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DNA Double Strand Break

MedGen UID:
267994
Concept ID:
C1511667
Cell or Molecular Dysfunction
Synonyms: Break, Double-Strand DNA; Break, Double-Stranded DNA; Breaks, Double-Strand DNA; Breaks, Double-Stranded DNA; DNA Break, Double-Strand; DNA Break, Double-Stranded; DNA Breaks, Double Stranded; DNA Breaks, Double-Strand; DNA Breaks, Double-Stranded; Double Strand DNA Breaks; Double Stranded DNA Break; Double Stranded DNA Breaks; Double-Strand DNA Break; Double-Strand DNA Breaks; Double-Stranded DNA Break; Double-Stranded DNA Breaks

Definition

A DNA Double Strand Break involves a disruption of the covalent linkages among the phosphodeoxyribose moieties within the sugar-phosphate backbone in both strands of a DNA molecule. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDNA Double Strand Break

Professional guidelines

PubMed

Golan T, Hammel P
J Natl Compr Canc Netw 2021 Apr;19(4):469-473. Epub 2021 Apr 1 doi: 10.6004/jnccn.2021.7031. PMID: 33845459
Yamauchi H, Takei J
Int J Clin Oncol 2018 Feb;23(1):45-51. Epub 2017 Nov 28 doi: 10.1007/s10147-017-1208-9. PMID: 29185095
O'Kane GM, Connor AA, Gallinger S
Trends Mol Med 2017 Dec;23(12):1121-1137. Epub 2017 Nov 10 doi: 10.1016/j.molmed.2017.10.007. PMID: 29133135

Recent clinical studies

Etiology

Schubert I
Int J Mol Sci 2021 May 13;22(10) doi: 10.3390/ijms22105171. PMID: 34068283Free PMC Article
Singh JK, van Attikum H
Semin Cell Dev Biol 2021 May;113:65-74. Epub 2020 Sep 19 doi: 10.1016/j.semcdb.2020.09.003. PMID: 32962915
Bader AS, Hawley BR, Wilczynska A, Bushell M
Br J Cancer 2020 Mar;122(5):613-623. Epub 2020 Jan 2 doi: 10.1038/s41416-019-0624-1. PMID: 31894141Free PMC Article
Slack J, Albert MH, Balashov D, Belohradsky BH, Bertaina A, Bleesing J, Booth C, Buechner J, Buckley RH, Ouachée-Chardin M, Deripapa E, Drabko K, Eapen M, Feuchtinger T, Finocchi A, Gaspar HB, Ghosh S, Gillio A, Gonzalez-Granado LI, Grunebaum E, Güngör T, Heilmann C, Helminen M, Higuchi K, Imai K, Kalwak K, Kanazawa N, Karasu G, Kucuk ZY, Laberko A, Lange A, Mahlaoui N, Meisel R, Moshous D, Muramatsu H, Parikh S, Pasic S, Schmid I, Schuetz C, Schulz A, Schultz KR, Shaw PJ, Slatter MA, Sykora KW, Tamura S, Taskinen M, Wawer A, Wolska-Kuśnierz B, Cowan MJ, Fischer A, Gennery AR; Inborn Errors Working Party of the European Society for Blood and Marrow Transplantation and the European Society for Immunodeficiencies; Stem Cell Transplant for Immunodeficiencies in Europe (SCETIDE); Center for International Blood and Marrow Transplant Research; Primary Immunodeficiency Treatment Consortium
J Allergy Clin Immunol 2018 Jan;141(1):322-328.e10. Epub 2017 Apr 7 doi: 10.1016/j.jaci.2017.02.036. PMID: 28392333Free PMC Article
Kass EM, Jasin M
FEBS Lett 2010 Sep 10;584(17):3703-8. Epub 2010 Aug 5 doi: 10.1016/j.febslet.2010.07.057. PMID: 20691183Free PMC Article

Diagnosis

Lu Z, Mao W, Yang H, Santiago-O'Farrill JM, Rask PJ, Mondal J, Chen H, Ivan C, Liu X, Liu CG, Xi Y, Masuda K, Carrami EM, Chen M, Tang Y, Pang L, Lakomy DS, Calin GA, Liang H, Ahmed AA, Vankayalapati H, Bast RC Jr
J Clin Invest 2022 Jun 1;132(11) doi: 10.1172/JCI146471. PMID: 35642638Free PMC Article
Cong K, Cantor SB
Mol Cell 2022 Jul 7;82(13):2363-2369. Epub 2022 May 13 doi: 10.1016/j.molcel.2022.04.023. PMID: 35568026Free PMC Article
Zhang C, Zhou B, Gu F, Liu H, Wu H, Yao F, Zheng H, Fu H, Chong W, Cai S, Huang M, Ma X, Guo Z, Li T, Deng W, Zheng M, Ji Q, Zhao Y, Ma Y, Wang QE, Tang TS, Guo C
Mol Cell 2022 Apr 7;82(7):1297-1312.e8. Epub 2022 Feb 25 doi: 10.1016/j.molcel.2022.01.020. PMID: 35219381
Zhao B, Rothenberg E, Ramsden DA, Lieber MR
Nat Rev Mol Cell Biol 2020 Dec;21(12):765-781. Epub 2020 Oct 19 doi: 10.1038/s41580-020-00297-8. PMID: 33077885Free PMC Article
Hühn D, Bolck HA, Sartori AA
Swiss Med Wkly 2013;143:w13837. Epub 2013 Jul 29 doi: 10.4414/smw.2013.13837. PMID: 23897299

Therapy

Lu Z, Mao W, Yang H, Santiago-O'Farrill JM, Rask PJ, Mondal J, Chen H, Ivan C, Liu X, Liu CG, Xi Y, Masuda K, Carrami EM, Chen M, Tang Y, Pang L, Lakomy DS, Calin GA, Liang H, Ahmed AA, Vankayalapati H, Bast RC Jr
J Clin Invest 2022 Jun 1;132(11) doi: 10.1172/JCI146471. PMID: 35642638Free PMC Article
Ray U, Raghavan SC
DNA Repair (Amst) 2021 Oct;106:103177. Epub 2021 Jul 9 doi: 10.1016/j.dnarep.2021.103177. PMID: 34325086
Ray U, Raghavan SC
Biochem Pharmacol 2020 Dec;182:114195. Epub 2020 Aug 13 doi: 10.1016/j.bcp.2020.114195. PMID: 32798465
Damia G
Mutat Res 2020 May-Dec;821:111692. Epub 2020 Feb 25 doi: 10.1016/j.mrfmmm.2020.111692. PMID: 32172133
Parvin S, Ramirez-Labrada A, Aumann S, Lu X, Weich N, Santiago G, Cortizas EM, Sharabi E, Zhang Y, Sanchez-Garcia I, Gentles AJ, Roberts E, Bilbao-Cortes D, Vega F, Chapman JR, Verdun RE, Lossos IS
Cancer Cell 2019 Sep 16;36(3):237-249.e6. Epub 2019 Aug 22 doi: 10.1016/j.ccell.2019.07.007. PMID: 31447348Free PMC Article

Prognosis

Patterson-Fortin J, Bose A, Tsai WC, Grochala C, Nguyen H, Zhou J, Parmar K, Lazaro JB, Liu J, McQueen K, Shapiro GI, Kozono D, D'Andrea AD
Cancer Res 2022 Oct 17;82(20):3815-3829. doi: 10.1158/0008-5472.CAN-22-1124. PMID: 35972384Free PMC Article
Chen Y, Zhao Y, Yang X, Ren X, Huang S, Gong S, Tan X, Li J, He S, Li Y, Hong X, Li Q, Ding C, Fang X, Ma J, Liu N
Nat Commun 2022 Jan 25;13(1):501. doi: 10.1038/s41467-022-28158-2. PMID: 35079021Free PMC Article
Ray U, Raghavan SC
DNA Repair (Amst) 2021 Oct;106:103177. Epub 2021 Jul 9 doi: 10.1016/j.dnarep.2021.103177. PMID: 34325086
Parvin S, Ramirez-Labrada A, Aumann S, Lu X, Weich N, Santiago G, Cortizas EM, Sharabi E, Zhang Y, Sanchez-Garcia I, Gentles AJ, Roberts E, Bilbao-Cortes D, Vega F, Chapman JR, Verdun RE, Lossos IS
Cancer Cell 2019 Sep 16;36(3):237-249.e6. Epub 2019 Aug 22 doi: 10.1016/j.ccell.2019.07.007. PMID: 31447348Free PMC Article
Slack J, Albert MH, Balashov D, Belohradsky BH, Bertaina A, Bleesing J, Booth C, Buechner J, Buckley RH, Ouachée-Chardin M, Deripapa E, Drabko K, Eapen M, Feuchtinger T, Finocchi A, Gaspar HB, Ghosh S, Gillio A, Gonzalez-Granado LI, Grunebaum E, Güngör T, Heilmann C, Helminen M, Higuchi K, Imai K, Kalwak K, Kanazawa N, Karasu G, Kucuk ZY, Laberko A, Lange A, Mahlaoui N, Meisel R, Moshous D, Muramatsu H, Parikh S, Pasic S, Schmid I, Schuetz C, Schulz A, Schultz KR, Shaw PJ, Slatter MA, Sykora KW, Tamura S, Taskinen M, Wawer A, Wolska-Kuśnierz B, Cowan MJ, Fischer A, Gennery AR; Inborn Errors Working Party of the European Society for Blood and Marrow Transplantation and the European Society for Immunodeficiencies; Stem Cell Transplant for Immunodeficiencies in Europe (SCETIDE); Center for International Blood and Marrow Transplant Research; Primary Immunodeficiency Treatment Consortium
J Allergy Clin Immunol 2018 Jan;141(1):322-328.e10. Epub 2017 Apr 7 doi: 10.1016/j.jaci.2017.02.036. PMID: 28392333Free PMC Article

Clinical prediction guides

Gillyard T, Davis J
Int Rev Cell Mol Biol 2021;364:111-137. Epub 2021 Aug 3 doi: 10.1016/bs.ircmb.2021.06.003. PMID: 34507781Free PMC Article
Blasiak J
Int J Mol Sci 2021 Feb 22;22(4) doi: 10.3390/ijms22042167. PMID: 33671579Free PMC Article
Hagiwara Y, Oike T, Niimi A, Yamauchi M, Sato H, Limsirichaikul S, Held KD, Nakano T, Shibata A
J Radiat Res 2019 Jan 1;60(1):69-79. doi: 10.1093/jrr/rry096. PMID: 30476166Free PMC Article
Azeroglu B, Leach DRF
FEBS Lett 2017 Apr;591(8):1101-1113. Epub 2017 Feb 28 doi: 10.1002/1873-3468.12583. PMID: 28155219Free PMC Article
Nahas SA, Gatti RA
Curr Opin Allergy Clin Immunol 2009 Dec;9(6):510-6. doi: 10.1097/ACI.0b013e328332be17. PMID: 19858715

Recent systematic reviews

Lee PP, Woodbine L, Gilmour KC, Bibi S, Cale CM, Amrolia PJ, Veys PA, Davies EG, Jeggo PA, Jones A
Clin Immunol 2013 Dec;149(3):464-74. Epub 2013 Aug 27 doi: 10.1016/j.clim.2013.08.006. PMID: 24230999

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