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High Grade Prostatic Intraepithelial Neoplasia, Foamy Variant

MedGen UID:
268854
•Concept ID:
C1512435
•
Neoplastic Process
Synonym: High-Grade Prostatic Intraepithelial Neoplasia, Foamy Variant

Definition

High grade prostatic intraepithelial neoplasia characterized by the presence of large glands with papillary infoldings that contain cells with xanthomatous cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh Grade Prostatic Intraepithelial Neoplasia, Foamy Variant

Recent clinical studies

Diagnosis

Rare histological patterns of prostatic ductal adenocarcinoma.
Lee TK, Miller JS, Epstein JI
Pathology 2010 Jun;42(4):319-24. doi: 10.3109/00313021003767314. PMID: 20438402
High-grade foamy gland prostatic adenocarcinoma on biopsy or transurethral resection: a morphologic study of 55 cases.
Zhao J, Epstein JI
Am J Surg Pathol 2009 Apr;33(4):583-90. doi: 10.1097/PAS.0b013e31818a5c6c. PMID: 19033862
Immunohistochemistry in diagnostic surgical pathology of the prostate.
Hameed O, Humphrey PA
Semin Diagn Pathol 2005 Feb;22(1):88-104. doi: 10.1053/j.semdp.2005.11.001. PMID: 16512601
Diagnosis and reporting of limited adenocarcinoma of the prostate on needle biopsy.
Epstein JI
Mod Pathol 2004 Mar;17(3):307-15. doi: 10.1038/modpathol.3800050. PMID: 14739905
Expression and diagnostic utility of alpha-methylacyl-CoA-racemase (P504S) in foamy gland and pseudohyperplastic prostate cancer.
Zhou M, Jiang Z, Epstein JI
Am J Surg Pathol 2003 Jun;27(6):772-8. doi: 10.1097/00000478-200306000-00007. PMID: 12766580

Prognosis

Expression and significance of cortactin and HDAC6 in human prostatic foamy gland carcinoma.
Hou H, Zhao L, Chen W, Li J, Zuo Q, Zhang G, Zhang X, Li X
Int J Exp Pathol 2015 Aug;96(4):248-54. Epub 2015 Jun 26 doi: 10.1111/iep.12132. PMID: 26112958Free PMC Article
Diagnosis and reporting of limited adenocarcinoma of the prostate on needle biopsy.
Epstein JI
Mod Pathol 2004 Mar;17(3):307-15. doi: 10.1038/modpathol.3800050. PMID: 14739905

Clinical prediction guides

High-grade foamy gland prostatic adenocarcinoma on biopsy or transurethral resection: a morphologic study of 55 cases.
Zhao J, Epstein JI
Am J Surg Pathol 2009 Apr;33(4):583-90. doi: 10.1097/PAS.0b013e31818a5c6c. PMID: 19033862

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