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Testicular non-seminomatous germ cell cancer

MedGen UID:
233162
•Concept ID:
C1334625
•
Neoplastic Process
Synonyms: Malignant Non-Seminomatous Germ Cell Cancer of Testis; malignant non-seminomatous germ cell cancer of testis; Malignant Non-Seminomatous Germ Cell Cancer of the Testis; malignant non-seminomatous germ cell cancer of the testis; Malignant Non-Seminomatous Germ Cell Neoplasm of Testis; malignant non-seminomatous germ cell neoplasm of testis; Malignant Non-Seminomatous Germ Cell Neoplasm of the Testis; malignant non-seminomatous germ cell neoplasm of the testis; Malignant Non-Seminomatous Germ Cell Tumor of Testis; malignant non-seminomatous germ cell tumor of testis; Malignant Non-Seminomatous Germ Cell Tumor of the Testis; malignant non-seminomatous germ cell tumor of the testis; malignant non-seminomatous germ cell tumour of testis; malignant non-seminomatous germ cell tumour of the testis; Malignant Testicular Non-Seminomatous Germ Cell Neoplasm; malignant testicular non-seminomatous germ cell neoplasm; Malignant Testicular Non-Seminomatous Germ Cell Tumor; malignant testicular non-seminomatous germ cell tumor; malignant testicular non-seminomatous germ cell tumour; testicular germ cell tumor non-seminomatous, malignant; testicular germ cell tumour non-seminomatous, malignant; Testicular Non-Seminomatous Germ Cell Cancer; testicular non-seminomatous germ cell cancer; testicular non-seminomatous germ cell tumor, malignant; Testicular Non-Seminomatous Malignant Germ Cell Neoplasm; testicular non-seminomatous malignant germ cell neoplasm
 
Monarch Initiative: MONDO:0003403

Definition

A classification of testicular cancers that arise in specialized sex cells called germ cells. Nonseminomas include embryonal carcinoma, teratoma, choriocarcinoma, and yolk sac tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular non-seminomatous germ cell cancer

Professional guidelines

PubMed

Low RBM3 protein expression correlates with clinical stage, prognostic classification and increased risk of treatment failure in testicular non-seminomatous germ cell cancer.
Olofsson SE, Nodin B, Gaber A, Eberhard J, Uhlén M, Jirström K, Jerkeman M
PLoS One 2015;10(3):e0121300. Epub 2015 Mar 26 doi: 10.1371/journal.pone.0121300. PMID: 25811459Free PMC Article
Current management of stage I testicular non-seminomatous germ cell tumours.
Pectasides D, Pectasides E, Constantinidou A, Aravantinos G
Crit Rev Oncol Hematol 2009 May;70(2):114-23. Epub 2008 Sep 19 doi: 10.1016/j.critrevonc.2008.07.018. PMID: 18805019
Long-term clinical outcome in patients with stage-I nonseminomatous germ cell cancer. A critical review of own treatment modalities in a retrospective study.
Seseke S, Bierwirth S, Strauss A, Ringert RH, Seseke F
Int Braz J Urol 2008 Nov-Dec;34(6):715-22; discussion 723-4. doi: 10.1590/s1677-55382008000600006. PMID: 19111076

Recent clinical studies

Etiology

Low RBM3 protein expression correlates with clinical stage, prognostic classification and increased risk of treatment failure in testicular non-seminomatous germ cell cancer.
Olofsson SE, Nodin B, Gaber A, Eberhard J, Uhlén M, Jirström K, Jerkeman M
PLoS One 2015;10(3):e0121300. Epub 2015 Mar 26 doi: 10.1371/journal.pone.0121300. PMID: 25811459Free PMC Article
Routine computerised tomographic scans of the thorax in surveillance of stage I testicular non-seminomatous germ-cell cancer--a necessary risk?
Harvey ML, Geldart TR, Duell R, Mead GM, Tung K
Ann Oncol 2002 Feb;13(2):237-42. doi: 10.1093/annonc/mdf032. PMID: 11886000

Therapy

Multiple relapses of mature teratoma, germinal and non-germ cell cancer in a patient treated with chemotherapy for testicular non-seminomatous germ cell cancer.
McKendrick JJ, Mead GM, Cowlishaw D
Clin Oncol (R Coll Radiol) 2003 May;15(3):128-31. doi: 10.1053/clon.2002.0164. PMID: 12801050
Routine computerised tomographic scans of the thorax in surveillance of stage I testicular non-seminomatous germ-cell cancer--a necessary risk?
Harvey ML, Geldart TR, Duell R, Mead GM, Tung K
Ann Oncol 2002 Feb;13(2):237-42. doi: 10.1093/annonc/mdf032. PMID: 11886000

Prognosis

Low RBM3 protein expression correlates with clinical stage, prognostic classification and increased risk of treatment failure in testicular non-seminomatous germ cell cancer.
Olofsson SE, Nodin B, Gaber A, Eberhard J, Uhlén M, Jirström K, Jerkeman M
PLoS One 2015;10(3):e0121300. Epub 2015 Mar 26 doi: 10.1371/journal.pone.0121300. PMID: 25811459Free PMC Article
Routine computerised tomographic scans of the thorax in surveillance of stage I testicular non-seminomatous germ-cell cancer--a necessary risk?
Harvey ML, Geldart TR, Duell R, Mead GM, Tung K
Ann Oncol 2002 Feb;13(2):237-42. doi: 10.1093/annonc/mdf032. PMID: 11886000

Clinical prediction guides

Low RBM3 protein expression correlates with clinical stage, prognostic classification and increased risk of treatment failure in testicular non-seminomatous germ cell cancer.
Olofsson SE, Nodin B, Gaber A, Eberhard J, Uhlén M, Jirström K, Jerkeman M
PLoS One 2015;10(3):e0121300. Epub 2015 Mar 26 doi: 10.1371/journal.pone.0121300. PMID: 25811459Free PMC Article

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