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Congenital Melanocytic Nevus

MedGen UID:
272090
•Concept ID:
C1318558
•
Neoplastic Process
Synonyms: Congenital dermal melanocytic nevus; Congenital melanocytic nevus; Congenital melanocytic nevus of skin; Congenital Melanocytic Nevus of Skin; Congenital Melanocytic Nevus of the Skin; Congenital Nevus of Skin; Congenital Nevus of the Skin; Congenital pigmented melanocytic nevus; Congenital pigmented melanocytic nevus of skin; Congenital pigmented nevus; Congenital pigmented nevus of skin; Congenital Pigmented Nevus of Skin; Congenital Pigmented Nevus of the Skin; Congenital Pigmented Skin Nevus; Congenital Skin Nevus
SNOMED CT: Congenital pigmented melanocytic nevus (398696001); Congenital pigmented melanocytic nevus of skin (398943008); Congenital melanocytic nevus (400151006); Congenital melanocytic nevus (398696001); Congenital pigmented nevus (398696001); Congenital dermal melanocytic nevus (398943008); Congenital melanocytic nevus of skin (398943008); Congenital pigmented nevus of skin (398943008)

Definition

A melanocytic nevus that is present at birth. It may present as a small macular, papular, or plaque-like lesion or as a large brown to black hairy skin lesion. [from NCI]

Professional guidelines

PubMed

Comparison of three different surgical approaches for the treatment of large/giant congenital melanocytic nevus.
Cheng X, Wang W, He Y, Bao W, Jia C, Dai T
J Cosmet Dermatol 2022 Oct;21(10):4609-4616. Epub 2022 Jul 19 doi: 10.1111/jocd.15219. PMID: 35810351
Treatment of maxillofacial congenital melanocytic nevus with percutaneous radiofrequency thermal ablation: A case series study.
Wang X, Chen W, Xie H, Jiang T, Weng C, Zhang Z, Lin X, Gao Y
Dermatol Ther 2021 Mar;34(2):e14876. Epub 2021 Feb 21 doi: 10.1111/dth.14876. PMID: 33583124
Laser treatment of congenital melanocytic nevi: a review of the literature.
Bray FN, Shah V, Nouri K
Lasers Med Sci 2016 Jan;31(1):197-204. Epub 2015 Nov 12 doi: 10.1007/s10103-015-1833-3. PMID: 26563957

Recent clinical studies

Etiology

Melanoma on congenital melanocytic nevi.
Alos L, Carrasco A, Teixidó C, Szumera-Ciećkiewicz A, Vicente A, Massi D, Carrera C
Pathol Res Pract 2024 Apr;256:155262. Epub 2024 Mar 11 doi: 10.1016/j.prp.2024.155262. PMID: 38518732
Topical therapy for regression and melanoma prevention of congenital giant nevi.
Choi YS, Erlich TH, von Franque M, Rachmin I, Flesher JL, Schiferle EB, Zhang Y, Pereira da Silva M, Jiang A, Dobry AS, Su M, Germana S, Lacher S, Freund O, Feder E, Cortez JL, Ryu S, Babila Propp T, Samuels YL, Zakka LR, Azin M, Burd CE, Sharpless NE, Liu XS, Meyer C, Austen WG Jr, Bojovic B, Cetrulo CL Jr, Mihm MC, Hoon DS, Demehri S, Hawryluk EB, Fisher DE
Cell 2022 Jun 9;185(12):2071-2085.e12. Epub 2022 May 12 doi: 10.1016/j.cell.2022.04.025. PMID: 35561684Free PMC Article
Imaging of pediatric cutaneous melanoma.
Kaste SC
Pediatr Radiol 2019 Oct;49(11):1476-1487. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04374-9. PMID: 31620848Free PMC Article
Common and not so Common Melanocytic Lesions in Children and Adolescents.
Yang C, Gru AA, Dehner LP
Pediatr Dev Pathol 2018 Mar-Apr;21(2):252-270. doi: 10.1177/1093526617751720. PMID: 29607755
Giant congenital melanocytic nevus.
Viana AC, Gontijo B, Bittencourt FV
An Bras Dermatol 2013 Nov-Dec;88(6):863-78. doi: 10.1590/abd1806-4841.20132233. PMID: 24474093Free PMC Article

Diagnosis

Imaging of pediatric cutaneous melanoma.
Kaste SC
Pediatr Radiol 2019 Oct;49(11):1476-1487. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04374-9. PMID: 31620848Free PMC Article
Common and not so Common Melanocytic Lesions in Children and Adolescents.
Yang C, Gru AA, Dehner LP
Pediatr Dev Pathol 2018 Mar-Apr;21(2):252-270. doi: 10.1177/1093526617751720. PMID: 29607755
Dysplastic nevus: Fact and fiction.
Rosendahl CO, Grant-Kels JM, Que SK
J Am Acad Dermatol 2015 Sep;73(3):507-12. Epub 2015 May 30 doi: 10.1016/j.jaad.2015.04.029. PMID: 26037217
Giant congenital melanocytic nevus.
Viana AC, Gontijo B, Bittencourt FV
An Bras Dermatol 2013 Nov-Dec;88(6):863-78. doi: 10.1590/abd1806-4841.20132233. PMID: 24474093Free PMC Article
Congenital melanocytic nevi.
Zayour M, Lazova R
Clin Lab Med 2011 Jun;31(2):267-80. doi: 10.1016/j.cll.2011.03.004. PMID: 21549240

Therapy

Psychosocial Experiences in Children With Congenital Melanocytic Nevus on the Face and Their Parents Throughout the Tissue Expansion Treatment.
Zhang C, Wu L, Zhao S, Wang Q, Li T, Wang J
J Craniofac Surg 2022 May 1;33(3):754-758. Epub 2021 Sep 17 doi: 10.1097/SCS.0000000000008151. PMID: 34538792
Transcriptome Analysis of Large to Giant Congenital Melanocytic Nevus Reveals Cell Cycle Arrest and Immune Evasion: Identifying Potential Targets for Treatment.
Wei B, Gu J, Duan R, Gao B, Wu M, Zhou S, Huang X, Xie F
J Immunol Res 2021;2021:8512200. Epub 2021 Dec 6 doi: 10.1155/2021/8512200. PMID: 34912899Free PMC Article
Cutaneous skeletal hypophosphatemia syndrome (CSHS) is a multilineage somatic mosaic RASopathy.
Lim YH, Ovejero D, Derrick KM; Yale Center for Mendelian Genomics, Collins MT, Choate KA
J Am Acad Dermatol 2016 Aug;75(2):420-7. doi: 10.1016/j.jaad.2015.11.012. PMID: 27444071Free PMC Article
Pediatric melanoma, moles, and sun safety.
Hawryluk EB, Liang MG
Pediatr Clin North Am 2014 Apr;61(2):279-91. Epub 2014 Jan 28 doi: 10.1016/j.pcl.2013.11.004. PMID: 24636646
Cutaneous lesions: benign and malignant.
Padgett JK
Facial Plast Surg Clin North Am 2005 May;13(2):195-202, v. doi: 10.1016/j.fsc.2004.11.006. PMID: 15817400

Prognosis

Congenital melanocytic nevus syndrome: An association between congenital melanocytic nevi and neurological abnormalities.
Ruth J
Semin Pediatr Neurol 2024 Oct;51:101153. Epub 2024 Sep 13 doi: 10.1016/j.spen.2024.101153. PMID: 39389659
Melanoma on congenital melanocytic nevi.
Alos L, Carrasco A, Teixidó C, Szumera-Ciećkiewicz A, Vicente A, Massi D, Carrera C
Pathol Res Pract 2024 Apr;256:155262. Epub 2024 Mar 11 doi: 10.1016/j.prp.2024.155262. PMID: 38518732
Paediatric melanoma: clinical update, genetic basis, and advances in diagnosis.
Merkel EA, Mohan LS, Shi K, Panah E, Zhang B, Gerami P
Lancet Child Adolesc Health 2019 Sep;3(9):646-654. Epub 2019 Jun 13 doi: 10.1016/S2352-4642(19)30116-6. PMID: 31204309
Common and not so Common Melanocytic Lesions in Children and Adolescents.
Yang C, Gru AA, Dehner LP
Pediatr Dev Pathol 2018 Mar-Apr;21(2):252-270. doi: 10.1177/1093526617751720. PMID: 29607755
Congenital melanocytic nevi.
Zayour M, Lazova R
Clin Lab Med 2011 Jun;31(2):267-80. doi: 10.1016/j.cll.2011.03.004. PMID: 21549240

Clinical prediction guides

Congenital melanocytic nevus syndrome: An association between congenital melanocytic nevi and neurological abnormalities.
Ruth J
Semin Pediatr Neurol 2024 Oct;51:101153. Epub 2024 Sep 13 doi: 10.1016/j.spen.2024.101153. PMID: 39389659
Cutaneous Melanoma Arising in Congenital Melanocytic Nevus: A Retrospective Observational Study.
Caccavale S, Calabrese G, Mattiello E, Broganelli P, Ramondetta A, Pieretti G, Alfano R, Argenziano G
Dermatology 2021;237(3):473-478. Epub 2020 Oct 14 doi: 10.1159/000510221. PMID: 33053549
Multiple Tissue Expansion for Giant Congenital Melanocytic Nevus.
Gonzalez Ruiz Y, López Gutiérrez JC
Ann Plast Surg 2017 Dec;79(6):e37-e40. doi: 10.1097/SAP.0000000000001215. PMID: 29053515
Congenital melanocytic nevus: two clinicopathological forms.
Magaña M, Sánchez-Romero E, Magaña P, Beck-Magaña A, Magaña-Lozano M
Am J Dermatopathol 2015 Jan;37(1):31-7. doi: 10.1097/DAD.0000000000000183. PMID: 25140664
Giant congenital melanocytic nevi.
Arneja JS, Gosain AK
Plast Reconstr Surg 2007 Aug;120(2):26e-40e. doi: 10.1097/01.prs.0000267583.63342.0a. PMID: 17632335

Recent systematic reviews

Treatments of palpebral congenital melanocytic nevus: a systematic review.
Camargo CP, Saliba M, Saad EA, Milan M, Caldera JM
Acta Cir Bras 2023;38:e384823. Epub 2023 Dec 1 doi: 10.1590/acb384823. PMID: 38055392Free PMC Article

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