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DNA Breaks

MedGen UID:
354581
Concept ID:
C1721104
Molecular Function
Synonyms: Break, DNA; Breaks, DNA; DNA Break

Definition

Interruptions in the sugar-phosphate backbone of DNA. [from MeSH]

Professional guidelines

PubMed

Yoon S, Lee BK, Kim KP
Phytomedicine 2023 Dec;121:155120. Epub 2023 Sep 28 doi: 10.1016/j.phymed.2023.155120. PMID: 37806154
Nambiar DK, Mishra D, Singh RP
Oncol Res 2023;31(4):405-421. Epub 2023 Jun 27 doi: 10.32604/or.2023.028310. PMID: 37415740Free PMC Article
Reilly NM, Yard BD, Pittman DL
Methods Mol Biol 2019;1999:3-29. doi: 10.1007/978-1-4939-9500-4_1. PMID: 31127567

Recent clinical studies

Etiology

Templeton CW, Laimins LA
Proc Natl Acad Sci U S A 2023 Aug 29;120(35):e2305907120. Epub 2023 Aug 23 doi: 10.1073/pnas.2305907120. PMID: 37611058Free PMC Article
Wang S, Meyer DH, Schumacher B
Nature 2023 Jan;613(7943):365-374. Epub 2022 Dec 21 doi: 10.1038/s41586-022-05544-w. PMID: 36544019Free PMC Article
Xu Y, Xu D
Essays Biochem 2020 Oct 26;64(5):765-777. doi: 10.1042/EBC20200007. PMID: 32648897
Coughlin SS
Adv Exp Med Biol 2019;1152:9-29. doi: 10.1007/978-3-030-20301-6_2. PMID: 31456177
Cuya SM, Bjornsti MA, van Waardenburg RCAM
Cancer Chemother Pharmacol 2017 Jul;80(1):1-14. Epub 2017 May 20 doi: 10.1007/s00280-017-3334-5. PMID: 28528358Free PMC Article

Diagnosis

Cong K, Cantor SB
Mol Cell 2022 Jul 7;82(13):2363-2369. Epub 2022 May 13 doi: 10.1016/j.molcel.2022.04.023. PMID: 35568026Free PMC Article
Wong N, John S, Nussenzweig A, Canela A
Methods Mol Biol 2021;2153:9-31. doi: 10.1007/978-1-0716-0644-5_2. PMID: 32840769
Chang HHY, Pannunzio NR, Adachi N, Lieber MR
Nat Rev Mol Cell Biol 2017 Aug;18(8):495-506. Epub 2017 May 17 doi: 10.1038/nrm.2017.48. PMID: 28512351Free PMC Article
Lieber MR
Annu Rev Biochem 2010;79:181-211. doi: 10.1146/annurev.biochem.052308.093131. PMID: 20192759Free PMC Article
Collins AR
Mol Biotechnol 2004 Mar;26(3):249-61. doi: 10.1385/MB:26:3:249. PMID: 15004294

Therapy

Cong K, Cantor SB
Mol Cell 2022 Jul 7;82(13):2363-2369. Epub 2022 May 13 doi: 10.1016/j.molcel.2022.04.023. PMID: 35568026Free PMC Article
Mirzayans R, Murray D
Int J Mol Sci 2020 Nov 29;21(23) doi: 10.3390/ijms21239090. PMID: 33260475Free PMC Article
Goldenberg DM, Sharkey RM
Expert Opin Biol Ther 2020 Aug;20(8):871-885. Epub 2020 May 12 doi: 10.1080/14712598.2020.1757067. PMID: 32301634
Goldenberg DM, Sharkey RM
MAbs 2019 Aug/Sep;11(6):987-995. Epub 2019 Jul 18 doi: 10.1080/19420862.2019.1632115. PMID: 31208270Free PMC Article
Cardillo TM, Govindan SV, Sharkey RM, Trisal P, Arrojo R, Liu D, Rossi EA, Chang CH, Goldenberg DM
Bioconjug Chem 2015 May 20;26(5):919-31. Epub 2015 May 8 doi: 10.1021/acs.bioconjchem.5b00223. PMID: 25915780

Prognosis

Nikjoo H, Rahmanian S, Taleei R
Prog Biophys Mol Biol 2024 Aug;190:1-18. Epub 2024 May 14 doi: 10.1016/j.pbiomolbio.2024.05.002. PMID: 38754703
Bakr A, Della Corte G, Veselinov O, Kelekçi S, Chen MM, Lin YY, Sigismondo G, Iacovone M, Cross A, Syed R, Jeong Y, Sollier E, Liu CS, Lutsik P, Krijgsveld J, Weichenhan D, Plass C, Popanda O, Schmezer P
Nucleic Acids Res 2024 Jun 10;52(10):5698-5719. doi: 10.1093/nar/gkae233. PMID: 38587186Free PMC Article
Lagunas-Rangel FA
Exp Hematol 2024 Apr;132:104172. Epub 2024 Feb 1 doi: 10.1016/j.exphem.2024.104172. PMID: 38309572
Genetta TL, Hurwitz JC, Clark EA, Herold BT, Khalil S, Abbas T, Larner JM
Nucleic Acids Res 2023 Oct 13;51(18):9863-9879. doi: 10.1093/nar/gkad723. PMID: 37665026Free PMC Article
Chen Y, Zhao Y, Yang X, Ren X, Huang S, Gong S, Tan X, Li J, He S, Li Y, Hong X, Li Q, Ding C, Fang X, Ma J, Liu N
Nat Commun 2022 Jan 25;13(1):501. doi: 10.1038/s41467-022-28158-2. PMID: 35079021Free PMC Article

Clinical prediction guides

Nikjoo H, Rahmanian S, Taleei R
Prog Biophys Mol Biol 2024 Aug;190:1-18. Epub 2024 May 14 doi: 10.1016/j.pbiomolbio.2024.05.002. PMID: 38754703
Diabate M, Islam MM, Nagy G, Banerjee T, Dhar S, Smith N, Adamovich AI, Starita LM, Parvin JD
PLoS Genet 2023 Aug;19(8):e1010739. Epub 2023 Aug 14 doi: 10.1371/journal.pgen.1010739. PMID: 37578980Free PMC Article
Karavolos S
Semin Reprod Med 2021 Nov;39(5-06):194-199. Epub 2021 Oct 18 doi: 10.1055/s-0041-1736261. PMID: 34662912
Mirzayans R, Murray D
Int J Mol Sci 2020 Nov 29;21(23) doi: 10.3390/ijms21239090. PMID: 33260475Free PMC Article
Collins AR
Mol Biotechnol 2004 Mar;26(3):249-61. doi: 10.1385/MB:26:3:249. PMID: 15004294

Recent systematic reviews

Stastna B, Dolezalova T, Matejkova K, Nemcova B, Zemankova P, Janatova M, Kleiblova P, Soukupova J, Kleibl Z
Int J Cancer 2024 Nov 1;155(9):1604-1615. Epub 2024 Jun 26 doi: 10.1002/ijc.35066. PMID: 38924040
Rivero Belenchón I, Congregado Ruiz CB, Saez C, Osman García I, Medina López RA
Int J Mol Sci 2023 Aug 19;24(16) doi: 10.3390/ijms241612978. PMID: 37629155Free PMC Article
Simon L, Emery B, Carrell DT
Adv Exp Med Biol 2019;1166:87-105. doi: 10.1007/978-3-030-21664-1_6. PMID: 31301048
Ricci E, Viganò P, Cipriani S, Somigliana E, Chiaffarino F, Bulfoni A, Parazzini F
Nutr J 2017 Jun 24;16(1):37. doi: 10.1186/s12937-017-0257-2. PMID: 28646871Free PMC Article
Jacobs DI, Bracken MB
BMC Med Genet 2012 Oct 26;13:97. doi: 10.1186/1471-2350-13-97. PMID: 23101479Free PMC Article

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