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FIGO Grade 2 Endometrial Mucinous Adenocarcinoma

MedGen UID:
268811
•Concept ID:
C1512253
•
Neoplastic Process

Definition

A primary mucinous adenocarcinoma of the endometrium that contains 6-50% non-squamous solid areas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFIGO Grade 2 Endometrial Mucinous Adenocarcinoma

Professional guidelines

PubMed

Compliance with adjuvant treatment guidelines in endometrial cancer: room for improvement in high risk patients.
Eggink FA, Mom CH, Boll D, Ezendam NPM, Kruitwagen RFPM, Pijnenborg JMA, van der Aa MA, Nijman HW
Gynecol Oncol 2017 Aug;146(2):380-385. Epub 2017 May 25 doi: 10.1016/j.ygyno.2017.05.025. PMID: 28552255
Nomogram for suboptimal cytoreduction at primary surgery for advanced stage ovarian cancer.
Gerestein CG, Eijkemans MJ, Bakker J, Elgersma OE, van der Burg ME, Kooi GS, Burger CW
Anticancer Res 2011 Nov;31(11):4043-9. PMID: 22110240

Recent clinical studies

Etiology

Ovarian preservation in gynecologic oncology: current indications and techniques.
Bizzarri N, Pavone M, Loverro M, Querleu D, Fagotti A, Scambia G
Curr Opin Oncol 2023 Sep 1;35(5):401-411. Epub 2023 Jul 13 doi: 10.1097/CCO.0000000000000969. PMID: 37498120
miR-497-5p Decreased Expression Associated with High-Risk Endometrial Cancer.
Fridrichova I, Kalinkova L, Karhanek M, Smolkova B, Machalekova K, Wachsmannova L, Nikolaieva N, Kajo K
Int J Mol Sci 2020 Dec 24;22(1) doi: 10.3390/ijms22010127. PMID: 33374439Free PMC Article
Histological grading of ovarian mucinous carcinoma - an outcome-based analysis of traditional and novel systems.
Busca A, Nofech-Mozes S, Olkhov-Mitsel E, Gien LT, Bassiouny D, Mirkovic J, Djordjevic B, Parra-Herran C
Histopathology 2020 Jul;77(1):26-34. Epub 2020 May 29 doi: 10.1111/his.14039. PMID: 31782197
Lymph Node Involvement Pattern and Survival Differences of FIGO IIIC and FIGO IIIA1 Ovarian Cancer Patients After Primary Complete Tumor Debulking Surgery: A 10-Year Retrospective Analysis of the Tumor Bank Ovarian Cancer Network.
Gasimli K, Braicu EI, Nassir M, Richter R, Babayeva A, Chekerov R, Darb-Esfahani S, Sehouli J, Muallem MZ
Ann Surg Oncol 2016 Apr;23(4):1279-86. Epub 2016 Jan 29 doi: 10.1245/s10434-015-4959-4. PMID: 26832880
Mucinous adenocarcinoma of the endometrium: case series and review of the literature.
Jalloul RJ, Elshaikh MA, Ali-Fehmi R, Haley MM, Yoon J, Mahan M, Munkarah AR
Int J Gynecol Cancer 2012 Jun;22(5):812-8. doi: 10.1097/IGC.0b013e31824aa877. PMID: 22569105

Diagnosis

Ovarian preservation in gynecologic oncology: current indications and techniques.
Bizzarri N, Pavone M, Loverro M, Querleu D, Fagotti A, Scambia G
Curr Opin Oncol 2023 Sep 1;35(5):401-411. Epub 2023 Jul 13 doi: 10.1097/CCO.0000000000000969. PMID: 37498120
Low grade endometrial endometrioid adenocarcinoma: A review and update with emphasis on morphologic variants, mimics, immunohistochemical and molecular features.
Lucas E, Carrick KS
Semin Diagn Pathol 2022 May;39(3):159-175. Epub 2022 Feb 11 doi: 10.1053/j.semdp.2022.02.002. PMID: 35397943
miR-497-5p Decreased Expression Associated with High-Risk Endometrial Cancer.
Fridrichova I, Kalinkova L, Karhanek M, Smolkova B, Machalekova K, Wachsmannova L, Nikolaieva N, Kajo K
Int J Mol Sci 2020 Dec 24;22(1) doi: 10.3390/ijms22010127. PMID: 33374439Free PMC Article
Mucinous adenocarcinoma of the endometrium: case series and review of the literature.
Jalloul RJ, Elshaikh MA, Ali-Fehmi R, Haley MM, Yoon J, Mahan M, Munkarah AR
Int J Gynecol Cancer 2012 Jun;22(5):812-8. doi: 10.1097/IGC.0b013e31824aa877. PMID: 22569105
The CYP1A1 Ile462Val polymorphism and platinum resistance of epithelial ovarian neoplasms.
Heubner M, Wimberger P, Riemann K, Kasimir-Bauer S, Otterbach F, Kimmig R, Siffert W
Oncol Res 2010;18(7):343-7. doi: 10.3727/096504010x12626118079903. PMID: 20377136

Therapy

Compliance with adjuvant treatment guidelines in endometrial cancer: room for improvement in high risk patients.
Eggink FA, Mom CH, Boll D, Ezendam NPM, Kruitwagen RFPM, Pijnenborg JMA, van der Aa MA, Nijman HW
Gynecol Oncol 2017 Aug;146(2):380-385. Epub 2017 May 25 doi: 10.1016/j.ygyno.2017.05.025. PMID: 28552255
The role of omentectomy and random peritoneal biopsies as part of comprehensive surgical staging in apparent early-stage epithelial ovarian cancer.
Lee JY, Kim HS, Chung HH, Kim JW, Park NH, Song YS
Ann Surg Oncol 2014 Aug;21(8):2762-6. Epub 2014 Apr 28 doi: 10.1245/s10434-014-3648-z. PMID: 24770785
Impact of complete cytoreduction leaving no gross residual disease associated with radical cytoreductive surgical procedures on survival in advanced ovarian cancer.
Chang SJ, Bristow RE, Ryu HS
Ann Surg Oncol 2012 Dec;19(13):4059-67. Epub 2012 Jul 6 doi: 10.1245/s10434-012-2446-8. PMID: 22766983
The CYP1A1 Ile462Val polymorphism and platinum resistance of epithelial ovarian neoplasms.
Heubner M, Wimberger P, Riemann K, Kasimir-Bauer S, Otterbach F, Kimmig R, Siffert W
Oncol Res 2010;18(7):343-7. doi: 10.3727/096504010x12626118079903. PMID: 20377136
Interferon-gamma in combination with carboplatin and paclitaxel as a safe and effective first-line treatment option for advanced ovarian cancer: results of a phase I/II study.
Marth C, Windbichler GH, Hausmaninger H, Petru E, Estermann K, Pelzer A, Mueller-Holzner E
Int J Gynecol Cancer 2006 Jul-Aug;16(4):1522-8. doi: 10.1111/j.1525-1438.2006.00622.x. PMID: 16884360

Prognosis

miR-497-5p Decreased Expression Associated with High-Risk Endometrial Cancer.
Fridrichova I, Kalinkova L, Karhanek M, Smolkova B, Machalekova K, Wachsmannova L, Nikolaieva N, Kajo K
Int J Mol Sci 2020 Dec 24;22(1) doi: 10.3390/ijms22010127. PMID: 33374439Free PMC Article
Histological grading of ovarian mucinous carcinoma - an outcome-based analysis of traditional and novel systems.
Busca A, Nofech-Mozes S, Olkhov-Mitsel E, Gien LT, Bassiouny D, Mirkovic J, Djordjevic B, Parra-Herran C
Histopathology 2020 Jul;77(1):26-34. Epub 2020 May 29 doi: 10.1111/his.14039. PMID: 31782197
Lymph Node Involvement Pattern and Survival Differences of FIGO IIIC and FIGO IIIA1 Ovarian Cancer Patients After Primary Complete Tumor Debulking Surgery: A 10-Year Retrospective Analysis of the Tumor Bank Ovarian Cancer Network.
Gasimli K, Braicu EI, Nassir M, Richter R, Babayeva A, Chekerov R, Darb-Esfahani S, Sehouli J, Muallem MZ
Ann Surg Oncol 2016 Apr;23(4):1279-86. Epub 2016 Jan 29 doi: 10.1245/s10434-015-4959-4. PMID: 26832880
Differences in Clinical and Biological Features Between Type I and Type II Tumors in FIGO Stages I-II Epithelial Ovarian Carcinoma.
Skirnisdottir I, Seidal T, Åkerud H
Int J Gynecol Cancer 2015 Sep;25(7):1239-47. doi: 10.1097/IGC.0000000000000484. PMID: 26035126Free PMC Article
Mucinous adenocarcinoma of the endometrium: case series and review of the literature.
Jalloul RJ, Elshaikh MA, Ali-Fehmi R, Haley MM, Yoon J, Mahan M, Munkarah AR
Int J Gynecol Cancer 2012 Jun;22(5):812-8. doi: 10.1097/IGC.0b013e31824aa877. PMID: 22569105

Clinical prediction guides

miR-497-5p Decreased Expression Associated with High-Risk Endometrial Cancer.
Fridrichova I, Kalinkova L, Karhanek M, Smolkova B, Machalekova K, Wachsmannova L, Nikolaieva N, Kajo K
Int J Mol Sci 2020 Dec 24;22(1) doi: 10.3390/ijms22010127. PMID: 33374439Free PMC Article
Results of optimal debulking surgery with bowel resection in patients with advanced ovarian cancer.
Derlatka P, Sienko J, Grabowska-Derlatka L, Palczewski P, Danska-Bidzinska A, Bidzinski M, Czajkowski K
World J Surg Oncol 2016 Feb 29;14:58. doi: 10.1186/s12957-016-0800-1. PMID: 26923029Free PMC Article
Laminin C1 expression by uterine carcinoma cells is associated with tumor progression.
Kashima H, Wu RC, Wang Y, Sinno AK, Miyamoto T, Shiozawa T, Wang TL, Fader AN, Shih IeM
Gynecol Oncol 2015 Nov;139(2):338-44. Epub 2015 Sep 3 doi: 10.1016/j.ygyno.2015.08.025. PMID: 26343160Free PMC Article
Differences in Clinical and Biological Features Between Type I and Type II Tumors in FIGO Stages I-II Epithelial Ovarian Carcinoma.
Skirnisdottir I, Seidal T, Åkerud H
Int J Gynecol Cancer 2015 Sep;25(7):1239-47. doi: 10.1097/IGC.0000000000000484. PMID: 26035126Free PMC Article
The CYP1A1 Ile462Val polymorphism and platinum resistance of epithelial ovarian neoplasms.
Heubner M, Wimberger P, Riemann K, Kasimir-Bauer S, Otterbach F, Kimmig R, Siffert W
Oncol Res 2010;18(7):343-7. doi: 10.3727/096504010x12626118079903. PMID: 20377136

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