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Adenocarcinoma in situ

MedGen UID:
87203
•Concept ID:
C0334276
•
Neoplastic Process
Synonyms: Adenocarcinoma in Situ; Adenocarcinoma in Situs; Adenocarcinoma, Intraepithelial; Adenocarcinoma, Preinvasive; Adenocarcinomas, Intraepithelial; Adenocarcinomas, Preinvasive; in Situ, Adenocarcinoma; Intraepithelial Adenocarcinoma; Intraepithelial Adenocarcinomas; Preinvasive Adenocarcinoma; Preinvasive Adenocarcinomas; Situ, Adenocarcinoma in
SNOMED CT: AIS - Adenocarcinoma in situ (51642000); Adenocarcinoma in situ (51642000)
 
Monarch Initiative: MONDO:0003218

Definition

A lesion in which the normally situated glands are partially or completely replaced by atypical cells with malignant characteristics. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoma in situ

Professional guidelines

PubMed

Risk Estimates Supporting the 2019 ASCCP Risk-Based Management Consensus Guidelines.
Egemen D, Cheung LC, Chen X, Demarco M, Perkins RB, Kinney W, Poitras N, Befano B, Locke A, Guido RS, Wiser AL, Gage JC, Katki HA, Wentzensen N, Castle PE, Schiffman M, Lorey TS
J Low Genit Tract Dis 2020 Apr;24(2):132-143. doi: 10.1097/LGT.0000000000000529. PMID: 32243308Free PMC Article
Diagnosis and Management of Adenocarcinoma in Situ: A Society of Gynecologic Oncology Evidence-Based Review and Recommendations.
Teoh D, Musa F, Salani R, Huh W, Jimenez E
Obstet Gynecol 2020 Apr;135(4):869-878. doi: 10.1097/AOG.0000000000003761. PMID: 32168211Free PMC Article
Minimizing over-diagnosis in lung cancer screening.
Grannis FW Jr
J Surg Oncol 2013 Oct;108(5):289-93. Epub 2013 Aug 26 doi: 10.1002/jso.23400. PMID: 24037999

Recent clinical studies

Therapy

Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors.
Arbyn M, Xu L, Simoens C, Martin-Hirsch PP
Cochrane Database Syst Rev 2018 May 9;5(5):CD009069. doi: 10.1002/14651858.CD009069.pub3. PMID: 29740819Free PMC Article
Lung cancer staging: a concise update.
Rami-Porta R, Call S, Dooms C, Obiols C, Sánchez M, Travis WD, Vollmer I
Eur Respir J 2018 May;51(5) Epub 2018 May 17 doi: 10.1183/13993003.00190-2018. PMID: 29700105
Cytology versus HPV testing for cervical cancer screening in the general population.
Koliopoulos G, Nyaga VN, Santesso N, Bryant A, Martin-Hirsch PP, Mustafa RA, Schünemann H, Paraskevaidis E, Arbyn M
Cochrane Database Syst Rev 2017 Aug 10;8(8):CD008587. doi: 10.1002/14651858.CD008587.pub2. PMID: 28796882Free PMC Article
Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer.
Saloman JL, Albers KM, Li D, Hartman DJ, Crawford HC, Muha EA, Rhim AD, Davis BM
Proc Natl Acad Sci U S A 2016 Mar 15;113(11):3078-83. Epub 2016 Feb 29 doi: 10.1073/pnas.1512603113. PMID: 26929329Free PMC Article
Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions.
FUTURE II Study Group
N Engl J Med 2007 May 10;356(19):1915-27. doi: 10.1056/NEJMoa061741. PMID: 17494925

Prognosis

Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma.
Nie M, Yao K, Zhu X, Chen N, Xiao N, Wang Y, Peng B, Yao L, Li P, Zhang P, Hu Z
Nat Commun 2021 Nov 10;12(1):6479. doi: 10.1038/s41467-021-26685-y. PMID: 34759281Free PMC Article
Long-Term Prognosis of Patients With Resected Adenocarcinoma In Situ and Minimally Invasive Adenocarcinoma of the Lung.
Yotsukura M, Asamura H, Motoi N, Kashima J, Yoshida Y, Nakagawa K, Shiraishi K, Kohno T, Yatabe Y, Watanabe SI
J Thorac Oncol 2021 Aug;16(8):1312-1320. Epub 2021 Apr 27 doi: 10.1016/j.jtho.2021.04.007. PMID: 33915249
Adenocarcinoma classification: patterns and prognosis.
Kuhn E, Morbini P, Cancellieri A, Damiani S, Cavazza A, Comin CE
Pathologica 2018 Mar;110(1):5-11. PMID: 30259909
Lung cancer staging: a concise update.
Rami-Porta R, Call S, Dooms C, Obiols C, Sánchez M, Travis WD, Vollmer I
Eur Respir J 2018 May;51(5) Epub 2018 May 17 doi: 10.1183/13993003.00190-2018. PMID: 29700105
The IASLC Lung Cancer Staging Project: Proposals for Coding T Categories for Subsolid Nodules and Assessment of Tumor Size in Part-Solid Tumors in the Forthcoming Eighth Edition of the TNM Classification of Lung Cancer.
Travis WD, Asamura H, Bankier AA, Beasley MB, Detterbeck F, Flieder DB, Goo JM, MacMahon H, Naidich D, Nicholson AG, Powell CA, Prokop M, Rami-Porta R, Rusch V, van Schil P, Yatabe Y; International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and Advisory Board Members
J Thorac Oncol 2016 Aug;11(8):1204-1223. Epub 2016 Apr 21 doi: 10.1016/j.jtho.2016.03.025. PMID: 27107787

Clinical prediction guides

Low-dose CT screening among never-smokers with or without a family history of lung cancer in Taiwan: a prospective cohort study.
Chang GC, Chiu CH, Yu CJ, Chang YC, Chang YH, Hsu KH, Wu YC, Chen CY, Hsu HH, Wu MT, Yang CT, Chong IW, Lin YC, Hsia TC, Lin MC, Su WC, Lin CB, Lee KY, Wei YF, Lan GY, Chan WP, Wang KL, Wu MH, Tsai HH, Chian CF, Lai RS, Shih JY, Wang CL, Hsu JS, Chen KC, Chen CK, Hsia JY, Peng CK, Tang EK, Hsu CL, Chou TY, Shen WC, Tsai YH, Tsai CM, Chen YM, Lee YC, Chen HY, Yu SL, Chen CJ, Wan YL, Hsiung CA, Yang PC; TALENT Investigators
Lancet Respir Med 2024 Feb;12(2):141-152. Epub 2023 Nov 29 doi: 10.1016/S2213-2600(23)00338-7. PMID: 38042167
Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma.
Nie M, Yao K, Zhu X, Chen N, Xiao N, Wang Y, Peng B, Yao L, Li P, Zhang P, Hu Z
Nat Commun 2021 Nov 10;12(1):6479. doi: 10.1038/s41467-021-26685-y. PMID: 34759281Free PMC Article
Long-Term Prognosis of Patients With Resected Adenocarcinoma In Situ and Minimally Invasive Adenocarcinoma of the Lung.
Yotsukura M, Asamura H, Motoi N, Kashima J, Yoshida Y, Nakagawa K, Shiraishi K, Kohno T, Yatabe Y, Watanabe SI
J Thorac Oncol 2021 Aug;16(8):1312-1320. Epub 2021 Apr 27 doi: 10.1016/j.jtho.2021.04.007. PMID: 33915249
Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors.
Arbyn M, Xu L, Simoens C, Martin-Hirsch PP
Cochrane Database Syst Rev 2018 May 9;5(5):CD009069. doi: 10.1002/14651858.CD009069.pub3. PMID: 29740819Free PMC Article
The IASLC Lung Cancer Staging Project: Proposals for Coding T Categories for Subsolid Nodules and Assessment of Tumor Size in Part-Solid Tumors in the Forthcoming Eighth Edition of the TNM Classification of Lung Cancer.
Travis WD, Asamura H, Bankier AA, Beasley MB, Detterbeck F, Flieder DB, Goo JM, MacMahon H, Naidich D, Nicholson AG, Powell CA, Prokop M, Rami-Porta R, Rusch V, van Schil P, Yatabe Y; International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and Advisory Board Members
J Thorac Oncol 2016 Aug;11(8):1204-1223. Epub 2016 Apr 21 doi: 10.1016/j.jtho.2016.03.025. PMID: 27107787

Recent systematic reviews

Comparison of different human papillomavirus (HPV) vaccine types and dose schedules for prevention of HPV-related disease in females and males.
Bergman H, Buckley BS, Villanueva G, Petkovic J, Garritty C, Lutje V, Riveros-Balta AX, Low N, Henschke N
Cochrane Database Syst Rev 2019 Nov 22;2019(11) doi: 10.1002/14651858.CD013479. PMID: 31755549Free PMC Article
Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors.
Arbyn M, Xu L, Simoens C, Martin-Hirsch PP
Cochrane Database Syst Rev 2018 May 9;5(5):CD009069. doi: 10.1002/14651858.CD009069.pub3. PMID: 29740819Free PMC Article
Cytology versus HPV testing for cervical cancer screening in the general population.
Koliopoulos G, Nyaga VN, Santesso N, Bryant A, Martin-Hirsch PP, Mustafa RA, Schünemann H, Paraskevaidis E, Arbyn M
Cochrane Database Syst Rev 2017 Aug 10;8(8):CD008587. doi: 10.1002/14651858.CD008587.pub2. PMID: 28796882Free PMC Article
Adenocarcinoma in situ of the uterine cervix--a systematic review.
Baalbergen A, Helmerhorst TJ
Int J Gynecol Cancer 2014 Nov;24(9):1543-8. doi: 10.1097/IGC.0000000000000260. PMID: 25238167
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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