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Breast fibroepithelial neoplasm

MedGen UID:
267408
Concept ID:
C1511309
Neoplastic Process
Synonyms: BFN; Breast Fibroepithelial Neoplasm; breast fibroepithelial neoplasm; breast fibroepithelial neoplasms; Breast Fibroepithelial Tumor; breast fibroepithelial tumor; breast fibroepithelial tumour
 
Monarch Initiative: MONDO:0021046

Definition

A benign, malignant, or borderline biphasic neoplasm that arises from the breast parenchyma. It is characterized by the presence of an epithelial and a mesenchymal (stromal) component. The typical examples are fibroadenoma and phyllodes tumor. [from NCI]

Professional guidelines

PubMed

Sars C, Sackey H, Frisell J, Dickman PW, Karlsson F, Kindts I, Marta GN, Freitas-Junior R, Tvedskov TF, Kassem L, Ali AS, Ihalainen H, Neron M, Kontos M, Kaidar-Person O, Meattini I, Francken AB, van Duijnhoven F, Moberg IO, Marinko T, Kollar A, Ahmed M, Remoundos D, Banks J, Jagsi R, Dossett LA, Lindqvist EK
Breast Cancer Res Treat 2023 Jun;199(2):293-304. Epub 2023 Mar 6 doi: 10.1007/s10549-023-06896-1. PMID: 36879102Free PMC Article
Saimura M, Koga K, Anan K, Mitsuyama S, Tamiya S
Breast Cancer 2018 Jul;25(4):470-478. Epub 2018 Feb 19 doi: 10.1007/s12282-018-0847-7. PMID: 29460095
Zhang Y, Kleer CG
Arch Pathol Lab Med 2016 Jul;140(7):665-71. doi: 10.5858/arpa.2016-0042-RA. PMID: 27362571

Recent clinical studies

Etiology

Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
de Vasconcelos Gaspar A, Melo L, Geraldes F, Belo J, Águas F
Breast Dis 2021;40(4):269-274. doi: 10.3233/BD-201043. PMID: 34120893
Leithner D, Moy L, Morris EA, Marino MA, Helbich TH, Pinker K
J Magn Reson Imaging 2019 Jun;49(7):e85-e100. Epub 2018 Sep 8 doi: 10.1002/jmri.26291. PMID: 30194749Free PMC Article
Zhang Y, Kleer CG
Arch Pathol Lab Med 2016 Jul;140(7):665-71. doi: 10.5858/arpa.2016-0042-RA. PMID: 27362571
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article

Diagnosis

Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Lerwill MF, Lee AHS, Tan PH
Virchows Arch 2022 Jan;480(1):45-63. Epub 2021 Sep 10 doi: 10.1007/s00428-021-03175-6. PMID: 34505197
Erickson LA, Chen B
Mayo Clin Proc 2020 Nov;95(11):2573-2574. doi: 10.1016/j.mayocp.2020.08.040. PMID: 33153651
Zhang Y, Kleer CG
Arch Pathol Lab Med 2016 Jul;140(7):665-71. doi: 10.5858/arpa.2016-0042-RA. PMID: 27362571
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article

Therapy

Chen Z, Zhang Y, Li W, Gao C, Huang F, Cheng L, Jin M, Xu X, Huang J
Nat Commun 2023 Jun 16;14(1):3469. doi: 10.1038/s41467-023-39059-3. PMID: 37328469Free PMC Article
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Papas Y, Asmar AE, Ghandour F, Hajj I
Breast J 2020 Feb;26(2):240-244. Epub 2019 Sep 3 doi: 10.1111/tbj.13523. PMID: 31478587
Hamed H, Fentiman IS
Int J Clin Pract 2001 Sep;55(7):461-4. PMID: 11594256
Wang DY, Fentiman IS
Breast Cancer Res Treat 1985;6(1):5-36. doi: 10.1007/BF01806008. PMID: 3902125

Prognosis

Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Lerwill MF, Lee AHS, Tan PH
Virchows Arch 2022 Jan;480(1):45-63. Epub 2021 Sep 10 doi: 10.1007/s00428-021-03175-6. PMID: 34505197
Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article
Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Lønning PE, Børresen-Dale AL
Proc Natl Acad Sci U S A 2001 Sep 11;98(19):10869-74. doi: 10.1073/pnas.191367098. PMID: 11553815Free PMC Article

Clinical prediction guides

Chen Z, Zhang Y, Li W, Gao C, Huang F, Cheng L, Jin M, Xu X, Huang J
Nat Commun 2023 Jun 16;14(1):3469. doi: 10.1038/s41467-023-39059-3. PMID: 37328469Free PMC Article
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Salati SA
Pol Przegl Chir 2020 Dec 7;93(1):40-48. doi: 10.5604/01.3001.0014.5676. PMID: 33729177
Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article

Recent systematic reviews

Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Toussaint A, Piaget-Rossel R, Stormacq C, Mathevet P, Lepigeon K, Taffé P
Breast Cancer Res Treat 2021 Jan;185(1):21-37. Epub 2020 Sep 15 doi: 10.1007/s10549-020-05924-8. PMID: 32935237
Costa RSS, Silva IFD
Asian Pac J Cancer Prev 2020 Sep 1;21(9):2485-2491. doi: 10.31557/APJCP.2020.21.9.2485. PMID: 32986343Free PMC Article
Brownstone ND, Celie KB, Spigland NA, Otterburn DM
Ann Plast Surg 2019 Nov;83(5):601-605. doi: 10.1097/SAP.0000000000001717. PMID: 30628932
El-Wakeel H, Umpleby HC
Breast 2003 Oct;12(5):302-7. doi: 10.1016/s0960-9776(03)00123-1. PMID: 14659144

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