Testicular yolk sac tumor, macrocystic pattern

MedGen UID:: 271772
•Concept ID:: C1515307
•: Neoplastic Process

Synonyms:	macrocystic pattern testicular yolk sac tumor; macrocystic pattern testicular yolk sac tumour; Testicular Yolk Sac Tumor, Macrocystic Pattern; testicular yolk sac tumor, macrocystic pattern

Monarch Initiative:	MONDO:0004106

Definition

A yolk sac tumor that arises from the testis and is characterized by the presence of collections of thin-walled spaces. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVTesticular yolk sac tumor, macrocystic pattern

Neoplasm by Morphology
- Germ cell tumor
  - Germ cell tumor of testis
    - Malignant testicular germ cell tumor
      - Testicular non-seminomatous germ cell cancer
        Testicular yolk sac tumor
        Testicular yolk sac tumor, macrocystic pattern

Recent clinical studies

Etiology

Yolk Sac Tumor of the Testis in Infants and Children: A Clinicopathologic Analysis of 33 Cases.

Cornejo KM, Frazier L, Lee RS, Kozakewich HP, Young RH
Am J Surg Pathol 2015 Aug;39(8):1121-31. doi: 10.1097/PAS.0000000000000432. PMID: 25828390

See all (1)

Diagnosis

FoxA2 is a reliable marker for the diagnosis of yolk sac tumour postpubertal-type.

Ricci C, Ambrosi F, Franceschini T, Giunchi F, Di Filippo G, Franchini E, Massari F, Mollica V, Tateo V, Bianchi FM, Colecchia M, Acosta AM, Fiorentino M
Histopathology 2023 Sep;83(3):465-476. Epub 2023 Jun 14 doi: 10.1111/his.14968. PMID: 37317674

Yolk Sac Tumor of the Testis in Infants and Children: A Clinicopathologic Analysis of 33 Cases.

Cornejo KM, Frazier L, Lee RS, Kozakewich HP, Young RH
Am J Surg Pathol 2015 Aug;39(8):1121-31. doi: 10.1097/PAS.0000000000000432. PMID: 25828390

Glypican 3 has a higher sensitivity than alpha-fetoprotein for testicular and ovarian yolk sac tumour: immunohistochemical investigation with analysis of histological growth patterns.

Zynger DL, McCallum JC, Luan C, Chou PM, Yang XJ
Histopathology 2010 May;56(6):750-7. doi: 10.1111/j.1365-2559.2010.03553.x. PMID: 20546340

See all (3)