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Bladder papillary clear cell adenocarcinoma

MedGen UID:
307286
•Concept ID:
C1511196
•
Neoplastic Process
Synonyms: Bladder Papillary Clear Cell Adenocarcinoma; bladder papillary clear cell adenocarcinoma
 
Monarch Initiative: MONDO:0004445

Definition

A rare morphologic variant of bladder adenocarcinoma characterized by the presence of malignant glandular epithelial cells and clear cells forming a papillary pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBladder papillary clear cell adenocarcinoma

Recent clinical studies

Etiology

The regulatory role of LncRNA HCG18 in various cancers.
Du Z, Wang B, Tan F, Wu Y, Chen J, Zhao F, Liu M, Zhou G, Yuan C
J Mol Med (Berl) 2023 Apr;101(4):351-360. Epub 2023 Mar 6 doi: 10.1007/s00109-023-02297-5. PMID: 36872315
The germline mutational landscape of genitourinary cancers and its indication for prognosis and risk.
Yang Y, Zhang G, Hu C, Luo W, Jiang H, Liu S, Yang H
BMC Urol 2022 Nov 30;22(1):196. doi: 10.1186/s12894-022-01141-1. PMID: 36451132Free PMC Article
GATA3 expression in clear cell adenocarcinoma of the lower urinary tract: a potential diagnostic pitfall.
Akgul M, Humble R, Osme A, Yuce S, Kocak EN, Najafzadeh P, Sangoi A, Pattnaik N, Mishra S, Sharma S, Shaker N, Kaushal S, Baisakh M, Lightle AR, Balzer BL, Xiao GQ, MacLennan GT, Osunkoya AO, Parwani A, Cheng L, Bellizzi A, Mohanty SK
Diagn Pathol 2022 Nov 1;17(1):87. doi: 10.1186/s13000-022-01269-6. PMID: 36320040Free PMC Article
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
The panoramic picture of pepsinogen gene family with pan-cancer.
Shen S, Li H, Liu J, Sun L, Yuan Y
Cancer Med 2020 Dec;9(23):9064-9080. Epub 2020 Oct 17 doi: 10.1002/cam4.3489. PMID: 33067881Free PMC Article

Diagnosis

GATA3 expression in clear cell adenocarcinoma of the lower urinary tract: a potential diagnostic pitfall.
Akgul M, Humble R, Osme A, Yuce S, Kocak EN, Najafzadeh P, Sangoi A, Pattnaik N, Mishra S, Sharma S, Shaker N, Kaushal S, Baisakh M, Lightle AR, Balzer BL, Xiao GQ, MacLennan GT, Osunkoya AO, Parwani A, Cheng L, Bellizzi A, Mohanty SK
Diagn Pathol 2022 Nov 1;17(1):87. doi: 10.1186/s13000-022-01269-6. PMID: 36320040Free PMC Article
Nephrogenic Adenoma Intermixed With Urothelial Carcinoma.
Kryvenko ON, Wasco MJ, Williamson SR
Arch Pathol Lab Med 2022 May 1;147(5):552-558. doi: 10.5858/arpa.2021-0620-OA. PMID: 35976666
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Pseudoneoplastic mimics of prostate and bladder carcinomas.
Hameed O, Humphrey PA
Arch Pathol Lab Med 2010 Mar;134(3):427-43. doi: 10.5858/134.3.427. PMID: 20196670
Clear cell neoplasms of the urinary tract and male reproductive system.
Humphrey PA
Semin Diagn Pathol 1997 Nov;14(4):240-52. PMID: 9383824

Therapy

Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Advanced clear-cell adenocarcinoma of the bladder successfully treated by radical surgery with adjuvant chemoradiotherapy.
Kurosaka S, Irie A, Mizoguchi H, Okuno N, Iwabuchi K, Baba S
Int J Clin Oncol 2005 Oct;10(5):362-5. doi: 10.1007/s10147-005-0497-6. PMID: 16247666
Tubulocystic clear cell adenocarcinoma arising within the prostate.
Pan CC, Chiang H, Chang YH, Epstein JI
Am J Surg Pathol 2000 Oct;24(10):1433-6. doi: 10.1097/00000478-200010000-00016. PMID: 11023108

Prognosis

The germline mutational landscape of genitourinary cancers and its indication for prognosis and risk.
Yang Y, Zhang G, Hu C, Luo W, Jiang H, Liu S, Yang H
BMC Urol 2022 Nov 30;22(1):196. doi: 10.1186/s12894-022-01141-1. PMID: 36451132Free PMC Article
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
The panoramic picture of pepsinogen gene family with pan-cancer.
Shen S, Li H, Liu J, Sun L, Yuan Y
Cancer Med 2020 Dec;9(23):9064-9080. Epub 2020 Oct 17 doi: 10.1002/cam4.3489. PMID: 33067881Free PMC Article
Advancing Pan-cancer Gene Expression Survial Analysis by Inclusion of Non-coding RNA.
Ye B, Shi J, Kang H, Oyebamiji O, Hill D, Yu H, Ness S, Ye F, Ping J, He J, Edwards J, Zhao YY, Guo Y
RNA Biol 2020 Nov;17(11):1666-1673. Epub 2019 Oct 18 doi: 10.1080/15476286.2019.1679585. PMID: 31607216Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article

Clinical prediction guides

The BRCAness Landscape of Cancer.
Guo M, Wang SM
Cells 2022 Dec 1;11(23) doi: 10.3390/cells11233877. PMID: 36497135Free PMC Article
GATA3 expression in clear cell adenocarcinoma of the lower urinary tract: a potential diagnostic pitfall.
Akgul M, Humble R, Osme A, Yuce S, Kocak EN, Najafzadeh P, Sangoi A, Pattnaik N, Mishra S, Sharma S, Shaker N, Kaushal S, Baisakh M, Lightle AR, Balzer BL, Xiao GQ, MacLennan GT, Osunkoya AO, Parwani A, Cheng L, Bellizzi A, Mohanty SK
Diagn Pathol 2022 Nov 1;17(1):87. doi: 10.1186/s13000-022-01269-6. PMID: 36320040Free PMC Article
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Advancing Pan-cancer Gene Expression Survial Analysis by Inclusion of Non-coding RNA.
Ye B, Shi J, Kang H, Oyebamiji O, Hill D, Yu H, Ness S, Ye F, Ping J, He J, Edwards J, Zhao YY, Guo Y
RNA Biol 2020 Nov;17(11):1666-1673. Epub 2019 Oct 18 doi: 10.1080/15476286.2019.1679585. PMID: 31607216Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article

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