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AJCC Grade 2 Sarcoma

MedGen UID:
272263
•Concept ID:
C1332067
•
Neoplastic Process
Synonyms: AJCC G2 Sarcoma; AJCC Grade II Sarcoma; Moderately Differentiated Sarcoma

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAJCC Grade 2 Sarcoma

Recent clinical studies

Etiology

Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial.
Long GV, Luke JJ, Khattak MA, de la Cruz Merino L, Del Vecchio M, Rutkowski P, Spagnolo F, Mackiewicz J, Chiarion-Sileni V, Kirkwood JM, Robert C, Grob JJ, de Galitiis F, Schadendorf D, Carlino MS, Mohr P, Dummer R, Gershenwald JE, Yoon CH, Wu XL, Fukunaga-Kalabis M, Krepler C, Eggermont AMM, Ascierto PA; KEYNOTE-716 Investigators
Lancet Oncol 2022 Nov;23(11):1378-1388. Epub 2022 Oct 18 doi: 10.1016/S1470-2045(22)00559-9. PMID: 36265502
A Proposed Staging System for Improved Prognostication of MDM2-amplified Liposarcoma.
Tucci JJ, Dashti NK, Cates JMM
Am J Surg Pathol 2021 Jan;45(1):101-107. doi: 10.1097/PAS.0000000000001554. PMID: 32796171
Evidence-based Tumor Staging of Skeletal Chondrosarcoma.
Compton ML, Cates JMM
Am J Surg Pathol 2020 Jan;44(1):111-119. doi: 10.1097/PAS.0000000000001397. PMID: 31651521
A prognostic model for resectable soft tissue and cutaneous angiosarcoma.
Sinnamon AJ, Neuwirth MG, McMillan MT, Ecker BL, Bartlett EK, Zhang PJ, Kelz RR, Fraker DL, Roses RE, Karakousis GC
J Surg Oncol 2016 Oct;114(5):557-563. Epub 2016 Jul 4 doi: 10.1002/jso.24352. PMID: 27378102
Soft tissue sarcomas.
Cormier JN, Pollock RE
CA Cancer J Clin 2004 Mar-Apr;54(2):94-109. doi: 10.3322/canjclin.54.2.94. PMID: 15061599

Diagnosis

Subcutaneous Leiomyosarcoma: An Aggressive Malignancy Portending a Significant Risk of Metastasis and Death.
Bresler SC, Gosnell HL, Ko JS, Angeles CV, Ronen S, Billings SD, Patel RM
Am J Surg Pathol 2023 Dec 1;47(12):1417-1424. Epub 2023 Sep 19 doi: 10.1097/PAS.0000000000002126. PMID: 37727934
Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial.
Long GV, Luke JJ, Khattak MA, de la Cruz Merino L, Del Vecchio M, Rutkowski P, Spagnolo F, Mackiewicz J, Chiarion-Sileni V, Kirkwood JM, Robert C, Grob JJ, de Galitiis F, Schadendorf D, Carlino MS, Mohr P, Dummer R, Gershenwald JE, Yoon CH, Wu XL, Fukunaga-Kalabis M, Krepler C, Eggermont AMM, Ascierto PA; KEYNOTE-716 Investigators
Lancet Oncol 2022 Nov;23(11):1378-1388. Epub 2022 Oct 18 doi: 10.1016/S1470-2045(22)00559-9. PMID: 36265502
Surgical resection for recurrent retroperitoneal leiomyosarcoma and liposarcoma.
Nathenson MJ, Barysauskas CM, Nathenson RA, Regine WF, Hanna N, Sausville E
World J Surg Oncol 2018 Oct 11;16(1):203. doi: 10.1186/s12957-018-1505-4. PMID: 30309356Free PMC Article
Comparison of the AJCC, MSTS, and Modified Spanier Systems for Clinical and Pathologic Staging of Osteosarcoma.
Cates JM
Am J Surg Pathol 2017 Mar;41(3):405-413. doi: 10.1097/PAS.0000000000000774. PMID: 28195881
Soft tissue sarcomas.
Cormier JN, Pollock RE
CA Cancer J Clin 2004 Mar-Apr;54(2):94-109. doi: 10.3322/canjclin.54.2.94. PMID: 15061599

Therapy

Development and validation of a nomogram for predicting prognosis of high-grade chondrosarcoma: A surveillance, epidemiology, and end results-based population analysis.
Sun Y, Ouyang C, Zhang Y, Li Y, Liu Y, Jiang M, Nong L, Gao G
J Orthop Surg (Hong Kong) 2023 May-Aug;31(2):10225536231174255. doi: 10.1177/10225536231174255. PMID: 37147017
Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial.
Long GV, Luke JJ, Khattak MA, de la Cruz Merino L, Del Vecchio M, Rutkowski P, Spagnolo F, Mackiewicz J, Chiarion-Sileni V, Kirkwood JM, Robert C, Grob JJ, de Galitiis F, Schadendorf D, Carlino MS, Mohr P, Dummer R, Gershenwald JE, Yoon CH, Wu XL, Fukunaga-Kalabis M, Krepler C, Eggermont AMM, Ascierto PA; KEYNOTE-716 Investigators
Lancet Oncol 2022 Nov;23(11):1378-1388. Epub 2022 Oct 18 doi: 10.1016/S1470-2045(22)00559-9. PMID: 36265502
Should High-grade Extraosseous Osteosarcoma Be Treated With Multimodality Therapy Like Other Soft Tissue Sarcomas?
Fan Z, Patel S, Lewis VO, Guadagnolo BA, Lin PP
Clin Orthop Relat Res 2015 Nov;473(11):3604-11. Epub 2015 Jul 22 doi: 10.1007/s11999-015-4463-y. PMID: 26197952Free PMC Article
Chemotherapy influences the pseudocapsule composition in soft tissue sarcomas.
O'Donnell PW, Manivel JC, Cheng EY, Clohisy DR
Clin Orthop Relat Res 2014 Mar;472(3):849-55. doi: 10.1007/s11999-013-3022-7. PMID: 23640206Free PMC Article
Preoperative and postoperative chemotherapy with ifosfamide and adriamycin for adult high-grade soft-tissue sarcomas in the extremities: Japan Clinical Oncology Group Study JCOG0304.
Tanaka K, Kawamoto H, Saito I, Yoshimura K, Fukuda H, Iwamoto Y
Jpn J Clin Oncol 2009 Apr;39(4):271-3. Epub 2009 Jan 20 doi: 10.1093/jjco/hyn153. PMID: 19155282

Prognosis

Subcutaneous Leiomyosarcoma: An Aggressive Malignancy Portending a Significant Risk of Metastasis and Death.
Bresler SC, Gosnell HL, Ko JS, Angeles CV, Ronen S, Billings SD, Patel RM
Am J Surg Pathol 2023 Dec 1;47(12):1417-1424. Epub 2023 Sep 19 doi: 10.1097/PAS.0000000000002126. PMID: 37727934
Evidence-based Tumor Staging of Skeletal Chondrosarcoma.
Compton ML, Cates JMM
Am J Surg Pathol 2020 Jan;44(1):111-119. doi: 10.1097/PAS.0000000000001397. PMID: 31651521
H3K27me3 and VEGF is associated with poor prognosis in patients with synovial sarcoma.
Diao Y, Zhang P, Dai R, Xu J, Feng H
Pathol Res Pract 2018 Jul;214(7):974-977. Epub 2018 May 20 doi: 10.1016/j.prp.2018.05.015. PMID: 29803658
A prognostic model for resectable soft tissue and cutaneous angiosarcoma.
Sinnamon AJ, Neuwirth MG, McMillan MT, Ecker BL, Bartlett EK, Zhang PJ, Kelz RR, Fraker DL, Roses RE, Karakousis GC
J Surg Oncol 2016 Oct;114(5):557-563. Epub 2016 Jul 4 doi: 10.1002/jso.24352. PMID: 27378102
Soft tissue sarcomas.
Cormier JN, Pollock RE
CA Cancer J Clin 2004 Mar-Apr;54(2):94-109. doi: 10.3322/canjclin.54.2.94. PMID: 15061599

Clinical prediction guides

Development and validation of a nomogram for predicting prognosis of high-grade chondrosarcoma: A surveillance, epidemiology, and end results-based population analysis.
Sun Y, Ouyang C, Zhang Y, Li Y, Liu Y, Jiang M, Nong L, Gao G
J Orthop Surg (Hong Kong) 2023 May-Aug;31(2):10225536231174255. doi: 10.1177/10225536231174255. PMID: 37147017
Multivariate evaluation of prognostic markers in synovial sarcoma.
Larque AB, Lozano-Calderon S, Cote GM, Chen YL, Hung YP, Deshpande V, Nielsen GP, Chebib I
J Clin Pathol 2023 Dec 14;77(1):16-21. doi: 10.1136/jcp-2022-208518. PMID: 36288948
A Proposed Staging System for Improved Prognostication of MDM2-amplified Liposarcoma.
Tucci JJ, Dashti NK, Cates JMM
Am J Surg Pathol 2021 Jan;45(1):101-107. doi: 10.1097/PAS.0000000000001554. PMID: 32796171
Evidence-based Tumor Staging of Skeletal Chondrosarcoma.
Compton ML, Cates JMM
Am J Surg Pathol 2020 Jan;44(1):111-119. doi: 10.1097/PAS.0000000000001397. PMID: 31651521
Comparison of the AJCC, MSTS, and Modified Spanier Systems for Clinical and Pathologic Staging of Osteosarcoma.
Cates JM
Am J Surg Pathol 2017 Mar;41(3):405-413. doi: 10.1097/PAS.0000000000000774. PMID: 28195881

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