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Esophageal squamous papilloma

MedGen UID:
272592
•Concept ID:
C1333467
•
Neoplastic Process
Synonyms: Esophageal Squamous Cell Papilloma; Esophageal Squamous Papilloma; esophageal squamous papilloma; Esophagus Squamous Cell Papilloma; esophagus squamous cell papilloma; esophagus squamous papilloma; oesophagus squamous papilloma; Squamous cell papilloma of esophagus; Squamous Cell Papilloma of Esophagus; squamous cell papilloma of esophagus; squamous cell papilloma of oesophagus; Squamous Cell Papilloma of the Esophagus; squamous cell papilloma of the esophagus; squamous cell papilloma of the oesophagus
SNOMED CT: Squamous cell papilloma of esophagus (1197270001)
 
HPO: HP:0031463
Monarch Initiative: MONDO:0004827

Definition

A rare benign epithelial tumor that is usually asymptomatic but can present with pyrosis and epigastric discomfort with or without dysphagia. Histopathologically, esophageal squamous papilloma has fingerlike projections lined with acanthotic stratified squamous epithelium with conservation of normal cellular with or without cellular atypia. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal squamous papilloma

Professional guidelines

PubMed

Differential diagnosis for esophageal protruded lesions using a deep convolution neural network in endoscopic images.
Zhang M, Zhu C, Wang Y, Kong Z, Hua Y, Zhang W, Si X, Ye B, Xu X, Li L, Heng D, Liu B, Tian S, Wu J, Dang Y, Zhang G
Gastrointest Endosc 2021 Jun;93(6):1261-1272.e2. Epub 2020 Oct 13 doi: 10.1016/j.gie.2020.10.005. PMID: 33065026
Infections of the esophagus: an update on risk factors, diagnosis, and management.
Hoversten P, Kamboj AK, Katzka DA
Dis Esophagus 2018 Dec 1;31(12) doi: 10.1093/dote/doy094. PMID: 30295751
Dissecting GI phenotype-genotype relationships in GERD and dyspepsia: an SNP here and an SNP there!
Jankowski JA, Talley NJ
Am J Gastroenterol 2009 Feb;104(2):286-8. Epub 2009 Jan 20 doi: 10.1038/ajg.2008.129. PMID: 19174788Free PMC Article

Recent clinical studies

Etiology

Gastroenterology healthcare in LGBTQ+ individuals.
Coelho R, Gonçalves R, Mendes F, Macedo G
Eur J Gastroenterol Hepatol 2024 Sep 1;36(9):1059-1067. Epub 2024 Jun 17 doi: 10.1097/MEG.0000000000002808. PMID: 38916210
Esophageal Squamous Papilloma in Children: A Single-center Case Series.
Tou AM, Al-Nimr AO
J Pediatr Gastroenterol Nutr 2021 May 1;72(5):690-692. doi: 10.1097/MPG.0000000000003066. PMID: 33847287
Tentacular-Type Esophageal Squamous Papilloma.
Zimmer V
Mayo Clin Proc 2019 Aug;94(8):1551. doi: 10.1016/j.mayocp.2019.03.025. PMID: 31378230
Using typical endoscopic features to diagnose esophageal squamous papilloma.
Wong MW, Bair MJ, Shih SC, Chu CH, Wang HY, Wang TE, Chang CW, Chen MJ
World J Gastroenterol 2016 Feb 21;22(7):2349-56. doi: 10.3748/wjg.v22.i7.2349. PMID: 26900297Free PMC Article
Squamous papilloma of the esophagus: report of six cases with long-term follow-up in four patients.
Fernández-Rodríguez CM, Badia-Figuerola N, Ruiz del Arbol L, Fernández-Seara J, Dominguez F, Avilés-Ruiz JF
Am J Gastroenterol 1986 Nov;81(11):1059-62. PMID: 3776954

Diagnosis

Gastroenterology healthcare in LGBTQ+ individuals.
Coelho R, Gonçalves R, Mendes F, Macedo G
Eur J Gastroenterol Hepatol 2024 Sep 1;36(9):1059-1067. Epub 2024 Jun 17 doi: 10.1097/MEG.0000000000002808. PMID: 38916210
Esophageal Squamous Papilloma: An Exceptional Lesion in Children.
González Jiménez D, Pérez Corte D, Pérez Solís D, Corrales Canel MB
Indian J Pediatr 2022 Feb;89(2):198-199. Epub 2021 Jan 30 doi: 10.1007/s12098-020-03652-x. PMID: 33515183
Tentacular-Type Esophageal Squamous Papilloma.
Zimmer V
Mayo Clin Proc 2019 Aug;94(8):1551. doi: 10.1016/j.mayocp.2019.03.025. PMID: 31378230
Esophageal squamous papilloma.
Abeid M, Labib S, Neizamy E
Gastrointest Endosc 2011 May;73(5):1035. Epub 2011 Mar 11 doi: 10.1016/j.gie.2010.11.017. PMID: 21396641
Squamous papilloma of the esophagus: report of six cases with long-term follow-up in four patients.
Fernández-Rodríguez CM, Badia-Figuerola N, Ruiz del Arbol L, Fernández-Seara J, Dominguez F, Avilés-Ruiz JF
Am J Gastroenterol 1986 Nov;81(11):1059-62. PMID: 3776954

Therapy

A rapidly regressive esophageal squamous papilloma.
Khan AT, Dhorajiya P, Lung E
Gastrointest Endosc 2019 Oct;90(4):684-685. Epub 2019 May 15 doi: 10.1016/j.gie.2019.05.015. PMID: 31102642
Induction of esophageal cancers by nitenpyram (NIT) in rats.
Xing LG, Wu YL, Zheng HN, Jia YY, Wu GF, Yang C
Eur Rev Med Pharmacol Sci 2018 Dec;22(24):8698-8711. doi: 10.26355/eurrev_201812_16635. PMID: 30575910
A case report: Does the ulcer belong to esophageal carcinoma or HIV?
Jia N, Tang Y, Li Y, Gan Y
Medicine (Baltimore) 2017 Dec;96(49):e9137. doi: 10.1097/MD.0000000000009137. PMID: 29245356Free PMC Article
Human papillomavirus type 16-positive esophageal papilloma at an endoscopic injection sclerotherapy site.
Yamada Y, Ninomiya M, Kato T, Nagaki M, Kato M, Hatakeyama H, Moriwaki H, Muto Y
Gastroenterology 1995 Feb;108(2):550-3. doi: 10.1016/0016-5085(95)90085-3. PMID: 7835598

Prognosis

Tentacular-Type Esophageal Squamous Papilloma.
Zimmer V
Mayo Clin Proc 2019 Aug;94(8):1551. doi: 10.1016/j.mayocp.2019.03.025. PMID: 31378230
Induction of esophageal cancers by nitenpyram (NIT) in rats.
Xing LG, Wu YL, Zheng HN, Jia YY, Wu GF, Yang C
Eur Rev Med Pharmacol Sci 2018 Dec;22(24):8698-8711. doi: 10.26355/eurrev_201812_16635. PMID: 30575910
A case report: Does the ulcer belong to esophageal carcinoma or HIV?
Jia N, Tang Y, Li Y, Gan Y
Medicine (Baltimore) 2017 Dec;96(49):e9137. doi: 10.1097/MD.0000000000009137. PMID: 29245356Free PMC Article
Using typical endoscopic features to diagnose esophageal squamous papilloma.
Wong MW, Bair MJ, Shih SC, Chu CH, Wang HY, Wang TE, Chang CW, Chen MJ
World J Gastroenterol 2016 Feb 21;22(7):2349-56. doi: 10.3748/wjg.v22.i7.2349. PMID: 26900297Free PMC Article
Squamous papilloma of the esophagus: report of six cases with long-term follow-up in four patients.
Fernández-Rodríguez CM, Badia-Figuerola N, Ruiz del Arbol L, Fernández-Seara J, Dominguez F, Avilés-Ruiz JF
Am J Gastroenterol 1986 Nov;81(11):1059-62. PMID: 3776954

Clinical prediction guides

Induction of esophageal cancers by nitenpyram (NIT) in rats.
Xing LG, Wu YL, Zheng HN, Jia YY, Wu GF, Yang C
Eur Rev Med Pharmacol Sci 2018 Dec;22(24):8698-8711. doi: 10.26355/eurrev_201812_16635. PMID: 30575910
Using typical endoscopic features to diagnose esophageal squamous papilloma.
Wong MW, Bair MJ, Shih SC, Chu CH, Wang HY, Wang TE, Chang CW, Chen MJ
World J Gastroenterol 2016 Feb 21;22(7):2349-56. doi: 10.3748/wjg.v22.i7.2349. PMID: 26900297Free PMC Article

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