U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Adenocarcinoma in situ

MedGen UID:
87203
Concept ID:
C0334276
Neoplastic Process
Synonyms: Adenocarcinoma in Situ; Adenocarcinoma in Situs; Adenocarcinoma, Intraepithelial; Adenocarcinoma, Preinvasive; Adenocarcinomas, Intraepithelial; Adenocarcinomas, Preinvasive; in Situ, Adenocarcinoma; Intraepithelial Adenocarcinoma; Intraepithelial Adenocarcinomas; Preinvasive Adenocarcinoma; Preinvasive Adenocarcinomas; Situ, Adenocarcinoma in
SNOMED CT: AIS - Adenocarcinoma in situ (51642000); Adenocarcinoma in situ (51642000)
 
Monarch Initiative: MONDO:0003218

Definition

A lesion in which the normally situated glands are partially or completely replaced by atypical cells with malignant characteristics. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoma in situ

Professional guidelines

PubMed

Egemen D, Cheung LC, Chen X, Demarco M, Perkins RB, Kinney W, Poitras N, Befano B, Locke A, Guido RS, Wiser AL, Gage JC, Katki HA, Wentzensen N, Castle PE, Schiffman M, Lorey TS
J Low Genit Tract Dis 2020 Apr;24(2):132-143. doi: 10.1097/LGT.0000000000000529. PMID: 32243308Free PMC Article
Teoh D, Musa F, Salani R, Huh W, Jimenez E
Obstet Gynecol 2020 Apr;135(4):869-878. doi: 10.1097/AOG.0000000000003761. PMID: 32168211Free PMC Article
Grannis FW Jr
J Surg Oncol 2013 Oct;108(5):289-93. Epub 2013 Aug 26 doi: 10.1002/jso.23400. PMID: 24037999

Recent clinical studies

Etiology

Kou J, Gu X, Kang L
Comput Math Methods Med 2022;2022:7267036. Epub 2022 Jul 26 doi: 10.1155/2022/7267036. PMID: 35928980Free PMC Article
Yotsukura M, Asamura H, Motoi N, Kashima J, Yoshida Y, Nakagawa K, Shiraishi K, Kohno T, Yatabe Y, Watanabe SI
J Thorac Oncol 2021 Aug;16(8):1312-1320. Epub 2021 Apr 27 doi: 10.1016/j.jtho.2021.04.007. PMID: 33915249
Teoh D, Musa F, Salani R, Huh W, Jimenez E
Obstet Gynecol 2020 Apr;135(4):869-878. doi: 10.1097/AOG.0000000000003761. PMID: 32168211Free PMC Article
Mase VJ Jr, Detterbeck FC
Clin Chest Med 2020 Mar;41(1):99-113. doi: 10.1016/j.ccm.2019.11.004. PMID: 32008632
Chen H, Carrot-Zhang J, Zhao Y, Hu H, Freeman SS, Yu S, Ha G, Taylor AM, Berger AC, Westlake L, Zheng Y, Zhang J, Ramachandran A, Zheng Q, Pan Y, Zheng D, Zheng S, Cheng C, Kuang M, Zhou X, Zhang Y, Li H, Ye T, Ma Y, Gao Z, Tao X, Han H, Shang J, Yu Y, Bao D, Huang Y, Li X, Zhang Y, Xiang J, Sun Y, Li Y, Cherniack AD, Campbell JD, Shi L, Meyerson M
Nat Commun 2019 Nov 29;10(1):5472. doi: 10.1038/s41467-019-13460-3. PMID: 31784532Free PMC Article

Diagnosis

Teoh D, Musa F, Salani R, Huh W, Jimenez E
Obstet Gynecol 2020 Apr;135(4):869-878. doi: 10.1097/AOG.0000000000003761. PMID: 32168211Free PMC Article
Mase VJ Jr, Detterbeck FC
Clin Chest Med 2020 Mar;41(1):99-113. doi: 10.1016/j.ccm.2019.11.004. PMID: 32008632
Feng SH, Yang ST
Diagn Interv Radiol 2019 Jul;25(4):270-279. doi: 10.5152/dir.2019.18458. PMID: 31295144Free PMC Article
Travis WD, Asamura H, Bankier AA, Beasley MB, Detterbeck F, Flieder DB, Goo JM, MacMahon H, Naidich D, Nicholson AG, Powell CA, Prokop M, Rami-Porta R, Rusch V, van Schil P, Yatabe Y; International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and Advisory Board Members
J Thorac Oncol 2016 Aug;11(8):1204-1223. Epub 2016 Apr 21 doi: 10.1016/j.jtho.2016.03.025. PMID: 27107787
Ronnett BM
Mod Pathol 2016 Jan;29 Suppl 1:S12-28. doi: 10.1038/modpathol.2015.131. PMID: 26715171

Therapy

Bergman H, Buckley BS, Villanueva G, Petkovic J, Garritty C, Lutje V, Riveros-Balta AX, Low N, Henschke N
Cochrane Database Syst Rev 2019 Nov 22;2019(11) doi: 10.1002/14651858.CD013479. PMID: 31755549Free PMC Article
Arbyn M, Xu L, Simoens C, Martin-Hirsch PP
Cochrane Database Syst Rev 2018 May 9;5(5):CD009069. doi: 10.1002/14651858.CD009069.pub3. PMID: 29740819Free PMC Article
Rami-Porta R, Call S, Dooms C, Obiols C, Sánchez M, Travis WD, Vollmer I
Eur Respir J 2018 May;51(5) Epub 2018 May 17 doi: 10.1183/13993003.00190-2018. PMID: 29700105
Koliopoulos G, Nyaga VN, Santesso N, Bryant A, Martin-Hirsch PP, Mustafa RA, Schünemann H, Paraskevaidis E, Arbyn M
Cochrane Database Syst Rev 2017 Aug 10;8(8):CD008587. doi: 10.1002/14651858.CD008587.pub2. PMID: 28796882Free PMC Article
FUTURE II Study Group
N Engl J Med 2007 May 10;356(19):1915-27. doi: 10.1056/NEJMoa061741. PMID: 17494925

Prognosis

Nie M, Yao K, Zhu X, Chen N, Xiao N, Wang Y, Peng B, Yao L, Li P, Zhang P, Hu Z
Nat Commun 2021 Nov 10;12(1):6479. doi: 10.1038/s41467-021-26685-y. PMID: 34759281Free PMC Article
Yotsukura M, Asamura H, Motoi N, Kashima J, Yoshida Y, Nakagawa K, Shiraishi K, Kohno T, Yatabe Y, Watanabe SI
J Thorac Oncol 2021 Aug;16(8):1312-1320. Epub 2021 Apr 27 doi: 10.1016/j.jtho.2021.04.007. PMID: 33915249
Kuhn E, Morbini P, Cancellieri A, Damiani S, Cavazza A, Comin CE
Pathologica 2018 Mar;110(1):5-11. PMID: 30259909
Rami-Porta R, Call S, Dooms C, Obiols C, Sánchez M, Travis WD, Vollmer I
Eur Respir J 2018 May;51(5) Epub 2018 May 17 doi: 10.1183/13993003.00190-2018. PMID: 29700105
Travis WD, Asamura H, Bankier AA, Beasley MB, Detterbeck F, Flieder DB, Goo JM, MacMahon H, Naidich D, Nicholson AG, Powell CA, Prokop M, Rami-Porta R, Rusch V, van Schil P, Yatabe Y; International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and Advisory Board Members
J Thorac Oncol 2016 Aug;11(8):1204-1223. Epub 2016 Apr 21 doi: 10.1016/j.jtho.2016.03.025. PMID: 27107787

Clinical prediction guides

Nie M, Yao K, Zhu X, Chen N, Xiao N, Wang Y, Peng B, Yao L, Li P, Zhang P, Hu Z
Nat Commun 2021 Nov 10;12(1):6479. doi: 10.1038/s41467-021-26685-y. PMID: 34759281Free PMC Article
Yotsukura M, Asamura H, Motoi N, Kashima J, Yoshida Y, Nakagawa K, Shiraishi K, Kohno T, Yatabe Y, Watanabe SI
J Thorac Oncol 2021 Aug;16(8):1312-1320. Epub 2021 Apr 27 doi: 10.1016/j.jtho.2021.04.007. PMID: 33915249
Bergman H, Buckley BS, Villanueva G, Petkovic J, Garritty C, Lutje V, Riveros-Balta AX, Low N, Henschke N
Cochrane Database Syst Rev 2019 Nov 22;2019(11) doi: 10.1002/14651858.CD013479. PMID: 31755549Free PMC Article
Arbyn M, Xu L, Simoens C, Martin-Hirsch PP
Cochrane Database Syst Rev 2018 May 9;5(5):CD009069. doi: 10.1002/14651858.CD009069.pub3. PMID: 29740819Free PMC Article
Travis WD, Asamura H, Bankier AA, Beasley MB, Detterbeck F, Flieder DB, Goo JM, MacMahon H, Naidich D, Nicholson AG, Powell CA, Prokop M, Rami-Porta R, Rusch V, van Schil P, Yatabe Y; International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and Advisory Board Members
J Thorac Oncol 2016 Aug;11(8):1204-1223. Epub 2016 Apr 21 doi: 10.1016/j.jtho.2016.03.025. PMID: 27107787

Recent systematic reviews

Bergman H, Buckley BS, Villanueva G, Petkovic J, Garritty C, Lutje V, Riveros-Balta AX, Low N, Henschke N
Cochrane Database Syst Rev 2019 Nov 22;2019(11) doi: 10.1002/14651858.CD013479. PMID: 31755549Free PMC Article
Arbyn M, Xu L, Simoens C, Martin-Hirsch PP
Cochrane Database Syst Rev 2018 May 9;5(5):CD009069. doi: 10.1002/14651858.CD009069.pub3. PMID: 29740819Free PMC Article
Koliopoulos G, Nyaga VN, Santesso N, Bryant A, Martin-Hirsch PP, Mustafa RA, Schünemann H, Paraskevaidis E, Arbyn M
Cochrane Database Syst Rev 2017 Aug 10;8(8):CD008587. doi: 10.1002/14651858.CD008587.pub2. PMID: 28796882Free PMC Article
Baalbergen A, Helmerhorst TJ
Int J Gynecol Cancer 2014 Nov;24(9):1543-8. doi: 10.1097/IGC.0000000000000260. PMID: 25238167
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...