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Bladder clear cell adenocarcinoma

MedGen UID:
272370
•Concept ID:
C1332557
•
Neoplastic Process
Synonyms: Bladder Clear Cell Adenocarcinoma; bladder clear cell adenocarcinoma; bladder mesonephric adenocarcinoma; Clear Cell Adenocarcinoma of Bladder; clear cell adenocarcinoma of bladder; Clear Cell Adenocarcinoma of the Bladder; clear cell adenocarcinoma of the bladder; Clear Cell Adenocarcinoma of the Urinary Bladder; clear cell adenocarcinoma of the urinary bladder; Clear Cell Adenocarcinoma of Urinary Bladder; clear cell adenocarcinoma of urinary bladder; Urinary Bladder Clear Cell Adenocarcinoma; urinary bladder clear cell adenocarcinoma
 
Monarch Initiative: MONDO:0003386

Definition

A bladder adenocarcinoma characterized by the presence of malignant glandular epithelial cells and clear cells distributed in a tubulo-cystic, papillary, or diffuse pattern. There is a female predilection. Clinical presentation includes hematuria and dysuria. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBladder clear cell adenocarcinoma

Professional guidelines

PubMed

APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
Clinical outcomes and patterns of population-based management of urachal carcinoma of the bladder: An analysis of the National Cancer Database.
Dursun F, Lim K, Svatek RS, Xu J, El-Zaatari ZM, Wenker EP, Klaassen ZW, Mansour AM, Muhammad T, Efstathiou E, Sonpavde GP, Wallis CJD, Satkunasivam R
Cancer Med 2022 Nov;11(22):4273-4282. Epub 2022 May 4 doi: 10.1002/cam4.4786. PMID: 35509235Free PMC Article
Should histologic variants alter definitive treatment of bladder cancer?
Willis DL, Porten SP, Kamat AM
Curr Opin Urol 2013 Sep;23(5):435-43. doi: 10.1097/MOU.0b013e328363e415. PMID: 23880739

Recent clinical studies

Etiology

Comprehensive Bioinformatic Investigation of TP53 Dysregulation in Diverse Cancer Landscapes.
Khan R, Pari B, Puszynski K
Genes (Basel) 2024 Apr 30;15(5) doi: 10.3390/genes15050577. PMID: 38790205Free PMC Article
The regulatory role of LncRNA HCG18 in various cancers.
Du Z, Wang B, Tan F, Wu Y, Chen J, Zhao F, Liu M, Zhou G, Yuan C
J Mol Med (Berl) 2023 Apr;101(4):351-360. Epub 2023 Mar 6 doi: 10.1007/s00109-023-02297-5. PMID: 36872315
The germline mutational landscape of genitourinary cancers and its indication for prognosis and risk.
Yang Y, Zhang G, Hu C, Luo W, Jiang H, Liu S, Yang H
BMC Urol 2022 Nov 30;22(1):196. doi: 10.1186/s12894-022-01141-1. PMID: 36451132Free PMC Article
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
What Is the Significance of Variant Histology in Urothelial Carcinoma?
Lobo N, Shariat SF, Guo CC, Fernandez MI, Kassouf W, Choudhury A, Gao J, Williams SB, Galsky MD, Taylor JA 3rd, Roupret M, Kamat AM
Eur Urol Focus 2020 Jul 15;6(4):653-663. Epub 2019 Sep 15 doi: 10.1016/j.euf.2019.09.003. PMID: 31530497

Diagnosis

APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
The regulatory role of LncRNA HCG18 in various cancers.
Du Z, Wang B, Tan F, Wu Y, Chen J, Zhao F, Liu M, Zhou G, Yuan C
J Mol Med (Berl) 2023 Apr;101(4):351-360. Epub 2023 Mar 6 doi: 10.1007/s00109-023-02297-5. PMID: 36872315
Non-urothelial and urothelial variants of bladder cancer.
Yu EM, Belay S, Li W, Aragon-Ching JB
Cancer Treat Res Commun 2022;33:100661. Epub 2022 Nov 20 doi: 10.1016/j.ctarc.2022.100661. PMID: 36442362
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
What Is the Significance of Variant Histology in Urothelial Carcinoma?
Lobo N, Shariat SF, Guo CC, Fernandez MI, Kassouf W, Choudhury A, Gao J, Williams SB, Galsky MD, Taylor JA 3rd, Roupret M, Kamat AM
Eur Urol Focus 2020 Jul 15;6(4):653-663. Epub 2019 Sep 15 doi: 10.1016/j.euf.2019.09.003. PMID: 31530497

Therapy

Final Results From a Phase I Trial and Expansion Cohorts of Cabozantinib and Nivolumab Alone or With Ipilimumab for Advanced/Metastatic Genitourinary Tumors.
Apolo AB, Girardi DM, Niglio SA, Nadal R, Kydd AR, Simon N, Ley L, Cordes LM, Chandran E, Steinberg SM, Lee S, Lee MJ, Rastogi S, Sato N, Cao L, Banday AR, Boudjadi S, Merino MJ, Toubaji A, Akbulut D, Redd B, Bagheri H, Costello R, Gurram S, Agarwal PK, Chalfin HJ, Valera V, Streicher H, Wright JJ, Sharon E, Figg WD, Parnes HL, Gulley JL, Saraiya B, Pal SK, Quinn D, Stein MN, Lara PN, Bottaro DP, Mortazavi A
J Clin Oncol 2024 Sep 1;42(25):3033-3046. Epub 2024 Jul 2 doi: 10.1200/JCO.23.02233. PMID: 38954785Free PMC Article
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Clear Cell Conundrum.
Schroeder SR, Albuquerque K
Int J Radiat Oncol Biol Phys 2019 Nov 15;105(4):690-691. doi: 10.1016/j.ijrobp.2018.02.167. PMID: 31655652
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Diethylstilboestrol and diethylstilboestrol dipropionate.
IARC Monogr Eval Carcinog Risk Chem Hum 1979 Dec;21:173-231. PMID: 397181

Prognosis

Pan-cancer analysis of G6PD carcinogenesis in human tumors.
Liu B, Fu X, Du Y, Feng Z, Chen R, Liu X, Yu F, Zhou G, Ba Y
Carcinogenesis 2023 Aug 18;44(6):525-534. doi: 10.1093/carcin/bgad043. PMID: 37335542
The germline mutational landscape of genitourinary cancers and its indication for prognosis and risk.
Yang Y, Zhang G, Hu C, Luo W, Jiang H, Liu S, Yang H
BMC Urol 2022 Nov 30;22(1):196. doi: 10.1186/s12894-022-01141-1. PMID: 36451132Free PMC Article
Bioinformatics analysis of prognostic value and immunological role of MeCP2 in pan-cancer.
Wang Y, Zhang Y, Wang F, Li T, Song X, Shi H, Du J, Zhang H, Jing H, Han J, Tong D, Zhang J
Sci Rep 2022 Nov 2;12(1):18518. doi: 10.1038/s41598-022-21328-8. PMID: 36323715Free PMC Article
What Is the Significance of Variant Histology in Urothelial Carcinoma?
Lobo N, Shariat SF, Guo CC, Fernandez MI, Kassouf W, Choudhury A, Gao J, Williams SB, Galsky MD, Taylor JA 3rd, Roupret M, Kamat AM
Eur Urol Focus 2020 Jul 15;6(4):653-663. Epub 2019 Sep 15 doi: 10.1016/j.euf.2019.09.003. PMID: 31530497
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article

Clinical prediction guides

APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
The BRCAness Landscape of Cancer.
Guo M, Wang SM
Cells 2022 Dec 1;11(23) doi: 10.3390/cells11233877. PMID: 36497135Free PMC Article
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Clear cell carcinoma of the urinary bladder: a systematic review.
Chan EO, Chan VW, Poon JY, Chan BH, Yu CP, Chiu PK, Ng CF, Teoh JY
Int Urol Nephrol 2021 May;53(5):815-824. Epub 2021 Jan 18 doi: 10.1007/s11255-020-02725-2. PMID: 33462714
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article

Recent systematic reviews

Clear cell carcinoma of the stomach: a rare tumor variant imparting poor prognosis.
Virgilio E, Rampioni GL, Lombardi M, Balducci G, Pilozzi E, Cavallini M
Acta Chir Belg 2023 Feb;123(1):65-67. Epub 2021 Mar 18 doi: 10.1080/00015458.2021.1900520. PMID: 33710937
Clear cell carcinoma of the urinary bladder: a systematic review.
Chan EO, Chan VW, Poon JY, Chan BH, Yu CP, Chiu PK, Ng CF, Teoh JY
Int Urol Nephrol 2021 May;53(5):815-824. Epub 2021 Jan 18 doi: 10.1007/s11255-020-02725-2. PMID: 33462714
Phenotypical and potential functional characteristics of different immune cells expressing CD28H/B7-H5 and their relationship with cancer prognosis.
Zhong C, Lang Q, Yu J, Wu S, Xu F, Tian Y
Clin Exp Immunol 2020 Apr;200(1):12-21. Epub 2020 Feb 4 doi: 10.1111/cei.13413. PMID: 31901178Free PMC Article
Clear cell urothelial carcinoma of the urinary bladder - a rare pathological entity. A case report and a systematic review of the literature.
Mihai I, Taban S, Cumpanas A, Olteanu EG, Iacob M, Dema A
Bosn J Basic Med Sci 2019 Nov 8;19(4):400-403. doi: 10.17305/bjbms.2019.4182. PMID: 30957722Free PMC Article

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