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Breast fibroepithelial neoplasm

MedGen UID:
267408
•Concept ID:
C1511309
•
Neoplastic Process
Synonyms: BFN; Breast Fibroepithelial Neoplasm; breast fibroepithelial neoplasm; breast fibroepithelial neoplasms; Breast Fibroepithelial Tumor; breast fibroepithelial tumor; breast fibroepithelial tumour
 
Monarch Initiative: MONDO:0021046

Definition

A benign, malignant, or borderline biphasic neoplasm that arises from the breast parenchyma. It is characterized by the presence of an epithelial and a mesenchymal (stromal) component. The typical examples are fibroadenoma and phyllodes tumor. [from NCI]

Professional guidelines

PubMed

European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.
Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
MRI-guided treatment in the breast.
Pediconi F, Marzocca F, Cavallo Marincola B, Napoli A
J Magn Reson Imaging 2018 Dec;48(6):1479-1488. Epub 2018 Oct 14 doi: 10.1002/jmri.26282. PMID: 30318672
Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates.
Zhang Y, Kleer CG
Arch Pathol Lab Med 2016 Jul;140(7):665-71. doi: 10.5858/arpa.2016-0042-RA. PMID: 27362571

Recent clinical studies

Etiology

European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.
Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
Imaging and Management of Fibroepithelial Lesions of the Breast: Radiologic-Pathologic Correlation.
Zhang M, Arjmandi FK, Porembka JH, Seiler SJ, Goudreau SH, Merchant K, Hwang H, Hayes JC
Radiographics 2023 Nov;43(11):e230051. doi: 10.1148/rg.230051. PMID: 37856317
Malignant phyllodes tumor of the breast: a systematic review.
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates.
Zhang Y, Kleer CG
Arch Pathol Lab Med 2016 Jul;140(7):665-71. doi: 10.5858/arpa.2016-0042-RA. PMID: 27362571
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article

Diagnosis

Malignant phyllodes tumor of the breast: a systematic review.
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Fibroepithelial tumours of the breast-a review.
Lerwill MF, Lee AHS, Tan PH
Virchows Arch 2022 Jan;480(1):45-63. Epub 2021 Sep 10 doi: 10.1007/s00428-021-03175-6. PMID: 34505197
Fibroadenoma of the Breast.
Erickson LA, Chen B
Mayo Clin Proc 2020 Nov;95(11):2573-2574. doi: 10.1016/j.mayocp.2020.08.040. PMID: 33153651
Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates.
Zhang Y, Kleer CG
Arch Pathol Lab Med 2016 Jul;140(7):665-71. doi: 10.5858/arpa.2016-0042-RA. PMID: 27362571
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article

Therapy

Feasibility and efficacy of ultrasound-guided high-intensity focused ultrasound of breast fibroadenoma.
Liang M, Zhang Z, Zhang C, Chen R, Xiao Y, Li Z, Li T, Liu Y, Ling L, Xie H, Chen L, Liu X, Wang S, Xia T
Int J Hyperthermia 2023;40(1):2240548. doi: 10.1080/02656736.2023.2240548. PMID: 37544652
Single cell profiling of female breast fibroadenoma reveals distinct epithelial cell compositions and therapeutic targets.
Chen Z, Zhang Y, Li W, Gao C, Huang F, Cheng L, Jin M, Xu X, Huang J
Nat Commun 2023 Jun 16;14(1):3469. doi: 10.1038/s41467-023-39059-3. PMID: 37328469Free PMC Article
Management of Stromal Lesions.
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Benign breast disease.
Hamed H, Fentiman IS
Int J Clin Pract 2001 Sep;55(7):461-4. PMID: 11594256
Tumorigenic aspects.
Kirk ME
Int J Gynaecol Obstet 1978-1979;16(6):473-8. doi: 10.1002/j.1879-3479.1979.tb00952.x. PMID: 39811

Prognosis

European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.
Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
Management of Stromal Lesions.
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Fibroepithelial tumours of the breast-a review.
Lerwill MF, Lee AHS, Tan PH
Virchows Arch 2022 Jan;480(1):45-63. Epub 2021 Sep 10 doi: 10.1007/s00428-021-03175-6. PMID: 34505197
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications.
Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Lønning PE, Børresen-Dale AL
Proc Natl Acad Sci U S A 2001 Sep 11;98(19):10869-74. doi: 10.1073/pnas.191367098. PMID: 11553815Free PMC Article

Clinical prediction guides

Single cell profiling of female breast fibroadenoma reveals distinct epithelial cell compositions and therapeutic targets.
Chen Z, Zhang Y, Li W, Gao C, Huang F, Cheng L, Jin M, Xu X, Huang J
Nat Commun 2023 Jun 16;14(1):3469. doi: 10.1038/s41467-023-39059-3. PMID: 37328469Free PMC Article
Management of Stromal Lesions.
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Breast fibroadenomas: a review in the light of current literature.
Salati SA
Pol Przegl Chir 2020 Dec 7;93(1):40-48. doi: 10.5604/01.3001.0014.5676. PMID: 33729177
Fibroepithelial lesions; The WHO spectrum.
Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article

Recent systematic reviews

Clinical efficacy and safety of ultrasound-guided high-intensity focused ultrasound for breast fibroadenoma: a systematic review and meta-analysis.
Wu X, Yue X, Liu H, Huang H, Yao D, Guo Y, Chen W, Zhang C
Int J Hyperthermia 2024;41(1):2374874. Epub 2024 Jul 25 doi: 10.1080/02656736.2024.2374874. PMID: 39053900
Malignant phyllodes tumor of the breast: a systematic review.
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Width of margins in phyllodes tumors of the breast: the controversy drags on?-a systematic review and meta-analysis.
Toussaint A, Piaget-Rossel R, Stormacq C, Mathevet P, Lepigeon K, Taffé P
Breast Cancer Res Treat 2021 Jan;185(1):21-37. Epub 2020 Sep 15 doi: 10.1007/s10549-020-05924-8. PMID: 32935237
P53 Expression in benign Breast Disease Development: A Systematic Review.
Costa RSS, Silva IFD
Asian Pac J Cancer Prev 2020 Sep 1;21(9):2485-2491. doi: 10.31557/APJCP.2020.21.9.2485. PMID: 32986343Free PMC Article
Pediatric Breast Fibroadenomas: A Systematic Review and Algorithm for Treatment.
Brownstone ND, Celie KB, Spigland NA, Otterburn DM
Ann Plast Surg 2019 Nov;83(5):601-605. doi: 10.1097/SAP.0000000000001717. PMID: 30628932

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