammary Paget's disease.
Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993Free PMC Article
Scrotal carcinoma.
Casasola Chamorro J, Gutiérrez García S, de Blas Gómez V
Arch Esp Urol 2011 Jul;64(6):541-3. PMID: 21791720
Secondary neoplasms of the urinary system and male genital organs.
Morichetti D, Mazzucchelli R, Lopez-Beltran A, Cheng L, Scarpelli M, Kirkali Z, Montorsi F, Montironi R
BJU Int 2009 Sep;104(6):770-6. Epub 2009 Jul 14 doi: 10.1111/j.1464-410X.2009.08746.x. PMID: 19624595

Clinical prediction guides

What to expect from a non-suspicious prostate MRI? A review.
Fiard G, Norris JM, Nguyen TA, Stavrinides V, Olivier J, Emberton M, Moore CM
Prog Urol 2020 Dec;30(16):986-999. Epub 2020 Sep 29 doi: 10.1016/j.purol.2020.09.012. PMID: 33008718
Contemporary Gleason grading and novel Grade Groups in clinical practice.
Magi-Galluzzi C, Montironi R, Epstein JI
Curr Opin Urol 2016 Sep;26(5):488-92. doi: 10.1097/MOU.0000000000000320. PMID: 27308734
Grading of prostatic adenocarcinoma: current state and prognostic implications.
Gordetsky J, Epstein J
Diagn Pathol 2016 Mar 9;11:25. doi: 10.1186/s13000-016-0478-2. PMID: 26956509Free PMC Article
New Genetic Markers for Prostate Cancer.
Leapman MS, Carroll PR
Urol Clin North Am 2016 Feb;43(1):7-15. Epub 2015 Oct 31 doi: 10.1016/j.ucl.2015.08.002. PMID: 26614025
The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: Definition of Grading Patterns and Proposal for a New Grading System.
Epstein JI, Egevad L, Amin MB, Delahunt B, Srigley JR, Humphrey PA; Grading Committee
Am J Surg Pathol 2016 Feb;40(2):244-52. doi: 10.1097/PAS.0000000000000530. PMID: 26492179

Recent systematic reviews

2022 Update on Prostate Cancer Epidemiology and Risk Factors-A Systematic Review.
Bergengren O, Pekala KR, Matsoukas K, Fainberg J, Mungovan SF, Bratt O, Bray F, Brawley O, Luckenbaugh AN, Mucci L, Morgan TM, Carlsson SV
Eur Urol 2023 Aug;84(2):191-206. Epub 2023 May 16 doi: 10.1016/j.eururo.2023.04.021. PMID: 37202314
Radiotherapy of oligometastatic prostate cancer: a systematic review.
Rogowski P, Roach M 3rd, Schmidt-Hegemann NS, Trapp C, von Bestenbostel R, Shi R, Buchner A, Stief C, Belka C, Li M
Radiat Oncol 2021 Mar 9;16(1):50. doi: 10.1186/s13014-021-01776-8. PMID: 33750437Free PMC Article
EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer-2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent.
Mottet N, van den Bergh RCN, Briers E, Van den Broeck T, Cumberbatch MG, De Santis M, Fanti S, Fossati N, Gandaglia G, Gillessen S, Grivas N, Grummet J, Henry AM, van der Kwast TH, Lam TB, Lardas M, Liew M, Mason MD, Moris L, Oprea-Lager DE, van der Poel HG, Rouvière O, Schoots IG, Tilki D, Wiegel T, Willemse PM, Cornford P
Eur Urol 2021 Feb;79(2):243-262. Epub 2020 Nov 7 doi: 10.1016/j.eururo.2020.09.042. PMID: 33172724
Surgery Versus Radiotherapy for Clinically-localized Prostate Cancer: A Systematic Review and Meta-analysis.
Wallis CJD, Saskin R, Choo R, Herschorn S, Kodama RT, Satkunasivam R, Shah PS, Danjoux C, Nam RK
Eur Urol 2016 Jul;70(1):21-30. Epub 2015 Dec 15 doi: 10.1016/j.eururo.2015.11.010. PMID: 26700655
Exercise for Men with Prostate Cancer: A Systematic Review and Meta-analysis.
Bourke L, Smith D, Steed L, Hooper R, Carter A, Catto J, Albertsen PC, Tombal B, Payne HA, Rosario DJ
Eur Urol 2016 Apr;69(4):693-703. Epub 2015 Nov 26 doi: 10.1016/j.eururo.2015.10.047. PMID: 26632144

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