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Adenocarcinoma in situ

MedGen UID:
87203
Concept ID:
C0334276
Neoplastic Process
Synonyms: Adenocarcinoma in Situ; Adenocarcinoma in Situs; Adenocarcinoma, Intraepithelial; Adenocarcinoma, Preinvasive; Adenocarcinomas, Intraepithelial; Adenocarcinomas, Preinvasive; in Situ, Adenocarcinoma; Intraepithelial Adenocarcinoma; Intraepithelial Adenocarcinomas; Preinvasive Adenocarcinoma; Preinvasive Adenocarcinomas; Situ, Adenocarcinoma in
SNOMED CT: AIS - Adenocarcinoma in situ (51642000); Adenocarcinoma in situ (51642000)
 
Monarch Initiative: MONDO:0003218

Definition

A lesion in which the normally situated glands are partially or completely replaced by atypical cells with malignant characteristics. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoma in situ

Professional guidelines

PubMed

Egemen D, Cheung LC, Chen X, Demarco M, Perkins RB, Kinney W, Poitras N, Befano B, Locke A, Guido RS, Wiser AL, Gage JC, Katki HA, Wentzensen N, Castle PE, Schiffman M, Lorey TS
J Low Genit Tract Dis 2020 Apr;24(2):132-143. doi: 10.1097/LGT.0000000000000529. PMID: 32243308Free PMC Article
Teoh D, Musa F, Salani R, Huh W, Jimenez E
Obstet Gynecol 2020 Apr;135(4):869-878. doi: 10.1097/AOG.0000000000003761. PMID: 32168211Free PMC Article
Ciavattini A, Giannella L, Delli Carpini G, Tsiroglou D, Sopracordevole F, Chiossi G, Di Giuseppe J; Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV)
Eur J Obstet Gynecol Reprod Biol 2019 Sep;240:273-277. Epub 2019 Jul 20 doi: 10.1016/j.ejogrb.2019.07.014. PMID: 31352128

Recent clinical studies

Etiology

Yotsukura M, Asamura H, Motoi N, Kashima J, Yoshida Y, Nakagawa K, Shiraishi K, Kohno T, Yatabe Y, Watanabe SI
J Thorac Oncol 2021 Aug;16(8):1312-1320. Epub 2021 Apr 27 doi: 10.1016/j.jtho.2021.04.007. PMID: 33915249
Alvarado-Cabrero I, Parra-Herran C, Stolnicu S, Roma A, Oliva E, Malpica A
Int J Gynecol Pathol 2021 Mar 1;40(Suppl 1):S48-S65. doi: 10.1097/PGP.0000000000000735. PMID: 33570863Free PMC Article
Teoh D, Musa F, Salani R, Huh W, Jimenez E
Obstet Gynecol 2020 Apr;135(4):869-878. doi: 10.1097/AOG.0000000000003761. PMID: 32168211Free PMC Article
Chen H, Carrot-Zhang J, Zhao Y, Hu H, Freeman SS, Yu S, Ha G, Taylor AM, Berger AC, Westlake L, Zheng Y, Zhang J, Ramachandran A, Zheng Q, Pan Y, Zheng D, Zheng S, Cheng C, Kuang M, Zhou X, Zhang Y, Li H, Ye T, Ma Y, Gao Z, Tao X, Han H, Shang J, Yu Y, Bao D, Huang Y, Li X, Zhang Y, Xiang J, Sun Y, Li Y, Cherniack AD, Campbell JD, Shi L, Meyerson M
Nat Commun 2019 Nov 29;10(1):5472. doi: 10.1038/s41467-019-13460-3. PMID: 31784532Free PMC Article
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547

Diagnosis

Teoh D, Musa F, Salani R, Huh W, Jimenez E
Obstet Gynecol 2020 Apr;135(4):869-878. doi: 10.1097/AOG.0000000000003761. PMID: 32168211Free PMC Article
Feng SH, Yang ST
Diagn Interv Radiol 2019 Jul;25(4):270-279. doi: 10.5152/dir.2019.18458. PMID: 31295144Free PMC Article
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
Travis WD, Asamura H, Bankier AA, Beasley MB, Detterbeck F, Flieder DB, Goo JM, MacMahon H, Naidich D, Nicholson AG, Powell CA, Prokop M, Rami-Porta R, Rusch V, van Schil P, Yatabe Y; International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and Advisory Board Members
J Thorac Oncol 2016 Aug;11(8):1204-1223. Epub 2016 Apr 21 doi: 10.1016/j.jtho.2016.03.025. PMID: 27107787
Yeh IT, LiVolsi VA, Noumoff JS
Pathol Res Pract 1991 Mar;187(2-3):129-44. doi: 10.1016/S0344-0338(11)80763-6. PMID: 2067992

Therapy

Arbyn M, Xu L, Simoens C, Martin-Hirsch PP
Cochrane Database Syst Rev 2018 May 9;5(5):CD009069. doi: 10.1002/14651858.CD009069.pub3. PMID: 29740819Free PMC Article
Rami-Porta R, Call S, Dooms C, Obiols C, Sánchez M, Travis WD, Vollmer I
Eur Respir J 2018 May;51(5) Epub 2018 May 17 doi: 10.1183/13993003.00190-2018. PMID: 29700105
Koliopoulos G, Nyaga VN, Santesso N, Bryant A, Martin-Hirsch PP, Mustafa RA, Schünemann H, Paraskevaidis E, Arbyn M
Cochrane Database Syst Rev 2017 Aug 10;8(8):CD008587. doi: 10.1002/14651858.CD008587.pub2. PMID: 28796882Free PMC Article
Harper DM, DeMars LR
Gynecol Oncol 2017 Jul;146(1):196-204. Epub 2017 Apr 22 doi: 10.1016/j.ygyno.2017.04.004. PMID: 28442134
FUTURE II Study Group
N Engl J Med 2007 May 10;356(19):1915-27. doi: 10.1056/NEJMoa061741. PMID: 17494925

Prognosis

Nie M, Yao K, Zhu X, Chen N, Xiao N, Wang Y, Peng B, Yao L, Li P, Zhang P, Hu Z
Nat Commun 2021 Nov 10;12(1):6479. doi: 10.1038/s41467-021-26685-y. PMID: 34759281Free PMC Article
Yotsukura M, Asamura H, Motoi N, Kashima J, Yoshida Y, Nakagawa K, Shiraishi K, Kohno T, Yatabe Y, Watanabe SI
J Thorac Oncol 2021 Aug;16(8):1312-1320. Epub 2021 Apr 27 doi: 10.1016/j.jtho.2021.04.007. PMID: 33915249
Alvarado-Cabrero I, Parra-Herran C, Stolnicu S, Roma A, Oliva E, Malpica A
Int J Gynecol Pathol 2021 Mar 1;40(Suppl 1):S48-S65. doi: 10.1097/PGP.0000000000000735. PMID: 33570863Free PMC Article
Kuhn E, Morbini P, Cancellieri A, Damiani S, Cavazza A, Comin CE
Pathologica 2018 Mar;110(1):5-11. PMID: 30259909
Rami-Porta R, Call S, Dooms C, Obiols C, Sánchez M, Travis WD, Vollmer I
Eur Respir J 2018 May;51(5) Epub 2018 May 17 doi: 10.1183/13993003.00190-2018. PMID: 29700105

Clinical prediction guides

Nie M, Yao K, Zhu X, Chen N, Xiao N, Wang Y, Peng B, Yao L, Li P, Zhang P, Hu Z
Nat Commun 2021 Nov 10;12(1):6479. doi: 10.1038/s41467-021-26685-y. PMID: 34759281Free PMC Article
Yotsukura M, Asamura H, Motoi N, Kashima J, Yoshida Y, Nakagawa K, Shiraishi K, Kohno T, Yatabe Y, Watanabe SI
J Thorac Oncol 2021 Aug;16(8):1312-1320. Epub 2021 Apr 27 doi: 10.1016/j.jtho.2021.04.007. PMID: 33915249
Alvarado-Cabrero I, Parra-Herran C, Stolnicu S, Roma A, Oliva E, Malpica A
Int J Gynecol Pathol 2021 Mar 1;40(Suppl 1):S48-S65. doi: 10.1097/PGP.0000000000000735. PMID: 33570863Free PMC Article
Arbyn M, Xu L, Simoens C, Martin-Hirsch PP
Cochrane Database Syst Rev 2018 May 9;5(5):CD009069. doi: 10.1002/14651858.CD009069.pub3. PMID: 29740819Free PMC Article
Travis WD, Asamura H, Bankier AA, Beasley MB, Detterbeck F, Flieder DB, Goo JM, MacMahon H, Naidich D, Nicholson AG, Powell CA, Prokop M, Rami-Porta R, Rusch V, van Schil P, Yatabe Y; International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and Advisory Board Members
J Thorac Oncol 2016 Aug;11(8):1204-1223. Epub 2016 Apr 21 doi: 10.1016/j.jtho.2016.03.025. PMID: 27107787

Recent systematic reviews

Bogaerts JMA, Steenbeek MP, van Bommel MHD, Bulten J, van der Laak JAWM, de Hullu JA, Simons M
Virchows Arch 2022 Apr;480(4):725-737. Epub 2021 Dec 1 doi: 10.1007/s00428-021-03244-w. PMID: 34850262Free PMC Article
Bergman H, Buckley BS, Villanueva G, Petkovic J, Garritty C, Lutje V, Riveros-Balta AX, Low N, Henschke N
Cochrane Database Syst Rev 2019 Nov 22;2019(11) doi: 10.1002/14651858.CD013479. PMID: 31755549Free PMC Article
Arbyn M, Xu L, Simoens C, Martin-Hirsch PP
Cochrane Database Syst Rev 2018 May 9;5(5):CD009069. doi: 10.1002/14651858.CD009069.pub3. PMID: 29740819Free PMC Article
Koliopoulos G, Nyaga VN, Santesso N, Bryant A, Martin-Hirsch PP, Mustafa RA, Schünemann H, Paraskevaidis E, Arbyn M
Cochrane Database Syst Rev 2017 Aug 10;8(8):CD008587. doi: 10.1002/14651858.CD008587.pub2. PMID: 28796882Free PMC Article
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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