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Adnexal Diseases

MedGen UID:
1763
•Concept ID:
C0001576
•
Disease or Syndrome
Synonyms: Adnexal Disease; Disease, Adnexal; Diseases, Adnexal

Definition

Diseases of the uterine appendages (ADNEXA UTERI) including diseases involving the OVARY, the FALLOPIAN TUBES, and ligaments of the uterus (BROAD LIGAMENT; ROUND LIGAMENT). [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdnexal Diseases

Professional guidelines

PubMed

Molecular changes driving low-grade serous ovarian cancer and implications for treatment.
Kelliher L, Yoeli-Bik R, Schweizer L, Lengyel E
Int J Gynecol Cancer 2024 Oct 7;34(10):1630-1638. doi: 10.1136/ijgc-2024-005305. PMID: 38950921Free PMC Article
Criteria for selection of laparoscopy for women with adnexal mass.
Barreta A, Sallum LF, Sarian LO, Bastos JF, Derchain S
JSLS 2014 Jul-Sep;18(3) doi: 10.4293/JSLS.2014.00215. PMID: 25392617Free PMC Article
Guidelines for drug treatment of male infertility.
Haidl G, Schill WB
Drugs 1991 Jan;41(1):60-8. doi: 10.2165/00003495-199141010-00006. PMID: 1706988

Recent clinical studies

Etiology

Scarless preventive surgery.
Rathat G, Blay L, Bakenga J, Roggen N, Peralta G, Baekelandt J
Int J Gynaecol Obstet 2023 Nov;163(2):701-702. Epub 2023 Aug 7 doi: 10.1002/ijgo.15039. PMID: 37548070
Adnexal Masses in Pregnancy.
Montes de Oca MK, Dotters-Katz SK, Kuller JA, Previs RA
Obstet Gynecol Surv 2021 Jul;76(7):437-450. doi: 10.1097/OGX.0000000000000909. PMID: 34324696
Adnexal Masses in Adolescents.
Northridge JL
Pediatr Ann 2020 Apr 1;49(4):e183-e187. doi: 10.3928/19382359-20200227-01. PMID: 32275763
Imaging of Adnexal Masses.
Thakur M, Timmerman D
Clin Obstet Gynecol 2017 Mar;60(1):38-45. doi: 10.1097/GRF.0000000000000261. PMID: 28005597
Re-torsion of the ovaries.
Hyttel TE, Bak GS, Larsen SB, Løkkegaard EC
Acta Obstet Gynecol Scand 2015 Mar;94(3):236-44. Epub 2014 Dec 11 doi: 10.1111/aogs.12542. PMID: 25412114

Diagnosis

Adnexal Masses in Adolescents.
Northridge JL
Pediatr Ann 2020 Apr 1;49(4):e183-e187. doi: 10.3928/19382359-20200227-01. PMID: 32275763
Adnexal Masses in Pregnancy.
McMinn E, Schwartz N
Clin Obstet Gynecol 2020 Jun;63(2):392-404. doi: 10.1097/GRF.0000000000000528. PMID: 32167949
Adnexal Torsion.
Adeyemi-Fowode O, McCracken KA, Todd NJ
J Pediatr Adolesc Gynecol 2018 Aug;31(4):333-338. Epub 2018 Apr 11 doi: 10.1016/j.jpag.2018.03.010. PMID: 29653167
Imaging of Adnexal Masses.
Thakur M, Timmerman D
Clin Obstet Gynecol 2017 Mar;60(1):38-45. doi: 10.1097/GRF.0000000000000261. PMID: 28005597
Practice Bulletin No. 174: Evaluation and Management of Adnexal Masses.
American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins—Gynecology
Obstet Gynecol 2016 Nov;128(5):e210-e226. doi: 10.1097/AOG.0000000000001768. PMID: 27776072

Therapy

The dark side of the moon: the immune-mediated adverse events of IL-17A/IL-17R inhibition.
Messina F, Piaserico S
J Dermatolog Treat 2022 Aug;33(5):2443-2454. Epub 2022 Apr 8 doi: 10.1080/09546634.2022.2062281. PMID: 35393910
Guideline No. 403: Initial Investigation and Management of Adnexal Masses.
Salvador S, Scott S, Glanc P, Eiriksson L, Jang JH, Sebastianelli A, Dean E
J Obstet Gynaecol Can 2020 Aug;42(8):1021-1029.e3. doi: 10.1016/j.jogc.2019.08.044. PMID: 32736853
Risk of complications in patients with conservatively managed ovarian tumours (IOTA5): a 2-year interim analysis of a multicentre, prospective, cohort study.
Froyman W, Landolfo C, De Cock B, Wynants L, Sladkevicius P, Testa AC, Van Holsbeke C, Domali E, Fruscio R, Epstein E, Dos Santos Bernardo MJ, Franchi D, Kudla MJ, Chiappa V, Alcazar JL, Leone FPG, Buonomo F, Hochberg L, Coccia ME, Guerriero S, Deo N, Jokubkiene L, Kaijser J, Coosemans A, Vergote I, Verbakel JY, Bourne T, Van Calster B, Valentin L, Timmerman D
Lancet Oncol 2019 Mar;20(3):448-458. Epub 2019 Feb 5 doi: 10.1016/S1470-2045(18)30837-4. PMID: 30737137
Re-torsion of the ovaries.
Hyttel TE, Bak GS, Larsen SB, Løkkegaard EC
Acta Obstet Gynecol Scand 2015 Mar;94(3):236-44. Epub 2014 Dec 11 doi: 10.1111/aogs.12542. PMID: 25412114
Adnexal torsion: review of the literature.
Sasaki KJ, Miller CE
J Minim Invasive Gynecol 2014 Mar-Apr;21(2):196-202. Epub 2013 Oct 12 doi: 10.1016/j.jmig.2013.09.010. PMID: 24126258

Prognosis

Adnexal masses during pregnancy: diagnosis, treatment, and prognosis.
Cathcart AM, Nezhat FR, Emerson J, Pejovic T, Nezhat CH, Nezhat CR
Am J Obstet Gynecol 2023 Jun;228(6):601-612. Epub 2022 Nov 19 doi: 10.1016/j.ajog.2022.11.1291. PMID: 36410423
ESGO/ISUOG/IOTA/ESGE Consensus Statement on preoperative diagnosis of ovarian tumors.
Timmerman D, Planchamp F, Bourne T, Landolfo C, du Bois A, Chiva L, Cibula D, Concin N, Fischerova D, Froyman W, Gallardo G, Lemley B, Loft A, Mereu L, Morice P, Querleu D, Testa AC, Vergote I, Vandecaveye V, Scambia G, Fotopoulou C
Ultrasound Obstet Gynecol 2021 Jul;58(1):148-168. Epub 2021 Jun 10 doi: 10.1002/uog.23635. PMID: 33794043
Guideline No. 403: Initial Investigation and Management of Adnexal Masses.
Salvador S, Scott S, Glanc P, Eiriksson L, Jang JH, Sebastianelli A, Dean E
J Obstet Gynaecol Can 2020 Aug;42(8):1021-1029.e3. doi: 10.1016/j.jogc.2019.08.044. PMID: 32736853
Imaging of Adnexal Masses.
Thakur M, Timmerman D
Clin Obstet Gynecol 2017 Mar;60(1):38-45. doi: 10.1097/GRF.0000000000000261. PMID: 28005597
Simple ultrasound-based rules for the diagnosis of ovarian cancer.
Timmerman D, Testa AC, Bourne T, Ameye L, Jurkovic D, Van Holsbeke C, Paladini D, Van Calster B, Vergote I, Van Huffel S, Valentin L
Ultrasound Obstet Gynecol 2008 Jun;31(6):681-90. doi: 10.1002/uog.5365. PMID: 18504770

Clinical prediction guides

Adnexal masses during pregnancy: diagnosis, treatment, and prognosis.
Cathcart AM, Nezhat FR, Emerson J, Pejovic T, Nezhat CH, Nezhat CR
Am J Obstet Gynecol 2023 Jun;228(6):601-612. Epub 2022 Nov 19 doi: 10.1016/j.ajog.2022.11.1291. PMID: 36410423
O-RADS MRI Risk Stratification System: Guide for Assessing Adnexal Lesions from the ACR O-RADS Committee.
Sadowski EA, Thomassin-Naggara I, Rockall A, Maturen KE, Forstner R, Jha P, Nougaret S, Siegelman ES, Reinhold C
Radiology 2022 Apr;303(1):35-47. Epub 2022 Jan 18 doi: 10.1148/radiol.204371. PMID: 35040672Free PMC Article
Guideline No. 403: Initial Investigation and Management of Adnexal Masses.
Salvador S, Scott S, Glanc P, Eiriksson L, Jang JH, Sebastianelli A, Dean E
J Obstet Gynaecol Can 2020 Aug;42(8):1021-1029.e3. doi: 10.1016/j.jogc.2019.08.044. PMID: 32736853
Imaging of Adnexal Masses.
Thakur M, Timmerman D
Clin Obstet Gynecol 2017 Mar;60(1):38-45. doi: 10.1097/GRF.0000000000000261. PMID: 28005597
Simple ultrasound-based rules for the diagnosis of ovarian cancer.
Timmerman D, Testa AC, Bourne T, Ameye L, Jurkovic D, Van Holsbeke C, Paladini D, Van Calster B, Vergote I, Van Huffel S, Valentin L
Ultrasound Obstet Gynecol 2008 Jun;31(6):681-90. doi: 10.1002/uog.5365. PMID: 18504770

Recent systematic reviews

Systematic Review and Meta-Analysis of O-RADS Ultrasound and O-RADS MRI for Risk Assessment of Ovarian and Adnexal Lesions.
Zhang Q, Dai X, Li W
AJR Am J Roentgenol 2023 Jul;221(1):21-33. Epub 2023 Feb 1 doi: 10.2214/AJR.22.28396. PMID: 36722758
O-RADS MRI: A Systematic Review and Meta-Analysis of Diagnostic Performance and Category-wise Malignancy Rates.
Rizzo S, Cozzi A, Dolciami M, Del Grande F, Scarano AL, Papadia A, Gui B, Gandolfo N, Catalano C, Manganaro L
Radiology 2023 Apr;307(1):e220795. Epub 2022 Nov 22 doi: 10.1148/radiol.220795. PMID: 36413127
Diagnostic accuracy of ultrasound signs for detecting adnexal torsion: systematic review and meta-analysis.
Garde I, Paredes C, Ventura L, Pascual MA, Ajossa S, Guerriero S, Vara J, Linares M, Alcázar JL
Ultrasound Obstet Gynecol 2023 Mar;61(3):310-324. Epub 2023 Feb 11 doi: 10.1002/uog.24976. PMID: 35751902
Surgical Management of Adnexal Masses in Pregnancy: A Systematic Review and Meta-analysis.
Cagino K, Li X, Thomas C, Delgado D, Christos P, Acholonu U Jr
J Minim Invasive Gynecol 2021 Jun;28(6):1171-1182.e2. Epub 2021 Jan 28 doi: 10.1016/j.jmig.2021.01.020. PMID: 33515746
Single-Port Laparoscopy vs Conventional Laparoscopy in Benign Adnexal Diseases: A Systematic Review and Meta-Analysis.
Schmitt A, Crochet P, Knight S, Tourette C, Loundou A, Agostini A
J Minim Invasive Gynecol 2017 Nov-Dec;24(7):1083-1095. Epub 2017 Jul 10 doi: 10.1016/j.jmig.2017.07.001. PMID: 28705751

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