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Enterochromaffin-Like Cell Neuroendocrine Tumor G1

MedGen UID:
272572
•Concept ID:
C1333401
•
Neoplastic Process
Synonyms: ECL Cell NET G1; Enterochromaffin-Like Cell Carcinoid Tumor; Enterochromaffin-Like Cell NET G1; Enterochromaffin-Like Cell Neuroendocrine Tumor

Definition

A well differentiated, low grade neuroendocrine neoplasm (carcinoid tumor) arising from the gastrointestinal tract. It is characterized by the presence of enterochromaffin-like type granules in the neoplastic cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEnterochromaffin-Like Cell Neuroendocrine Tumor G1

Recent clinical studies

Etiology

Gastric neuroendocrine neoplasms and precursor lesions: Case reports and literature review.
Boeriu A, Dobru D, Fofiu C, Brusnic O, Onişor D, Mocan S
Medicine (Baltimore) 2022 Jan 14;101(2):e28550. doi: 10.1097/MD.0000000000028550. PMID: 35029217Free PMC Article
The NETest liquid biopsy is diagnostic for gastric neuroendocrine tumors: observations on the blood-based identification of microscopic and macroscopic residual diseaseOK.
Malczewska A, Procner A, Walter A, Kusnierz K, Zajecki W, Aslanian H, Kos-Kudla B
BMC Gastroenterol 2020 Jul 23;20(1):235. doi: 10.1186/s12876-020-01348-2. PMID: 32703157Free PMC Article

Diagnosis

Gastric neuroendocrine neoplasms and precursor lesions: Case reports and literature review.
Boeriu A, Dobru D, Fofiu C, Brusnic O, Onişor D, Mocan S
Medicine (Baltimore) 2022 Jan 14;101(2):e28550. doi: 10.1097/MD.0000000000028550. PMID: 35029217Free PMC Article
The NETest liquid biopsy is diagnostic for gastric neuroendocrine tumors: observations on the blood-based identification of microscopic and macroscopic residual diseaseOK.
Malczewska A, Procner A, Walter A, Kusnierz K, Zajecki W, Aslanian H, Kos-Kudla B
BMC Gastroenterol 2020 Jul 23;20(1):235. doi: 10.1186/s12876-020-01348-2. PMID: 32703157Free PMC Article
ECL-cell carcinoids and carcinoma in patients homozygous for an inactivating mutation in the gastric H(+) K(+) ATPase alpha subunit.
Fossmark R, Calvete O, Mjønes P, Benitez J, Waldum HL
APMIS 2016 Jul;124(7):561-6. Epub 2016 May 6 doi: 10.1111/apm.12546. PMID: 27150581
Histologic characterization and improved prognostic evaluation of 209 gastric neuroendocrine neoplasms.
La Rosa S, Inzani F, Vanoli A, Klersy C, Dainese L, Rindi G, Capella C, Bordi C, Solcia E
Hum Pathol 2011 Oct;42(10):1373-84. Epub 2011 May 4 doi: 10.1016/j.humpath.2011.01.018. PMID: 21531442

Therapy

A case of enterochromaffin-like cell neuroendocrine tumor associated with parietal cell dysfunction which was successfully treated with somatostatin analogue.
Hirai R, Haruma K, Okada H, Itakura J, Mizuno M
Clin J Gastroenterol 2022 Apr;15(2):363-367. Epub 2022 Jan 4 doi: 10.1007/s12328-021-01581-6. PMID: 34982362

Prognosis

Gastric neuroendocrine neoplasms and precursor lesions: Case reports and literature review.
Boeriu A, Dobru D, Fofiu C, Brusnic O, Onişor D, Mocan S
Medicine (Baltimore) 2022 Jan 14;101(2):e28550. doi: 10.1097/MD.0000000000028550. PMID: 35029217Free PMC Article
Histologic characterization and improved prognostic evaluation of 209 gastric neuroendocrine neoplasms.
La Rosa S, Inzani F, Vanoli A, Klersy C, Dainese L, Rindi G, Capella C, Bordi C, Solcia E
Hum Pathol 2011 Oct;42(10):1373-84. Epub 2011 May 4 doi: 10.1016/j.humpath.2011.01.018. PMID: 21531442

Clinical prediction guides

The NETest liquid biopsy is diagnostic for gastric neuroendocrine tumors: observations on the blood-based identification of microscopic and macroscopic residual diseaseOK.
Malczewska A, Procner A, Walter A, Kusnierz K, Zajecki W, Aslanian H, Kos-Kudla B
BMC Gastroenterol 2020 Jul 23;20(1):235. doi: 10.1186/s12876-020-01348-2. PMID: 32703157Free PMC Article
Histologic characterization and improved prognostic evaluation of 209 gastric neuroendocrine neoplasms.
La Rosa S, Inzani F, Vanoli A, Klersy C, Dainese L, Rindi G, Capella C, Bordi C, Solcia E
Hum Pathol 2011 Oct;42(10):1373-84. Epub 2011 May 4 doi: 10.1016/j.humpath.2011.01.018. PMID: 21531442

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