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Testicular granulosa cell tumor

MedGen UID:
237001
•Concept ID:
C1336709
•
Neoplastic Process
Synonyms: Granulosa Cell Neoplasm of Testis; granulosa cell neoplasm of testis; Granulosa Cell Neoplasm of the Testis; granulosa cell neoplasm of the testis; Granulosa Cell Tumor of Testis; granulosa cell tumor of testis; Granulosa Cell Tumor of the Testis; granulosa cell tumor of the testis; granulosa cell tumour of testis; granulosa cell tumour of the testis; Testicular Granulosa Cell Neoplasm; testicular granulosa cell neoplasm; Testicular Granulosa Cell Tumor; testicular granulosa cell tumor; testis granulosa cell tumor; testis granulosa cell tumour
 
Monarch Initiative: MONDO:0003395

Definition

A rare sex cord-stromal tumor that arises from the testis. It is characterized by the presence of granulosa-like cells and Call-Exner bodies. There are two variants described, the adult and the juvenile. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular granulosa cell tumor

Professional guidelines

PubMed

Risk factors and treatment outcomes of 239 patients with testicular granulosa cell tumors: a systematic review of published case series data.
Grogg JB, Schneider K, Bode PK, Kranzbühler B, Eberli D, Sulser T, Beyer J, Lorch A, Hermanns T, Fankhauser CD
J Cancer Res Clin Oncol 2020 Nov;146(11):2829-2841. Epub 2020 Jul 27 doi: 10.1007/s00432-020-03326-3. PMID: 32719989Free PMC Article
DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry.
Schultz KAP, Harris AK, Finch M, Dehner LP, Brown JB, Gershenson DM, Young RH, Field A, Yu W, Turner J, Cost NG, Schneider DT, Stewart DR, Frazier AL, Messinger Y, Hill DA
Gynecol Oncol 2017 Dec;147(3):521-527. Epub 2017 Oct 14 doi: 10.1016/j.ygyno.2017.09.034. PMID: 29037807Free PMC Article
Müllerian inhibiting substance in the diagnosis and management of intersex and gonadal abnormalities.
Gustafson ML, Lee MM, Asmundson L, MacLaughlin DT, Donahoe PK
J Pediatr Surg 1993 Mar;28(3):439-44. doi: 10.1016/0022-3468(93)90245-g. PMID: 8468660

Recent clinical studies

Etiology

Granulosa cell tumor of testis: clinicopathological correlation of a rare tumor.
Rane SU, Menon S, Desai S, Bakshi G, Joshi A
Indian J Pathol Microbiol 2014 Oct-Dec;57(4):564-73. doi: 10.4103/0377-4929.142665. PMID: 25308008

Diagnosis

Adult-Type Granulosa Cell Tumor of the Testis in a 16-Year-Old: A Case Report and Review of the Literature.
Mendelson J, Babajanian M, Brenseke W, Bhandari S, Gitlin J
Urology 2024 Aug;190:e21-e23. Epub 2024 Jun 17 doi: 10.1016/j.urology.2024.06.025. PMID: 38897318
Malignant granulosa cell tumor of testis with metastasis to liver: Case report and review of literature.
Bordiya S, Priyanka K, Garg D
Indian J Pathol Microbiol 2020 Jul-Sep;63(3):470-471. doi: 10.4103/IJPM.IJPM_436_18. PMID: 32769343
Adult granulosa cell tumor of the testis masquerading as hydrocele.
Vallonthaiel AG, Kakkar A, Singh A, Dogra PN, Ray R
Int Braz J Urol 2015 Nov-Dec;41(6):1226-31. doi: 10.1590/S1677-5538.IBJU.2014.0187. PMID: 26742984Free PMC Article
Granulosa cell tumor of testis: clinicopathological correlation of a rare tumor.
Rane SU, Menon S, Desai S, Bakshi G, Joshi A
Indian J Pathol Microbiol 2014 Oct-Dec;57(4):564-73. doi: 10.4103/0377-4929.142665. PMID: 25308008
Testicular granulosa cell tumor, adult type.
Gupta A, Mathur SK, Reddy CP, Arora B
Indian J Pathol Microbiol 2008 Jul-Sep;51(3):405-6. doi: 10.4103/0377-4929.42536. PMID: 18723972

Therapy

Response to antiangiogenesis therapy in a patient with advanced adult-type testicular granulosa cell tumor.
Harrison MR, Huang W, Liu G, Gee J
Oncology (Williston Park) 2009 Aug;23(9):792-5. PMID: 19777766Free PMC Article

Prognosis

Adult granulosa cell tumor of the testis masquerading as hydrocele.
Vallonthaiel AG, Kakkar A, Singh A, Dogra PN, Ray R
Int Braz J Urol 2015 Nov-Dec;41(6):1226-31. doi: 10.1590/S1677-5538.IBJU.2014.0187. PMID: 26742984Free PMC Article
Granulosa cell tumor of testis: clinicopathological correlation of a rare tumor.
Rane SU, Menon S, Desai S, Bakshi G, Joshi A
Indian J Pathol Microbiol 2014 Oct-Dec;57(4):564-73. doi: 10.4103/0377-4929.142665. PMID: 25308008
Adult testicular granulosa cell tumor: a review of the literature for clinicopathologic predictors of malignancy.
Hanson JA, Ambaye AB
Arch Pathol Lab Med 2011 Jan;135(1):143-6. doi: 10.5858/2009-0512-RSR.1. PMID: 21204721
Testicular granulosa cell tumor, adult type.
Gupta A, Mathur SK, Reddy CP, Arora B
Indian J Pathol Microbiol 2008 Jul-Sep;51(3):405-6. doi: 10.4103/0377-4929.42536. PMID: 18723972
Testicular granulosa cell tumor of adult type: a new case and a review of the literature.
Ditonno P, Lucarelli G, Battaglia M, Mancini V, Palazzo S, Trabucco S, Bettocchi C, Paolo Selvaggi F
Urol Oncol 2007 Jul-Aug;25(4):322-5. doi: 10.1016/j.urolonc.2006.08.019. PMID: 17628299

Clinical prediction guides

Adult testicular granulosa cell tumor: a review of the literature for clinicopathologic predictors of malignancy.
Hanson JA, Ambaye AB
Arch Pathol Lab Med 2011 Jan;135(1):143-6. doi: 10.5858/2009-0512-RSR.1. PMID: 21204721
Testicular granulosa cell tumor of the adult type.
Nistal M, Lázaro R, García J, Paniagua R
Arch Pathol Lab Med 1992 Mar;116(3):284-7. PMID: 1536615

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