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Abasic Site Formation

MedGen UID:
267624
•Concept ID:
C1510710
•
Cell or Molecular Dysfunction
Synonym: Formation of Abasic Site

Definition

Abasic Site Formation involves the creation of an apurinic or apyrimidinic site resulting from the loss of a purine or pyrimidine residue from DNA. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbasic Site Formation

Recent clinical studies

Therapy

The choice of nucleotide inserted opposite abasic sites formed within chromosomal DNA reveals the polymerase activities participating in translesion DNA synthesis.
Chan K, Resnick MA, Gordenin DA
DNA Repair (Amst) 2013 Nov;12(11):878-89. Epub 2013 Aug 26 doi: 10.1016/j.dnarep.2013.07.008. PMID: 23988736Free PMC Article

Prognosis

Pathways of Metabolite-Related Damage to a Synthetic p53 Gene Exon 7 Oligonucleotide Using Magnetic Enzyme Bioreactor Beads and LC-MS/MS Sequencing.
Malla S, Kadimisetty K, Jiang D, Choudhary D, Rusling JF
Biochemistry 2018 Jul 3;57(26):3883-3893. Epub 2018 May 23 doi: 10.1021/acs.biochem.8b00271. PMID: 29750510Free PMC Article

Clinical prediction guides

Pathways of Metabolite-Related Damage to a Synthetic p53 Gene Exon 7 Oligonucleotide Using Magnetic Enzyme Bioreactor Beads and LC-MS/MS Sequencing.
Malla S, Kadimisetty K, Jiang D, Choudhary D, Rusling JF
Biochemistry 2018 Jul 3;57(26):3883-3893. Epub 2018 May 23 doi: 10.1021/acs.biochem.8b00271. PMID: 29750510Free PMC Article
Redox state alters anti-cancer effects of wedelolactone.
Benes P, Alexova P, Knopfova L, Spanova A, Smarda J
Environ Mol Mutagen 2012 Aug;53(7):515-24. Epub 2012 Jun 26 doi: 10.1002/em.21712. PMID: 22733624
Raloxifene and desmethylarzoxifene block estrogen-induced malignant transformation of human breast epithelial cells.
Kastrati I, Edirisinghe PD, Hemachandra LP, Chandrasena ER, Choi J, Wang YT, Bolton JL, Thatcher GR
PLoS One 2011;6(11):e27876. Epub 2011 Nov 29 doi: 10.1371/journal.pone.0027876. PMID: 22140478Free PMC Article

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