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Mammary Tumorigenesis

MedGen UID:
269149
•Concept ID:
C1512981
•
Neoplastic Process

Definition

Production of a new growth or growths in the mammary gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMammary Tumorigenesis

Professional guidelines

PubMed

Toxicity endpoint selections for a simazine risk assessment.
Silva M, Iyer P
Birth Defects Res B Dev Reprod Toxicol 2014 Aug;101(4):308-24. Epub 2014 Jul 30 doi: 10.1002/bdrb.21114. PMID: 25078261
Prevention and treatment of experimental estrogen receptor-negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl Ester and the rexinoid LG100268.
Liby K, Risingsong R, Royce DB, Williams CR, Yore MM, Honda T, Gribble GW, Lamph WW, Vannini N, Sogno I, Albini A, Sporn MB
Clin Cancer Res 2008 Jul 15;14(14):4556-63. doi: 10.1158/1078-0432.CCR-08-0040. PMID: 18628471Free PMC Article
Cyclooxygenase-2: a target for the prevention and treatment of breast cancer.
Howe LR, Subbaramaiah K, Brown AM, Dannenberg AJ
Endocr Relat Cancer 2001 Jun;8(2):97-114. doi: 10.1677/erc.0.0080097. PMID: 11397667

Recent clinical studies

Etiology

Dysregulation of splicing variants and spliceosome components in breast cancer.
Gahete MD, Herman-Sanchez N, Fuentes-Fayos AC, Lopez-Canovas JL, Luque RM
Endocr Relat Cancer 2022 Sep 1;29(9):R123-R142. Epub 2022 Aug 1 doi: 10.1530/ERC-22-0019. PMID: 35728261
RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors.
Patel PS, Abraham KJ, Guturi KKN, Halaby MJ, Khan Z, Palomero L, Ho B, Duan S, St-Germain J, Algouneh A, Mateo F, El Ghamrasni S, Barbour H, Barnes DR, Beesley J, Sanchez O, Berman HK, Brown GW, Affar EB, Chenevix-Trench G, Antoniou AC, Arrowsmith CH, Raught B, Pujana MA, Mekhail K, Hakem A, Hakem R
J Clin Invest 2021 Feb 1;131(3) doi: 10.1172/JCI140105. PMID: 33529165Free PMC Article
p16INK4a suppresses BRCA1-deficient mammary tumorigenesis.
Scott A, Bai F, Chan HL, Liu S, Ma J, Slingerland JM, Robbins DJ, Capobianco AJ, Pei XH
Oncotarget 2016 Dec 20;7(51):84496-84507. doi: 10.18632/oncotarget.13015. PMID: 27811360Free PMC Article
Toxicity endpoint selections for a simazine risk assessment.
Silva M, Iyer P
Birth Defects Res B Dev Reprod Toxicol 2014 Aug;101(4):308-24. Epub 2014 Jul 30 doi: 10.1002/bdrb.21114. PMID: 25078261
Mouse modifier genes in mammary tumorigenesis and metastasis.
Winter SF, Hunter KW
J Mammary Gland Biol Neoplasia 2008 Sep;13(3):337-42. Epub 2008 Jul 26 doi: 10.1007/s10911-008-9089-1. PMID: 18661105

Diagnosis

Dysregulation of splicing variants and spliceosome components in breast cancer.
Gahete MD, Herman-Sanchez N, Fuentes-Fayos AC, Lopez-Canovas JL, Luque RM
Endocr Relat Cancer 2022 Sep 1;29(9):R123-R142. Epub 2022 Aug 1 doi: 10.1530/ERC-22-0019. PMID: 35728261
Dissecting the heterogeneity and tumorigenesis of BRCA1 deficient mammary tumors via single cell RNA sequencing.
Sun H, Zeng J, Miao Z, Lei KC, Huang C, Hu L, Su SM, Chan UI, Miao K, Zhang X, Zhang A, Guo S, Chen S, Meng Y, Deng M, Hao W, Lei H, Lin Y, Yang Z, Tang D, Wong KH, Zhang XD, Xu X, Deng CX
Theranostics 2021;11(20):9967-9987. Epub 2021 Oct 25 doi: 10.7150/thno.63995. PMID: 34815798Free PMC Article
Noncanonical TGF-β signaling during mammary tumorigenesis.
Parvani JG, Taylor MA, Schiemann WP
J Mammary Gland Biol Neoplasia 2011 Jun;16(2):127-46. Epub 2011 Mar 31 doi: 10.1007/s10911-011-9207-3. PMID: 21448580Free PMC Article
Minireview: Obesity and breast cancer: the estrogen connection.
Cleary MP, Grossmann ME
Endocrinology 2009 Jun;150(6):2537-42. Epub 2009 Apr 16 doi: 10.1210/en.2009-0070. PMID: 19372199Free PMC Article
The ras signaling pathway in mammary tumorigenesis and metastasis.
Malaney S, Daly RJ
J Mammary Gland Biol Neoplasia 2001 Jan;6(1):101-13. doi: 10.1023/a:1009572700317. PMID: 11467446

Therapy

mTOR inhibition abrogates human mammary stem cells and early breast cancer progression markers.
Bouamar H, Broome LE, Lathrop KI, Jatoi I, Brenner AJ, Nazarullah A, Gorena KM, Garcia M, Chen Y, Kaklamani V, Sun LZ
Breast Cancer Res 2023 Oct 30;25(1):131. doi: 10.1186/s13058-023-01727-z. PMID: 37904250Free PMC Article
The anti-tumor effect of RANKL inhibition in malignant solid tumors - A systematic review.
de Groot AF, Appelman-Dijkstra NM, van der Burg SH, Kroep JR
Cancer Treat Rev 2018 Jan;62:18-28. Epub 2017 Nov 2 doi: 10.1016/j.ctrv.2017.10.010. PMID: 29154022
PIN1 in breast development and cancer: a clinical perspective.
Rustighi A, Zannini A, Campaner E, Ciani Y, Piazza S, Del Sal G
Cell Death Differ 2017 Feb;24(2):200-211. Epub 2016 Nov 11 doi: 10.1038/cdd.2016.122. PMID: 27834957Free PMC Article
Melatonin and mammary pathological growth.
Cos S, Sánchez-Barceló EJ
Front Neuroendocrinol 2000 Apr;21(2):133-70. doi: 10.1006/frne.1999.0194. PMID: 10764528
Timing of dietary fat exposure and mammary tumorigenesis: role of estrogen receptor and protein kinase C activity.
Hilakivi-Clarke L, Clarke R
Mol Cell Biochem 1998 Nov;188(1-2):5-12. PMID: 9823005

Prognosis

MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis.
Cho MG, Kumar RJ, Lin CC, Boyer JA, Shahir JA, Fagan-Solis K, Simpson DA, Fan C, Foster CE, Goddard AM, Lerner LM, Ellington SW, Wang Q, Wang Y, Ho AY, Liu P, Perou CM, Zhang Q, McGinty RK, Purvis JE, Gupta GP
Nature 2024 Jan;625(7995):585-592. Epub 2024 Jan 10 doi: 10.1038/s41586-023-06889-6. PMID: 38200309Free PMC Article
Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers.
Soyama H, Nishio M, Otani J, Sakuma T, Takao S, Hara S, Masuda T, Mimori K, Toyokuni S, Lydon JP, Nakao K, Nishina H, Fukumoto T, Maehama T, Suzuki A
Proc Natl Acad Sci U S A 2022 Jul 19;119(29):e2123134119. Epub 2022 Jul 11 doi: 10.1073/pnas.2123134119. PMID: 35858357Free PMC Article
Dysregulation of splicing variants and spliceosome components in breast cancer.
Gahete MD, Herman-Sanchez N, Fuentes-Fayos AC, Lopez-Canovas JL, Luque RM
Endocr Relat Cancer 2022 Sep 1;29(9):R123-R142. Epub 2022 Aug 1 doi: 10.1530/ERC-22-0019. PMID: 35728261
Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis.
Rudnick JA, Monkkonen T, Mar FA, Barnes JM, Starobinets H, Goldsmith J, Roy S, Bustamante Eguiguren S, Weaver VM, Debnath J
Genes Dev 2021 Jul 1;35(13-14):963-975. Epub 2021 Jun 24 doi: 10.1101/gad.345629.120. PMID: 34168038Free PMC Article
TGIF function in oncogenic Wnt signaling.
Razzaque MS, Atfi A
Biochim Biophys Acta 2016 Apr;1865(2):101-4. Epub 2015 Nov 11 doi: 10.1016/j.bbcan.2015.10.003. PMID: 26522669

Clinical prediction guides

Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers.
Soyama H, Nishio M, Otani J, Sakuma T, Takao S, Hara S, Masuda T, Mimori K, Toyokuni S, Lydon JP, Nakao K, Nishina H, Fukumoto T, Maehama T, Suzuki A
Proc Natl Acad Sci U S A 2022 Jul 19;119(29):e2123134119. Epub 2022 Jul 11 doi: 10.1073/pnas.2123134119. PMID: 35858357Free PMC Article
Ecdysoneless Overexpression Drives Mammary Tumorigenesis through Upregulation of C-MYC and Glucose Metabolism.
Mohapatra BC, Mirza S, Bele A, Gurumurthy CB, Raza M, Saleem I, Storck MD, Sarkar A, Kollala SS, Shukla SK, Southekal S, Wagner KU, Qiu F, Lele SM, Alsaleem MA, Rakha EA, Guda C, Singh PK, Cardiff RD, Band H, Band V
Mol Cancer Res 2022 Sep 2;20(9):1391-1404. doi: 10.1158/1541-7786.MCR-22-0122. PMID: 35675041Free PMC Article
Transgenic mouse models of breast cancer.
Regua AT, Arrigo A, Doheny D, Wong GL, Lo HW
Cancer Lett 2021 Sep 28;516:73-83. Epub 2021 Jun 6 doi: 10.1016/j.canlet.2021.05.027. PMID: 34090924Free PMC Article
Mutant SF3B1 promotes AKT- and NF-κB-driven mammary tumorigenesis.
Liu B, Liu Z, Chen S, Ki M, Erickson C, Reis-Filho JS, Durham BH, Chang Q, de Stanchina E, Sun Y, Rabadan R, Abdel-Wahab O, Chandarlapaty S
J Clin Invest 2021 Jan 4;131(1) doi: 10.1172/JCI138315. PMID: 33031100Free PMC Article
It takes two to tango in the microenvironment!
Ursini-Siegel J, Park M
Breast Cancer Res 2013 Mar 12;15(2):102. doi: 10.1186/bcr3388. PMID: 23510134Free PMC Article

Recent systematic reviews

The anti-tumor effect of RANKL inhibition in malignant solid tumors - A systematic review.
de Groot AF, Appelman-Dijkstra NM, van der Burg SH, Kroep JR
Cancer Treat Rev 2018 Jan;62:18-28. Epub 2017 Nov 2 doi: 10.1016/j.ctrv.2017.10.010. PMID: 29154022
Alcohol consumption and cancer risk: understanding possible causal mechanisms for breast and colorectal cancers.
Oyesanmi O, Snyder D, Sullivan N, Reston J, Treadwell J, Schoelles KM
Evid Rep Technol Assess (Full Rep) 2010 Nov;(197):1-151. PMID: 23126574Free PMC Article

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