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Reticular pattern testicular yolk sac tumor

MedGen UID:
271773
•Concept ID:
C1515308
•
Neoplastic Process
Synonyms: reticular pattern testicular yolk sac tumor; Testicular Yolk Sac Tumor, Microcystic Pattern; testicular yolk Sac tumor, microcystic pattern; Testicular Yolk Sac Tumor, Reticular Pattern; testicular yolk Sac tumor, reticular pattern
 
Monarch Initiative: MONDO:0004547

Definition

A yolk sac tumor that arises from the testis and is characterized by the presence of a meshwork of small vacuolated cells resulting in a honeycomb appearance. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReticular pattern testicular yolk sac tumor

Recent clinical studies

Etiology

High-level expression of divergent endodermal lineage markers in gonadal and extra-gonadal yolk sac tumors.
Shojaei H, Hong H, Redline RW
Mod Pathol 2016 Oct;29(10):1278-88. Epub 2016 Jul 22 doi: 10.1038/modpathol.2016.131. PMID: 27443515
Yolk Sac Tumor of the Testis in Infants and Children: A Clinicopathologic Analysis of 33 Cases.
Cornejo KM, Frazier L, Lee RS, Kozakewich HP, Young RH
Am J Surg Pathol 2015 Aug;39(8):1121-31. doi: 10.1097/PAS.0000000000000432. PMID: 25828390
Renal medullary carcinoma: report of seven cases from Brazil.
Watanabe IC, Billis A, Guimarães MS, Alvarenga M, de Matos AC, Cardinalli IA, Filippi RZ, de Castro MG, Suzigan S
Mod Pathol 2007 Sep;20(9):914-20. Epub 2007 Jul 20 doi: 10.1038/modpathol.3800934. PMID: 17643096
Primary germ cell tumors of the mediastinum: III. Yolk sac tumor, embryonal carcinoma, choriocarcinoma, and combined nonteratomatous germ cell tumors of the mediastinum--a clinicopathologic and immunohistochemical study of 64 cases.
Moran CA, Suster S, Koss MN
Cancer 1997 Aug 15;80(4):699-707. PMID: 9264353
Immunohistochemical demonstration of hemoglobin F (HbF) in testicular germ cell tumors.
Jacobsen GK, Jacobsen M
Oncodev Biol Med 1983;4(6):C45-51. PMID: 6196750

Diagnosis

FoxA2 is a reliable marker for the diagnosis of yolk sac tumour postpubertal-type.
Ricci C, Ambrosi F, Franceschini T, Giunchi F, Di Filippo G, Franchini E, Massari F, Mollica V, Tateo V, Bianchi FM, Colecchia M, Acosta AM, Fiorentino M
Histopathology 2023 Sep;83(3):465-476. Epub 2023 Jun 14 doi: 10.1111/his.14968. PMID: 37317674
Pure post-pubertal yolk sac tumor of the testis: An extremely rare and aggressive entity.
Patel S, Satturwar S, Khan W, Ashman D, Quiroga-Garza GM
Ann Diagn Pathol 2023 Apr;63:152086. Epub 2022 Dec 23 doi: 10.1016/j.anndiagpath.2022.152086. PMID: 36580878
Yolk Sac Tumor of the Testis in Infants and Children: A Clinicopathologic Analysis of 33 Cases.
Cornejo KM, Frazier L, Lee RS, Kozakewich HP, Young RH
Am J Surg Pathol 2015 Aug;39(8):1121-31. doi: 10.1097/PAS.0000000000000432. PMID: 25828390
The yolk sac tumor: reflections on a remarkable neoplasm and two of the many intrigued by it-Gunnar Teilum and Aleksander Talerman-and the bond it formed between them.
Young RH
Int J Surg Pathol 2014 Dec;22(8):677-87. Epub 2014 Nov 12 doi: 10.1177/1066896914558265. PMID: 25395492
Solid pattern yolk sac tumor: a morphologic and immunohistochemical study of 52 cases.
Kao CS, Idrees MT, Young RH, Ulbright TM
Am J Surg Pathol 2012 Mar;36(3):360-7. doi: 10.1097/PAS.0b013e31823c510b. PMID: 22261704

Therapy

Seminoma with tubular, microcystic, and related patterns: a study of 28 cases of unusual morphologic variants that often cause confusion with yolk sac tumor.
Ulbright TM, Young RH
Am J Surg Pathol 2005 Apr;29(4):500-5. doi: 10.1097/01.pas.0000155146.60670.3f. PMID: 15767805
Establishment of a testicular carcinoma cell line producing alpha-fetoprotein.
Ueno M, Nakashima J, Ohigashi T, Deguchi N, Ban S, Akita M, Murai M
BJU Int 2001 Oct;88(6):611-21. doi: 10.1046/j.1464-410x.2001.02357.x. PMID: 11678760

Prognosis

Juvenile granulosa cell tumors of the testis: a clinicopathologic study of 70 cases with emphasis on its wide morphologic spectrum.
Kao CS, Cornejo KM, Ulbright TM, Young RH
Am J Surg Pathol 2015 Sep;39(9):1159-69. doi: 10.1097/PAS.0000000000000450. PMID: 26076062
Yolk Sac Tumor of the Testis in Infants and Children: A Clinicopathologic Analysis of 33 Cases.
Cornejo KM, Frazier L, Lee RS, Kozakewich HP, Young RH
Am J Surg Pathol 2015 Aug;39(8):1121-31. doi: 10.1097/PAS.0000000000000432. PMID: 25828390
Solid pattern yolk sac tumor: a morphologic and immunohistochemical study of 52 cases.
Kao CS, Idrees MT, Young RH, Ulbright TM
Am J Surg Pathol 2012 Mar;36(3):360-7. doi: 10.1097/PAS.0b013e31823c510b. PMID: 22261704
Pure yolk sac tumors in genital and extragenital sites: study on three pedriatic cases, with cytological findings on two.
Sironi M, Assi A, Quaglia G, Tonnarelli G, Cozzi L
Adv Clin Path 1999 Jul;3(3):55-62. PMID: 10655574
Primary germ cell tumors of the mediastinum: III. Yolk sac tumor, embryonal carcinoma, choriocarcinoma, and combined nonteratomatous germ cell tumors of the mediastinum--a clinicopathologic and immunohistochemical study of 64 cases.
Moran CA, Suster S, Koss MN
Cancer 1997 Aug 15;80(4):699-707. PMID: 9264353

Clinical prediction guides

High-level expression of divergent endodermal lineage markers in gonadal and extra-gonadal yolk sac tumors.
Shojaei H, Hong H, Redline RW
Mod Pathol 2016 Oct;29(10):1278-88. Epub 2016 Jul 22 doi: 10.1038/modpathol.2016.131. PMID: 27443515
Yolk Sac Tumor of the Testis in Infants and Children: A Clinicopathologic Analysis of 33 Cases.
Cornejo KM, Frazier L, Lee RS, Kozakewich HP, Young RH
Am J Surg Pathol 2015 Aug;39(8):1121-31. doi: 10.1097/PAS.0000000000000432. PMID: 25828390
Solid pattern yolk sac tumor: a morphologic and immunohistochemical study of 52 cases.
Kao CS, Idrees MT, Young RH, Ulbright TM
Am J Surg Pathol 2012 Mar;36(3):360-7. doi: 10.1097/PAS.0b013e31823c510b. PMID: 22261704
Seminoma with tubular, microcystic, and related patterns: a study of 28 cases of unusual morphologic variants that often cause confusion with yolk sac tumor.
Ulbright TM, Young RH
Am J Surg Pathol 2005 Apr;29(4):500-5. doi: 10.1097/01.pas.0000155146.60670.3f. PMID: 15767805
Primary germ cell tumors of the mediastinum: III. Yolk sac tumor, embryonal carcinoma, choriocarcinoma, and combined nonteratomatous germ cell tumors of the mediastinum--a clinicopathologic and immunohistochemical study of 64 cases.
Moran CA, Suster S, Koss MN
Cancer 1997 Aug 15;80(4):699-707. PMID: 9264353

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