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Disorder of female genital system

MedGen UID:: 9003
•Concept ID:: C0017411
•: Disease or Syndrome

Synonyms:	Diseases, Female Genital; Diseases, Gynecologic; Female Genital Disease; Female Genital Diseases; Genital Disease, Female; Genital Diseases, Female; Gynecologic Disease; Gynecologic Diseases
SNOMED CT:	Disease of female genital organ (244938009); Disorder of female genital organs (244938009); Disorder of female genital system (310789003); Disorder of female genital tract (310789003); Disease of female genital system (310789003); Gynecological disease (310789003)

Definition

Pathological processes involving the female reproductive tract (GENITALIA, FEMALE). [from MeSH]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDisorder of female genital system

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Disorder of the genitourinary system
        Diseases, Genital
        Disorder of female genital system
        Adnexal Diseases
        Disorder of ovary
        Anovulation
        Neoplasm of ovary
        Oophoritis
        Ovarian cyst
        Ovarian hyperstimulation syndrome
        Ovarian Non-Neoplastic Disorder
        Ovarian torsion
        Premature ovarian failure
        Premature ovarian insufficiency
        Fallopian tube disorder
        Fallopian Tube Non-Neoplastic Disorder
        Neoplasm of fallopian tube
        Salpingitis
        Pelvic inflammatory disease
        Adnexitis
        AIDS-Related Pelvic Inflammatory Disease
        Endometritis
        Parametritis
        Dyspareunia
        Endometriosis
        Atypical Endometriosis
        Cervical endometriosis
        Endometriosis of thorax
        Fallopian tube endometriosis
        Ovarian endometriosis
        Vaginal Endometriosis
        Female infertility
        Genital herpes
        Gynatresia
        Infection, Reproductive Tract
        Tuberculosis, Female Genital
        Uterine disorder
        Cervix disorder
        Cervical insufficiency
        Cervical Non-Neoplastic Disorder
        Cervical Polyp
        Cervicitis
        Dysplasia of cervix
        Erosion of cervix
        Neoplasm of uterine cervix
        Endometrial disorder
        Endometrial neoplasm
        Hyperplasia of the endometrium
        Tamoxifen-related endometrial lesion
        Endometriosis of uterus
        Hematometra
        Neoplasm of uterus
        Corpus uteri neoplasm
        Uterine adenofibroma
        Uterine benign neoplasm
        Uterine cancer
        Uterine cervix myxoma
        Uterine leiomyoma
        Uterine myxoma
        Pyometritis
        Retroversion of uterus
        Uterine Hemorrhage
        Menorrhagia
        Metrorrhagia
        Post-partum hemorrhage
        Uterine inversion
        Uterine Non-Neoplastic Disorder
        Uterine Corpus Non-Neoplastic Disorder
        Uterine prolapse
        Uterine polyp
        Endometrial polyp
        Uterine rupture
        Perforation of uterus
        Vaginal disorder
        Hematocolpos
        Hydrocolpos
        Vaginal discharge
        White vaginal discharge
        Vaginal fistula
        Rectovaginal fistula
        Vesicovaginal fistula
        Vaginal neoplasm
        Benign vaginal neoplasm
        Cervical clear cell adenocarcinoma
        Malignant Vaginal Neoplasm
        Vaginal clear cell adenocarcinoma
        Vaginal Germ Cell Tumor
        Vaginal glandular neoplasm
        Vaginal Mixed Epithelial and Mesenchymal Neoplasm
        Vaginal myxoma
        Vaginal Soft Tissue Neoplasm
        Vaginal squamous tumor
        Vaginal Non-Neoplastic Disorder
        Atrophy of vagina
        Imperforate Vagina
        Polyp of vagina
        Vaginitis
        Vaginismus
        Psychologic vaginismus
        Vulvar disease
        Pruritus vulvae
        Vulvar lichen sclerosus
        Vulvar neoplasm
        Bartholin gland carcinoma
        Bartholin gland neoplasm
        Malignant Vulvar Neoplasm
        Squamous cell carcinoma of the vulva
        Vulvar adenocarcinoma
        Vulvar benign neoplasm
        Vulvar Germ Cell Tumor
        Vulvar glandular neoplasm
        Vulvar granular cell tumor
        Vulvar intraepithelial neoplasia
        Vulvar Melanocytic Neoplasm
        Vulvar melanoma
        Vulvar Neoplasm of Skin Appendage Origin
        Vulvar Phyllodes Tumor
        Vulvar Soft Tissue Neoplasm
        Vulvar squamous neoplasm
        Vulvar Non-Neoplastic Disorder
        Polyp of vulva
        Vulval Infection
        Vulvar dystrophy
        Vulvitis
        Vulvar vestibulitis
        Vulvovaginitis
        Vulvodynia

Professional guidelines

PubMed

Management of Symptomatic Uterine Leiomyomas: ACOG Practice Bulletin, Number 228.

Obstet Gynecol 2021 Jun 1;137(6):e100-e115. doi: 10.1097/AOG.0000000000004401. PMID: 34011888

Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome.

Teede HJ, Misso ML, Costello MF, Dokras A, Laven J, Moran L, Piltonen T, Norman RJ; International PCOS Network
Fertil Steril 2018 Aug;110(3):364-379. Epub 2018 Jul 19 doi: 10.1016/j.fertnstert.2018.05.004. PMID: 30033227 Free PMC Article

Clinical Management of Endometriosis.

Falcone T, Flyckt R
Obstet Gynecol 2018 Mar;131(3):557-571. doi: 10.1097/AOG.0000000000002469. PMID: 29420391

See all (22030)

Recent clinical studies

Etiology

Genital Ulcers: Differential Diagnosis and Management.

Roett MA
Am Fam Physician 2020 Mar 15;101(6):355-361. PMID: 32163252

Acute Pelvic Pain.

Dewey K, Wittrock C
Emerg Med Clin North Am 2019 May;37(2):207-218. doi: 10.1016/j.emc.2019.01.012. PMID: 30940367

Complications associated with intimate body piercings.

Lee B, Vangipuram R, Petersen E, Tyring SK
Dermatol Online J 2018 Jul 15;24(7) PMID: 30261561

Clindamycin.

Soper DE
Obstet Gynecol Clin North Am 1992 Sep;19(3):483-96. PMID: 1436926

Genital psoriasis.

Farber EM, Nall L
Cutis 1992 Oct;50(4):263-6. PMID: 1424790

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Diagnosis

Urogenital infections.

Wagenlehner F
World J Urol 2020 Jan;38(1):1-2. doi: 10.1007/s00345-019-03039-4. PMID: 31788716

Three-Dimensional Volume Imaging in Gynecology.

Benacerraf BR
Obstet Gynecol Clin North Am 2019 Dec;46(4):755-781. Epub 2019 Oct 3 doi: 10.1016/j.ogc.2019.07.008. PMID: 31677753

Genitourinary Procedures.

Jones MP, Mekuria K
Emerg Med Clin North Am 2019 Nov;37(4):811-819. doi: 10.1016/j.emc.2019.07.014. PMID: 31563209

Female Nonobstetric Genitourinary Emergencies.

Mahonski S, Hu KM
Emerg Med Clin North Am 2019 Nov;37(4):771-784. doi: 10.1016/j.emc.2019.07.012. PMID: 31563207

Genital diseases in the mature woman.

Matthews N, Wong V, Brooks J, Kroumpouzos G
Clin Dermatol 2018 Mar-Apr;36(2):208-221. Epub 2017 Oct 3 doi: 10.1016/j.clindermatol.2017.10.012. PMID: 29566925

See all (123209)

Therapy

Primary cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy (HIPEC) for FIGO stage III epithelial ovarian cancer: OVHIPEC-2, a phase III randomized clinical trial.

Koole S, van Stein R, Sikorska K, Barton D, Perrin L, Brennan D, Zivanovic O, Mosgaard BJ, Fagotti A, Colombo PE, Sonke G, Driel WJV; OVHIPEC-2 Steering Committee and the Dutch OVHIPEC group
Int J Gynecol Cancer 2020 Jun;30(6):888-892. Epub 2020 Mar 23 doi: 10.1136/ijgc-2020-001231. PMID: 32205449 Free PMC Article

Robot-assisted surgery in gynaecology.

Lawrie TA, Liu H, Lu D, Dowswell T, Song H, Wang L, Shi G
Cochrane Database Syst Rev 2019 Apr 15;4(4):CD011422. doi: 10.1002/14651858.CD011422.pub2. PMID: 30985921 Free PMC Article

Is the NCI MATCH trial a match for gynecologic oncology?

Moore KN, Mannel RS
Gynecol Oncol 2016 Jan;140(1):161-6. Epub 2015 Nov 14 doi: 10.1016/j.ygyno.2015.11.003. PMID: 26586415

2-methoxyestradiol and disorders of female reproductive tissues.

Pinto MP, Medina RA, Owen GI
Horm Cancer 2014 Oct;5(5):274-83. Epub 2014 Apr 25 doi: 10.1007/s12672-014-0181-2. PMID: 24764201 Free PMC Article

An overview of the current status of clinical trials on endometriosis: issues and concerns.

Guo SW
Fertil Steril 2014 Jan;101(1):183-190.e4. Epub 2013 Oct 7 doi: 10.1016/j.fertnstert.2013.08.050. PMID: 24112527

See all (92345)

Prognosis

Modern treatment of vulvar cancer.

Merlo S
Radiol Oncol 2020 Sep 22;54(4):371-376. doi: 10.2478/raon-2020-0053. PMID: 32960779 Free PMC Article

Cesarean section one hundred years 1920-2020: the Good, the Bad and the Ugly.

Antoine C, Young BK
J Perinat Med 2020 Sep 4;49(1):5-16. doi: 10.1515/jpm-2020-0305. PMID: 32887190

A Review of Cervical Cancer: Incidence and Disparities.

Buskwofie A, David-West G, Clare CA
J Natl Med Assoc 2020 Apr;112(2):229-232. Epub 2020 Apr 8 doi: 10.1016/j.jnma.2020.03.002. PMID: 32278478

Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis.

Arbyn M, Weiderpass E, Bruni L, de Sanjosé S, Saraiya M, Ferlay J, Bray F
Lancet Glob Health 2020 Feb;8(2):e191-e203. Epub 2019 Dec 4 doi: 10.1016/S2214-109X(19)30482-6. PMID: 31812369 Free PMC Article

Risk factors for endometrial cancer: An umbrella review of the literature.

Raglan O, Kalliala I, Markozannes G, Cividini S, Gunter MJ, Nautiyal J, Gabra H, Paraskevaidis E, Martin-Hirsch P, Tsilidis KK, Kyrgiou M
Int J Cancer 2019 Oct 1;145(7):1719-1730. Epub 2019 Feb 20 doi: 10.1002/ijc.31961. PMID: 30387875

See all (77130)

Clinical prediction guides

Diet and Nutrition in Gynecological Disorders: A Focus on Clinical Studies.

Afrin S, AlAshqar A, El Sabeh M, Miyashita-Ishiwata M, Reschke L, Brennan JT, Fader A, Borahay MA
Nutrients 2021 May 21;13(6) doi: 10.3390/nu13061747. PMID: 34063835 Free PMC Article

Genital Ulcers: Differential Diagnosis and Management.

Roett MA
Am Fam Physician 2020 Mar 15;101(6):355-361. PMID: 32163252

An Update of Neuroendocrine Tumors of the Female Reproductive System.

Kefeli M, Usubütün A
Turk Patoloji Derg 2015;31 Suppl 1:128-44. doi: 10.5146/tjpath.2015.01320. PMID: 26177323

Reassessing hysterectomy.

Stewart EA, Shuster LT, Rocca WA
Minn Med 2012 Mar;95(3):36-9. PMID: 22611818 Free PMC Article

Criteria for diagnosis of Behçet's disease. International Study Group for Behçet's Disease.

Lancet 1990 May 5;335(8697):1078-80. PMID: 1970380

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Recent systematic reviews

Role of human papillomavirus (HPV) vaccination on HPV infection and recurrence of HPV related disease after local surgical treatment: systematic review and meta-analysis.

Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074 Free PMC Article

Endometrial hyperplasia as a risk factor of endometrial cancer.

Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185 Free PMC Article

Clinical Practice Guidelines on the Diagnosis and Management of Polycystic Ovary Syndrome: A Systematic Review and Quality Assessment Study.

Al Wattar BH, Fisher M, Bevington L, Talaulikar V, Davies M, Conway G, Yasmin E
J Clin Endocrinol Metab 2021 Jul 13;106(8):2436-2446. doi: 10.1210/clinem/dgab232. PMID: 33839790 Free PMC Article

EULAR recommendations for women's health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome.

Andreoli L, Bertsias GK, Agmon-Levin N, Brown S, Cervera R, Costedoat-Chalumeau N, Doria A, Fischer-Betz R, Forger F, Moraes-Fontes MF, Khamashta M, King J, Lojacono A, Marchiori F, Meroni PL, Mosca M, Motta M, Ostensen M, Pamfil C, Raio L, Schneider M, Svenungsson E, Tektonidou M, Yavuz S, Boumpas D, Tincani A
Ann Rheum Dis 2017 Mar;76(3):476-485. Epub 2016 Jul 25 doi: 10.1136/annrheumdis-2016-209770. PMID: 27457513 Free PMC Article

The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis.

Bozdag G, Mumusoglu S, Zengin D, Karabulut E, Yildiz BO
Hum Reprod 2016 Dec;31(12):2841-2855. Epub 2016 Sep 22 doi: 10.1093/humrep/dew218. PMID: 27664216

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